{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:10:30Z","timestamp":1793329830973,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.nbd.2010.05.027","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T04:55:06Z","timestamp":1275540906000},"page":"207-215","source":"Crossref","is-referenced-by-count":94,"title":["Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease"],"prefix":"10.1016","volume":"40","author":[{"given":"Kun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Askew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun S.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2010.05.027_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000091921","article-title":"Changes in expression of N-methyl-d-aspartate receptor subunits occur early in the R6\/2 mouse model of Huntington's disease","volume":"28","author":"Ali","year":"2006","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib2","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1523\/JNEUROSCI.14-09-05559.1994","article-title":"Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex","volume":"14","author":"Arriza","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00005072-199704000-00013","article-title":"Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease\u2014an in situ hybridization study","volume":"56","author":"Arzberger","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2010.05.027_bib4","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/brain\/awf180","article-title":"Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation","volume":"125","author":"Behrens","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2010.05.027_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-7091-0579-5_14","article-title":"The N-methyl-d-aspartate antagonist memantine retards progression of Huntington's disease","author":"Beister","year":"2004","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.nbd.2010.05.027_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-2007-973660","article-title":"The mechanism and functional roles of protein palmitoylation in the nervous system","volume":"28","author":"Bizzozero","year":"1997","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.nbd.2010.05.027_bib7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2010.05.027_bib9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2144\/04362RR02","article-title":"Labeling and quantifying sites of protein palmitoylation","volume":"36","author":"Drisdel","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.nbd.2010.05.027_bib10","doi-asserted-by":"crossref","first-page":"10502","DOI":"10.1523\/JNEUROSCI.3315-04.2004","article-title":"The role of palmitoylation in functional expression of nicotinic alpha7 receptors","volume":"24","author":"Drisdel","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0005-2760(98)00130-1","article-title":"Signalling functions of protein palmitoylation","volume":"1436","author":"Dunphy","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2010.05.027_bib12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrn940","article-title":"Protein palmitoylation: a regulator of neuronal development and function","volume":"3","author":"el-Husseini Ael","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib13","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1523\/JNEUROSCI.17-21-08363.1997","article-title":"Glutamate transporter protein subtypes are expressed differentially during rat CNS development","volume":"17","author":"Furuta","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mcn.2009.01.002","article-title":"Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation","volume":"40","author":"Gouix","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.nbd.2005.08.007","article-title":"Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models","volume":"21","author":"Graham","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.05.027_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.nbd.2010.05.027_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1083\/jcb.200610151","article-title":"Palmitoylation-dependent protein sorting","volume":"176","author":"Greaves","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2010.05.027_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11064-007-9463-1","article-title":"Glutamate uptake is reduced in prefrontal cortex in Huntington's disease","volume":"33","author":"Hassel","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2010.05.027_bib19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/366562a0","article-title":"Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide","volume":"366","author":"Hess","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2010.05.027_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"Hodgson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.05.027_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.conb.2005.08.001","article-title":"Modulation of neuronal protein trafficking and function by palmitoylation","volume":"15","author":"Huang","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2010.05.027_bib22","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2004.11.027","article-title":"Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins","volume":"44","author":"Huang","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.05.027_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fj.08-127399","article-title":"Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity","author":"Huang","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2010.05.027_bib24","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1523\/JNEUROSCI.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease","volume":"29","author":"Joshi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07605","article-title":"Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation","volume":"456","author":"Kang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2010.05.027_bib26","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1124\/mol.55.6.1044","article-title":"Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult","volume":"55","author":"Koch","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2010.05.027_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuron.2010.01.010","article-title":"Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease","volume":"65","author":"Levine","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.05.027_bib28","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1006\/nbdi.2001.0430","article-title":"Impaired glutamate uptake in the R6 Huntington's disease transgenic mice","volume":"8","author":"Lievens","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.05.027_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: policing protein stability and traffic","volume":"8","author":"Linder","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2010.05.027_bib30","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"issue":"Suppl 2","key":"10.1016\/j.nbd.2010.05.027_bib31","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1007\/s100720200081","article-title":"Amantadine in Huntington's disease: open-label video-blinded study","volume":"23","author":"Lucetti","year":"2002","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.nbd.2010.05.027_bib32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2010.05.027_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/263517a0","article-title":"Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids","volume":"263","author":"McGeer","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2010.05.027_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2008.02.004","article-title":"Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6\/2 mouse","volume":"153","author":"Miller","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2010.05.027_bib35","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2010.05.027_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.0953-816X.2000.01379.x","article-title":"Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6\/1 Huntington transgenic mice","volume":"13","author":"Nicniocaill","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib37","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1152\/jn.91138.2008","article-title":"Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn","volume":"101","author":"Nie","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2010.05.027_bib38","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2010.05.027_bib39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/10738584070130060401","article-title":"The dichotomy of NMDA receptor signaling","volume":"13","author":"Papadia","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2010.05.027_bib40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0197-0186(98)00055-2","article-title":"The family of sodium-dependent glutamate transporters: a focus on the GLT-1\/EAAT2 subtype","volume":"33","author":"Robinson","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2010.05.027_bib41","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cell.2006.03.042","article-title":"Global analysis of protein palmitoylation in yeast","volume":"125","author":"Roth","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2010.05.027_bib42","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199205283262204","article-title":"Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis","volume":"326","author":"Rothstein","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2010.05.027_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2010.05.027_bib44","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","article-title":"Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain","volume":"219","author":"Schwarcz","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.nbd.2010.05.027_bib45","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","article-title":"Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity","volume":"171","author":"Shin","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2010.05.027_bib46","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2010.05.027_bib47","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1523\/JNEUROSCI.1207-08.2008","article-title":"Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand","volume":"28","author":"Soriano","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib48","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jnr.20651","article-title":"Alterations in N-methyl-d-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6\/2 mouse model of Huntington's disease","volume":"82","author":"Starling","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2010.05.027_bib49","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2010.05.027_bib50","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2010.05.027_bib51","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1460-9568.1994.tb00587.x","article-title":"Differential expression of two glial glutamate transporters in the rat brain: an in situ hybridization study","volume":"6","author":"Torp","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib52","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1093\/hmg\/ddi407","article-title":"Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease","volume":"14","author":"Van Raamsdonk","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2010.05.027_bib53","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/hmg\/ddi147","article-title":"Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease","volume":"14","author":"Van Raamsdonk","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2010.05.027_bib54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2202-7-80","article-title":"Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease","volume":"7","author":"Van Raamsdonk","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2010.05.027_bib55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nbd.2006.12.010","article-title":"Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain","volume":"26","author":"Van Raamsdonk","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2010.05.027_bib56","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110001890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996110001890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T16:00:48Z","timestamp":1559145648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996110001890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0969996110001890"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2010.05.027","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}