{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:52:02Z","timestamp":1789620722196,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["1R21NS047432"],"award-info":[{"award-number":["1R21NS047432"]}]},{"name":"NIH","award":["1R01NS36362"],"award-info":[{"award-number":["1R01NS36362"]}]},{"name":"NIH","award":["1R01NS45325"],"award-info":[{"award-number":["1R01NS45325"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.nbd.2010.04.016","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T07:11:36Z","timestamp":1273561896000},"page":"318-326","source":"Crossref","is-referenced-by-count":66,"title":["Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (\u0394E) TorsinA in transgenic mice"],"prefix":"10.1016","volume":"39","author":[{"given":"Michelle E.","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrette","family":"Andre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Pelta-Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sluzas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Gonzalez-Alegre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Bogush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren E.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Iacovitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle E.","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2010.04.016_bib1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1212\/01.WNL.0000149764.34953.BF","article-title":"Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation","volume":"64","author":"Asanuma","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2010.04.016_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-8993(03)03164-0","article-title":"Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain","volume":"986","author":"Augood","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib26","first-page":"53","article-title":"Dopamine transmission in DYT1 dystonia","volume":"94","author":"Augood","year":"2004","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1471-4159.2007.04590.x","article-title":"Dopamine release is impaired in a mouse model of DYT1 dystonia","volume":"102","author":"Balcioglu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2010.04.016_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/gene.20118","article-title":"DARPP-32 genomic fragments drive Cre expression in postnatal striatum","volume":"42","author":"Bogush","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.nbd.2010.04.016_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(01)00350-6","article-title":"TorsinA: movement at many levels","volume":"31","author":"Breakefield","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.04.016_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrn2337","article-title":"The pathophysiological basis of dystonias","volume":"9","author":"Breakefield","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib6","first-page":"849","article-title":"Dystonia: phenotypes and genotypes","volume":"159","author":"Bressman","year":"2003","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib7","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/hmg\/ddn206","article-title":"Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse","volume":"17","author":"Brown","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"Suppl. 3","key":"10.1016\/j.nbd.2010.04.016_bib8","doi-asserted-by":"crossref","first-page":"S570","DOI":"10.1002\/mds.22019","article-title":"Molecular mechanisms underlying levodopa-induced dyskinesia","volume":"23","author":"Calabresi","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2010.04.016_bib9","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1523\/JNEUROSCI.5157-04.2005","article-title":"Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans","volume":"25","author":"Cao","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib10","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1212\/WNL.0b013e3181aa538f","article-title":"Abnormal striatal and thalamic dopamine neurotransmission: genotype-related features of dystonia","volume":"72","author":"Carbon","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2010.04.016_bib11","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.1523\/JNEUROSCI.21-19-07841.2001","article-title":"Novel Ca2+ dependence and time course of somatodendritic dopamine release: substantia nigra versus striatum","volume":"21","author":"Chen","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib12","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1152\/jn.2001.85.6.2468","article-title":"H(2)O(2) is a novel, endogenous modulator of synaptic dopamine release","volume":"85","author":"Chen","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2010.04.016_bib13","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1152\/japplphysiol.00132.2003","article-title":"Genotypic differences in ethanol sensitivity in two tests of motor incoordination","volume":"95","author":"Crabbe","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.nbd.2010.04.016_bib14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.expneurol.2005.08.025","article-title":"Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia","volume":"196","author":"Dang","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neures.2006.09.005","article-title":"Motor deficits and hyperactivity in Dyt1 knockdown mice","volume":"56","author":"Dang","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.expneurol.2008.09.019","article-title":"Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease","volume":"215","author":"Dupuis","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0896-6273(03)00192-2","article-title":"Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice","volume":"38","author":"Gainetdinov","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.04.016_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1073858403255839","article-title":"D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease","volume":"9","author":"Gerfen","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2010.04.016_bib46","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1083\/jcb.200411026","article-title":"The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein","volume":"168","author":"Goodchild","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2010.04.016_bib19","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuron.2005.11.010","article-title":"Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope","volume":"48","author":"Goodchild","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.04.016_bib20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuroscience.2008.09.028","article-title":"Consequences of the DYT1 mutation on torsinA oligomerization and degradation","volume":"157","author":"Gordon","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2010.04.016_bib21","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1074\/jbc.M704097200","article-title":"The dystonia-associated protein torsinA modulates synaptic vesicle recycling","volume":"283","author":"Granata","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2010.04.016_bib22","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1471-4159.2009.06095.x","article-title":"TorsinA and dystonia: from nuclear envelope to synapse","volume":"109","author":"Granata","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2010.04.016_bib23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2007.04.015","article-title":"Overexpression of human wildtype torsinA and human DeltaGAG torsinA in a transgenic mouse model causes phenotypic abnormalities","volume":"27","author":"Grundmann","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.04.016_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.nbd.2005.10.012","article-title":"Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics","volume":"22","author":"Hewett","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.04.016_bib25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1471-4159.2010.06590.x","article-title":"Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo","volume":"113","author":"Hewett","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2010.04.016_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0169-328X(02)00694-0","article-title":"The human tyrosine hydroxylase gene promoter","volume":"112","author":"Kessler","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib28","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1523\/JNEUROSCI.20-12-04405.2000","article-title":"Dopamine-deficient mice are hypersensitive to dopamine receptor agonists","volume":"20","author":"Kim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(01)03014-1","article-title":"Immunocytochemical characterization of torsin proteins in mouse brain","volume":"922","author":"Konakova","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib30","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1523\/JNEUROSCI.11-09-02703.1991","article-title":"Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics","volume":"11","author":"Kuczenski","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2010.04.016_bib32","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/neu.20313","article-title":"Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration","volume":"66","author":"Muraro","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.nbd.2010.04.016_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.nbd.2010.03.003","article-title":"Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia","volume":"38","author":"Napolitano","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.04.016_bib34","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1242\/jcs.029454","article-title":"TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton","volume":"121","author":"Nery","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2010.04.016_bib35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng0997-40","article-title":"The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein","volume":"17","author":"Ozelius","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2010.04.016_bib36","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1098-2396(19990915)33:4<304::AID-SYN7>3.0.CO;2-Z","article-title":"Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus","volume":"33","author":"Page","year":"1999","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2010.04.016_bib37","series-title":"Encyclopedia of Sensors","first-page":"313","article-title":"Dopamine release in brain slices","author":"Patel","year":"2006"},{"key":"10.1016\/j.nbd.2010.04.016_bib38","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1523\/JNEUROSCI.0181-09.2009","article-title":"Mobilization of intracellular calcium stores facilitates somatodendritic dopamine release","volume":"29","author":"Patel","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2006.07.006","article-title":"Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia","volume":"24","author":"Pisani","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.04.016_bib41","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tins.2007.07.008","article-title":"Re-emergence of striatal cholinergic interneurons in movement disorders","volume":"30","author":"Pisani","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/WCO.0b013e328307bf07","article-title":"Clinical features of dystonia: a pathophysiological revisitation","volume":"21","author":"Quartarone","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0306-4522(00)00073-7","article-title":"Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model","volume":"97","author":"Rehders","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2010.04.016_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nn1244","article-title":"Nicotine amplifies reward-related dopamine signals in striatum","volume":"7","author":"Rice","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib45","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/sj.npp.1301000","article-title":"Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine","volume":"31","author":"Schank","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2010.04.016_bib47","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1523\/JNEUROSCI.0855-05.2005","article-title":"Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation","volume":"25","author":"Sharma","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.04.016_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0006-8993(00)02702-5","article-title":"TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease","volume":"877","author":"Shashidharan","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(99)02232-5","article-title":"Immunohistochemical localization and distribution of torsinA in normal human and rat brain","volume":"853","author":"Shashidharan","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2010.04.016_bib50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/hmg\/ddi012","article-title":"Transgenic mouse model of early-onset DYT1 dystonia","volume":"14","author":"Shashidharan","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2010.04.016_bib51","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1073\/pnas.0308088101","article-title":"Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant","volume":"101","author":"Torres","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2010.04.016_bib52","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.biopsych.2006.11.032","article-title":"Spatiotemporal pattern of striatal ERK1\/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors","volume":"62","author":"Westin","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2010.04.016_bib53","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.expneurol.2008.04.020","article-title":"Commentary: dopaminergic dysfunction in DYT1 dystonia","volume":"212","author":"Wichmann","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2010.04.016_bib54","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1073\/pnas.90.12.5667","article-title":"Extracellular dopamine concentration in the retina of the clawed frog, Xenopus laevis","volume":"90","author":"Witkovsky","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2010.04.016_bib55","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.expneurol.2007.12.027","article-title":"Abnormal motor function and dopamine neurotransmission in DYT1 DeltaGAG transgenic mice","volume":"210","author":"Zhao","year":"2008","journal-title":"Exp. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110001324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110001324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:21:30Z","timestamp":1559085690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996110001324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0969996110001324"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2010.04.016","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}