{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:28:13Z","timestamp":1792477693888,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.nbd.2011.06.016","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T18:25:11Z","timestamp":1309890311000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3\u03b2"],"prefix":"10.1016","volume":"44","author":[{"given":"Fernando","family":"Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.06.016_bb0005","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jss.2008.08.004","article-title":"Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride","volume":"159","author":"Adler","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.nbd.2011.06.016_bb0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/BC.2009.033","article-title":"Glutathione dysregulation and the etiology and progression of human diseases","volume":"390","author":"Ballatori","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.nbd.2011.06.016_bb0015","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1523\/JNEUROSCI.5704-10.2011","article-title":"Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3{beta}","volume":"31","author":"Bardai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000089617","article-title":"Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase","volume":"2","author":"Bendotti","year":"2005","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nbd.2011.06.016_bb0025","doi-asserted-by":"crossref","first-page":"21934","DOI":"10.1074\/jbc.M802481200","article-title":"Differential regulation of STAT family members by glycogen synthase kinase-3","volume":"283","author":"Beurel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.06.016_bb0030","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1042\/BST0351127","article-title":"Chronic microglial activation and progressive dopaminergic neurotoxicity","volume":"35","author":"Block","year":"2007","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.nbd.2011.06.016_bb0135","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0306-4522(02)00743-1","article-title":"Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers","volume":"117","author":"Bown","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.06.016_bb0035","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.4049\/jimmunol.168.8.4070","article-title":"Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia","volume":"168","author":"Branger","year":"2002","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.nbd.2011.06.016_bb0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tibs.2008.04.015","article-title":"A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code","volume":"33","author":"Calao","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0045","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/sj.mp.4001893","article-title":"Valproate protects dopaminergic neurons in midbrain neuron\/glia cultures by stimulating the release of neurotrophic factors from astrocytes","volume":"11","author":"Chen","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2011.06.016_bb0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2007.06.053","article-title":"Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity","volume":"149","author":"Chen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.06.016_bb0055","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","author":"Chuang","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcp.2008.09.014","article-title":"A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells","volume":"77","author":"Correa","year":"2009","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.nbd.2011.06.016_bb0065","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/glia.21151","article-title":"The Nrf2-inducible antioxidant defence in astrocytes can be both up- and down-regulated by activated microglia: involvement of p38 MAPK","volume":"59","author":"Correa","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2011.06.016_bb0070","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.neuroscience.2006.11.010","article-title":"Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate","volume":"144","author":"Cui","year":"2007","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.nbd.2011.06.016_bb0075","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.neuroscience.2006.02.065","article-title":"Valproic acid induces caspase 3-mediated apoptosis in microglial cells","volume":"140","author":"Dragunow","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2011.06.016_bb0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1523\/JNEUROSCI.19-02-00562.1999","article-title":"Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione","volume":"19","author":"Dringen","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0085","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.nbd.2009.07.019","article-title":"Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo","volume":"36","author":"Faraco","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2011.06.016_bb0095","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2010.08.024","article-title":"Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures","volume":"41","author":"Gibbons","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.06.016_bb0100","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1016\/j.febslet.2009.10.010","article-title":"Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1\/2) and JNK","volume":"583","author":"Goven","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2011.06.016_bb0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00964164","article-title":"Cellular composition of a cerebral hemisphere primary culture","volume":"9","author":"Hansson","year":"1984","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2011.06.016_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000069046","article-title":"Evidence that p38 mitogen-activated protein kinase contributes to neonatal hypoxic\u2013ischemic brain injury","volume":"24","author":"Hee","year":"2002","journal-title":"Dev. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2011.06.016_bb0115","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.2353\/ajpath.2007.060898","article-title":"Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2","volume":"170","author":"Hubbs","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0120","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/sj.bjp.0705682","article-title":"Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids","volume":"141","author":"Huuskonen","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0125","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","article-title":"The transcription factor Nrf2 is a therapeutic target against brain inflammation","volume":"181","author":"Innamorato","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1006\/bbrc.1999.0316","article-title":"Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I","volume":"256","author":"Inokoshi","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.06.016_bb0140","doi-asserted-by":"crossref","first-page":"F662","DOI":"10.1152\/ajprenal.00421.2009","article-title":"Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure","volume":"298","author":"Kim","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1242\/jcs.01562","article-title":"Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3","volume":"118","author":"Kim","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0150","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action","volume":"321","author":"Kim","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2011.06.016_bb0155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2011.06.016_bb0160","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/MCB.26.1.221-229.2006","article-title":"Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0165","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1523\/JNEUROSCI.5467-07.2008","article-title":"Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition","volume":"28","author":"Leng","year":"2008","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2011.06.016_bb0170","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-kappaB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"7\u20138","key":"10.1016\/j.nbd.2011.06.016_bb0175","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuropharm.2010.09.022","article-title":"Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons","volume":"60","author":"Marinova","year":"2011","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.nbd.2011.06.016_bb0180","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2011.02.035","article-title":"Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress","volume":"406","author":"Mercado","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.06.016_bb0185","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.4049\/jimmunol.0900006","article-title":"Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2","volume":"182","author":"Naidu","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0190","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.tips.2009.07.002","article-title":"Sodium valproate: an old drug with new roles","volume":"30","author":"Nalivaeva","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0195","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.brainresbull.2008.11.010","article-title":"Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB","volume":"78","author":"Niu","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2011.06.016_bb0200","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1471-4159.2005.03241.x","article-title":"Gap junction blockage limits intercellular spreading of astrocytic apoptosis induced by metabolic depression","volume":"94","author":"Nodin","year":"2005","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.nbd.2011.06.016_bb0205","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1128\/MCB.01204-10","article-title":"SCF(beta-TrCP) promotes Glycogen synthase kinase-3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner","volume":"31","author":"Rada","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative diseases","volume":"66","author":"Ramsey","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mcn.2008.06.007","article-title":"Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death","volume":"39","author":"Rojo","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2011.06.016_bb0220","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.2007.05124.x","article-title":"GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress","volume":"105","author":"Rojo","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.06.016_bb0225","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1073\/pnas.0737363100","article-title":"Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway","volume":"100","author":"Ryu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2011.06.016_bb0230","doi-asserted-by":"crossref","first-page":"14841","DOI":"10.1074\/jbc.M513737200","article-title":"Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2","volume":"281","author":"Salazar","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.06.016_bb0235","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0006-2952(02)00897-3","article-title":"Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress","volume":"63","author":"Solis","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2011.06.016_bb0240","doi-asserted-by":"crossref","first-page":"28230","DOI":"10.1074\/jbc.M413103200","article-title":"Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling","volume":"280","author":"Song","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.06.016_bb0245","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/MCB.01639-08","article-title":"Acetylation of Nrf2 by p300\/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response","volume":"29","author":"Sun","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"50","key":"10.1016\/j.nbd.2011.06.016_bb0250","doi-asserted-by":"crossref","first-page":"13574","DOI":"10.1523\/JNEUROSCI.4099-08.2008","article-title":"Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis","volume":"28","author":"Vargas","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.06.016_bb0255","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S1461145708009024","article-title":"Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons","volume":"11","author":"Wu","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.nbd.2011.06.016_bb0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2010.07.004","article-title":"The role of p38 MAPK in valproic acid induced microglia apoptosis","volume":"482","author":"Xie","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.06.016_bb0265","doi-asserted-by":"crossref","first-page":"e8579","DOI":"10.1371\/journal.pone.0008579","article-title":"Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice","volume":"5","author":"Yu","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.nbd.2011.06.016_bb0270","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cellsig.2011.01.014","article-title":"Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway","volume":"23","author":"Yu","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.nbd.2011.06.016_bb0275","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.jcbfm.9600502","article-title":"Anti-inflammatory effects of the 70kDa heat shock protein in experimental stroke","volume":"28","author":"Zheng","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:06:37Z","timestamp":1760850397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111002233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0969996111002233"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.06.016","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3\u03b2","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2011.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}