{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:40:27Z","timestamp":1791232827286,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.nbd.2008.04.005","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T07:39:49Z","timestamp":1209886789000},"page":"198-208","source":"Crossref","is-referenced-by-count":68,"title":["A possible link between astrocyte activation and tau nitration in Alzheimer's disease"],"prefix":"10.1016","volume":"31","author":[{"given":"Juan F.","family":"Reyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peleg M.","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Guillozet-Bongaarts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester I.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2008.04.005_bib1","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1073\/pnas.95.10.5795","article-title":"Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism","volume":"95","author":"Akama","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2008.04.005_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0169-328X(95)00051-S","article-title":"Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease","volume":"31","author":"Alonso","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2008.04.005_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2008.04.005_bib5","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/tx9501445","article-title":"Oxidative damage and tyrosine nitration from peroxynitrite","volume":"9","author":"Beckman","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.nbd.2008.04.005_bib8","doi-asserted-by":"crossref","first-page":"C","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide and peroxynitrite: the good the bad and the ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.nbd.2008.04.005_bib6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0079-6123(08)61151-6","article-title":"Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration","volume":"103","author":"Beckman","year":"1994","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2008.04.005_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0076-6879(94)33026-3","article-title":"Oxidative chemistry of peroxynitrite","volume":"233","author":"Beckman","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.nbd.2008.04.005_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/B:NEUR.0000044190.96426.b9","article-title":"Tau epitope display in progressive supranuclear palsy and corticobasal degeneration","volume":"33","author":"Berry","year":"2004","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.nbd.2008.04.005_bib10","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1083\/jcb.101.4.1371","article-title":"The distribution of tau in the mammalian central nervous system","volume":"101","author":"Binder","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2008.04.005_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.nbd.2008.04.005_bib12","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1523\/JNEUROSCI.5480-05.2006","article-title":"Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide","volume":"26","author":"Brahmachari","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2008.04.005_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0169-328X(96)00003-4","article-title":"AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease","volume":"39","author":"Buee-Scherrer","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2008.04.005_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(04)00173-5","article-title":"The nitration of tau protein in neurone-like PC12 cells","volume":"562","author":"Cappelletti","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2008.04.005_bib15","doi-asserted-by":"crossref","first-page":"32789","DOI":"10.1074\/jbc.271.51.32789","article-title":"The structural basis of monoclonal antibody Alz50\u2032s selectivity for Alzheimer's disease pathology","volume":"271","author":"Carmel","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2008.04.005_bib16","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1073\/pnas.89.10.4378","article-title":"Primary structure of high molecular weight tau present in the peripheral nervous system","volume":"89","author":"Couchie","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib17","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1523\/JNEUROSCI.1487-05.2005","article-title":"Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase","volume":"25","author":"Derkinderen","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2008.04.005_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1750-3639.1994.tb00838.x","article-title":"GFAP and astrogliosis","volume":"4","author":"Eng","year":"1994","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2008.04.005_bib19","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1630428100","article-title":"Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease","volume":"100","author":"Gamblin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/JAD-2003-5201","article-title":"Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease","volume":"5","author":"Garcia-Sierra","year":"2003","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.nbd.2008.04.005_bib21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/exnr.2002.8014","article-title":"Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease","volume":"177","author":"Ghoshal","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2008.04.005_bib22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","article-title":"Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.nbd.2008.04.005_bib23","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2008.04.005_bib24","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","article-title":"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of alzheimer disease: identification as the microtubule-associated protein tau","volume":"85","author":"Goedert","year":"1988","journal-title":"PNAS"},{"key":"10.1016\/j.nbd.2008.04.005_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2008.04.005_bib26","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2008.04.005_bib27","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib28","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neurobiolaging.2004.09.019","article-title":"Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease","volume":"26","author":"Guillozet-Bongaarts","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2008.04.005_bib29","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1046\/j.1471-4159.1998.71062465.x","article-title":"New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry","volume":"71","author":"Hanger","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2008.04.005_bib30","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1128\/MCB.9.4.1381","article-title":"Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains","volume":"9","author":"Himmler","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2008.04.005_bib31","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0002-9440(10)63462-1","article-title":"Nitration of tau protein is linked to neurodegeneration in tauopathies","volume":"163","author":"Horiguchi","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2008.04.005_bib32","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1523\/JNEUROSCI.1988-04.2004","article-title":"Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease","volume":"24","author":"Horowitz","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2008.04.005_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-8993(99)01804-1","article-title":"Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation","volume":"842","author":"Hu","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.nbd.2008.04.005_bib34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ana.410230410","article-title":"Alz-50 antibody recognizes Alzheimer-related neuronal changes","volume":"23","author":"Hyman","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2008.04.005_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-5793(95)00307-U","article-title":"Peroxynitrite-mediated oxidative protein modifications","volume":"364","author":"Ischiropoulos","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2008.04.005_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0003-9861(92)90431-U","article-title":"Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase","volume":"298","author":"Ischiropoulos","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.nbd.2008.04.005_bib37","doi-asserted-by":"crossref","first-page":"11584","DOI":"10.1073\/pnas.95.20.11584","article-title":"An activity in rat tissues that modifies nitrotyrosine-containing proteins","volume":"95","author":"Kamisaki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0034-5288(98)90116-3","article-title":"Variations in effectiveness of antigen retrieval pretreatments for diagnostic immunohistochemistry","volume":"64","author":"Kanai","year":"1998","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.nbd.2008.04.005_bib39","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-8993(92)91476-U","article-title":"Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments","volume":"597","author":"Ksiezak-Reding","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2008.04.005_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(98)00663-3","article-title":"Inflammatory molecule release by beta-amyloid-treated T98G astrocytoma cells: role of prostaglandins and modulation by paracetamol","volume":"360","author":"Landolfi","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2008.04.005_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.3122323","article-title":"The primary structure and heterogeneity of tau protein from mouse brain","volume":"239","author":"Lee","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.nbd.2008.04.005_bib43","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.nbd.2008.04.005_bib44","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1523\/JNEUROSCI.4162-03.2004","article-title":"Phosphorylation of tau by fyn: implications for Alzheimer's disease","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2008.04.005_bib45","doi-asserted-by":"crossref","first-page":"10369","DOI":"10.1073\/pnas.92.22.10369","article-title":"Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes","volume":"92","author":"LoPresti","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib64","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1083\/jcb.4.2.177","article-title":"Polarization optical properties of the pancreatic acinar cell of the mouse","volume":"4","author":"Munger","year":"2004","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1016\/j.nbd.2008.04.005_bib46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neurobiolaging.2004.01.007","article-title":"Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease","volume":"25","author":"Nagele","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2008.04.005_bib47","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.nbd.2008.04.005_bib48","first-page":"123","article-title":"Tau protein immunoreactivity in dementia of the Alzheimer type. I. Morphology, evolution, distribution, and pathogenetic implications","volume":"60","author":"Papasozomenos","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.nbd.2008.04.005_bib49","first-page":"375","article-title":"Tau protein immunoreactivity in dementia of the Alzheimer type: II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer's abnormal filaments","volume":"60","author":"Papasozomenos","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.nbd.2008.04.005_bib50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cm.970080303","article-title":"Phosphorylation determines two distinct species of tau in the central nervous system","volume":"8","author":"Papasozomenos","year":"1987","journal-title":"Cell Motil. Cytoskelet."},{"key":"10.1016\/j.nbd.2008.04.005_bib51","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jnr.20180","article-title":"Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma","volume":"77","author":"Pawate","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2008.04.005_bib52","first-page":"129","article-title":"[Antigen retrieval by microwave oven with buffer of citric acid]","volume":"54","author":"Pellicer","year":"1994","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.nbd.2008.04.005_bib53","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1021\/bi047982v","article-title":"Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease","volume":"44","author":"Reynolds","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2008.04.005_bib54","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1021\/bi051028w","article-title":"Site-specific nitration differentially influences tau assembly in vitro","volume":"44","author":"Reynolds","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2008.04.005_bib55","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1523\/JNEUROSCI.2143-06.2006","article-title":"Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies","volume":"26","author":"Reynolds","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2008.04.005_bib56","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/brain\/awg085","article-title":"Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders","volume":"126","author":"Schofield","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2008.04.005_bib57","doi-asserted-by":"crossref","first-page":"24290","DOI":"10.1016\/S0021-9258(19)51080-8","article-title":"Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure","volume":"269","author":"Schweers","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2008.04.005_bib58","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1471-4159.1991.tb11405.x","article-title":"Altered protein tyrosine phosphorylation in Alzheimer's disease","volume":"56","author":"Shapiro","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2008.04.005_bib59","first-page":"693","article-title":"Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues","volume":"64","author":"Shin","year":"1991","journal-title":"Lab. Invest."},{"key":"10.1016\/j.nbd.2008.04.005_bib60","first-page":"937","article-title":"Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method","volume":"140","author":"Shin","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2008.04.005_bib61","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M000206200","article-title":"Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies","volume":"275","author":"Souza","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2008.04.005_bib62","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1073\/pnas.94.8.4113","article-title":"Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments","volume":"94","author":"Spillantini","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2008.04.005_bib63","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI118821","article-title":"Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51\/KC in oligodendrocytes","volume":"98","author":"Tani","year":"1996","journal-title":"J. Clin. Invest."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996108000752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996108000752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T18:23:15Z","timestamp":1631211795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996108000752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0969996108000752"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2008.04.005","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}