{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:28:28Z","timestamp":1791217708216,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.nbd.2010.03.013","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T13:08:55Z","timestamp":1269349735000},"page":"98-104","source":"Crossref","is-referenced-by-count":149,"title":["Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling"],"prefix":"10.1016","volume":"39","author":[{"given":"Roberto","family":"Cilia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Soo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"van Eimeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Pellecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pezzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 9","key":"10.1016\/j.nbd.2010.03.013_bib1","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1093\/brain\/awp170","article-title":"At-risk for pathological gambling: imaging neural reward processing under chronic dopamine agonists","volume":"132","author":"Abler","year":"2009","journal-title":"Brain"},{"issue":"Pt 12","key":"10.1016\/j.nbd.2010.03.013_bib2","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1093\/brain\/awh607","article-title":"PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation","volume":"128","author":"Adams","year":"2005","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.nbd.2010.03.013_bib3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/1531-8257(199911)14:6<940::AID-MDS1005>3.0.CO;2-Y","article-title":"The effect of dopamine agonist therapy on dopamine transporter imaging in Parkinson's disease","volume":"14","author":"Ahlskog","year":"1999","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2010.03.013_bib4","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"issue":"6","key":"10.1016\/j.nbd.2010.03.013_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2165\/00002018-200932060-00004","article-title":"Behavioural adverse effects of dopaminergic treatments in Parkinson's disease: incidence, neurobiological basis, management and prevention","volume":"32","author":"Antonini","year":"2009","journal-title":"Drug Saf."},{"issue":"Pt 9","key":"10.1016\/j.nbd.2010.03.013_bib6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/brain\/awp094","article-title":"Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients","volume":"132","author":"B\u00f3di","year":"2009","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.nbd.2010.03.013_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00259-007-0621-0","article-title":"Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs","volume":"35","author":"Booij","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2010.03.013_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/jnnp.62.2.133","article-title":"[123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease","volume":"62","author":"Booij","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.nbd.2010.03.013_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bcp.2007.06.043","article-title":"The neurobiology and genetics of impulse control disorders: relationships to drug addictions","volume":"75","author":"Brewer","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2010.03.013_bib10","series-title":"Introduction to Multivariate Analysis","author":"Chatfield","year":"1980"},{"key":"10.1016\/j.nbd.2010.03.013_bib11","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1001\/archneur.65.12.1604","article-title":"Functional abnormalities underlying pathological gambling in Parkinson disease","volume":"65","author":"Cilia","year":"2008","journal-title":"Arch. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2010.03.013_bib12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.neuroimage.2004.06.045","article-title":"The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease","volume":"23","author":"Colloby","year":"2004","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.nbd.2010.03.013_bib13","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0028-3932(03)00117-9","article-title":"l-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease","volume":"41","author":"Cools","year":"2003","journal-title":"Neuropsychologia"},{"issue":"4","key":"10.1016\/j.nbd.2010.03.013_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1176\/appi.neuropsych.19.4.473","article-title":"Pathological gambling associated with cabergoline therapy in a patient with a pituitary prolactinoma","volume":"19","author":"Davie","year":"2007","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.nbd.2010.03.013_bib15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJMoa000827","article-title":"Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease","volume":"345","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.nbd.2010.03.013_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1073\/pnas.0805517106","article-title":"Variation in dopamine genes influences responsivity of the human reward system","volume":"106","author":"Dreher","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.nbd.2010.03.013_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/wnf.0b013e31804c780e","article-title":"Gambling and increased sexual desire with dopaminergic medications in restless legs syndrome","volume":"30","author":"Driver-Dunckley","year":"2007","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.nbd.2010.03.013_bib18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ana.20822","article-title":"Compulsive drug use linked to sensitized ventral striatal dopamine transmission","volume":"59","author":"Evans","year":"2006","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2010.03.013_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5694\/j.1326-5377.2009.tb02289.x","article-title":"Pathological gambling and hypersexuality in cabergoline-treated prolactinoma","volume":"190","author":"Falhammar","year":"2009","journal-title":"Med. J. Aust."},{"issue":"1","key":"10.1016\/j.nbd.2010.03.013_bib20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.mp.4002086","article-title":"Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity","volume":"14","author":"Forbes","year":"2009","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.nbd.2010.03.013_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/npp.2008.124","article-title":"DAT genotype modulates brain and behavioral responses elicited by cigarette cues","volume":"34","author":"Franklin","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.nbd.2010.03.013_bib22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10519-006-9115-2","article-title":"Genetics of dopamine and its contribution to cocaine addiction","volume":"37","author":"Haile","year":"2007","journal-title":"Behav. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2010.03.013_bib23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10899-009-9123-2","article-title":"Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia","volume":"25","author":"Holman","year":"2009","journal-title":"J. Gambl. Stud."},{"key":"10.1016\/j.nbd.2010.03.013_bib24","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1073\/pnas.95.7.4029","article-title":"Profound neuronal plasticity in response to inactivation of the dopamine transporter","volume":"95","author":"Jones","year":"1998","journal-title":"PNAS"},{"issue":"9","key":"10.1016\/j.nbd.2010.03.013_bib25","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2967\/jnumed.106.038646","article-title":"Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images","volume":"48","author":"Kas","year":"2007","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nbd.2010.03.013_bib26","unstructured":"Klein, T.A., Neumann, J., Reuter, M., Hennig, J., von Cramon, D.Y., Ullsperger, M., 2007. Genetically determined differences in learning from errors. Science 318 (5856), 1642\u20131645."},{"issue":"11","key":"10.1016\/j.nbd.2010.03.013_bib27","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/nn1583","article-title":"Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction","volume":"8","author":"Kreek","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2010.03.013_bib28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/jcbfm.1994.131","article-title":"Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects","volume":"14","author":"Laruelle","year":"1994","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2010.03.013_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1531-8249(200004)47:4<493::AID-ANA13>3.0.CO;2-4","article-title":"In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease","volume":"47","author":"Lee","year":"2000","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.nbd.2010.03.013_bib30","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/mds.22678","article-title":"Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease","volume":"24","author":"Lee","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2010.03.013_bib31","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1176\/ajp.144.9.1184","article-title":"The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers","volume":"144","author":"Lesieur","year":"1987","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.nbd.2010.03.013_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/YPG.0b013e32832a4f7b","article-title":"Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population","volume":"19","author":"Lind","year":"2009","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.nbd.2010.03.013_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/bbrc.1995.1773","article-title":"Dopamine transporter gene polymorphism and alcoholism","volume":"211","author":"Muramatsu","year":"1995","journal-title":"Biochem. Biophys. Commun."},{"issue":"28","key":"10.1016\/j.nbd.2010.03.013_bib34","doi-asserted-by":"crossref","first-page":"9395","DOI":"10.1523\/JNEUROSCI.23-28-09395.2003","article-title":"Hyperdopaminergic mutant mice have higher \u201cwanting\u201d but not \u201cliking\u201d for sweet rewards","volume":"23","author":"Peci\u00f1a","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.03.013_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res. Brain Rev."},{"key":"10.1016\/j.nbd.2010.03.013_bib36","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.neuropsychologia.2009.02.005","article-title":"Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype","volume":"47","author":"Roussos","year":"2009","journal-title":"Neuropsychologia"},{"issue":"Pt 7","key":"10.1016\/j.nbd.2010.03.013_bib37","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/brain\/awh485","article-title":"Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease","volume":"128","author":"Scherfler","year":"2005","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.nbd.2010.03.013_bib38","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/mds.21505","article-title":"Role of DAT-SPECT in the diagnostic work up of parkinsonism","volume":"22","author":"Scherfler","year":"2007","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.nbd.2010.03.013_bib39","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1369-1600.2009.00171.x","article-title":"The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds","volume":"14","author":"Schmid","year":"2009","journal-title":"Addict. Biol."},{"issue":"2","key":"10.1016\/j.nbd.2010.03.013_bib40","first-page":"134","article-title":"Eating disorders with binge-eating behaviour are associated with the s allele of the 3\u2032-UTR VNTR polymorphism of the dopamine transporter gene","volume":"29","author":"Shinohara","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.nbd.2010.03.013_bib41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/ana.21204","article-title":"Dopamine transporter relation to dopamine turnover in Parkinson's disease: a positron emission tomography study","volume":"62","author":"Sossi","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2010.03.013_bib42","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/brain\/awp054","article-title":"Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study","volume":"132","author":"Steeves","year":"2009","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.nbd.2010.03.013_bib43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1212\/01.wnl.0000252368.25106.b6","article-title":"Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists","volume":"68","author":"Tippmann-Peikert","year":"2007","journal-title":"Neurology"},{"issue":"14","key":"10.1016\/j.nbd.2010.03.013_bib44","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1212\/01.wnl.0000338631.73211.56","article-title":"PET demonstrates reduced dopamine transporter expression in PD with dyskinesias","volume":"72","author":"Troiano","year":"2009","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.nbd.2010.03.013_bib45","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00259-008-0729-x","article-title":"Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT","volume":"35","author":"Varrone","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"8","key":"10.1016\/j.nbd.2010.03.013_bib46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/archneur.64.8.1089","article-title":"Medication-related impulse control and repetitive behaviors in Parkinson disease","volume":"64","author":"Voon","year":"2007","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.nbd.2010.03.013_bib47","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S1474-4422(09)70287-X","article-title":"Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders","volume":"8","author":"Voon","year":"2009","journal-title":"Lancet Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110000744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110000744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T07:21:04Z","timestamp":1591168864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996110000744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0969996110000744"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2010.03.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}