{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:27:39Z","timestamp":1780345659495,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"NIH Office of Research Infrastructure Program","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]},{"DOI":"10.13039\/501100002803","name":"Cariplo Foundation","doi-asserted-by":"crossref","award":["2009-2543"],"award-info":[{"award-number":["2009-2543"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"crossref","award":["GGP10120"],"award-info":[{"award-number":["GGP10120"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Progetto Strategico Alzheimer RF2007 of the Italian Ministry of Health"},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","award":["NIRG-10-171655"],"award-info":[{"award-number":["NIRG-10-171655"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ricerca Corrente Italian Ministry of Health"},{"name":"Monzino Foundation"},{"name":"AFaR 2012","award":["ID 13"],"award-info":[{"award-number":["ID 13"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.nbd.2013.10.024","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T05:17:19Z","timestamp":1383283039000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Expression of A2V-mutated A\u03b2 in Caenorhabditis elegans results in oligomer formation and toxicity"],"prefix":"10.1016","volume":"62","author":[{"given":"Luisa","family":"Diomede","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Fede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Bagnati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fiordaliso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Salio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Catania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Paterlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Benussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bastone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Stravalaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2013.10.024_bb0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/prca.200900166","article-title":"Optimization protocol for amyloid-beta peptides detection in human cerebrospinal fluid using SELDI TOF MS","volume":"4","author":"Albertini","year":"2010","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.nbd.2013.10.024_bb0010","first-page":"787","article-title":"Novel approaches for studying amyloidogenic peptides\/proteins","volume":"5","author":"Beeg","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2013.10.024_bb0015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Bertram","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2013.10.024_bb0020","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1073\/pnas.0910723107","article-title":"EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity","volume":"107","author":"Bieschke","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2013.10.024_bb0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ab.2006.08.005","article-title":"Exploring \u201cone-shot\u201d kinetics and small molecule analysis using the ProteOn XPR36 array biosensor","volume":"358","author":"Bravman","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.nbd.2013.10.024_bb0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000334762","article-title":"Intraneuronal A\u03b2 accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease","volume":"10","author":"Capetillo-Zarate","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nbd.2013.10.024_bb0035","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1126\/science.1168979","article-title":"A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis","volume":"323","author":"Di Fede","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.10.024_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pneurobio.2012.06.004","article-title":"Good gene, bad gene: new APP variant may be both","volume":"99","author":"Di Fede","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2013.10.024_bb0045","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.nbd.2010.07.002","article-title":"Tetracycline and its analogues protect Caenorhabditis elegans from beta amyloid-induced toxicity by targeting oligomers","volume":"40","author":"Diomede","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2013.10.024_bb0050","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3233\/JAD-2010-1267","article-title":"Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta","volume":"19","author":"Dosanjh","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2013.10.024_bb0055","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nsmb.1437","article-title":"EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers","volume":"15","author":"Ehrnhoefer","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.nbd.2013.10.024_bb0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00429-009-0235-3","article-title":"Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system","volume":"214","author":"Ewald","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nbd.2013.10.024_bb0065","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(90)90493-X","article-title":"The unc-86 gene product couples cell lineage and cell identity in C. elegans","volume":"63","author":"Finney","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2013.10.024_bb0070","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-010-0747-1","article-title":"Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features","volume":"120","author":"Giaccone","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2013.10.024_bb0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neubiorev.2006.07.007","article-title":"Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid","volume":"31","author":"Gimenez-Llort","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2013.10.024_bb0080","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2013.10.024_bb0085","doi-asserted-by":"crossref","first-page":"77sr1","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer''s disease: the challenge of the second century","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2013.10.024_bb0090","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans","volume":"92","author":"Link","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2013.10.024_bb0095","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0197-4580(00)00237-2","article-title":"Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34","volume":"22","author":"Link","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2013.10.024_bb0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.nbd.2013.10.024_bb0105","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/nprot.2006.281","article-title":"Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay","volume":"1","author":"Mahoney","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2013.10.024_bb0110","doi-asserted-by":"crossref","first-page":"22697","DOI":"10.1074\/jbc.C109.028514","article-title":"The Caenorhabditis elegans A beta 1\u201342 model of Alzheimer disease predominantly expresses A beta 3\u201342","volume":"284","author":"McColl","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2013.10.024_bb0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/genetics\/140.2.527","article-title":"Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase","volume":"140","author":"Nguyen","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2013.10.024_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(03)00067-4","article-title":"Causative and susceptibility genes for Alzheimer's disease: a review","volume":"61","author":"Rocchi","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2013.10.024_bb0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/338313a0","article-title":"The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch","volume":"338","author":"Ruvkun","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2013.10.024_bb0130","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.conb.2009.09.009","article-title":"Caenorhabditis elegans: a model system for systems neuroscience","volume":"19","author":"Sengupta","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2013.10.024_bb0135","doi-asserted-by":"crossref","first-page":"27796","DOI":"10.1074\/jbc.M111.334979","article-title":"Specific recognition of biologically active amyloid-beta oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans","volume":"287","author":"Stravalaci","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2013.10.024_bb0140","doi-asserted-by":"crossref","first-page":"e1000350","DOI":"10.1371\/journal.pgen.1000350","article-title":"An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans","volume":"5","author":"Wang","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2013.10.024_bb0145","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.lfs.2012.02.001","article-title":"Intraneuronal Abeta accumulation and neurodegeneration: lessons from transgenic models","volume":"91","author":"Wirths","year":"2012","journal-title":"Life Sci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113002994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996113002994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T10:24:12Z","timestamp":1646994252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996113002994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":29,"alternative-id":["S0969996113002994"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2013.10.024","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of A2V-mutated A\u03b2 in Caenorhabditis elegans results in oligomer formation and toxicity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2013.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}