{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:48:05Z","timestamp":1791499685110,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH068437"],"award-info":[{"award-number":["MH068437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS36867"],"award-info":[{"award-number":["NS36867"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.nbd.2005.03.012","type":"journal-article","created":{"date-parts":[[2005,4,24]],"date-time":"2005-04-24T07:16:06Z","timestamp":1114326966000},"page":"314-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice"],"prefix":"10.1016","volume":"20","author":[{"given":"Tuhin","family":"Virmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveena","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ege T.","family":"Kavalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2005.03.012_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cne.10492","article-title":"Palmitoyl protein thioesterase 1 is targeted to the axons in neurons","volume":"455","author":"Ahtiainen","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2005.03.012_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0896-6273(03)00718-9","article-title":"Role of beta-catenin in synaptic vesicle localization and presynaptic assembly","volume":"40","author":"Bamji","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2005.03.012_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0959-4388(96)80121-8","article-title":"Imaging exocytosis and endocytosis","volume":"6","author":"Betz","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2005.03.012_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.nbd.2004.02.010","article-title":"Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis","volume":"16","author":"Bible","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2005.03.012_bib5","doi-asserted-by":"crossref","first-page":"37957","DOI":"10.1074\/jbc.M301225200","article-title":"The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2","volume":"278","author":"Calero","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2005.03.012_bib6","doi-asserted-by":"crossref","first-page":"22566","DOI":"10.1016\/S0021-9258(18)41567-0","article-title":"Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras","volume":"268","author":"Camp","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2005.03.012_bib7","doi-asserted-by":"crossref","first-page":"23212","DOI":"10.1016\/S0021-9258(17)31641-1","article-title":"Molecular cloning and expression of palmitoyl-protein thioesterase","volume":"269","author":"Camp","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2005.03.012_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/neu.20022","article-title":"Age-associated synapse elimination in mouse parasympathetic ganglia","volume":"60","author":"Coggan","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.nbd.2005.03.012_bib9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1126\/science.275.5298.356","article-title":"Alterations in synaptic strength preceding axon withdrawal","volume":"275","author":"Colman","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2005.03.012_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0167-4889(03)00094-6","article-title":"Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins","volume":"1641","author":"Dietrich","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2005.03.012_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.emboj.7600015","article-title":"The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion","volume":"23","author":"Dietrich","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2005.03.012_bib12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrn940","article-title":"Protein palmitoylation: a regulator of neuronal development and function","volume":"3","author":"el-Husseini","year":"2002","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.nbd.2005.03.012_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0896-6273(04)00190-4","article-title":"The synaptic vesicle protein CSP alpha prevents presynaptic degeneration","volume":"42","author":"Fernandez-Chacon","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2005.03.012_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/jmg.2003.013680","article-title":"Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy","volume":"41","author":"Garcia","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2005.03.012_bib15","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1091\/mbc.e03-07-0493","article-title":"Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs","volume":"15","author":"Gauthier-Campbell","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2005.03.012_bib16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1023\/B:NEUR.0000020629.51673.f5","article-title":"The relationship of neuromuscular synapse elimination to synaptic degeneration and pathology: insights from WldS and other mutant mice","volume":"32","author":"Gillingwater","year":"2003","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.nbd.2005.03.012_bib17","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1073\/pnas.251485198","article-title":"Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice","volume":"98","author":"Gupta","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2005.03.012_bib18","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1073\/pnas.2033229100","article-title":"Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features","volume":"100","author":"Gupta","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2005.03.012_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00697751","article-title":"Infantile type of so-called neuronal ceroid lipofuscinosis: Part II. Histological and electron microscopic studies","volume":"26","author":"Haltia","year":"1973","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2005.03.012_bib20","doi-asserted-by":"crossref","first-page":"12748","DOI":"10.1073\/pnas.171442798","article-title":"Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1\u201343 photoconversion","volume":"98","author":"Harata","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2005.03.012_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/mgme.2000.2961","article-title":"Expression of palmitoyl protein thioesterase in neurons","volume":"69","author":"Heinonen","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.nbd.2005.03.012_bib22","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1002\/j.1460-2075.1996.tb00909.x","article-title":"Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis","volume":"15","author":"Hellsten","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2005.03.012_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.cellbio.16.1.483","article-title":"Dynamin and its role in membrane fission","volume":"16","author":"Hinshaw","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2005.03.012_bib24","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3877","article-title":"The neuronal ceroid lipofuscinoses","author":"Hofmann","year":"2001"},{"key":"10.1016\/j.nbd.2005.03.012_bib25","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1046\/j.0014-2956.2001.02530.x","article-title":"Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)","volume":"268","author":"Holopainen","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.nbd.2005.03.012_bib26","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1242\/jcs.01030","article-title":"Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters","volume":"117","author":"Kanaani","year":"2004","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.nbd.2005.03.012_bib27","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1073\/pnas.96.22.12893","article-title":"Activity-dependent regulation of synaptic clustering in a hippocampal culture system","volume":"96","author":"Kavalali","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2005.03.012_bib28","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1523\/JNEUROSCI.1037-04.2004","article-title":"The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ","volume":"24","author":"Keller","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2005.03.012_bib29","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.1523\/JNEUROSCI.20-23-08771.2000","article-title":"Disparity in neurotransmitter release probability among competing inputs during neuromuscular synapse elimination","volume":"20","author":"Kopp","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2005.03.012_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/10.1.69","article-title":"Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)","volume":"10","author":"Lehtovirta","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2005.03.012_bib31","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1073\/pnas.93.19.10046","article-title":"Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase","volume":"93","author":"Lu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2005.03.012_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1388-1981(02)00158-0","article-title":"The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function","volume":"1583","author":"Lu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2005.03.012_bib33","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1523\/JNEUROSCI.22-03-00654.2002","article-title":"Development of vesicle pools during maturation of hippocampal synapses","volume":"22","author":"Mozhayeva","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2005.03.012_bib34","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1128\/MCB.21.11.3775-3788.2001","article-title":"Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster","volume":"21","author":"Nakano","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2005.03.012_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4067\/S0716-97602002000200005","article-title":"Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons","volume":"35","author":"Patterson","year":"2002","journal-title":"Biol. Res."},{"key":"10.1016\/j.nbd.2005.03.012_bib36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/375493a0","article-title":"Distinct pools of synaptic vesicles in neurotransmitter release","volume":"375","author":"Pieribone","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2005.03.012_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0092-8674(93)90487-B","article-title":"Short-term synaptic plasticity is altered in mice lacking synapsin I","volume":"75","author":"Rosahl","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2005.03.012_bib38","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0896-6273(00)80146-4","article-title":"Definition of the readily releasable pool of vesicles at hippocampal synapses","volume":"16","author":"Rosenmund","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2005.03.012_bib39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0896-6273(03)00667-6","article-title":"Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin","volume":"40","author":"Schuske","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2005.03.012_bib40","first-page":"3424","article-title":"Increased levels of glycoproteins containing mannose 6-phosphate in human breast carcinomas","volume":"55","author":"Sleat","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.nbd.2005.03.012_bib41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.biochem.73.011303.073954","article-title":"Palmitoylation of intracellular signaling proteins: regulation and function","volume":"73","author":"Smotrys","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.nbd.2005.03.012_bib42","doi-asserted-by":"crossref","first-page":"27456","DOI":"10.1074\/jbc.272.43.27456","article-title":"Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity","volume":"272","author":"Soyombo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2005.03.012_bib43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0896-6273(02)01014-0","article-title":"Unrestricted synaptic growth in spinster\u2014A late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation","volume":"36","author":"Sweeney","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2005.03.012_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.1103","article-title":"Adult neuronal ceroid lipofuscinosis with palmitoyl-protein thioesterase deficiency: first adult-onset patients of a childhood disease","volume":"50","author":"van Diggelen","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2005.03.012_bib45","doi-asserted-by":"crossref","first-page":"15831","DOI":"10.1074\/jbc.271.26.15831","article-title":"Lysosomal targeting of palmitoyl-protein thioesterase","volume":"271","author":"Verkruyse","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2005.03.012_bib46","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/376584a0","article-title":"Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis","volume":"376","author":"Vesa","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2005.03.012_bib47","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1023\/B:NEUR.0000020623.62043.33","article-title":"Activity-dependent elimination of neuromuscular synapses","volume":"32","author":"Wyatt","year":"2003","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.nbd.2005.03.012_bib48","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.conb.2004.05.013","article-title":"Presynaptic terminal differentiation: transport and assembly","volume":"14","author":"Zhen","year":"2004","journal-title":"Curr. Opin. Neurobiol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996105000768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996105000768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T22:48:46Z","timestamp":1756939726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996105000768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0969996105000768"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2005.03.012","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2005.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}