{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:07:58Z","timestamp":1791180478884,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":562,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0601364"],"award-info":[{"award-number":["G0601364"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.nbd.2011.08.003","type":"journal-article","created":{"date-parts":[[2011,8,14]],"date-time":"2011-08-14T23:01:40Z","timestamp":1313362900000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Post mortem cerebrospinal fluid \u03b1-synuclein levels are raised in multiple system atrophy and distinguish this from the other \u03b1-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies"],"prefix":"10.1016","volume":"45","author":[{"given":"P.G.","family":"Foulds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thurston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Holton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gerhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Allsop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.08.003_bb0005","doi-asserted-by":"crossref","unstructured":"Aerts, M.B., et al., in press. CSF \u03b1-synuclein does not discriminate between parkinsonian disorders. Neurobiol Aging. doi:10.1016\/j.neurobiolaging.2010.12.001.","DOI":"10.1016\/j.neurobiolaging.2010.12.001"},{"issue":"Suppl. 3","key":"10.1016\/j.nbd.2011.08.003_bb0010","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/S1353-8020(09)70802-8","article-title":"Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease","volume":"15","author":"Angot","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2011.08.003_bb0015","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of \u03b1-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.08.003_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000112832","article-title":"Red blood cells are the major source of alpha-synuclein in blood","volume":"5","author":"Barbour","year":"2008","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nbd.2011.08.003_bb0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(03)00530-1","article-title":"CSF markers for incipient Alzheimer's Disease","volume":"2","author":"Blennow","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0035","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.03-0098fje","article-title":"Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma","volume":"17","author":"El-Agnaf","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2011.08.003_bb0040","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1096\/fj.03-1449com","article-title":"Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease","volume":"20","author":"El-Agnaf","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2011.08.003_bb0045","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1523\/JNEUROSCI.5699-09.2010","article-title":"Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival","volume":"30","author":"Emmanouilidou","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.003_bb0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrneurol.2010.78","article-title":"Progress towards a molecular biomarker for Parkinson disease","volume":"6","author":"Foulds","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"Alpha-synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2011.01.005","article-title":"Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro \u03b1-synuclein fibril formation","volume":"491","author":"Hirohata","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.08.003_bb0065","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/brain\/awq008","article-title":"DJ-1 and \u03b1-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease","volume":"133","author":"Hong","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2011.08.003_bb0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2011.08.003_bb0075","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1212\/WNL.57.8.1497","article-title":"Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease","volume":"57","author":"Hughes","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.08.003_bb0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00401-008-0456-1","article-title":"Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis","volume":"117","author":"Kasai","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0085","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.1523\/JNEUROSCI.0692-05.2005","article-title":"Intravesicular localization and exocytosis of alpha-synuclein and its aggregates","volume":"25","author":"Lee","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.003_bb0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.expneurol.2008.06.004","article-title":"Direct quantification of CSF \u03b1-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration","volume":"213","author":"Mollenhauer","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0100","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1474-4422(11)70014-X","article-title":"\u03b1-synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study","volume":"10","author":"Mollenhauer","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0105","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.expneurol.2007.11.019","article-title":"Relationship of phosphorylated \u03b1-synuclein and tau accumulation to Ab deposition in the cerebral cortex of dementia with Lewy bodies","volume":"210","author":"Obi","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0110","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neulet.2008.11.015","article-title":"Cerebrospinal fluid \u03b1-synuclein in neurodegenerative disorders: a marker of synapse loss?","volume":"450","author":"Ohrfelt","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.08.003_bb0115","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awn349","article-title":"Detection of elevated levels of soluble {\u03b1lph}-synuclein oligomers in post mortem brain extracts from patients with dementia with Lewy bodies","volume":"132","author":"Paleologou","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2011.08.003_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1468-1331.9.s3.3.x","article-title":"The differential diagnosis of Parkinson's disease","volume":"9","author":"Poewe","year":"2002","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/JAD-2010-100186","article-title":"CSF \u03b1-synuclein does not discriminate Dementia with Lewy bodies from Alzheimer's disease","volume":"22","author":"Reesink","year":"2010","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.nbd.2011.08.003_bb0130","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2007.09.048","article-title":"Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of \u03b1-synuclein","volume":"363","author":"Sasakawa","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.08.003_bb0135","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2217\/bmm.10.93","article-title":"Biomarker research in Parkinson's disease: objective measures needed for patient stratification in future cause-directed trials","volume":"4","author":"Schlossmacher","year":"2010","journal-title":"Biomarkers"},{"key":"10.1016\/j.nbd.2011.08.003_bb0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0896-6273(03)00024-2","article-title":"The formation of highly soluble oligomers of \u03b1-synuclein is regulated by fatty acids and enhanced in Parkinson's disease","volume":"37","author":"Sharon","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.08.003_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/ana.22311","article-title":"Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression","author":"Shi","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.08.003_bb0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2006.07.006","article-title":"Alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy","volume":"25","author":"Shults","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.08.003_bb0155","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-2009-0955","article-title":"Cerebrospinal alpha synuclein does not discriminate between dementia disorders","volume":"16","author":"Spies","year":"2009","journal-title":"J. Alzheimer Dis."},{"key":"10.1016\/j.nbd.2011.08.003_bb0160","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.08.003_bb0165","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.nbd.2011.08.003_bb0170","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2006.08.024","article-title":"Decreased \u03b1-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease","volume":"349","author":"Tokuda","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.08.003_bb0175","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/WNL.0b013e3181fd613b","article-title":"Detection of elevated levels of \u03b1-synuclein oligomers in CSF from patients with Parkinson disease","volume":"75","author":"Tokuda","year":"2010","journal-title":"Neurology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:38:47Z","timestamp":1714660727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111002579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0969996111002579"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.08.003","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post mortem cerebrospinal fluid \u03b1-synuclein levels are raised in multiple system atrophy and distinguish this from the other \u03b1-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2011.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}