{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:24:00Z","timestamp":1790645040214,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC100-2321-B-006-002"],"award-info":[{"award-number":["NSC100-2321-B-006-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC99-2923-B-006-001-MY3"],"award-info":[{"award-number":["NSC99-2923-B-006-001-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health Research Institute of Taiwan","award":["NHRI-EX101-10117NI"],"award-info":[{"award-number":["NHRI-EX101-10117NI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.nbd.2011.12.031","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T18:29:39Z","timestamp":1325010579000},"page":"1111-1120","source":"Crossref","is-referenced-by-count":69,"title":["Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model"],"prefix":"10.1016","volume":"45","author":[{"given":"Ya-Hsin","family":"Hsiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinn-Rung","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Wu","family":"Gean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2011.12.031_bb0005","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1212\/WNL.57.8.1515","article-title":"Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease","volume":"57","author":"Adair","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2011.12.031_bb0010","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1126\/science.276.5321.2042","article-title":"Regulatory phosphorylation of AMPA-type glutamate receptors by CaMKII during long-term potentiation","volume":"276","author":"Barria","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.12.031_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.mp.4002101","article-title":"The amyloidogenic potential and behavioral correlates of stress","volume":"14","author":"Catania","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2011.12.031_bb0020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0896-6273(01)80044-1","article-title":"Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality","volume":"18","author":"Chae","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.12.031_bb0025","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1471-4159.2007.04589.x","article-title":"Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine","volume":"102","author":"Chan","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0030","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1471-4159.2009.06177.x","article-title":"Dietary deficiency increases presenilin expression, gamma-secretase activity, and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine","volume":"110","author":"Chan","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0035","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1046\/j.1471-4159.2003.01580.x","article-title":"The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice","volume":"84","author":"Farr","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2006.06.042","article-title":"Protective effect of N-acetyl-l-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice","volume":"1109","author":"Fu","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2011.12.031_bb0045","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+\/calmodulin-dependent protein kinase II synaptic distribution","volume":"284","author":"Gu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0050","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2011.12.031_bb0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/npp.2011.69","article-title":"The involvement of Cdk5 activator p35 in social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit in the transgenic","volume":"36","author":"Hsiao","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2011.12.031_bb0060","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1073\/pnas.94.4.1550","article-title":"Amyloid precursor protein processing and A\u03b242 deposition in a transgenic mouse model of Alzheimer disease","volume":"94","author":"Johnson-Wood","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2011.12.031_bb0065","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jnr.20087","article-title":"Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke","volume":"76","author":"Khan","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2011.12.031_bb0070","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","article-title":"Evidence that production and release of amyloid beta-protein involves the endocytic pathway","volume":"269","author":"Koo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0075","doi-asserted-by":"crossref","first-page":"17166","DOI":"10.1074\/jbc.M907757199","article-title":"Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25","volume":"275","author":"Kusakawa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0080","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/35012636","article-title":"Neurotoxicity induces cleavage of p35 to p25 by calpain","volume":"405","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.12.031_bb0085","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3945\/jn.109.109785","article-title":"Green tea (\u2212)-epigallocatechin-3-gallate inhibits \u03b2-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-\u03baB pathways in mice","volume":"139","author":"Lee","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.nbd.2011.12.031_bb0090","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1096\/fj.02-0881fje","article-title":"Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (\u2212)-epigallocatechin-3-gallate","volume":"17","author":"Levites","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2011.12.031_bb0095","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1073\/pnas.0701055104","article-title":"Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies","volume":"104","author":"Luo","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2011.12.031_bb0100","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.51.32528","article-title":"Phosphorylation of the \u03b1-amino-3-hydroxy-5-methylisoxazole 4-propionic acid receptor GluR1 subunit by calcium\/calmodulin-dependent kinase II","volume":"272","author":"Mammen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0105","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1046\/j.1471-4159.2003.02291.x","article-title":"Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (\u2212)-epigallocatechin-3-gallate: implications for neurodegenerative diseases","volume":"88","author":"Mandel","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0110","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1101\/gad.10.7.816","article-title":"The cdk5\/p35 kinase is essential for neurite outgrowth during neuronal differentiation","volume":"10","author":"Nikolic","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2011.12.031_bb0115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0896-6273(03)00259-9","article-title":"Cdk5 is a key factor in tau aggregation and tangle formation in vivo","volume":"38","author":"Noble","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2011.12.031_bb0120","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/ptr.1519","article-title":"In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia","volume":"18","author":"Okello","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.nbd.2011.12.031_bb0125","doi-asserted-by":"crossref","first-page":"e14015","DOI":"10.1371\/journal.pone.0014015","article-title":"Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease","volume":"5","author":"Parachikova","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2011.12.031_bb0130","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/45159","article-title":"Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration","volume":"402","author":"Patrick","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.12.031_bb0135","doi-asserted-by":"crossref","first-page":"18851","DOI":"10.1074\/jbc.274.27.18851","article-title":"Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42","volume":"274","author":"Perez","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2011.12.031_bb0140","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.1521-05.2005","article-title":"Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice","volume":"25","author":"Rezai-Zadeh","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.12.031_bb0145","doi-asserted-by":"crossref","first-page":"11061","DOI":"10.1523\/JNEUROSCI.3034-05.2005","article-title":"Soluble \u03b2-amyloid1\u201340 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses","volume":"25","author":"Roselli","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2011.12.031_bb0150","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.biopsych.2009.04.033","article-title":"Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats","volume":"66","author":"Schiavone","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2011.12.031_bb0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.20101","article-title":"Progressive age-related development of Alzheimer-like pathology in APP\/PS1 mice","volume":"55","author":"Trinchese","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2011.12.031_bb0160","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/371419a0","article-title":"p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2011.12.031_bb0165","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1096\/fj.06-6281com","article-title":"Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease","volume":"20","author":"Wang","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2011.12.031_bb0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/archpsyc.64.2.234","article-title":"Loneliness and risk of Alzheimer disease","volume":"64","author":"Wilson","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.nbd.2011.12.031_bb0180","doi-asserted-by":"crossref","first-page":"21353","DOI":"10.1073\/pnas.0812872106","article-title":"PKCdelta regulates cortical radial migration by stabilizing the Cdk5 activator p35","volume":"106","author":"Zhao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111004062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996111004062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T19:41:46Z","timestamp":1640202106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996111004062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0969996111004062"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2011.12.031","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}