{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:29:07Z","timestamp":1791350947676,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.nbd.2011.10.025","type":"journal-article","created":{"date-parts":[[2011,11,5]],"date-time":"2011-11-05T20:44:41Z","timestamp":1320525881000},"page":"572-580","source":"Crossref","is-referenced-by-count":262,"title":["Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis"],"prefix":"10.1016","volume":"46","author":[{"given":"Samay","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.10.025_bb0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1750-3639.2005.tb00097.x","article-title":"Profound cardiac sympathetic denervation occurs in Parkinson disease","volume":"15","author":"Amino","year":"2005","journal-title":"Brain Path."},{"key":"10.1016\/j.nbd.2011.10.025_bb0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","article-title":"Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen","volume":"110","author":"Braak","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2011.10.025_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson's disease-related pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-007-0303-9","article-title":"Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine","volume":"115","author":"Burke","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0025","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1523\/JNEUROSCI.0319-07.2007","article-title":"Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration","volume":"27","author":"Caudle","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.10.025_bb0030","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1474-4422(03)00555-6","article-title":"Dysautonomia in Parkinson's disease: neurocardiological abnormalities","volume":"2","author":"Goldstein","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10286-006-0317-8","article-title":"Orthostatic hypotension as an early finding in Parkinson disease","volume":"16","author":"Goldstein","year":"2006","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10286-009-0002-9","article-title":"Cardiac sympathetic neuroimaging: summary of the First International Symposium","volume":"19","author":"Goldstein","year":"2009","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/CIRCULATIONAHA.108.805887","article-title":"Neurogenic orthostatic hypotension: a pathophysiological approach","volume":"119","author":"Goldstein","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.nbd.2011.10.025_bb0115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02281111","article-title":"Non-invasive detection of sympathetic neurocirculatory failure","volume":"10","author":"Goldstein","year":"2000","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1172\/JCI113298","article-title":"Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans","volume":"81","author":"Goldstein","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2011.10.025_bb0055","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJM199703063361004","article-title":"Sympathetic cardioneuropathy in dysautonomias","volume":"336","author":"Goldstein","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2011.10.025_bb0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10286-002-0020-3","article-title":"Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor","volume":"12","author":"Goldstein","year":"2002","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0080","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1212\/WNL.58.8.1247","article-title":"Orthostatic hypotension from sympathetic denervation in Parkinson's disease","volume":"58","author":"Goldstein","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.10.025_bb0075","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1212\/01.WNL.0000058766.46428.F3","article-title":"Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension","volume":"60","author":"Goldstein","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.10.025_bb0045","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/01.HYP.0000188052.69549.e4","article-title":"Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment","volume":"46","author":"Goldstein","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.nbd.2011.10.025_bb0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s10286-007-0396-1","article-title":"Cardiac sympathetic denervation preceding motor signs in Parkinson disease","volume":"17","author":"Goldstein","year":"2007","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0050","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.parkreldis.2008.01.010","article-title":"Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy","volume":"14","author":"Goldstein","year":"2008","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2011.10.025_bb0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1212\/WNL.0b013e3181ca014c","article-title":"Association of anosmia with autonomic failure in Parkinson disease","volume":"74","author":"Goldstein","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.10.025_bb0065","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1172\/JCI45803","article-title":"Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases","volume":"121","author":"Goldstein","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.nbd.2011.10.025_bb0110","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1468-1331.2010.03246.x","article-title":"Catechols in post-mortem brain of patients with Parkinson disease","volume":"18","author":"Goldstein","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0070","doi-asserted-by":"crossref","unstructured":"Goldstein, D. S., et al., in press-a. Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. Clin. Auton. Res. doi:10.1016\/j.jns.2011.04.011.","DOI":"10.1016\/j.jns.2011.04.011"},{"key":"10.1016\/j.nbd.2011.10.025_bb0095","doi-asserted-by":"crossref","unstructured":"Goldstein, D. S., et al., in press-b. Autonomic dysfunction in PD: a window to early detection? J. Neurol. Sci. doi:10.1007\/s10286-011-0136-4.","DOI":"10.1007\/s10286-011-0136-4"},{"key":"10.1016\/j.nbd.2011.10.025_bb0120","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.parkreldis.2008.04.002","article-title":"Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension","volume":"15","author":"Imrich","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2011.10.025_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10286-009-0012-7","article-title":"Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab","volume":"19","author":"Imrich","year":"2009","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0130","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/tx800405v","article-title":"Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate","volume":"22","author":"Jinsmaa","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0135","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.parkreldis.2009.12.010","article-title":"Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease","volume":"16","author":"Kashihara","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2011.10.025_bb0140","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.0000083721.49847.D7","article-title":"Norepinephrine precursor therapy in neurogenic orthostatic hypotension","volume":"108","author":"Kaufmann","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.nbd.2011.10.025_bb0145","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-4547(20000515)60:4<552::AID-JNR14>3.0.CO;2-U","article-title":"Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde","volume":"60","author":"Lamensdorf","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0150","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(00)02309-X","article-title":"3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells","volume":"868","author":"Lamensdorf","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0155","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jnr.10880","article-title":"Semi-chronic increase in striatal level of 3,4-dihydroxyphenylacetaldehyde does not result in alteration of nigrostriatal dopaminergic neurones","volume":"75","author":"Legros","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0160","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ana.10236","article-title":"Progressive loss of cardiac sympathetic innervation in Parkinson's disease","volume":"52","author":"Li","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1124\/pr.59.2.1","article-title":"Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase","volume":"59","author":"Marchitti","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2011.10.025_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(94)90002-7","article-title":"Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat","volume":"63","author":"Mitchell","year":"1994","journal-title":"Neuroscience"},{"issue":"Suppl 2","key":"10.1016\/j.nbd.2011.10.025_bb0175","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.3949\/ccjm.76.s2.11","article-title":"Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation","volume":"76","author":"Moak","year":"2009","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.nbd.2011.10.025_bb0180","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuron.2009.01.033","article-title":"Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons","volume":"62","author":"Mosharov","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.10.025_bb0185","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0140-6736(76)91681-0","article-title":"Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine","volume":"2","author":"Nanda","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2011.10.025_bb0195","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/jnnp.73.6.776","article-title":"Sympathetic cardiac denervation in Parkinson's disease and pure autonomic failure but not in multiple system atrophy","volume":"73","author":"Orimo","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2011.10.025_bb0190","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00401-006-0160-y","article-title":"Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy","volume":"113","author":"Orimo","year":"2007","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.nbd.2011.10.025_bb0200","doi-asserted-by":"crossref","first-page":"e15251","DOI":"10.1371\/journal.pone.0015251","article-title":"The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis","volume":"5","author":"Panneton","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2011.10.025_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.31.1.1","article-title":"Pharmacologic distinction of different orthostatic hypotension syndromes","volume":"31","author":"Polinsky","year":"1981","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.10.025_bb0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10286-010-0098-y","article-title":"Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation","volume":"21","author":"Rahman","year":"2011","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.nbd.2011.10.025_bb0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archneur.64.3.381","article-title":"Adrenergic and vagal baroreflex sensitivity in autonomic failure","volume":"64","author":"Schrezenmaier","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0225","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2362.1990.tb01909.x","article-title":"Adrenergic supersensitivity in parkinsonians with orthostatic hypotension","volume":"20","author":"Senard","year":"1990","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.nbd.2011.10.025_bb0220","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00002826-199302000-00008","article-title":"Effects of yohimbine on plasma catecholamine levels in orthostatic hypotension related to Parkinson disease or multiple system atrophy","volume":"16","author":"Senard","year":"1993","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0230","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1161\/01.CIR.101.23.2710","article-title":"Sympathetically mediated hypertension in autonomic failure","volume":"101","author":"Shannon","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.nbd.2011.10.025_bb0240","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1212\/01.WNL.0000052690.91036.FF","article-title":"Neurotransmitter specificity of sympathetic denervation in Parkinson's disease","volume":"60","author":"Sharabi","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.10.025_bb0235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.WNF.0000220822.80640.0D","article-title":"Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes","volume":"29","author":"Sharabi","year":"2006","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.nbd.2011.10.025_bb0245","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1523\/JNEUROSCI.1495-09.2009","article-title":"Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity","volume":"29","author":"Taylor","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.10.025_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2011.04.016","article-title":"Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis","author":"Velseboer","year":"2011","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2011.10.025_bb0255","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJM200009213431204","article-title":"Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies","volume":"343","author":"Vernino","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2011.10.025_bb0260","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1212\/01.wnl.0000219640.59984.a7","article-title":"Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD","volume":"66","author":"Yoshita","year":"2006","journal-title":"Neurology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111003573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111003573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:20:38Z","timestamp":1560903638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111003573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0969996111003573"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.10.025","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}