{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:52:11Z","timestamp":1790401931494,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.nbd.2009.11.006","type":"journal-article","created":{"date-parts":[[2009,11,14]],"date-time":"2009-11-14T05:11:19Z","timestamp":1258175479000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation"],"prefix":"10.1016","volume":"37","author":[{"given":"Gerd","family":"Meyer zu H\u00f6rste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Heidenreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Mausberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmar C.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneloor L.M.A.","family":"ten Asbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 T.","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd C.","family":"Kieseier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2009.11.006_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0022-510X(90)90058-U","article-title":"Immunopathological factors in peripheral nerve allograft rejection: quantification of lymphocyte invasion and major histocompatibility complex expression","volume":"96","author":"Ansselin","year":"1990","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2009.11.006_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0165-5728(91)90181-6","article-title":"The effects of West Nile virus on major histocompatibility complex class I and II molecule expression by Lewis rat Schwann cells in vitro","volume":"35","author":"Argall","year":"1991","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-5728(92)90209-4","article-title":"Interactions between CD4+ T-cells and rat Schwann cells in vitro. 2. Cytotoxic effects of P2-specific CD4+ T-cell lines on Lewis rat Schwann cells","volume":"40","author":"Argall","year":"1992","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/mus.880130204","article-title":"Rat and human Schwann cells in vitro can synthesize and express MHC molecules","volume":"13","author":"Armati","year":"1990","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nbd.2009.11.006_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mcn.2004.09.001","article-title":"Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene","volume":"28","author":"Berghoff","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2009.11.006_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF01191706","article-title":"Rat Schwann cells can be induced to express major histocompatibility complex class II molecules in vivo","volume":"21","author":"Bergsteinsdottir","year":"1992","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.nbd.2009.11.006_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/glia.10235","article-title":"T-cell cytotoxicity of human Schwann cells: TNFalpha promotes fasL-mediated apoptosis and IFN gamma perforin-mediated lysis","volume":"43","author":"Bonetti","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2009.11.006_bib8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-5728(90)90082-X","article-title":"Quantitative analysis of endoneurial T-cells in human sural nerve biopsies","volume":"26","author":"Cornblath","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-5728(93)90086-E","article-title":"Schwann cells are able to present exogenous mycobacterial hsp70 to antigen-specific T lymphocytes","volume":"43","author":"Ford","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib10","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/nm.1881","article-title":"Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis","volume":"14","author":"Friese","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2009.11.006_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-5728(00)00270-8","article-title":"Flow cytometric analysis of infiltrating cells in the peripheral nerves in experimental allergic neuritis","volume":"108","author":"Fujioka","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/brain\/awh017","article-title":"Coexistent hereditary and inflammatory neuropathy","volume":"127","author":"Ginsberg","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/cimm.1995.1187","article-title":"Synergistic effect of IFN-gamma and TNF-alpha on expression of immune molecules and antigen presentation by Schwann cells","volume":"165","author":"Gold","year":"1995","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib14","series-title":"Peripheral Neuropathy","first-page":"2197","article-title":"The Guillain-Barr\u00e9 syndromes","author":"Griffin","year":"2005"},{"issue":"Pt. 5","key":"10.1016\/j.nbd.2009.11.006_bib15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/brain\/118.5.1263","article-title":"Non-neural-specific T lymphocytes can orchestrate inflammatory peripheral neuropathy","volume":"118","author":"Harvey","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib16","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(05)67665-9","article-title":"Guillain-Barre syndrome","volume":"366","author":"Hughes","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2009.11.006_bib17","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1523\/JNEUROSCI.1921-06.2006","article-title":"Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes","volume":"26","author":"Ip","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2009.11.006_bib18","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1073\/pnas.88.12.5096","article-title":"Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse","volume":"88","author":"Jat","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2009.11.006_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0301-0082(00)00060-5","article-title":"The role of macrophages in immune-mediated damage to the peripheral nervous system","volume":"64","author":"Kiefer","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2009.11.006_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/mus.20076","article-title":"Advances in understanding and treatment of immune-mediated disorders of the peripheral nervous system","volume":"30","author":"Kieseier","year":"2004","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nbd.2009.11.006_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/eji.1830190128","volume":"19","author":"Kingston","year":"1989","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib22","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/brain\/awg072","article-title":"Preserved myelin integrity and reduced axonopathy in connexin32-deficient mice lacking the recombination activating gene-1","volume":"126","author":"Kobsar","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-5728(97)00063-5","article-title":"The distribution and abundance of MHC and ICAM-1 on Schwann cells in vitro","volume":"77","author":"Lilje","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000163743","article-title":"Differences in the capacity of gamma-interferons from different species to induce class I and II major histocompatibility complex antigens on neonatal rat Schwann cells in vitro","volume":"60","author":"Lisak","year":"1992","journal-title":"Pathobiology"},{"key":"10.1016\/j.nbd.2009.11.006_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.nbd.2009.11.006_bib26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/WNL.38.6.848","article-title":"HLA-DR Schwann cell reactivity in peripheral neuropathies of different origins","volume":"38","author":"Mancardi","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2009.11.006_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mus.20893","article-title":"The immunocompetence of Schwann cells","volume":"37","author":"Meyer zu Horste","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nbd.2009.11.006_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/glia.20903","article-title":"Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies","volume":"58","author":"Meyer zu Horste","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2009.11.006_bib29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0022-510X(91)90065-F","article-title":"Class II antigen expression in peripheral neuropathies","volume":"102","author":"Mitchell","year":"1991","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2009.11.006_bib30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(88)91043-4","article-title":"Introduction of soluble protein into the class I pathway of antigen processing and presentation","volume":"54","author":"Moore","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2009.11.006_bib31","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/brain\/123.8.1660","article-title":"Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy","volume":"123","author":"Murata","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0387-7604(01)00205-4","article-title":"Inflammatory pathological changes in a 2-year-old boy with Charcot-Marie-Tooth disease","volume":"23","author":"Nakai","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.nbd.2009.11.006_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ana.410210404","article-title":"Class II antigen expression and inflammatory cells in the Guillain-Barre syndrome","volume":"21","author":"Pollard","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2009.11.006_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneumeth.2008.06.029","article-title":"Myelination competent conditionally immortalized mouse Schwann cells","volume":"174","author":"Saavedra","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2009.11.006_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF01795311","article-title":"Gamma interferon, but not Mycobacterium leprae, induces major histocompatibility class II antigens on cultured rat Schwann cells","volume":"16","author":"Samuel","year":"1987","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.nbd.2009.11.006_bib36","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/(SICI)1097-4598(199604)19:4<474::AID-MUS8>3.0.CO;2-9","article-title":"Inflammatory infiltrates in sural nerve biopsies in Guillain-Barre syndrome and chronic inflammatory demyelinating neuropathy","volume":"19","author":"Schmidt","year":"1996","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nbd.2009.11.006_bib37","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.4049\/jimmunol.166.10.5883","article-title":"Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4+ Th1 cells: a novel immunopathogenic mechanism of nerve damage in leprosy","volume":"166","author":"Spierings","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/intimm\/5.3.249","article-title":"Cortical neurons selectively inhibit MHC class II induction in astrocytes but not in microglial cells","volume":"5","author":"Tontsch","year":"1993","journal-title":"Int. Immunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib39","first-page":"507","article-title":"Intercellular regulation of major histocompatibility complex class I expression in neural cells","volume":"80","author":"Tontsch","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.nbd.2009.11.006_bib40","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-5728(91)90019-4","article-title":"Interferon-gamma inhibition suppresses experimental allergic neuritis: modulation of major histocompatibility complex expression of Schwann cells in vitro","volume":"31","author":"Tsai","year":"1991","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2009.11.006_bib42","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1097\/00001756-199806220-00029","article-title":"IFN-gamma induces coordinate expression of MHC class I-mediated antigen presentation machinery molecules in adult mouse Schwann cells","volume":"9","author":"Tsuyuki","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2009.11.006_bib43","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/brain\/123.10.2020","article-title":"Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy","volume":"123","author":"Van Rhijn","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib44","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/brain\/awg207","article-title":"Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barre syndrome","volume":"126","author":"Wanschitz","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2009.11.006_bib45","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/eji.1830161214","article-title":"Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes","volume":"16","author":"Wekerle","year":"1986","journal-title":"Eur. J. Immunol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996109003283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996109003283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:05:38Z","timestamp":1760850338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996109003283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0969996109003283"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2009.11.006","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2009.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}