{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:53:14Z","timestamp":1789735994605,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fund for Scientific Research Flanders\u201d (FWO-Vlaanderen)"},{"name":"University of Leuven (KU Leuven)"},{"name":"Belgian Government"},{"name":"European Community's Health Seventh Framework Programme","award":["259867"],"award-info":[{"award-number":["259867"]}]},{"name":"FWO-Vlaanderen"},{"name":"Intramural Research Program of the National Human Genome Research Institute"},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.nbd.2013.08.006","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T16:49:03Z","timestamp":1376930943000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice"],"prefix":"10.1016","volume":"60","author":[{"given":"Kim A.","family":"Staats","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Van Helleputte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bento-Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Van Hoecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey","family":"Shatunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Jaspers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert H.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Liston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Robberecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Al-Chalabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludo","family":"Van Den Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2013.08.006_bb0005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrneurol.2011.150","article-title":"Clinical genetics of amyotrophic lateral sclerosis: what do we really know?","volume":"7","author":"Andersen","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0010","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1074\/jbc.275.6.3761","article-title":"Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression","volume":"275","author":"Azuma","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2013.08.006_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00439-005-1296-x","article-title":"Evidence for a novel glaucoma locus at chromosome 3p21\u201322","volume":"117","author":"Baird","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0020","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","article-title":"Unraveling the mechanisms involved in motor neuron degeneration in ALS","volume":"27","author":"Bruijn","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2013.08.006_bb0025","first-page":"314","article-title":"RPR 119990, a novel \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis","volume":"299","author":"Canton","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2013.08.006_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-510X(02)00339-8","article-title":"Low concentrations of glutamate induce apoptosis in cultured neurons: implications for amyotrophic lateral sclerosis","volume":"206","author":"Cid","year":"2003","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2013.08.006_bb0035","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"Dejesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2013.08.006_bb0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/ana.21344","article-title":"TDP-43 A315T mutation in familial motor neuron disease","volume":"63","author":"Gitcho","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0050","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.1523\/JNEUROSCI.2315-06.2006","article-title":"Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS","volume":"26","author":"Gould","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2013.08.006_bb0055","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.2337\/db10-1500","article-title":"Genetic defect in phospholipase Cdelta1 protects mice from obesity by regulating thermogenesis and adipogenesis","volume":"60","author":"Hirata","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2013.08.006_bb0060","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/ng.132","article-title":"TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis","volume":"40","author":"Kabashi","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ajhg.2011.05.014","article-title":"Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1","volume":"88","author":"Kiuru","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.277.5325.559","article-title":"Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis","volume":"277","author":"Kostic","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0075","doi-asserted-by":"crossref","first-page":"e32768","DOI":"10.1371\/journal.pone.0032768","article-title":"A high-density genome-wide association screen of sporadic ALS in US veterans","volume":"7","author":"Kwee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2013.08.006_bb0080","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0085","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/bbrc.1999.1035","article-title":"Molecular cloning and expression analysis of a mouse phospholipase C-delta1","volume":"261","author":"Lee","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2013.08.006_bb0090","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jnnp.2009.183525","article-title":"Incidence of amyotrophic lateral sclerosis in Europe","volume":"81","author":"Logroscino","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2013.08.006_bb0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature08971","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis","volume":"465","author":"Maruyama","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2013.08.006_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001447.pub3","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","volume":"3","author":"Miller","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.nbd.2013.08.006_bb0105","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1093\/emboj\/cdg302","article-title":"Phospholipase Cdelta1 is required for skin stem cell lineage commitment","volume":"22","author":"Nakamura","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2013.08.006_bb0110","doi-asserted-by":"crossref","first-page":"10979","DOI":"10.1128\/MCB.25.24.10979-10988.2005","article-title":"Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development","volume":"25","author":"Nakamura","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2010.01.081","article-title":"Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-delta1 into the nucleus","volume":"472","author":"Okada","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2013.08.006_bb0120","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF","volume":"9","author":"Pun","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2013.08.006_bb0125","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2013.08.006_bb0135","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2013.08.006_bb0145","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","article-title":"A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants","volume":"316","author":"Scott","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1469-1809.1995.tb01608.x","article-title":"Monte Carlo tests for associations between disease and alleles at highly polymorphic loci","volume":"59","author":"Sham","year":"1995","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0155","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1474-4422(10)70197-6","article-title":"Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study","volume":"9","author":"Shatunov","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0160","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/CIRCULATIONAHA.111.064303","article-title":"Coronary vasospasm induced in transgenic mouse with increased phospholipase C-delta1 activity","volume":"125","author":"Shibutani","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.nbd.2013.08.006_bb0165","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jnr.490410315","article-title":"Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons","volume":"41","author":"Shimohama","year":"1995","journal-title":"J. Neurosci. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2013.08.006_bb0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000213716","article-title":"Differential involvement of phospholipase C isozymes in Alzheimer's disease","volume":"41","author":"Shimohama","year":"1995","journal-title":"Gerontology"},{"key":"10.1016\/j.nbd.2013.08.006_bb0175","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/hmg\/ddn375","article-title":"Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration","volume":"18","author":"Simpson","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0180","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0185","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbrc.2012.10.094","article-title":"Neuronal overexpression of IP(3) receptor 2 is detrimental in mutant SOD1 mice","volume":"429","author":"Staats","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2013.08.006_bb0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2012.06.050","article-title":"Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1G93A mice","volume":"220","author":"Staats","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2013.08.006_bb0195","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2006.11.037","article-title":"Caspase-dependent apoptosis induced by calcineurin inhibitors was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical cells","volume":"1133","author":"Takadera","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2013.08.006_bb0200","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jnr.20715","article-title":"Glutamate AMPA receptors change in motor neurons of SOD1(G93A) transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease","volume":"83","author":"Tortarolo","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2013.08.006_bb0205","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.23-12-04942.2003","article-title":"Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death","volume":"23","author":"Van Damme","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2013.08.006_bb0210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(03)00314-8","article-title":"The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"343","author":"Van Damme","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2013.08.006_bb0215","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(07)70222-3","article-title":"ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study","volume":"6","author":"van Es","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2013.08.006_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng.2007.52","article-title":"Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis","volume":"40","author":"van Es","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0225","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ng.442","article-title":"Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis","volume":"41","author":"van Es","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2013.08.006_bb0230","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.08.006_bb0235","doi-asserted-by":"crossref","first-page":"e8175","DOI":"10.1371\/journal.pone.0008175","article-title":"The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci","volume":"4","author":"Wain","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2013.08.006_bb0240","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1440-1789.2005.00648.x","article-title":"Is motoneuronal cell death in amyotrophic lateral sclerosis apoptosis?","volume":"25","author":"Yamazaki","year":"2005","journal-title":"Neuropathology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113002271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113002271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:03:50Z","timestamp":1588968230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996113002271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":48,"alternative-id":["S0969996113002271"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2013.08.006","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2013.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}