{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:19:43Z","timestamp":1789985983054,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.nbd.2012.05.013","type":"journal-article","created":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T04:20:25Z","timestamp":1338697225000},"page":"40-51","source":"Crossref","is-referenced-by-count":68,"title":["Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice"],"prefix":"10.1016","volume":"48","author":[{"given":"Austen J.","family":"Milnerwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja D.","family":"Sepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare M.","family":"Gladding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley","family":"Coquinco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy Yi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Cynader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2012.05.013_bb0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/321168a0","article-title":"Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid","volume":"321","author":"Beal","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2012.05.013_bb0005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0304-3940(90)90702-B","article-title":"Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons","volume":"108","author":"Beal","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2012.05.013_bb0015","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993","article-title":"Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid","volume":"13","author":"Beal","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2202-9-11","article-title":"A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity","volume":"9","author":"Bengtson","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0025","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1523\/JNEUROSCI.1905-05.2005","article-title":"Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation","volume":"25","author":"Berberich","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.1244","article-title":"NMDA receptor function in mouse models of Huntington disease","volume":"66","author":"Cepeda","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2012.05.013_bb0035","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/j.1471-4159.2006.03991.x","article-title":"The chemical biology of clinically tolerated NMDA receptor antagonists","volume":"97","author":"Chen","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2012.05.013_bb0040","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1046\/j.1471-4159.1999.0721890.x","article-title":"Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin","volume":"72","author":"Chen","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2012.05.013_bb0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0070-2153(06)75002-5","article-title":"Selective neuronal degeneration in Huntington's disease","volume":"75","author":"Cowan","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.nbd.2012.05.013_bb0050","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/263244a0","article-title":"Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea","volume":"263","author":"Coyle","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2012.05.013_bb0065","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease","volume":"81","author":"Fan","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2012.05.013_bb0070","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","article-title":"Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0055","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1523\/JNEUROSCI.2491-09.2009","article-title":"Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease","volume":"29","author":"Fan","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0060","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1471-4159.2010.06994.x","article-title":"N-methyl-d-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95","volume":"115","author":"Fan","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2012.05.013_bb0075","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1523\/JNEUROSCI.3455-07.2007","article-title":"Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease","volume":"27","author":"Fernandes","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0080","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.mcn.2011.05.001","article-title":"Mechanisms underlying NMDA receptor synaptic\/extrasynaptic distribution and function","volume":"48","author":"Gladding","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0085","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mcn.2009.01.002","article-title":"Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation","volume":"40","author":"Gouix","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0090","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.5473-08.2009","article-title":"Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease","volume":"29","author":"Graham","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0095","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.neuron.2008.09.002","article-title":"From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function","volume":"59","author":"Greer","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1570-9639(02)00455-7","article-title":"Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated","volume":"1600","author":"Hardingham","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2012.05.013_bb0105","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrn2911","article-title":"Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders","volume":"11","author":"Hardingham","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuron.2005.03.005","article-title":"Modulation of triheteromeric NMDA receptors by N-terminal domain ligands","volume":"46","author":"Hatton","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0120","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1523\/JNEUROSCI.5599-08.2009","article-title":"In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease","volume":"29","author":"Heng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0125","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1113\/jphysiol.2006.105510","article-title":"Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons","volume":"572","author":"Ivanov","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2012.05.013_bb0130","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culturing hippocampal neurons","volume":"1","author":"Kaech","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2012.05.013_bb0135","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1523\/JNEUROSCI.4129-11.2012","article-title":"Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons","volume":"32","author":"Kaufman","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0140","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuron.2005.04.031","article-title":"Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking","volume":"46","author":"Kim","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0145","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-006-0273-6","article-title":"NMDA receptor function: subunit composition versus spatial distribution","volume":"326","author":"Kohr","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2012.05.013_bb0150","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1096\/fj.08-107268","article-title":"Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors","volume":"22","author":"Leveille","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2012.05.013_bb0155","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1523\/JNEUROSCI.5115-09.2010","article-title":"Suppression of the intrinsic apoptosis pathway by synaptic activity","volume":"30","author":"Leveille","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0160","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1097-4547(19991115)58:4<515::AID-JNR5>3.0.CO;2-F","article-title":"Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease","volume":"58","author":"Levine","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2012.05.013_bb0165","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1152\/jn.00308.2004","article-title":"Enhanced striatal NR2B-containing N-methyl-d-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease","volume":"92","author":"Li","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2012.05.013_bb0170","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0175","doi-asserted-by":"crossref","first-page":"7351","DOI":"10.1523\/JNEUROSCI.17-19-07351.1997","article-title":"Redistribution and stabilization of cell surface glutamate receptors during synapse formation","volume":"17","author":"Mammen","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0180","doi-asserted-by":"crossref","first-page":"33719","DOI":"10.1074\/jbc.M111.236521","article-title":"Impaired {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin","volume":"286","author":"Mandal","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2012.05.013_bb0185","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/263517a0","article-title":"Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids","volume":"263","author":"McGeer","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2012.05.013_bb0190","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2007.142448","article-title":"Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load","volume":"585","author":"Milnerwood","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2012.05.013_bb0195","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","article-title":"Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease","volume":"33","author":"Milnerwood","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0200","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddl092","article-title":"Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease","volume":"15","author":"Milnerwood","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2012.05.013_bb0205","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0210","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.nbd.2012.05.013_bb0215","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2012.05.013_bb0220","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/jnnp.2009.171926","article-title":"Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease","volume":"81","author":"Orth","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2012.05.013_bb0225","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn2071","article-title":"Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses","volume":"11","author":"Papadia","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0230","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/nprot.2006.316","article-title":"Microfluidic culture platform for neuroscience research","volume":"1","author":"Park","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2012.05.013_bb0235","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2012.05.013_bb0240","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2012.05.013_bb0245","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.biopsych.2008.12.026","article-title":"Abnormal motor cortex excitability in preclinical and very early Huntington's disease","volume":"65","author":"Schippling","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2012.05.013_bb0250","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.nbd.2005.08.001","article-title":"Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease","volume":"21","author":"Shehadeh","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2012.05.013_bb0255","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2012.05.013_bb0260","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0166-2236(90)90106-K","article-title":"The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones","volume":"13","author":"Smith","year":"1990","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0265","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jnr.20651","article-title":"Alterations in N-methyl-d-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6\/2 mouse model of Huntington's disease","volume":"82","author":"Starling","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2012.05.013_bb0270","doi-asserted-by":"crossref","first-page":"11126","DOI":"10.1523\/JNEUROSCI.6244-10.2011","article-title":"Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses","volume":"31","author":"Tapia","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0275","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuron.2009.12.007","article-title":"Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin","volume":"65","author":"Twelvetrees","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0280","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(02)00615-3","article-title":"Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease","volume":"33","author":"Zeron","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2012.05.013_bb0285","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.mcn.2003.11.014","article-title":"Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease","volume":"25","author":"Zeron","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2012.05.013_bb0290","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2008.03.010","article-title":"Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease","volume":"31","author":"Zhang","year":"2008","journal-title":"Neurobiol. Dis."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112001994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112001994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T05:52:22Z","timestamp":1561787542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996112001994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0969996112001994"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2012.05.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}