{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:37:35Z","timestamp":1791398255803,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004229","name":"Fondazione Mariani","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004229","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministery of Health"},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201cAssociazione italiana per la Sindrome da Ipoventilazione Centrale Congenita\u201d"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.nbd.2011.09.007","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T12:48:05Z","timestamp":1316695685000},"page":"508-518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins"],"prefix":"10.1016","volume":"45","author":[{"given":"Eleonora","family":"Di Zanni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bachetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazia","family":"Prigione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Di Lascio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Fornasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ravazzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Ceccherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.09.007_bb0005","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1093\/hmg\/ddg293","article-title":"Involvement of the ubiquitin\u2013proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy","volume":"12","author":"Abu-Baker","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1089\/104454900439773","article-title":"Paired-like homeodomain proteins Phox2a\/Arix and Phox2b\/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription","volume":"19","author":"Adachi","year":"2000","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.gde.2005.04.003","article-title":"The other trinucleotide repeat: polyalanine expansion disorders","volume":"15","author":"Albrecht","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.nbd.2011.09.007_bb0020","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1196\/annals.1354.056","article-title":"Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes","volume":"1067","author":"Ali","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2011.09.007_bb0025","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ng1130","article-title":"Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome","volume":"33","author":"Amiel","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0030","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/hmg\/ddi188","article-title":"Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital central hypoventilation syndrome","volume":"14","author":"Bachetti","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biocel.2006.08.014","article-title":"Geldanamycin promotes nuclear localisation and clearance of PHOX2B misfolded proteins containing polyalanine expansions","volume":"39","author":"Bachetti","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/jmg.2003.014548","article-title":"Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy","volume":"41","author":"Bao","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0045","doi-asserted-by":"crossref","first-page":"13290","DOI":"10.1074\/jbc.M608616200","article-title":"Transcription factor PHOX2A regulates the human alpha3 nicotinic receptor subunit gene promoter","volume":"282","author":"Benfante","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.09.007_bb0050","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1021\/bi963015b","article-title":"Polyalanine-based peptides as models for self-associated beta-pleated-sheet complexes","volume":"36","author":"Blondelle","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2011.09.007_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0959-437X(02)00322-2","article-title":"Phox2 genes \u2014 from patterning to connectivity","volume":"12","author":"Brunet","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.nbd.2011.09.007_bb0060","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1097\/00001756-199412000-00006","article-title":"Congo red protects against toxicity of beta-amyloid peptides on rat hippocampal neurones","volume":"5","author":"Burgevin","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2011.09.007_bb0065","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/ijms11082839","article-title":"Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway","volume":"11","author":"Chen","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2011.09.007_bb0070","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.nbd.2011.09.007_bb0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-0-387-46401-5_8","article-title":"Neuroprotective effects of curcumin","volume":"595","author":"Cole","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0080","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/adc.55.11.901","article-title":"Congenital central hypoventilation syndrome. A report of successful experience with bilateral diaphragmatic pacing","volume":"55","author":"Coleman","year":"1980","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.nbd.2011.09.007_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/502","article-title":"Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1","volume":"19","author":"Cummings","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/hmg\/ddi422","article-title":"Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy","volume":"15","author":"Davies","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejpn.2011.02.005","article-title":"Toward a therapeutic strategy for polyalanine expansions disorders: In vivo and in vitro models for drugs analysis","volume":"15","author":"Di Zanni","year":"2011","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/bbrc.1995.1770","article-title":"Formation of an extremely stable polyalanine beta-sheet macromolecule","volume":"211","author":"Forood","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.09.007_bb0105","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1471-4159.1992.tb08470.x","article-title":"Effects of sulfate ions on Alzheimer beta\/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions","volume":"59","author":"Fraser","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.09.007_bb0110","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.M410210200","article-title":"Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease","volume":"280","author":"Gardian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.09.007_bb0115","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/hmg\/ddh144","article-title":"Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach","volume":"13","author":"Hay","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0120","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1158\/1078-0432.CCR-08-0221","article-title":"A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer","volume":"14","author":"Heath","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.nbd.2011.09.007_bb0125","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1073\/pnas.110138997","article-title":"Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy","volume":"97","author":"Heiser","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.nbd.2011.09.007_bb0130","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","article-title":"Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cm.10057","article-title":"Cytoplasmic dynein\/dynactin mediates the assembly of aggresomes","volume":"53","author":"Johnston","year":"2002","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.nbd.2011.09.007_bb0140","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1586\/14737140.6.11.1559","article-title":"Targeting events in melanoma carcinogenesis for the prevention of melanoma","volume":"6","author":"Lao","year":"2006","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.nbd.2011.09.007_bb0145","doi-asserted-by":"crossref","first-page":"12243","DOI":"10.1073\/pnas.91.25.12243","article-title":"Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red","volume":"91","author":"Lorenzo","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.nbd.2011.09.007_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/jmg.2003.015412","article-title":"PHOX2B mutations and polyalanine expansions correlate with the severity of the respiratory phenotype and associated symptoms in both congenital and late onset Central Hypoventilation syndrome","volume":"41","author":"Matera","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0155","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1517\/14728214.7.2.277","article-title":"Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents","volume":"7","author":"Neckers","year":"2002","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.nbd.2011.09.007_bb0160","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1242\/dev.124.20.4065","article-title":"Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis","volume":"24","author":"Pattyn","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.nbd.2011.09.007_bb0165","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/20700","article-title":"The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives","volume":"399","author":"Pattyn","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.09.007_bb0170","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.resp.2010.06.013","article-title":"Congenital central hypoventilation syndrome and the PHOX2B gene: a model of respiratory and autonomic dysregulation","volume":"173","author":"Patwari","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0175","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1158\/1078-0432.CCR-06-2233","article-title":"Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers","volume":"13","author":"Ramanathan","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.nbd.2011.09.007_bb0180","doi-asserted-by":"crossref","first-page":"e8753","DOI":"10.1371\/journal.pone.0008753","article-title":"17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy","volume":"5","author":"Riedel","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2011.09.007_bb0185","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10637-006-9208-z","article-title":"A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma","volume":"24","author":"Ronnen","year":"2006","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.nbd.2011.09.007_bb0190","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00439-003-1036-z","article-title":"Molecular analysis of congenital central hypoventilation syndrome","volume":"114","author":"Sasaki","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0195","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1110\/ps.03214703","article-title":"Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation","volume":"12","author":"Scheuermann","year":"2003","journal-title":"Protein Sci."},{"key":"10.1016\/j.nbd.2011.09.007_bb0200","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"61","key":"10.1016\/j.nbd.2011.09.007_bb0205","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/prot.20536","article-title":"Poly-(L-ala- 782 nine) expansions form core beta-sheets that nucleate amyloid assembly","volume":"783","author":"Shinchuk","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.nbd.2011.09.007_bb0210","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/hmg\/10.12.1307","article-title":"Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease","volume":"10","author":"Sittler","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.resp.2010.03.015","article-title":"Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel","volume":"171","author":"Straus","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.nbd.2011.09.007_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/auto.5233","article-title":"Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls","volume":"4","author":"Tanida","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2011.09.007_bb0225","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2009.01.031","article-title":"Induction of heat shock response by curcumin in human leukemia cells","volume":"279","author":"Teiten","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.nbd.2011.09.007_bb0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12263-009-0152-3","article-title":"Chemopreventive potential of curcumin in prostate cancer","volume":"5","author":"Teiten","year":"2010","journal-title":"Genes Nutr."},{"key":"10.1016\/j.nbd.2011.09.007_bb0235","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1093\/hmg\/ddi401","article-title":"Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction","volume":"14","author":"Trochet","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0240","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1093\/hmg\/ddi395","article-title":"Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells","volume":"14","author":"Wang","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2011.09.007_bb0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbrc.2008.02.162","article-title":"Induction of expression and co-localization of heat shock polypeptides with the polyalanine expansion mutant of poly(A)-binding protein N1 after chemical stress","volume":"370","author":"Wang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2011.09.007_bb0250","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nm1298","article-title":"17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration","volume":"11","author":"Waza","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2011.09.007_bb0255","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/rccm.200402-245PP","article-title":"Genetics of congenital central hypoventilation syndrome: lessons from a seemingly orphan disease","volume":"170","author":"Weese-Mayer","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111003172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111003172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:42:56Z","timestamp":1714660976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111003172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0969996111003172"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.09.007","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2011.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}