{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:20:42Z","timestamp":1790500842357,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"DOD","doi-asserted-by":"publisher","award":["W81XWH-07-1-0275"],"award-info":[{"award-number":["W81XWH-07-1-0275"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TSC","award":["NS053588"],"award-info":[{"award-number":["NS053588"]}]},{"DOI":"10.13039\/100000097","name":"NIH\/NCRR","doi-asserted-by":"publisher","award":["TL1RR024147"],"award-info":[{"award-number":["TL1RR024147"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NIH\/NINDS","doi-asserted-by":"publisher","award":["RO1-NS060804"],"award-info":[{"award-number":["RO1-NS060804"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Schissler Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.nbd.2012.10.014","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T14:31:34Z","timestamp":1351780294000},"page":"93-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":174,"special_numbering":"C","title":["Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex"],"prefix":"10.1016","volume":"51","author":[{"given":"R. Michelle","family":"Reith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Shahrukh","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gambello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.nbd.2012.10.014_bb0005","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/00001756-199906030-00005","article-title":"The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans","volume":"10","author":"Abell","year":"1999","journal-title":"Neuroreport"},{"issue":"13","key":"10.1016\/j.nbd.2012.10.014_bb0010","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/hmg\/ddn102","article-title":"The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits","volume":"17","author":"Allan","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1176\/appi.ajp.160.2.262","article-title":"Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism","volume":"160","author":"Allen","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0020","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.57.7.1269","article-title":"Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction","volume":"57","author":"Asano","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2012.10.014_bb0630","series-title":"Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR","author":"Association, A. P.","year":"2000"},{"issue":"55","key":"10.1016\/j.nbd.2012.10.014_bb0030","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1038\/sj.onc.1205962","article-title":"Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration","volume":"21","author":"Astrinidis","year":"2002","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0035","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1086\/302648","article-title":"Complete inactivation of the TSC2 gene leads to formation of hamartomas","volume":"65","author":"Au","year":"1999","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/GIM.0b013e31803068c7","article-title":"Genotype\/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States","volume":"9","author":"Au","year":"2007","journal-title":"Genet. Med."},{"issue":"9","key":"10.1016\/j.nbd.2012.10.014_bb0045","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1212\/WNL.53.9.2145","article-title":"MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults","volume":"53","author":"Aylward","year":"1999","journal-title":"Neurology"},{"issue":"Pt 5","key":"10.1016\/j.nbd.2012.10.014_bb0050","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/brain\/121.5.889","article-title":"A clinicopathological study of autism","volume":"121","author":"Bailey","year":"1998","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0055","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1023\/A:1026048027397","article-title":"Autistic behavior in young boys with fragile X syndrome","volume":"28","author":"Bailey","year":"1998","journal-title":"J. Autism Dev. Disord."},{"issue":"3\u20134","key":"10.1016\/j.nbd.2012.10.014_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<93::AID-GENE10>3.0.CO;2-W","article-title":"Cre recombinase expression in cerebellar Purkinje cells","volume":"28","author":"Barski","year":"2000","journal-title":"Genesis"},{"issue":"5","key":"10.1016\/j.nbd.2012.10.014_bb0065","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1542\/peds.108.5.1155","article-title":"Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation","volume":"108","author":"Bertrand","year":"2001","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.devcel.2007.03.020","article-title":"The two TORCs and Akt","volume":"12","author":"Bhaskar","year":"2007","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0075","first-page":"87","article-title":"Neuroanatomy of language processing studied with functional MRI","volume":"4","author":"Binder","year":"1997","journal-title":"Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0080","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1523\/JNEUROSCI.17-01-00353.1997","article-title":"Human brain language areas identified by functional magnetic resonance imaging","volume":"17","author":"Binder","year":"1997","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0085","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1440-1789.2008.00920.x","article-title":"Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex","volume":"28","author":"Boer","year":"2008","journal-title":"Neuropathology"},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0090","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10803-006-0125-y","article-title":"Psychopathology in children and adolescents with autism compared to young people with intellectual disability","volume":"36","author":"Brereton","year":"2006","journal-title":"J. Autism Dev. Disord."},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0095","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"Butler","year":"2005","journal-title":"J. Med. Genet."},{"issue":"1020","key":"10.1016\/j.nbd.2012.10.014_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1098\/rstb.1979.0055","article-title":"Structural and quantitative studies on the normal C3H and Lurcher mutant mouse","volume":"287","author":"Caddy","year":"1979","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0105","first-page":"44","article-title":"Clinical manifestations of autism and schizophrenia in childhood","volume":"69","author":"Cappon","year":"1953","journal-title":"Can. Med. Assoc. J."},{"issue":"12","key":"10.1016\/j.nbd.2012.10.014_bb0110","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jnen\/63.12.1236","article-title":"Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation","volume":"63","author":"Chan","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2012.10.014_bb0115","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2011.08.020","article-title":"Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: a Diffusion Tensor Imaging study","volume":"1417","author":"Cheon","year":"2011","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0635","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nbd.2011.07.018","article-title":"Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant\/negative form of tuberin","volume":"45","author":"Chevere-Torres","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/00221320309597501","article-title":"Spatial reversal as a measure of executive functioning in children with autism","volume":"164","author":"Coldren","year":"2003","journal-title":"J. Genet. Psychol."},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0130","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","article-title":"Identification and characterization of the tuberous sclerosis gene on chromosome 16","volume":"75","author":"Consortium, E. C. T. S","year":"1993","journal-title":"Cell"},{"issue":"2\u20133","key":"10.1016\/j.nbd.2012.10.014_bb0135","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.psychres.2008.02.005","article-title":"Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development","volume":"166","author":"Corbett","year":"2009","journal-title":"Psychiatry Res."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0140","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0959-4388(97)80016-5","article-title":"Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism","volume":"7","author":"Courchesne","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2012.10.014_bb0145","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijdevneu.2005.01.003","article-title":"Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity","volume":"23","author":"Courchesne","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0150","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1212\/WNL.44.2.214","article-title":"The brain in infantile autism: posterior fossa structures are abnormal","volume":"44","author":"Courchesne","year":"1994","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1750-3639.2007.00096.x","article-title":"Mouse behavioral assays relevant to the symptoms of autism","volume":"17","author":"Crawley","year":"2007","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0160","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuron.2008.03.001","article-title":"Behavioral phenotyping strategies for mutant mice","volume":"57","author":"Crawley","year":"2008","journal-title":"Neuron"},{"issue":"13","key":"10.1016\/j.nbd.2012.10.014_bb0170","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.nbd.2012.10.014_bb0165","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1212\/WNL.0b013e3181e04325","article-title":"Biallelic TSC gene inactivation in tuberous sclerosis complex","volume":"74","author":"Crino","year":"2010","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0175","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/0883073810361789","article-title":"Autism spectrum disorders in tuberous sclerosis: pathogenetic pathways and implications for treatment","volume":"25","author":"Curatolo","year":"2012","journal-title":"J. Child Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0180","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/316951","article-title":"Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs","volume":"68","author":"Dabora","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.nbd.2012.10.014_bb0185","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.2307\/1132265","article-title":"Neuropsychological correlates of early symptoms of autism","volume":"69","author":"Dawson","year":"1998","journal-title":"Child Dev."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00787-006-0570-3","article-title":"The psychopathologies of children and adolescents with tuberous sclerosis complex (TSC): a postal survey of UK families","volume":"16","author":"de Vries","year":"2007","journal-title":"Eur. Child Adolesc. Psychiatry"},{"issue":"9","key":"10.1016\/j.nbd.2012.10.014_bb0195","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/08830738040190090401","article-title":"Brain abnormalities in tuberous sclerosis complex","volume":"19","author":"DiMario","year":"2004","journal-title":"J. Child Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-1819.2011.02210.x","article-title":"Reduced thalamus volume in non-right-handed male patients with autism spectrum disorders","volume":"65","author":"Egawa","year":"2011","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molmed.2010.10.002","article-title":"Rapamycin for treating tuberous sclerosis and autism spectrum disorders","volume":"17","author":"Ehninger","year":"2011","journal-title":"Trends Mol. Med."},{"issue":"8","key":"10.1016\/j.nbd.2012.10.014_bb0205","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1788","article-title":"Reversal of learning deficits in a Tsc2+\/\u2212 mouse model of tuberous sclerosis","volume":"14","author":"Ehninger","year":"2008","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0210","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/mp.2010.115","article-title":"Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice","volume":"17","author":"Ehninger","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.nbd.2012.10.014_bb0220","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/08830738060210100301","article-title":"Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates","volume":"21","author":"Eluvathingal","year":"2006","journal-title":"J. Child Neurol."},{"issue":"11","key":"10.1016\/j.nbd.2012.10.014_bb0225","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1212\/01.WNL.0000146197.44568.CD","article-title":"Cerebellar lesions in the PICA but not SCA territory impair cognition","volume":"63","author":"Exner","year":"2004","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1019861721160","article-title":"Purkinje cell size is reduced in cerebellum of patients with autism","volume":"22","author":"Fatemi","year":"2002","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0640","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0010-0277(95)00692-R","article-title":"Other minds in the brain: a functional imaging study of \u201ctheory of mind\u201d in story comprehension","volume":"57","author":"Fletcher","year":"1995","journal-title":"Cognition"},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1469-7610.1977.tb00443.x","article-title":"Infantile autism: a genetic study of 21 twin pairs","volume":"18","author":"Folstein","year":"1977","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"5445","key":"10.1016\/j.nbd.2012.10.014_bb0250","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1126\/science.286.5445.1692","article-title":"Interacting minds\u2014a biological basis","volume":"286","author":"Frith","year":"1999","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.nbd.2012.10.014_bb0255","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.1128\/MCB.24.21.9508-9516.2004","article-title":"Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development","volume":"24","author":"Gangloff","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0260","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1469-8749.1994.tb11765.x","article-title":"Autistic behaviour and attention deficits in tuberous sclerosis: a population-based study","volume":"36","author":"Gillberg","year":"1994","journal-title":"Dev. Med. Child Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0265","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0361-9230(90)90189-7","article-title":"Connections of the caudal cerebellar interpositus complex in a new world monkey (Cebus apella)","volume":"25","author":"Gonzalo-Ruiz","year":"1990","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0270","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.21317","article-title":"Cognitive deficits in Tsc1+\/\u2212 mice in the absence of cerebral lesions and seizures","volume":"62","author":"Goorden","year":"2007","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0275","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejpn.2007.02.003","article-title":"The cerebellum and cognition","volume":"11","author":"Gordon","year":"2007","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"10","key":"10.1016\/j.nbd.2012.10.014_bb0280","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/hmg\/3.10.1833","article-title":"The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor","volume":"3","author":"Green","year":"1994","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0285","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ng0294-193","article-title":"Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients","volume":"6","author":"Green","year":"1994","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0645","first-page":"299","article-title":"Emergence and maintenance of stereotypy and self-injury","volume":"96","author":"Guess","year":"1991","journal-title":"Am. J. Ment. Retard."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02178163","article-title":"Development of the brainstem and cerebellum in autistic patients","volume":"25","author":"Hashimoto","year":"1995","journal-title":"J. Autism Dev. Disord."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0300","first-page":"400","article-title":"Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions","volume":"59","author":"Henske","year":"1996","journal-title":"Am. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0305","first-page":"1639","article-title":"Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors","volume":"151","author":"Henske","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0310","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/dvg.20271","article-title":"Generation of a conditional disruption of the Tsc2 gene","volume":"45","author":"Hernandez","year":"2007","journal-title":"Genesis"},{"issue":"1\u20132","key":"10.1016\/j.nbd.2012.10.014_bb0315","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2004.01.008","article-title":"Stress and anxious-related behaviors in Lurcher mutant mice","volume":"1003","author":"Hilber","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2012.10.014_bb0320","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-244X-9-35","article-title":"Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders","volume":"9","author":"Hofvander","year":"2009","journal-title":"BMC Psychiatry"},{"issue":"1610","key":"10.1016\/j.nbd.2012.10.014_bb0325","first-page":"641","article-title":"Integration of sensory and motor processing underlying social behaviour in tungara frogs","volume":"274","author":"Hoke","year":"2007","journal-title":"Proc. Biol. Sci."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0330","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1\u2013TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0335","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1469-8749.1987.tb02135.x","article-title":"Psychiatric disorder among children with tuberous sclerosis","volume":"29","author":"Hunt","year":"1987","journal-title":"Dev. Med. Child Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0340","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF01046223","article-title":"A prevalence study of autism in tuberous sclerosis","volume":"23","author":"Hunt","year":"1993","journal-title":"J. Autism Dev. Disord."},{"issue":"9","key":"10.1016\/j.nbd.2012.10.014_bb0350","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"15","key":"10.1016\/j.nbd.2012.10.014_bb0345","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0355","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/08830738030180070501","article-title":"Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging study","volume":"18","author":"Kaufmann","year":"2003","journal-title":"J. Child Neurol."},{"issue":"23","key":"10.1016\/j.nbd.2012.10.014_bb0360","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1523\/JNEUROSCI.23-23-08432.2003","article-title":"Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate","volume":"23","author":"Kelly","year":"2003","journal-title":"J. Neurosci."},{"issue":"21","key":"10.1016\/j.nbd.2012.10.014_bb0365","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.0600674103","article-title":"Failing to deactivate: resting functional abnormalities in autism","volume":"103","author":"Kennedy","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.nbd.2012.10.014_bb0370","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/cercor\/bhp135","article-title":"Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity","volume":"19","author":"Krienen","year":"2009","journal-title":"Cereb. Cortex"},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0375","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","article-title":"Pten regulates neuronal arborization and social interaction in mice","volume":"50","author":"Kwon","year":"2006","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0380","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.gene.2012.01.020","article-title":"Integrative gene network analysis provides novel regulatory relationships, genetic contributions and susceptible targets in autism spectrum disorders","volume":"496","author":"Lee","year":"2012","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0650","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1460-9568.2009.07073.x","article-title":"Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism","volume":"31","author":"Martin","year":"2012","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0390","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajmg.b.20119","article-title":"Association between the neurofibromatosis-1 (NF1) locus and autism in the Japanese population","volume":"131B","author":"Marui","year":"2004","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0395","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ridd.2009.06.003","article-title":"Intellectual disability and its relationship to autism spectrum disorders","volume":"30","author":"Matson","year":"2009","journal-title":"Res. Dev. Disabil."},{"issue":"21","key":"10.1016\/j.nbd.2012.10.014_bb0400","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1523\/JNEUROSCI.5540-06.2007","article-title":"A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival","volume":"27","author":"Meikle","year":"2007","journal-title":"J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2012.10.014_bb0405","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0165-0173(99)00040-5","article-title":"Basal ganglia and cerebellar loops: motor and cognitive circuits","volume":"31","author":"Middleton","year":"2000","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0410","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1523\/JNEUROSCI.21-02-00700.2001","article-title":"Cerebellar projections to the prefrontal cortex of the primate","volume":"21","author":"Middleton","year":"2001","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2012.10.014_bb0415","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0420","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains","volume":"176","author":"Moy","year":"2007","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.nbd.2012.10.014_bb0425","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1542\/peds.113.5.e472","article-title":"The genetics of autism","volume":"113","author":"Muhle","year":"2004","journal-title":"Pediatrics"},{"issue":"15","key":"10.1016\/j.nbd.2012.10.014_bb0430","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1128\/MCB.24.15.6710-6718.2004","article-title":"mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells","volume":"24","author":"Murakami","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0435","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nn.2477","article-title":"Tsc2-Rheb signaling regulates EphA-mediated axon guidance","volume":"13","author":"Nie","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0440","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1086\/321972","article-title":"Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions","volume":"69","author":"Niida","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.nbd.2012.10.014_bb0445","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1212\/WNL.0b013e3182104347","article-title":"Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex","volume":"76","author":"Numis","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2012.10.014_bb0450","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1749-6632.1991.tb37754.x","article-title":"Epidemiology of tuberous sclerosis","volume":"615","author":"Osborne","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"Pt 12","key":"10.1016\/j.nbd.2012.10.014_bb0455","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1093\/brain\/awh287","article-title":"Neuropathological findings in autism","volume":"127","author":"Palmen","year":"2004","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.nbd.2012.10.014_bb0460","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s10072-004-0325-1","article-title":"Pure post-stroke cerebellar cognitive affective syndrome: a case report","volume":"25","author":"Paulus","year":"2004","journal-title":"Neurol. Sci."},{"issue":"7344","key":"10.1016\/j.nbd.2012.10.014_bb0465","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction","volume":"472","author":"Peca","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2012.10.014_bb0655","first-page":"1","volume":"58","author":"Prevention, C. f. D. C. a.","year":"2006"},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0475","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1750-3639.2010.00416.x","article-title":"Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events","volume":"20","author":"Qin","year":"2010","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0485","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nbd.2011.02.014","article-title":"Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration","volume":"43","author":"Reith","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.nbd.2012.10.014_bb0490","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/syn.20960","article-title":"Connecting the dots of the cerebro-cerebellar role in cognitive function: neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex","volume":"65","author":"Rogers","year":"2011","journal-title":"Synapse"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0495","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01537863","article-title":"Diagnosis and definition of childhood autism","volume":"8","author":"Rutter","year":"1978","journal-title":"J. Autism Child. Schizophr."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0500","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-0173(03)00151-6","article-title":"The cerebellum: organization, functions and its role in nociception","volume":"42","author":"Saab","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0505","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sarbassov","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"issue":"Pt 4","key":"10.1016\/j.nbd.2012.10.014_bb0510","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/brain\/121.4.561","article-title":"The cerebellar cognitive affective syndrome","volume":"121","author":"Schmahmann","year":"1998","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0515","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2788.2011.01423.x","article-title":"Mental health aspects of autistic spectrum disorders in children","volume":"56","author":"Skokauskas","year":"2012","journal-title":"J. Intellect. Disabil. Res."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0520","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01048239","article-title":"Autism and tuberous sclerosis","volume":"22","author":"Smalley","year":"1992","journal-title":"J. Autism Dev. Disord."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0525","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pscychresns.2010.07.001","article-title":"Reduced thalamic volume observed across different subgroups of autism spectrum disorders","volume":"184","author":"Tamura","year":"2010","journal-title":"Psychiatry Res."},{"issue":"Pt 10","key":"10.1016\/j.nbd.2012.10.014_bb0530","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1093\/brain\/awm201","article-title":"Disorders of cognitive and affective development in cerebellar malformations","volume":"130","author":"Tavano","year":"2007","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.nbd.2012.10.014_bb0535","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/nn1566","article-title":"Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2","volume":"8","author":"Tavazoie","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0540","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-009-1466-y","article-title":"Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety","volume":"204","author":"Thomas","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"7413","key":"10.1016\/j.nbd.2012.10.014_bb0660","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0550","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-3223(02)01530-5","article-title":"Reduced thalamic volume in high-functioning individuals with autism","volume":"53","author":"Tsatsanis","year":"2003","journal-title":"Biol. Psychiatry"},{"issue":"5327","key":"10.1016\/j.nbd.2012.10.014_bb0555","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0560","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0665","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s10519-010-9399-0","article-title":"Epilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in rats","volume":"41","author":"Waltereit","year":"2011","journal-title":"Behav. Genet."},{"issue":"7","key":"10.1016\/j.nbd.2012.10.014_bb0570","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/hmg\/ddp025","article-title":"Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse","volume":"18","author":"Way","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0575","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1023\/A:1005679108529","article-title":"Autism and the cerebellum: evidence from tuberous sclerosis","volume":"30","author":"Weber","year":"2000","journal-title":"J. Autism Dev. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0580","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01531339","article-title":"Language, social, and cognitive impairments in autism and severe mental retardation","volume":"11","author":"Wing","year":"1981","journal-title":"J. Autism Dev. Disord."},{"issue":"9","key":"10.1016\/j.nbd.2012.10.014_bb0585","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/08830738040190090701","article-title":"Autism and tuberous sclerosis","volume":"19","author":"Wiznitzer","year":"2004","journal-title":"J. Child Neurol."},{"issue":"1431","key":"10.1016\/j.nbd.2012.10.014_bb0590","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1098\/rstb.2002.1238","article-title":"A unifying computational framework for motor control and social interaction","volume":"358","author":"Wolpert","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"3","key":"10.1016\/j.nbd.2012.10.014_bb0595","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2310\/7010.2006.00046","article-title":"Study of the relationship between tuberous sclerosis complex and autistic disorder","volume":"21","author":"Wong","year":"2006","journal-title":"J. Child Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2012.10.014_bb0600","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(92)90067-J","article-title":"The medial dorsal nucleus is one of the thalamic relays of the cerebellocerebral responses to the frontal association cortex in the monkey: horseradish peroxidase and fluorescent dye double staining study","volume":"579","author":"Yamamoto","year":"1992","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.nbd.2012.10.014_bb0605","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/aur.62","article-title":"Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study","volume":"2","author":"Yip","year":"2009","journal-title":"Autism Res."},{"issue":"24","key":"10.1016\/j.nbd.2012.10.014_bb0610","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1073\/pnas.1005620107","article-title":"Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism","volume":"107","author":"Young","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.nbd.2012.10.014_bb0615","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"15","key":"10.1016\/j.nbd.2012.10.014_bb0620","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1101\/gad.16750211","article-title":"Tsc1 mutant neural stem\/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle","volume":"25","author":"Zhou","year":"2011","journal-title":"Genes Dev."},{"issue":"6644","key":"10.1016\/j.nbd.2012.10.014_bb0625","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/42009","article-title":"Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene","volume":"388","author":"Zuo","year":"1997","journal-title":"Nature"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112003427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996112003427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:35Z","timestamp":1760140535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996112003427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":124,"alternative-id":["S0969996112003427"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2012.10.014","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2012.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}