{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:12:27Z","timestamp":1791324747391,"version":"4.3.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.nbd.2011.04.009","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T11:10:50Z","timestamp":1303211450000},"page":"379-387","source":"Crossref","is-referenced-by-count":21,"title":["Reduced expression of conditioned fear in the R6\/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex"],"prefix":"10.1016","volume":"43","author":[{"given":"Adam G.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Ummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Rebec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.04.009_bb0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0165-0270(82)90002-4","article-title":"Quantification, smoothing, and confidence limits for single-units' histograms","volume":"5","author":"Abeles","year":"1982","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2011.04.009_bb0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1258\/002367706777611488","article-title":"Laboratory environments and rodents' behavioural needs: a review","volume":"40","author":"Balcombe","year":"2006","journal-title":"Lab. Anim."},{"key":"10.1016\/j.nbd.2011.04.009_bb0015","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1037\/0735-7044.117.6.1233","article-title":"Exploratory activity and fear conditioning abnormalities develop early in R6\/2 Huntington's disease transgenic mice","volume":"117","author":"Bolivar","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0020","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3758\/BF03199629","article-title":"Conditioned fear assessed by freezing and by the suppression of three different baselines","volume":"8","author":"Bouton","year":"1980","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.nbd.2011.04.009_bb0285","series-title":"Methods of behavior analysis in neuroscience","year":"2009"},{"key":"10.1016\/j.nbd.2011.04.009_bb0025","doi-asserted-by":"crossref","first-page":"8474","DOI":"10.1523\/JNEUROSCI.0378-09.2009","article-title":"Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure","volume":"29","author":"Burgos-Robles","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0030","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0035","doi-asserted-by":"crossref","first-page":"e00033","DOI":"10.1042\/AN20090058","article-title":"Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms","volume":"2","author":"Cepeda","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.nbd.2011.04.009_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nlm.2009.06.002","article-title":"Progressive imbalance in the interaction between spatial and procedural memory systems in the R6\/2 mouse model of Huntington's disease","volume":"92","author":"Ciamei","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2011.04.009_bb0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1523\/JNEUROSCI.5327-06.2007","article-title":"Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears","volume":"27","author":"Corcoran","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2010.12.035","article-title":"Huntington's disease: can mice lead the way to treatment?","volume":"69","author":"Crook","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.04.009_bb0055","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2011.04.009_bb0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(98)00736-7","article-title":"Striking changes in anxiety in Huntington's disease transgenic mice","volume":"805","author":"File","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2011.04.009_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2008.06.005","article-title":"Rodent genetic models of Huntington disease","volume":"32","author":"Heng","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.04.009_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.01.024","article-title":"Early behavioral deficits in R6\/2 mice suitable for use in preclinical drug testing","volume":"20","author":"Hickey","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.04.009_bb0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2008.08.041","article-title":"Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice","volume":"157","author":"Hickey","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.04.009_bb0080","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2337\/diabetes.48.3.649","article-title":"Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes","volume":"48","author":"Hurlbert","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2011.04.009_bb0085","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington's disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0090","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemonic functions in early Huntington's disease","volume":"119","author":"Lawrence","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2011.04.009_bb0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1364-6613(98)01231-5","article-title":"Cognitive functions and corticostriatal circuits: insights from Huntington's disease","volume":"2","author":"Lawrence","year":"1998","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"LeDoux","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0105","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999","article-title":"Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation","volume":"19","author":"Lione","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2011.04.009_bb0115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.10295","article-title":"Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6\/2 transgenic mice","volume":"449","author":"Meade","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2009.05.007","article-title":"Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models","volume":"35","author":"Menalled","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.04.009_bb0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nature01138","article-title":"Neurons in medial prefrontal cortex signal memory for fear extinction","volume":"420","author":"Milad","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.04.009_bb0130","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1152\/jn.90606.2008","article-title":"Dysregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease","volume":"100","author":"Miller","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0135","first-page":"21","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Montoya","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0140","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0145","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the R6\/1 Huntington's disease transgenic mouse","volume":"122","author":"Naver","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.04.009_bb0150","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1093\/hmg\/ddl394","article-title":"Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease","volume":"15","author":"Nguyen","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.04.009_bb0155","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease","volume":"25","author":"Paulsen","year":"2004","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0160","series-title":"Conditioned reflexes; an investigation of the physiological activity of the cerebral cortex","author":"Pavlov","year":"1927"},{"key":"10.1016\/j.nbd.2011.04.009_bb0165","series-title":"The Mouse Brain in Stereotaxic Coordinates, Deluxe Second Edition (with CD-ROM)","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.nbd.2011.04.009_bb0170","first-page":"143","article-title":"Comparison of logistic regression and linear discriminant analysis: a simulation study","volume":"1","author":"Pohar","year":"2004","journal-title":"Metodoloski Zvezki"},{"key":"10.1016\/j.nbd.2011.04.009_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","article-title":"Neural mechanisms of extinction learning and retrieval","volume":"33","author":"Quirk","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2011.04.009_bb0180","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biopsych.2006.03.010","article-title":"Prefrontal mechanisms in extinction of conditioned fear","volume":"60","author":"Quirk","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2011.04.009_bb0185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.31887\/DCNS.2007.9.2\/arosenblatt","article-title":"Neuropsychiatry of Huntington's disease","volume":"9","author":"Rosenblatt","year":"2007","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0190","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neubiorev.2004.09.004","article-title":"Understanding contextual fear conditioning: insights from a two-process model","volume":"28","author":"Rudy","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2011.04.009_bb0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2008.09.017","article-title":"Use of magnetic resonance imaging for anatomical phenotyping of the R6\/2 mouse model of Huntington's disease","volume":"33","author":"Sawiak","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.04.009_bb0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nbd.2008.09.016","article-title":"Voxel-based morphometry in the R6\/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry","volume":"33","author":"Sawiak","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.04.009_bb0205","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/j.1460-9568.2006.05014.x","article-title":"Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction","volume":"24","author":"Sierra-Mercado","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0210","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/npp.2010.184","article-title":"Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear","volume":"36","author":"Sierra-Mercado","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2011.04.009_bb0215","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.conb.2010.02.005","article-title":"Prefrontal control of fear: more than just extinction","volume":"20","author":"Sotres-Bayon","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0220","series-title":"Electronic Statistics Textbook","author":"Statsoft inc","year":"2010"},{"key":"10.1016\/j.nbd.2011.04.009_bb0225","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jnnp.2006.098368","article-title":"Functional connectivity of the prefrontal cortex in Huntington's disease","volume":"78","author":"Thiruvady","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2011.04.009_bb0230","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1468-1331.2007.01975.x","article-title":"Cognitive changes in asymptomatic carriers of the Huntington disease mutation gene","volume":"14","author":"Verny","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0235","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1101\/lm.306106","article-title":"Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear","volume":"13","author":"Vidal-Gonzalez","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.nbd.2011.04.009_bb0240","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/hmg\/12.6.617","article-title":"Transgenic rat model of Huntington's disease","volume":"12","author":"von Horsten","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.04.009_bb0245","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1523\/JNEUROSCI.2804-08.2008","article-title":"Altered information processing in the prefrontal cortex of Huntington's disease mouse models","volume":"28","author":"Walker","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0250","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0301-0511(87)90019-6","article-title":"A simple randomisation procedure for validating discriminant analysis: a methodological note","volume":"24","author":"Wastell","year":"1987","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0255","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1523\/JNEUROSCI.4595-06.2007","article-title":"Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice","volume":"27","author":"Wellman","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.04.009_bb0260","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awm210","article-title":"Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI","volume":"130","author":"Wolf","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2011.04.009_bb0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2008.05.017","article-title":"Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease","volume":"213","author":"Wolf","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.04.009_bb0270","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hbm.20502","article-title":"Cortical dysfunction in patients with Huntington's disease during working memory performance","volume":"30","author":"Wolf","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nbd.2011.04.009_bb0275","doi-asserted-by":"crossref","first-page":"e9077","DOI":"10.1371\/journal.pone.0009077","article-title":"Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease","volume":"5","author":"Wood","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2011.04.009_bb0280","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1076\/jcen.20.4.565.1468","article-title":"The subcortical dementia of Huntington's disease","volume":"20","author":"Zakzanis","year":"1998","journal-title":"J. Clin. Exp. Neuropsychol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111001264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111001264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:58:02Z","timestamp":1637531882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111001264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0969996111001264"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.04.009","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}