{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:22:08Z","timestamp":1791303728114,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.nbd.2012.02.012","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T02:37:43Z","timestamp":1331001463000},"page":"625-634","source":"Crossref","is-referenced-by-count":68,"title":["8OHdG as a marker for Huntington disease progression"],"prefix":"10.1016","volume":"46","author":[{"given":"Jeffrey D.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne R.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Juhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair R.","family":"Leavitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2012.02.012_bb0005","series-title":"Second International Symposium on Information Theory","first-page":"267","article-title":"Information theory as an extension of the maximum likelihood principle","author":"Akaike","year":"1973"},{"key":"10.1016\/j.nbd.2012.02.012_bb0190","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"AC-19","author":"Akaike","year":"1974","journal-title":"IEEE Trans. Autom. Control"},{"key":"10.1016\/j.nbd.2012.02.012_bb0015","series-title":"Model-based Inference in the Life Sciences: A Primer on Evidence","author":"Anderson","year":"2008"},{"key":"10.1016\/j.nbd.2012.02.012_bb0020","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.4088\/JCP.v69n1111","article-title":"Obsessive and compulsive symptoms in prediagnosed Huntington's disease","volume":"69","author":"Beglinger","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nbd.2012.02.012_bb0025","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/mds.22601","article-title":"Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study","volume":"24","author":"Biglan","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2012.02.012_bb0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0891-5849(99)00113-6","article-title":"A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2\u2032-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods","volume":"27","author":"Bogdanov","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2012.02.012_bb0035","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease","volume":"79","author":"Bogdanov","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2012.02.012_bb0045","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1089\/ars.2006.8.2061","article-title":"Oxidative damage in Huntington's disease pathogenesis","volume":"8","author":"Browne","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2012.02.012_bb0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2012.02.012_bb0050","series-title":"Model Selection and Multimodel Inference","author":"Burnham","year":"2002"},{"key":"10.1016\/j.nbd.2012.02.012_bb0055","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2007.05.093","article-title":"Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients","volume":"359","author":"Chen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2012.02.012_bb0060","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric symptoms in Huntington's disease before diagnosis: the PREDICT-HD study","volume":"62","author":"Duff","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2012.02.012_bb0065","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1212\/WNL.0b013e3181eccfa2","article-title":"Mild cognitive impairment in prediagnosed Huntington disease","volume":"75","author":"Duff","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2012.02.012_bb0070","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000194318.74946.b6","article-title":"Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG","volume":"66","author":"Hersch","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2012.02.012_bb0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/biomet\/76.2.297","article-title":"Regression and time series model selection in small samples","volume":"76","author":"Hurvich","year":"1989","journal-title":"Biometrika"},{"key":"10.1016\/j.nbd.2012.02.012_bb0080","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/nbdi.2002.0466","article-title":"Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy","volume":"9","author":"Kikuchi","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2012.02.012_bb0085","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00415-007-0611-y","article-title":"Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: a cross-sectional study","volume":"254","author":"Klepac","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.nbd.2012.02.012_bb0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin. Genet."},{"key":"10.1016\/j.nbd.2012.02.012_bb0095","series-title":"Longitudinal Data Analysis for the Behavioral Sciences Using R","author":"Long","year":"2012"},{"key":"10.1016\/j.nbd.2012.02.012_bb0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","volume":"21","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.nbd.2012.02.012_bb0105","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/clinchem\/30.9.1477","article-title":"n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters","volume":"30","author":"Matson","year":"1984","journal-title":"Clin. Chem."},{"key":"10.1016\/j.nbd.2012.02.012_bb0110","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0024-3205(87)90192-5","article-title":"EC array sensor concepts and data","volume":"41","author":"Matson","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2012.02.012_bb0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/brain\/awq280","article-title":"Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment","volume":"134","author":"Nopoulos","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2012.02.012_bb0120","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archneur.63.6.883","article-title":"Preparing for preventive clinical trials: the Predict-HD study","volume":"63","author":"Paulsen","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2012.02.012_bb0125","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2012.02.012_bb0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosis for Huntington disease","volume":"82","author":"Paulsen","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2012.02.012_bb0135","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/mds.23337","article-title":"Challenges assessing clinical endpoints in early Huntington disease","volume":"25","author":"Paulsen","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2012.02.012_bb0140","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(99)00578-9","article-title":"Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex","volume":"272","author":"Polidori","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2012.02.012_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2012.02.012_bb0150","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/0929867013372922","article-title":"Chemistry and biochemistry of oxidative stress in neurodegenerative disease","volume":"8","author":"Sayre","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2012.02.012_bb0155","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2008.05.014","article-title":"Proteomic and oxidative stress analysis in human brain samples of Huntington disease","volume":"45","author":"Sorolla","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2012.02.012_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0020937","article-title":"Neurocognitive signs in prodromal Huntington disease","volume":"25","author":"Stout","year":"2011","journal-title":"Neuropsychology"},{"key":"10.1016\/j.nbd.2012.02.012_bb0165","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2012.02.012_bb0195","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2012.02.012_bb0200","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-hydroxy-2\u2032 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis","year":"2009","journal-title":"J. Environ. Sci. Health C"},{"key":"10.1016\/j.nbd.2012.02.012_bb0180","series-title":"Linear Mixed Models for Longitudinal Data","author":"Verbeke","year":"2000"},{"key":"10.1016\/j.nbd.2012.02.012_bb0185","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/ajmg.b.31232","article-title":"Indexing disease progression at study entry with individuals at-risk for Huntington disease","volume":"156","author":"Zhang","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T15:25:42Z","timestamp":1593789942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996112000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0969996112000678"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2012.02.012","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}