{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:34:19Z","timestamp":1790854459045,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.nbd.2006.08.011","type":"journal-article","created":{"date-parts":[[2006,9,30]],"date-time":"2006-09-30T11:24:12Z","timestamp":1159615452000},"page":"455-465","source":"Crossref","is-referenced-by-count":23,"title":["Oral uridine pro-drug PN401 is neuroprotective in the R6\/2 and N171-82Q mouse models of Huntington's disease"],"prefix":"10.1016","volume":"24","author":[{"given":"Joel A.","family":"Saydoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando A.G.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Brenneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Cardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid W.","family":"von Borstel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Burr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2006.08.011_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nbdi.2001.0406","article-title":"Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease","volume":"8","author":"Andreassen","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2006.08.011_bib2","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1097\/00001756-200110290-00044","article-title":"Lipoic acid improves survival in transgenic mouse models of Huntington's disease","volume":"12","author":"Andreassen","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.nbd.2006.08.011_bib3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2006.08.011_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/cvr\/17.3.145","article-title":"Effect of uridine supply on glycogen resynthesis after ischaemia in the isolated perfused rat heart","volume":"17","author":"Aussedat","year":"1983","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.nbd.2006.08.011_bib5","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","article-title":"Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib6","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1523\/JNEUROSCI.23-12-05149.2003","article-title":"Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways","volume":"23","author":"Barnabe-Heider","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00019052-199412000-00012","article-title":"Neurochemistry and toxin models in Huntington's disease","volume":"7","author":"Beal","year":"1994","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0005-2728(98)00114-5","article-title":"Mitochondrial dysfunction in neurodegenerative diseases","volume":"1366","author":"Beal","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2006.08.011_bib9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/ana.20624","article-title":"Mitochondria take center stage in aging and neurodegeneration","volume":"58","author":"Beal","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib10","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993","article-title":"Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid","volume":"13","author":"Beal","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease","volume":"79","author":"Bogdanov","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1023\/B:NERE.0000014824.04728.dd","article-title":"The energetics of Huntington's disease","volume":"29","author":"Browne","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2006.08.011_bib13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1471-4159.1998.71010281.x","article-title":"Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis","volume":"71","author":"Browne","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington's disease","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2006.08.011_bib16","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","article-title":"Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease","volume":"24","author":"Canals","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0165-6147(99)01298-5","article-title":"Uridine and its nucleotides: biological actions, therapeutic potentials","volume":"20","author":"Connolly","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2006.08.011_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1022642114734","article-title":"Mitochondrial dysfunction in neurodegeneration","volume":"29","author":"Cooper","year":"1997","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.nbd.2006.08.011_bib20","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1073\/pnas.0403649101","article-title":"Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication","volume":"101","author":"Coskun","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2006.08.011_bib21","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2006.08.011_bib22","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1073\/pnas.0536856100","article-title":"Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice","volume":"100","author":"Duan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2006.08.011_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1399-0004.1985.tb00185.x","article-title":"Diabetes mellitus in Huntington disease","volume":"27","author":"Farrer","year":"1985","journal-title":"Clin. Genet."},{"key":"10.1016\/j.nbd.2006.08.011_bib24","series-title":"Mitochondria and Free Radicals in Neurodegenerative Diseases","first-page":"229","article-title":"[10]Mitochondrial dysfunction as a model for Huntington's disease using the electron transport chain inhibitor 3-nitropropionic acid","author":"Ferrante","year":"1997"},{"key":"10.1016\/j.nbd.2006.08.011_bib25","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1523\/JNEUROSCI.20-12-04389.2000","article-title":"Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease","volume":"20","author":"Ferrante","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(00)02237-X","article-title":"Brain-derived neurotrophic factor in Huntington disease","volume":"866","author":"Ferrer","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.08.011_bib27","first-page":"93","article-title":"Is there a role for uridine and pyrimidine nucleosides in the treatment of vascular dementia?","volume":"17","author":"Fornai","year":"2002","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2005.10.056","article-title":"Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine","volume":"1066","author":"Garcia","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.08.011_bib29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.M410210200","article-title":"Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease","volume":"280","author":"Gardian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2006.08.011_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1200\/JCO.2000.18.1.167","article-title":"Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies","volume":"18","author":"Hidalgo","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.nbd.2006.08.011_bib31","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1200\/JCO.1997.15.4.1511","article-title":"Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer","volume":"15","author":"Kelsen","year":"1997","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.nbd.2006.08.011_bib32","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/nbdi.2000.0327","article-title":"Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum","volume":"8","author":"Kim","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2006.08.011_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00004647-200001000-00016","article-title":"Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid","volume":"20","author":"Kim","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.08.011_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1385\/NMM:6:2-3:087","article-title":"Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity","volume":"6","author":"Klivenyi","year":"2004","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.nbd.2006.08.011_bib35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/77046","article-title":"Gene-expression profile of the ageing brain in mice","volume":"25","author":"Lee","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2006.08.011_bib36","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","article-title":"Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice","volume":"82","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib37","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.21-21-08473.2001","article-title":"Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice","volume":"21","author":"Li","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1328-0163(97)90029-4","article-title":"Uridine preserves ATP during hypoxic perfusion of the rat heart","volume":"6","author":"Lin","year":"1997","journal-title":"Asia Pacific Heart Journal"},{"key":"10.1016\/j.nbd.2006.08.011_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1006859115450","article-title":"Dihydroorotate-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides","volume":"174","author":"Loffler","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1385\/NMM:4:1-2:7","article-title":"Huntington's disease","volume":"4","author":"MacDonald","year":"2003","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.nbd.2006.08.011_bib41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2006.08.011_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00254098","article-title":"Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine","volume":"24","author":"Martin","year":"1989","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.nbd.2006.08.011_bib43","first-page":"107","article-title":"Correction of renal tubular acidosis (RTA) in mitochondrial disease patients treated with triacetyluridine (PN401)","volume":"1","author":"Naviaux","year":"2001","journal-title":"Mitochondrion"},{"key":"10.1016\/j.nbd.2006.08.011_bib44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/ana.410260606","article-title":"Abnormalities of the electron transport chain in idiopathic Parkinson's disease","volume":"26","author":"Parker","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib45","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1212\/WNL.40.8.1302","article-title":"Cytochrome oxidase deficiency in Alzheimer's disease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.08.011_bib46","series-title":"Parkinson's Disease and Movement Disorders","first-page":"341","article-title":"Huntington's disease","author":"Penney","year":"1998"},{"key":"10.1016\/j.nbd.2006.08.011_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1998.7006","article-title":"Recent advances on the pathogenesis of Huntington's disease","volume":"157","author":"Petersen","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib48","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2006.08.011_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2003.09.049","article-title":"Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease","volume":"994","author":"Saydoff","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.08.011_bib50","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1016\/S0197-4580(04)80716-4","article-title":"Uridine prodrug PN401 has beneficial effects in models of Alzheimer's disease, hypoxia and oxidative stress","volume":"25","author":"Saydoff","year":"2004","journal-title":"Neurobiology Aging"},{"key":"10.1016\/j.nbd.2006.08.011_bib51","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/j.1471-4159.1990.tb05809.x","article-title":"Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease","volume":"55","author":"Schapira","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib52","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/8.3.397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"Schilling","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2006.08.011_bib53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0197-0186(95)00122-0","article-title":"Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity","volume":"29","author":"Schulz","year":"1996","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2006.08.011_bib54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1006852306789","article-title":"The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases","volume":"174","author":"Schulz","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.nbd.2006.08.011_bib55","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","article-title":"Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism","volume":"24","author":"Spires","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2006.08.011_bib60","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneumeth.2004.03.026","article-title":"Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression","volume":"140","author":"Szapacs","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2006.08.011_bib56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/1531-8249(199901)45:1<25::AID-ART6>3.0.CO;2-E","article-title":"Biochemical abnormalities and excitotoxicity in Huntington's disease brain","volume":"45","author":"Tabrizi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2006.08.011_bib57","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0006-2952(00)00436-6","article-title":"Effect of oral CDP-choline on plasma choline and uridine levels in human","volume":"60","author":"Wurtman","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2006.08.011_bib58","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1212\/WNL.39.9.1203","article-title":"Evidence in a lethal infantile mitochondrial disease for a nuclear mutation affecting respiratory complexes I and IV","volume":"39","author":"Zheng","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2006.08.011_bib59","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106001963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106001963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T11:33:52Z","timestamp":1555846432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996106001963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0969996106001963"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2006.08.011","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}