{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:31:18Z","timestamp":1776382278393,"version":"3.51.2"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.nbd.2006.10.013","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T12:14:00Z","timestamp":1166012040000},"page":"506-513","source":"Crossref","is-referenced-by-count":39,"title":["Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia"],"prefix":"10.1016","volume":"25","author":[{"given":"Dorothe","family":"Burggraf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Trinkl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Dichgans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2006.10.013_bib1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1097\/00004647-200012000-00007","article-title":"Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94","volume":"20","author":"Asahi","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.10.013_bib2","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1111\/j.1460-9568.2004.03757.x","article-title":"Rt-PA causes a significant increase in endogenous u-PA during experimental focal cerebral ischemia","volume":"20","author":"Burggraf","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2006.10.013_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neulet.2005.05.045","article-title":"A new approach to reduce the number of animals used in experimental focal cerebral ischemia models","volume":"386","author":"Burggraf","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2006.10.013_bib4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/80538","article-title":"Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2006.10.013_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF02736854","article-title":"Doxycycline treatment reduces ischemic brain damage in transient middle cerebral artery occlusion in the rat","volume":"9","author":"Clark","year":"1997","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2006.10.013_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000077145","article-title":"Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline","volume":"41","author":"Courtman","year":"2004","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0006-8993(99)01843-0","article-title":"Early appearance of activated matrix metalloproteinase-9 and blood\u2013brain barrier disruption in mice after focal cerebral ischemia and reperfusion","volume":"842","author":"Fujimura","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib8","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.STR.0000119383.76447.05","article-title":"Focal cerebral ischemia induces active proteases that degrade microvascular matrix","volume":"35","author":"Fukuda","year":"2004","journal-title":"Stroke."},{"key":"10.1016\/j.nbd.2006.10.013_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub","year":"1998","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1902\/jop.2002.73.1.79","article-title":"Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives","volume":"73","author":"Grenier","year":"2002","journal-title":"J. Periodontol."},{"key":"10.1016\/j.nbd.2006.10.013_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-005-2540-3","article-title":"Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition","volume":"270","author":"Griffin","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.nbd.2006.10.013_bib12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00004647-200205000-00004","article-title":"Microvascular basal lamina injury following experimental focal cerebral ischemia and reperfusion","volume":"22","author":"Hamann","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.10.013_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/08959374980120010301","article-title":"Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells","volume":"12","author":"Hanemaaijer","year":"1998","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0003-2697(80)90338-3","article-title":"Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates","volume":"102","author":"Heussen","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.nbd.2006.10.013_bib15","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1161\/01.STR.32.6.1341","article-title":"Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion","volume":"32","author":"Hosomi","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2006.10.013_bib16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/sj.jcbfm.9600025","article-title":"Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia\u2013ischemia","volume":"25","author":"Jantzie","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.10.013_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/(SICI)1097-4644(19960301)60:3<341::AID-JCB6>3.0.CO;2-W","article-title":"Transcriptional downregulation of stromelysin by tetracycline","volume":"60","author":"Jonat","year":"1996","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.nbd.2006.10.013_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1179\/016164102101200636","article-title":"Tissue-saving infarct volumetry using histochemistry validated by MRI in rat focal ischemia","volume":"24","author":"Kloss","year":"2002","journal-title":"Neurol. Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/sj.jcbfm.9600040","article-title":"Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice","volume":"25","author":"Koistinaho","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.10.013_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/0929867013373660","article-title":"CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1\u2013MMP activity: relevance to cancer","volume":"8","author":"Lee","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2006.10.013_bib21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1749-6632.2001.tb03511.x","article-title":"Elements of the fibrinolytic system","volume":"936","author":"Lijnen","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2006.10.013_bib22","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0741-5214(03)01022-X","article-title":"Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells","volume":"38","author":"Liu","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.nbd.2006.10.013_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2006.10.013_bib24","first-page":"12","article-title":"Cellular matrix remodeling by metalloproteinases and plasminogen activators","volume":"49","author":"Mignatti","year":"1995","journal-title":"Kidney Int., Suppl."},{"key":"10.1016\/j.nbd.2006.10.013_bib25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF00230493","article-title":"Temperature effect on immunostaining of microtubule-associated protein 2 and synaptophysin after 30 minutes of forebrain ischemia in rat","volume":"85","author":"Miyazawa","year":"1993","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2006.10.013_bib26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainres.2005.02.062","article-title":"Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage","volume":"1044","author":"Morimoto","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib27","doi-asserted-by":"crossref","first-page":"14100","DOI":"10.1074\/jbc.M601820200","article-title":"Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs","volume":"281","author":"Nelson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2006.10.013_bib28","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.nbd.2006.10.013_bib29","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1067\/mva.2002.123757","article-title":"Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice","volume":"35","author":"Prall","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.nbd.2006.10.013_bib30","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2006.10.013_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0950-3536(05)80269-0","article-title":"Plasminogen activators and plasminogen activator inhibitors: biochemical aspects","volume":"8","author":"Rijken","year":"1995","journal-title":"Bailliere's Clin. Haematol."},{"key":"10.1016\/j.nbd.2006.10.013_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/ejvs.2002.1598","article-title":"Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline","volume":"23","author":"Roach","year":"2002","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.nbd.2006.10.013_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0033-0620(99)70003-4","article-title":"Ischemic brain edema","volume":"42","author":"Rosenberg","year":"1999","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.nbd.2006.10.013_bib34","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00004647-199605000-00002","article-title":"Proteolytic cascade enzymes increase in focal cerebral ischemia in rat","volume":"16","author":"Rosenberg","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2006.10.013_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s000110050742","article-title":"Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1","volume":"50","author":"Sadowski","year":"2001","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/00006123-199810000-00107","article-title":"Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain","volume":"43","author":"Schreiber","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.nbd.2006.10.013_bib37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/AAC.37.3.592","article-title":"Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase","volume":"37","author":"Sorsa","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.nbd.2006.10.013_bib38","doi-asserted-by":"crossref","first-page":"F91","DOI":"10.1152\/ajprenal.00051.2004","article-title":"Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury","volume":"288","author":"Sutton","year":"2005","journal-title":"Am. J. Physiol.: Renal Physiol."},{"key":"10.1016\/j.nbd.2006.10.013_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0167-4889(93)90097-9","article-title":"Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts","volume":"1220","author":"Takahashi","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2006.10.013_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.1994.tb24731.x","article-title":"Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes","volume":"732","author":"Uitto","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2006.10.013_bib41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0006-8993(02)04045-3","article-title":"Effects of minocycline alone and in combination with mild hypothermia in embolic stroke","volume":"963","author":"Wang","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2006.10.013_bib42","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1001\/archderm.130.6.748","article-title":"Inhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase C","volume":"130","author":"Webster","year":"1994","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.nbd.2006.10.013_bib43","first-page":"4","article-title":"Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats","volume":"26","author":"Xu","year":"2004","journal-title":"BMC Neurol."},{"key":"10.1016\/j.nbd.2006.10.013_bib44","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2006.10.013_bib45","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1073\/pnas.96.23.13496","article-title":"A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window","volume":"96","author":"Yrjanheikki","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106002853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996106002853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:25:42Z","timestamp":1547141142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996106002853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0969996106002853"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2006.10.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}