{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:21Z","timestamp":1788871581927,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"SRU Student\/Faculty Research Grants"},{"name":"NIH","award":["R01GM103369"],"award-info":[{"award-number":["R01GM103369"]}]},{"name":"NIH","award":["R01AG025046"],"award-info":[{"award-number":["R01AG025046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.nbd.2012.12.020","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T01:43:47Z","timestamp":1357955027000},"page":"289-296","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency"],"prefix":"10.1016","volume":"54","author":[{"given":"Stacy L.","family":"Hrizo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Palladino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2012.12.020_bb0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbadis.2003.08.002","article-title":"Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency","volume":"1639","author":"Ahmed","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2012.12.020_bb0010","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/j.1742-4658.2012.08516.x","article-title":"Cellular models to investigate biochemical pathways in Parkinson's disease","volume":"279","author":"Alberio","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2012.12.020_bb0015","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/(SICI)1098-1004(1997)10:4<290::AID-HUMU4>3.0.CO;2-L","article-title":"Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency","volume":"10","author":"Arya","year":"1997","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.nbd.2012.12.020_bb0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2012.12.020_bb0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-2010-1375","article-title":"Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration","volume":"20","author":"Butterfield","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2012.12.020_bb0030","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1534\/genetics.106.063206","article-title":"Drosophila model of human inherited triosephosphate isomerase deficiency glycolytic enzymopathy","volume":"174","author":"Celotto","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2012.12.020_bb0035","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/brb3.73","article-title":"A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease","volume":"4","author":"Celotto","year":"2012","journal-title":"Brain Behav."},{"key":"10.1016\/j.nbd.2012.12.020_bb0040","first-page":"1260","article-title":"Human triosephosphate isomerase deficiency resulting from mutation of Phe-240","volume":"52","author":"Chang","year":"1993","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2012.12.020_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12640-011-9276-5","article-title":"Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activation","volume":"21","author":"Collins","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2012.12.020_bb0050","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1073\/pnas.83.20.7903","article-title":"Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme","volume":"83","author":"Daar","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2012.12.020_bb0055","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3233\/JAD-2011-101884","article-title":"Three postulates to help identify the cause of Alzheimer's disease","volume":"24","author":"de la Torre","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2012.12.020_bb0060","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/BF02026706","article-title":"Triosephosphate isomerase deficiency: haemolytic anaemia, myopathy with altered mitochondria and mental retardation due to a new variant with accelerated enzyme catabolism and diminished specific activity","volume":"150","author":"Eber","year":"1991","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.nbd.2012.12.020_bb0065","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/brain\/aws012","article-title":"NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury","volume":"135","author":"Fischer","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2012.12.020_bb0070","doi-asserted-by":"crossref","first-page":"26188","DOI":"10.1074\/jbc.M710521200","article-title":"Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones","volume":"283","author":"Fujikake","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2012.12.020_bb0075","doi-asserted-by":"crossref","first-page":"14987","DOI":"10.1073\/pnas.0606887103","article-title":"wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death","volume":"103","author":"Gnerer","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2012.12.020_bb0080","doi-asserted-by":"crossref","first-page":"e7580","DOI":"10.1371\/journal.pone.0007580","article-title":"Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster","volume":"4","author":"Grover","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2012.12.020_bb0085","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2011.06.017","article-title":"Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells","volume":"14","author":"Gruning","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2012.12.020_bb0090","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/brain\/awp023","article-title":"Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation","volume":"132","author":"Guix","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2012.12.020_bb0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1601-183X.2011.00748.x","article-title":"Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila","volume":"11","author":"Hirano","year":"2012","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2012.12.020_bb0100","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.nbd.2010.08.011","article-title":"Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI sugarkill pathogenesis in Drosophila","volume":"40","author":"Hrizo","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2012.12.020_bb0105","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.bbrc.2003.12.033","article-title":"Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria","volume":"313","author":"Jeong","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2012.12.020_bb0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/bcmd.2000.0280","article-title":"Diminished blood levels of reduced glutathione and alpha-tocopherol in two triosephosphate isomerase-deficient brothers","volume":"26","author":"Karg","year":"2000","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.nbd.2012.12.020_bb0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/ars.2010.3797","article-title":"The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response","volume":"15","author":"Kruger","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2012.12.020_bb0120","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.neurobiolaging.2009.10.014","article-title":"Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration","volume":"32","author":"Kulic","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2012.12.020_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/bbrc.2001.5735","article-title":"Structural and functional characterization of human NAD kinase","volume":"288","author":"Lerner","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2012.12.020_bb0130","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.nbd.2011.08.022","article-title":"Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis","volume":"45","author":"Liu","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2012.12.020_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10715760903321788","article-title":"Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells","volume":"44","author":"Miyazawa","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.nbd.2012.12.020_bb0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1042\/bst0300030","article-title":"Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease","volume":"30","author":"Olah","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.nbd.2012.12.020_bb0145","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1182\/blood.V98.10.3106","article-title":"Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency","volume":"98","author":"Orosz","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.nbd.2012.12.020_bb0150","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15216540601115960","article-title":"Triosephosphate isomerase deficiency: facts and doubts","volume":"58","author":"Orosz","year":"2006","journal-title":"IUBMB Life."},{"key":"10.1016\/j.nbd.2012.12.020_bb0155","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2164-6-182","article-title":"Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures\u2014linking genome-wide transcriptional changes to cellular physiology","volume":"6","author":"Pocsi","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1016\/j.nbd.2012.12.020_bb0160","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/BJ20061638","article-title":"The power to reduce: pyridine nucleotides\u2014small molecules with a multitude of functions","volume":"402","author":"Pollak","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2012.12.020_bb0165","doi-asserted-by":"crossref","first-page":"33562","DOI":"10.1074\/jbc.M704442200","article-title":"NAD kinase levels control the NADPH concentration in human cells","volume":"282","author":"Pollak","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2012.12.020_bb0170","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.pone.0000030","article-title":"Triose phosphate isomerase deficiency is caused by altered dimerization\u2013not catalytic inactivity\u2013of the mutant enzymes","volume":"1","author":"Ralser","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2012.12.020_bb0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/jbiol61","article-title":"Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress","volume":"6","author":"Ralser","year":"2007","journal-title":"J. Biol."},{"key":"10.1016\/j.nbd.2012.12.020_bb0180","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM196502042720503","article-title":"Hereditary hemolytic anemia with triosephosphate isomerase deficiency","volume":"272","author":"Schneider","year":"1965","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2012.12.020_bb0185","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress","volume":"6","author":"Schulz","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2012.12.020_bb0190","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1534\/genetics.108.087551","article-title":"Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology","volume":"179","author":"Seigle","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2012.12.020_bb0195","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1073\/pnas.0305888101","article-title":"Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes","volume":"101","author":"Thorpe","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2012.12.020_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-3-3","article-title":"Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons","volume":"3","author":"Wang","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2012.12.020_bb0205","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.bcp.2009.02.024","article-title":"Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells","volume":"77","author":"Wang","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2012.12.020_bb0210","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1523\/JNEUROSCI.3410-10.2011","article-title":"Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model","volume":"31","author":"Wang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2012.12.020_bb0215","doi-asserted-by":"crossref","first-page":"e34745","DOI":"10.1371\/journal.pone.0034745","article-title":"Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster","volume":"7","author":"Weber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2012.12.020_bb0220","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1074\/jbc.272.12.7908","article-title":"The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide","volume":"272","author":"Wemmie","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2012.12.020_bb0225","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/ars.2007.1672","article-title":"NAD+\/NADH and NADP+\/NADPH in cellular functions and cell death: regulation and biological consequences","volume":"10","author":"Ying","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2012.12.020_bb0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1097-2765(00)80118-5","article-title":"Direct sensing of heat and oxidation by Drosophila heat shock transcription factor","volume":"2","author":"Zhong","year":"1998","journal-title":"Mol. Cell"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T02:41:00Z","timestamp":1562553660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996113000119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":46,"alternative-id":["S0969996113000119"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2012.12.020","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}