{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:39:06Z","timestamp":1771569546160,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.nbd.2006.07.008","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:52:19Z","timestamp":1157730739000},"page":"280-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington\u2019s disease"],"prefix":"10.1016","volume":"24","author":[{"given":"Shotaro","family":"Kishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Hakky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Warby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2006.07.008_bib1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1212\/01.wnl.0000175977.57661.b1","article-title":"Association between BDNF Val66Met polymorphism and age at onset in Huntington disease","volume":"65","author":"Alberch","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.07.008_bib2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00221-005-0233-5","article-title":"Chemical characterization of newly generated neurons in the striatum of adult primates","volume":"170","author":"Bedard","year":"2006","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2006.07.008_bib3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2005.09.022","article-title":"BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects","volume":"59","author":"Bueller","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(03)00436-1","article-title":"Modulation of age at onset in Huntington\u2019s disease and spinocerebellar ataxia type 2 patients originated from eastern India","volume":"345","author":"Chattopadhyay","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib5","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1523\/JNEUROSCI.0348-04.2004","article-title":"Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons","volume":"24","author":"Chen","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molbrainres.2005.07.008","article-title":"Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males","volume":"140","author":"Cheng","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2006.07.008_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neulet.2005.01.008","article-title":"Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer\u2019s disease (AD) and quantitative measures of AD progression","volume":"379","author":"Desai","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib36","unstructured":"Di Maria, E., Marasco, A., Tartari, M., Ciotti, P., Abbruzzese, G., Novelli, G., Bellone, E., Cattaneo, E., Mandich, P., in press. No evidence of association between BDNF gene variants and age at onset in Huntington's disease. Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2006.07.008_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ajmg.a.20190","article-title":"Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease","volume":"119","author":"Djouss\u00e9\u2019","year":"2003","journal-title":"Am. J. Med. Genet., A"},{"key":"10.1016\/j.nbd.2006.07.008_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2006.07.008_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2006.07.008_bib11","doi-asserted-by":"crossref","first-page":"0.109","DOI":"10.1038\/35039051","article-title":"Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease","volume":"1","author":"Gusella","year":"2000","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nrg706","article-title":"No post-genetics era in human disease research","volume":"3","author":"Gusella","year":"2002","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib37","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib38","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.mp.4001799","article-title":"The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills","volume":"11","author":"Harris","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/gepi.10295","article-title":"Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics","volume":"26","author":"Horvath","year":"2004","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.nbd.2006.07.008_bib15","article-title":"The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression","author":"Hwang","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2006.07.008_bib16","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1523\/JNEUROSCI.19-13-05409.1999","article-title":"Expression of the striatal DARPP-32\/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro","volume":"19","author":"Ivkovic","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib17","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1212\/01.wnl.0000187075.81589.fd","article-title":"BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD study","volume":"65","author":"Karamohamed","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.07.008_bib39","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nn1699","article-title":"BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex","volume":"9","author":"Kleim","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/sj.mp.4000792","article-title":"A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer\u2019s disease","volume":"6","author":"Kunugi","year":"2001","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1086\/378133","article-title":"A genome scan for modifiers of age at onset in Huntington disease: the HD MAPS study","volume":"73","author":"Li","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ajmg.b.30109","article-title":"Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson\u2019s disease","volume":"134B","author":"Liu","year":"2005","journal-title":"Am. J. Med. Genet., B Neuropsychiatr. Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajmg.b.30215","article-title":"Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder","volume":"139","author":"Lohoff","year":"2005","journal-title":"Am. J. Med. Genet., B Neuropsychiatr. Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib22","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1212\/WNL.53.6.1330","article-title":"Evidence for the GluR6 gene associated with younger onset age of Huntington\u2019s disease","volume":"53","author":"MacDonald","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.07.008_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10048-005-0023-z","article-title":"The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington\u2019s disease","volume":"7","author":"Metzger","year":"2006","journal-title":"Neurogenetics"},{"key":"10.1016\/j.nbd.2006.07.008_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0165-3806(96)83489-4","article-title":"Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro","volume":"90","author":"Nakao","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.nbd.2006.07.008_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(02)00231-8","article-title":"Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington\u2019s disease","volume":"328","author":"Naze","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2005.11.067","article-title":"The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology","volume":"397","author":"Nemoto","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/342288","article-title":"The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study","volume":"71","author":"Neves-Pereira","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.mp.4001575","article-title":"BDNF gene is a risk factor for schizophrenia in a Scottish population","volume":"10","author":"Neves-Pereira","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2006.02.054","article-title":"Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms","volume":"401","author":"Numata","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neulet.2005.02.017","article-title":"Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism","volume":"381","author":"Olin","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.07.008_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2006.051623","article-title":"The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus (SLE)","author":"Oroszi","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2006.07.008_bib13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1212\/01.wnl.0000204230.16619.d9","article-title":"The association of CAG repeat length with clinical progression in Huntington disease","volume":"66","author":"Rosenblatt","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.07.008_bib31","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1073\/pnas.94.8.3872","article-title":"Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease","volume":"94","author":"Rubinsztein","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2006.07.008_bib41","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.mp.4001685","article-title":"Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample","volume":"10","author":"Strauss","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.mp.4001656","article-title":"Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation","volume":"10","author":"Szeszko","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2006.07.008_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000090673","article-title":"The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population","volume":"21","author":"Tsai","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.nbd.2006.07.008_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1460-9568.1995.tb01057.x","article-title":"The neurotrophins BDNF, NT-3 and NT-4\/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro","volume":"7","author":"Ventimiglia","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2006.07.008_bib33","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington\u2019s disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2006.07.008_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ajmg.b.30332","article-title":"Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence","volume":"141","author":"Zhang","year":"2006","journal-title":"Am. J. Med. Genet. B Neuropyschiatr. Genet."},{"key":"10.1016\/j.nbd.2006.07.008_bib34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nbd.2006.07.008_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ng1219","article-title":"Huntingtin interacts with REST\/NRSF to modulate the transcription of NRSE-controlled neuronal genes","volume":"35","author":"Zuccato","year":"2003","journal-title":"Nat. Genet."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106001732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106001732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T04:59:39Z","timestamp":1760849979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996106001732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0969996106001732"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2006.07.008","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2006.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}