{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:12:25Z","timestamp":1769584345007,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.nbd.2011.08.018","type":"journal-article","created":{"date-parts":[[2011,8,27]],"date-time":"2011-08-27T13:22:12Z","timestamp":1314451332000},"page":"236-242","source":"Crossref","is-referenced-by-count":21,"title":["Gene therapy for amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"48","author":[{"given":"Thais","family":"Federici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Boulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.08.018_bb0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/104303402753812458","article-title":"Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy","volume":"13","author":"Acsadi","year":"2002","journal-title":"Hum. Gene. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/hmg\/9.5.803","article-title":"Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2","volume":"9","author":"Azzouz","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0015","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1172\/JCI22922","article-title":"Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy","volume":"114","author":"Azzouz","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2011.08.018_bb0020","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature02544","article-title":"VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model","volume":"429","author":"Azzouz","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.08.018_bb0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brainresrev.2004.05.003","article-title":"A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis","volume":"47","author":"Barbeito","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.nbd.2011.08.018_bb0030","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/hmg\/10.18.1925","article-title":"Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice","volume":"10","author":"Bordet","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0320","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2990.1996.tb00907.x","article-title":"Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease","volume":"22","author":"Bruijn","year":"1996","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0035","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","article-title":"Unraveling the mechanisms involved in motor neuron degeneration in ALS","volume":"27","author":"Bruijn","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.018_bb0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1086071","article-title":"Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice","volume":"302","author":"Clement","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.08.018_bb0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ana.20901","article-title":"Recovery from paralysis in adult rats using embryonic stem cells","volume":"60","author":"Deshpande","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0050","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.1158799","article-title":"Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons","volume":"321","author":"Dimos","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.08.018_bb0055","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/hmg\/ddq514","article-title":"Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice","volume":"20","author":"Dominguez","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0060","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1389450111007011250","article-title":"Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments","volume":"11","author":"Dupuis","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.nbd.2011.08.018_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.coph.2009.03.007","article-title":"Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models","volume":"9","author":"Dupuis","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0070","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/mt.2009.71","article-title":"Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons","volume":"17","author":"Duque","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0075","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.08.018_bb0080","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/mus.20439","article-title":"Gene-based treatment of motor neuron diseases","volume":"33","author":"Federici","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nbd.2011.08.018_bb0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1752-8062.2008.00084.x","article-title":"Preclinical safety validation of a stabilized viral vector direct injection approach to the cervical spinal cord","volume":"2","author":"Federici","year":"2009","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.nbd.2011.08.018_bb0090","series-title":"ASGCT 14th Annual Meeting","first-page":"S250","article-title":"Robust motor neuron transduction following intrathecal delivery of AAV9.GFP to pigs","author":"Federici","year":"2011"},{"key":"10.1016\/j.nbd.2011.08.018_bb0095","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nbt.1515","article-title":"Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes","volume":"27","author":"Foust","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0105","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nbt.1610","article-title":"Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN","volume":"28","author":"Foust","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0110","series-title":"ASGCT 14th Annual Meeting","first-page":"S152","article-title":"Biodistribution of IV Injected AAV9 in young cynomologus macaques","author":"Foust","year":"2011"},{"key":"10.1016\/j.nbd.2011.08.018_bb0115","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nbd.2008.12.003","article-title":"Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS","volume":"33","author":"Franz","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2011.08.018_bb0120","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/mus.20418","article-title":"Neuroprotective adeno-associated virus Bcl-(x)L gene transfer in models of motor neuron disease","volume":"32","author":"Garrity-Moses","year":"2005","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.nbd.2011.08.018_bb0125","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/mt.2011.72","article-title":"Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates","volume":"19","author":"Gray","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0130","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/hmg\/ddg267","article-title":"Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice","volume":"12","author":"Guo","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0135","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.08.018_bb0140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.410390203","article-title":"Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis","volume":"39","author":"Gurney","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0145","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.032539299","article-title":"Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)","volume":"99","author":"Howland","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S A."},{"key":"10.1016\/j.nbd.2011.08.018_bb0150","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.08.018_bb0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.brainres.2007.09.034","article-title":"Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS","volume":"1185","author":"Lepore","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2011.08.018_bb0160","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/nn.2210","article-title":"Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease","volume":"11","author":"Lepore","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.018_bb0165","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/hmg\/ddg143","article-title":"Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy","volume":"12","author":"Lesbordes","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2217\/rme.11.6","article-title":"Stem cell technology for the study and treatment of motor neuron diseases","volume":"6","author":"Lunn","year":"2011","journal-title":"Regen. Med."},{"key":"10.1016\/j.nbd.2011.08.018_bb0175","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1474-4422(08)70065-6","article-title":"Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial","volume":"7","author":"Marks","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0325","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jnr.20708","article-title":"Disease progression of human SOD1 (G93A) transgenic ALS model rats","volume":"83","author":"Matsumoto","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2011.08.018_bb0180","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(11)70022-9","article-title":"Induced pluripotent stem cells: a new revolution for clinical neurology?","volume":"10","author":"Mattis","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2008.06.059","article-title":"A SMNDelta7 read-through product confers functionality to the SMNDelta7 protein","volume":"442","author":"Mattis","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.08.018_bb0190","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/jmg.2010.077180","article-title":"SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations","volume":"47","author":"Millecamps","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2011.08.018_bb0195","series-title":"Neuroscience 2010 (San Diego, CA)","article-title":"Motor nerve root pathology in canine degenerative myelopathy with a mutation in the superoxide dismutase 1 gene","author":"Morgan","year":"2010"},{"key":"10.1016\/j.nbd.2011.08.018_bb0200","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.018_bb0205","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.expneurol.2006.03.028","article-title":"Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice","volume":"201","author":"Pardo","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0210","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm1205","article-title":"Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model","volume":"11","author":"Ralph","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2011.08.018_bb0215","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nm1207","article-title":"Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS","volume":"11","author":"Raoul","year":"2005","journal-title":"Nat. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2011.08.018_bb0220","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ana.21543","article-title":"Current hypotheses for the underlying biology of amyotrophic lateral sclerosis","volume":"65","author":"Rothstein","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0225","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/17482960701856300","article-title":"Design, power, and interpretation of studies in the standard murine model of ALS","volume":"9","author":"Scott","year":"2008","journal-title":"Amyotroph. Lateral Scler."},{"issue":"Suppl. 2","key":"10.1016\/j.nbd.2011.08.018_bb0230","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF03160574","article-title":"Glutamate, excitotoxicity and amyotrophic lateral sclerosis","volume":"244","author":"Shaw","year":"1997","journal-title":"J. Neurol."},{"key":"10.1016\/j.nbd.2011.08.018_bb0235","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/14712590903514074","article-title":"Viral vector-mediated gene transfer for CNS disease","volume":"10","author":"Snyder","year":"2010","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0240","doi-asserted-by":"crossref","DOI":"10.1089\/hum.2011.008","article-title":"Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery","author":"Snyder","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0245","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1212\/01.wnl.0000335970.78664.36","article-title":"Subcutaneous IGF-1 is not beneficial in 2-year ALS trial","volume":"71","author":"Sorenson","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.08.018_bb0250","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1532-950X.2009.00626.x","article-title":"Esophageal dysfunction in dogs with idiopathic laryngeal paralysis: a controlled cohort study","volume":"39","author":"Stanley","year":"2010","journal-title":"Vet. Surg."},{"key":"10.1016\/j.nbd.2011.08.018_bb0255","doi-asserted-by":"crossref","first-page":"e689","DOI":"10.1371\/journal.pone.0000689","article-title":"GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS","volume":"2","author":"Suzuki","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2011.08.018_bb0330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/17482960600982447","article-title":"Sexual dimorphism in disease onset and progression of a rat model of ALS","volume":"8","author":"Suzuki","year":"2007","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.nbd.2011.08.018_bb0260","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/mt.2008.197","article-title":"Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS","volume":"16","author":"Suzuki","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0265","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/mt.2008.73","article-title":"Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice","volume":"16","author":"Towne","year":"2008","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.nbd.2011.08.018_bb0270","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/gt.2009.119","article-title":"Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6","volume":"17","author":"Towne","year":"2009","journal-title":"Gene Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0275","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/mt.2010.260","article-title":"Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice","volume":"19","author":"Towne","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2011.08.018_bb0280","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11910-010-0160-0","article-title":"Research advances in amyotrophic lateral sclerosis, 2009 to 2010","volume":"11","author":"Traub","year":"2011","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.nbd.2011.08.018_bb0285","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2011.08.018_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000830","article-title":"Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy","volume":"2","author":"Valori","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2011.08.018_bb0335","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0960-8966(03)00104-4","article-title":"Sexual differences in onset of disease and response to exercise in a transgenic model of ALS","volume":"13","author":"Veldink","year":"2003","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.nbd.2011.08.018_bb0295","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.drudis.2007.10.011","article-title":"Strategic approaches to developing drug treatments for ALS","volume":"13","author":"Vincent","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.nbd.2011.08.018_bb0340","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/00001756-200305230-00029","article-title":"Assessing disease onset and progression in the SOD1 mouse model of ALS","volume":"14","author":"Weydt","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2011.08.018_bb0300","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1097\/00001756-200310270-00017","article-title":"Cells over-expressing EAAT2 protect motoneurons from excitotoxic death in vitro","volume":"14","author":"Wisman","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2011.08.018_bb0305","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn2047","article-title":"Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2011.08.018_bb0310","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0304-3940(02)00454-8","article-title":"Effect on motor neuron survival in mutant SOD1 (G93A) transgenic mice by Bcl-2 expression using retrograde axonal transport of adenoviral vectors","volume":"328","author":"Yamashita","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2011.08.018_bb0315","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1371\/journal.pmed.0040039","article-title":"Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord","volume":"4","author":"Yan","year":"2007","journal-title":"PLoS Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111002841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T13:25:21Z","timestamp":1543584321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111002841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0969996111002841"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.08.018","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}