{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:16:05Z","timestamp":1791080165742,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.nbd.2011.05.005","type":"journal-article","created":{"date-parts":[[2011,5,21]],"date-time":"2011-05-21T04:27:09Z","timestamp":1305952029000},"page":"516-525","source":"Crossref","is-referenced-by-count":24,"title":["Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults"],"prefix":"10.1016","volume":"43","author":[{"given":"Joshua","family":"Hogins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Mennerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.05.005_bb0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00004647-200206000-00009","article-title":"Selective proteasomal dysfunction in the hippocampal CA1 region after transient forebrain ischemia","volume":"22","author":"Asai","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2011.05.005_bb0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-540-74805-2_8","article-title":"Presynaptic signaling by heterotrimeric G-proteins","volume":"184","author":"Brown","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.nbd.2011.05.005_bb0015","doi-asserted-by":"crossref","first-page":"35071","DOI":"10.1074\/jbc.M203300200","article-title":"Staring, a novel E3 ubiquitin\u2013protein ligase that targets syntaxin 1 for degradation","volume":"277","author":"Chin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.05.005_bb0020","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0304-3940(85)90069-2","article-title":"Glutamate neurotoxicity in cortical cell culture is calcium dependent","volume":"58","author":"Choi","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.05.005_bb0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1523\/JNEUROSCI.07-02-00369.1987","article-title":"Ionic dependence of glutamate neurotoxicity","volume":"7","author":"Choi","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.ne.13.030190.001131","article-title":"The role of glutamate neurotoxicity in hypoxic\u2013ischemic neuronal death","volume":"13","author":"Choi","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0035","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1523\/JNEUROSCI.4960-10.2011","article-title":"Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses","volume":"31","author":"Crawford","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.27.070203.144317","article-title":"Ubiquitin-dependent regulation of the synapse","volume":"27","author":"DiAntonio","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0045","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn1927","article-title":"Cerebral preconditioning and ischaemic tolerance","volume":"7","author":"Gidday","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0050","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1523\/JNEUROSCI.13-08-03510.1993","article-title":"Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury","volume":"13","author":"Goldberg","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0055","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.19-05-01657.1999","article-title":"Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors","volume":"19","author":"Grabb","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0306-4522(02)00370-6","article-title":"Preconditioned resistance to oxygen-glucose deprivation-induced cortical neuronal death: alterations in vesicular GABA and glutamate release","volume":"115","author":"Grabb","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.05.005_bb0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbagrm.2007.12.010","article-title":"Roles of ubiquitination at the synapse","volume":"1779","author":"Haas","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2011.05.005_bb0070","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrn961","article-title":"Ubiquitin and the synapse","volume":"3","author":"Hegde","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0075","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1523\/JNEUROSCI.4965-09.2010","article-title":"A role for the ubiquitin\u2013proteasome system in activity-dependent presynaptic silencing","volume":"30","author":"Jiang","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0006-8993(91)91596-S","article-title":"\u2018Ischemic tolerance\u2019 phenomenon detected in various brain regions","volume":"561","author":"Kitagawa","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2011.05.005_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2005.04.053","article-title":"Ischemic tolerance induction in organotypic hippocampal slices: role for the GABAA receptor?","volume":"384","author":"Lange-Asschenfeldt","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.05.005_bb0090","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrn2229","article-title":"Pathologically activated therapeutics for neuroprotection","volume":"8","author":"Lipton","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0095","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.bbrc.2005.02.086","article-title":"Evidence that insulin secretion influences SNAP-25 through proteasomal activation","volume":"329","author":"Ma","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.05.005_bb0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-cellbio-100109-104129","article-title":"Ubiquitination in postsynaptic function and plasticity","volume":"26","author":"Mabb","year":"2010","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2011.05.005_bb0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1523\/JNEUROSCI.3474-07.2008","article-title":"Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance","volume":"28","author":"Meller","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0110","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1152\/jn.1995.73.1.320","article-title":"Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures","volume":"73","author":"Mennerick","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2011.05.005_bb0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.05.005_bb0120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0896-6273(04)00184-9","article-title":"Plastic elimination of functional glutamate release sites by depolarization","volume":"42","author":"Moulder","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.05.005_bb0125","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1523\/JNEUROSCI.5498-05.2006","article-title":"Physiological activity depresses synaptic function through an effect on vesicle priming","volume":"26","author":"Moulder","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0130","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1523\/JNEUROSCI.5317-07.2008","article-title":"A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing","volume":"28","author":"Moulder","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0135","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1523\/JNEUROSCI.22-03-00654.2002","article-title":"Development of vesicle pools during maturation of hippocampal synapses","volume":"22","author":"Mozhayeva","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0896-6273(01)00500-1","article-title":"Inactivity produces increases in neurotransmitter release and synapse size","volume":"32","author":"Murthy","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.05.005_bb0145","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00004647-200202000-00004","article-title":"Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist","volume":"22","author":"Nakamura","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2011.05.005_bb0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1471-4892(02)00002-4","article-title":"Excitotoxicity, apoptosis and neuropsychiatric disorders","volume":"3","author":"Olney","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2011.05.005_bb0155","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1126\/science.172.3980.294","article-title":"Monosodium glutamate effects","volume":"172","author":"Olney","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.05.005_bb0160","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0306-4522(96)00311-9","article-title":"Anoxic preconditioning in hippocampal slices: role of adenosine","volume":"75","author":"Perez-Pinzon","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.05.005_bb0165","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.05.005_bb0170","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1523\/JNEUROSCI.04-07-01884.1984","article-title":"Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death","volume":"4","author":"Rothman","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0175","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1046\/j.1471-4159.2001.00203.x","article-title":"Cellular defenses against excitotoxic insults","volume":"76","author":"Sapolsky","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.05.005_bb0180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2004.11.025","article-title":"Astrocytes exert a pro-apoptotic effect on neurons in postnatal hippocampal cultures","volume":"131","author":"Shute","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.05.005_bb0185","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrn2499","article-title":"Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction","volume":"9","author":"Tai","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0190","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.coph.2007.09.010","article-title":"Ubiquitin\u2013proteasome system as a modulator of cell fate","volume":"8","author":"Thompson","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2011.05.005_bb0195","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1074\/jbc.M107857200","article-title":"Regulation of synaptophysin degradation by mammalian homologues of seven in absentia","volume":"277","author":"Wheeler","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.05.005_bb0200","doi-asserted-by":"crossref","first-page":"11333","DOI":"10.1523\/JNEUROSCI.1684-06.2006","article-title":"Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons","volume":"26","author":"Willeumier","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0205","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1523\/JNEUROSCI.11-05-01375.1991","article-title":"Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus","volume":"11","author":"Yoon","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.05.005_bb0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0163-7258(93)90043-D","article-title":"Excitotoxic neuronal damage and neuropsychiatric disorders","volume":"59","author":"Zorumski","year":"1993","journal-title":"Pharmacol. Ther."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111001598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111001598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T21:33:42Z","timestamp":1560202422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111001598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0969996111001598"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.05.005","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}