{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:01:54Z","timestamp":1791352914281,"version":"4.3.1"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.nbd.2007.03.013","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T07:13:35Z","timestamp":1176275615000},"page":"11-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"27","author":[{"given":"Yunmin","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Youn","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un Jung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2007.03.013_bib1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/nbdi.1999.0259","article-title":"Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson\u2019s disease","volume":"6","author":"Andersson","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2007.03.013_bib2","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1523\/JNEUROSCI.21-24-09930.2001","article-title":"cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum","volume":"21","author":"Andersson","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1460-9568.2000.00896.x","article-title":"Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system","volume":"12","author":"Barneoud","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1096\/fj.03-0576fje","article-title":"High-frequency stimulation of both zona incerta and subthalamic nucleus induces a similar normalization of basal ganglia metabolic activity in experimental parkinsonism","volume":"18","author":"Benazzouz","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2007.03.013_bib5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-4886(03)00250-4","article-title":"A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson\u2019s disease","volume":"184","author":"Bibbiani","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0149-7634(98)00019-0","article-title":"Acute cocaine effects on stereotype and defense: an ethoexperimental approach","volume":"23","author":"Blanchard","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2007.03.013_bib7","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0022-3565(25)24503-7","article-title":"Continuous administration decreases and pulsatile administration increases behavioral sensitivity to a novel dopamine D2 agonist (U-91356A) in MPTP-exposed monkeys","volume":"272","author":"Blanchet","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2007.03.013_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mds.870130507","article-title":"Amantadine reduces levodopa-induced dyskinesias in Parkinsonian monkeys","volume":"13","author":"Blanchet","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02245739","article-title":"Characterisation of dyskinesias induced by l-DOPA in MPTP-treated squirrel monkeys","volume":"102","author":"Boyce","year":"1990","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nbd.2007.03.013_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mds.870050103","article-title":"Induction of chorea and dystonia in Parkinsonian primates","volume":"5","author":"Boyce","year":"1990","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib11","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1046\/j.0953-816x.2001.01800.x","article-title":"Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat","volume":"14","author":"Breit","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-8993(99)01268-8","article-title":"Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson\u2019s model rats","volume":"828","author":"Carlson","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib13","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1111\/j.1471-4159.2006.03696.x","article-title":"Role of striatal l-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats","volume":"96","author":"Carta","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2007.03.013_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00726-001-0116-4","article-title":"Transcription factors involved in the pathogenesis of l-DOPA-induced dyskinesia in a rat model of Parkinson\u2019s disease","volume":"23","author":"Cenci","year":"2002","journal-title":"Amino Acids"},{"key":"10.1016\/j.nbd.2007.03.013_bib15","first-page":"2694","article-title":"l-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA","volume":"10","author":"Cenci","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nrn877","article-title":"Animal models of neurological deficits: how relevant is the rat?","volume":"3","author":"Cenci","year":"2002","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0306-4522(98)00217-6","article-title":"Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson\u2019s disease: studies on medial forebrain bundle and striatal lesions","volume":"88","author":"Chang","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2007.03.013_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0022-510X(89)90117-2","article-title":"Drug-induced dyskinesia in primates rendered hemi-Parkinsonian by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)","volume":"90","author":"Clarke","year":"1989","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2007.03.013_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbr.2004.06.016","article-title":"The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization","volume":"157","author":"Corda","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/mds.1112","article-title":"Intravenous amantadine improves levadopa-induced dyskinesias: an acute double-blind placebo-controlled study","volume":"16","author":"Del Dotto","year":"2001","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1460-9568.1996.tb01220.x","article-title":"Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum","volume":"8","author":"Doucet","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib22","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1523\/JNEUROSCI.3080-04.2004","article-title":"Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein","volume":"24","author":"Fleming","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib23","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/mds.10289","article-title":"Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson\u2019s disease","volume":"17","author":"Fox","year":"2002","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib74","unstructured":"Franklin, K.B.J., Paxinos, G., 1997. The Mouse Brain in Stereotaxic Coordinates. Academic Press, Inc., San Diego, CA."},{"key":"10.1016\/j.nbd.2007.03.013_bib24","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1523\/JNEUROSCI.5326-05.2006","article-title":"A critical interaction between NR2B and MAGUK in l-DOPA induced dyskinesia","volume":"26","author":"Gardoni","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib25","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.2147780","article-title":"D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons","volume":"250","author":"Gerfen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.nbd.2007.03.013_bib26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.11-04-01016.1991","article-title":"Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis","volume":"11","author":"Gerfen","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/exnr.1998.6819","article-title":"Characterization of enhanced behavioral responses to l-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease","volume":"151","author":"Henry","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0169-328X(03)00162-1","article-title":"Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice","volume":"114","author":"Hwang","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib29","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1523\/JNEUROSCI.3718-04.2005","article-title":"3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson\u2019s disease","volume":"25","author":"Hwang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib30","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1212\/WNL.45.3_Suppl_3.S6","article-title":"The rationale for the use of dopamine agonists in Parkinson\u2019s disease","volume":"45","author":"Jenner","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2007.03.013_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-4328(99)00068-6","article-title":"Akinesia and postural abnormality after unilateral dopamine depletion","volume":"104","author":"Johnson","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.expneurol.2004.10.002","article-title":"A simple rodent assay for the in vivo identification of agents with potential to reduce levodopa-induced dyskinesia in Parkinson\u2019s disease","volume":"191","author":"Johnston","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib75","unstructured":"Kang, U.J., Ding, Y., Rokosik, S., Koh, H., 2005. Fos-B expression in the penduncopontine nucleus correlates with the persistence of I-dopa-induced dyskinesia in mice with unilateral 6-hydroxydopamine lesions Program No. 566.12.2005. Society for Neuroscience, Washington, DC."},{"key":"10.1016\/j.nbd.2007.03.013_bib33","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1212\/01.WNL.0000095219.22086.31","article-title":"Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson\u2019s disease","volume":"61","author":"Kase","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2007.03.013_bib34","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1523\/JNEUROSCI.2840-04.2005","article-title":"D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways","volume":"25","author":"Kovoor","year":"2005","journal-title":"J. Neurosci."},{"issue":"Pt. 7","key":"10.1016\/j.nbd.2007.03.013_bib35","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/brain\/123.7.1365","article-title":"Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson\u2019s disease","volume":"123","author":"Lee","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2007.03.013_bib36","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tips.2005.06.007","article-title":"New ideas on the origin of l-DOPA-induced dyskinesias: age, genes and neural plasticity","volume":"26","author":"Linazasoro","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2007.03.013_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.0953-816x.2001.01843.x","article-title":"Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson\u2019s disease","volume":"15","author":"Lundblad","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib38","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1046\/j.1471-4159.2003.01632.x","article-title":"Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia","volume":"84","author":"Lundblad","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2007.03.013_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2004.01.007","article-title":"A model of l-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function","volume":"16","author":"Lundblad","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2007.03.013_bib40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.expneurol.2005.02.002","article-title":"Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia","volume":"194","author":"Lundblad","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ana.410310514","article-title":"Selective D2 receptor stimulation induces dyskinesia in Parkinsonian monkeys","volume":"31","author":"Luquin","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/mds.870070204","article-title":"Levodopa-induced dyskinesias in Parkinson\u2019s disease: clinical and pharmacological classification","volume":"7","author":"Luquin","year":"1992","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.870090103","article-title":"Levodopa-induced dyskinesias in Parkinson\u2019s disease phenomenology and pathophysiology","volume":"9","author":"Marconi","year":"1994","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2007.03.013_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.expneurol.2005.11.002","article-title":"Motor complications in Parkinson\u2019s disease and the clinical significance of rotational behavior in the rat: have we wasted our time?","volume":"197","author":"Marin","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib45","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/1098-2396(20000915)37:4<298::AID-SYN7>3.0.CO;2-A","article-title":"Increased behavioral response to dopaminergic stimulation of the subthalamic nucleus after nigrostriatal lesions","volume":"37","author":"Mehta","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2007.03.013_bib46","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tins.2004.07.009","article-title":"Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?","volume":"27","author":"Mena-Segovia","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresbull.2004.10.011","article-title":"Validation of the l-DOPA-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists","volume":"68","author":"Monville","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2007.03.013_bib48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0306-4522(88)90256-4","article-title":"Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists","volume":"25","author":"Morris","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2007.03.013_bib49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02896851","article-title":"Localization of striatal opioid gene expression, and its modulation by the mesostriatal dopamine pathway: an in situ hybridization study","volume":"1","author":"Morris","year":"1989","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib50","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1523\/JNEUROSCI.2582-06.2006","article-title":"Phenotype of striatofugal medium spiny neurons in Parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia","volume":"26","author":"Nadjar","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib51","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1093\/brain\/awf259","article-title":"Reversal of akinesia in experimental Parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus","volume":"125","author":"Nandi","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2007.03.013_bib52","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/exnr.2000.7444","article-title":"Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson\u2019s disease","volume":"165","author":"Nash","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib53","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.0230529100","article-title":"Pitx3 is required for development of substantia nigra dopaminergic neurons","volume":"100","author":"Nunes","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt. 9","key":"10.1016\/j.nbd.2007.03.013_bib54","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/brain\/123.9.1767","article-title":"The pedunculopontine nucleus and Parkinson\u2019s disease","volume":"123","author":"Pahapill","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2007.03.013_bib55","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1212\/01.wnl.0000215250.82576.87","article-title":"Practice parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"66","author":"Pahwa","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2007.03.013_bib57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopsych.2005.05.044","article-title":"ERK phosphorylation and FosB expression are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice","volume":"59","author":"Pavon","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2007.03.013_bib58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0166-4328(97)00080-6","article-title":"Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat","volume":"90","author":"Phillips","year":"1998","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib59","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nn1040","article-title":"Loss of bidirectional striatal synaptic plasticity in l-DOPA-induced dyskinesia","volume":"6","author":"Picconi","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib60","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/brain\/awl127","article-title":"Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism","volume":"129","author":"Plaha","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2007.03.013_bib61","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0896-6273(03)00321-0","article-title":"RGS9 modulates dopamine signaling in the basal ganglia","volume":"38","author":"Rahman","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2007.03.013_bib62","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1111\/j.1460-9568.1996.tb01318.x","article-title":"Bilateral 6-hydroxydopamine-induced lesion of the nigrostriatal dopamine pathway reproduces the effects of unilateral lesion on substance P but not on enkephalin expression in rat basal ganglia","volume":"8","author":"Salin","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib63","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1242\/dev.01022","article-title":"Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3","volume":"131","author":"Smidt","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.nbd.2007.03.013_bib64","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.mcn.2005.07.018","article-title":"Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system","volume":"30","author":"Smits","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib65","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/exnr.2000.7374","article-title":"Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors","volume":"163","author":"Steece-Collier","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib66","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s002210050545","article-title":"Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior","volume":"123","author":"Steiner","year":"1998","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2005.11.026","article-title":"Developing a preclinical model of Parkinson\u2019s disease: a study of behaviour in rats with graded 6-OHDA lesions","volume":"169","author":"Truong","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2007.03.013_bib68","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/dev.00464","article-title":"Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons","volume":"130","author":"van den Munckhof","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.nbd.2007.03.013_bib69","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1471-4159.2005.03522.x","article-title":"Striatal neuroadaptation and rescue of locomotor deficit by l-DOPA in aphakia mice, a model of Parkinson\u2019s disease","volume":"96","author":"van den Munckhof","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2007.03.013_bib70","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/nbdi.2002.0499","article-title":"l-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of Parkinson\u2019s disease: relation to motor and cellular parameters of nigrostriatal function","volume":"10","author":"Winkler","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2007.03.013_bib71","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.expneurol.2004.09.005","article-title":"Testing forelimb placing \u201cacross the midline\u201d reveals distinct, lesion-dependent patterns of recovery in rats","volume":"191","author":"Woodlee","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2007.03.013_bib72","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1523\/JNEUROSCI.3554-06.2006","article-title":"Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice","volume":"26","author":"Xiao","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2007.03.013_bib73","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1073\/pnas.98.4.1982","article-title":"Hyperactivity and impaired response habituation in hyperdopaminergic mice","volume":"98","author":"Zhuang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996107000642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996107000642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:00:35Z","timestamp":1760850035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996107000642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0969996107000642"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2007.03.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2007.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}