{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:35:39Z","timestamp":1761489339099},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.nbd.2014.03.013","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T21:52:43Z","timestamp":1396043563000},"page":"71-78","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster"],"prefix":"10.1016","volume":"67","author":[{"given":"A.","family":"Murali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Maue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Dolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.03.013_bb0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0074-7742(06)75005-X","article-title":"Development of motoneuron electrical properties and motor output","volume":"75","author":"Baines","year":"2006","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2014.03.013_bb0010","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1523\/JNEUROSCI.3406-12.2013","article-title":"A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity","volume":"33","author":"Biasini","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.genet.39.110304.095804","article-title":"Drosophila as a model for human neurodegenerative disease","volume":"39","author":"Bilen","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.nbd.2014.03.013_bb0020","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"issue":"49","key":"10.1016\/j.nbd.2014.03.013_bb0025","doi-asserted-by":"crossref","first-page":"13258","DOI":"10.1523\/JNEUROSCI.3109-08.2008","article-title":"Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities","volume":"28","author":"Chiesa","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0030","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A Drosophila model of Parkinson's disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.03.013_bb0035","doi-asserted-by":"crossref","first-page":"e1000507","DOI":"10.1371\/journal.pgen.1000507","article-title":"In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms","volume":"5","author":"Fernandez-Funez","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2014.03.013_bb0040","doi-asserted-by":"crossref","first-page":"36897","DOI":"10.1074\/jbc.M110.174391","article-title":"Sequence-dependent prion protein misfolding and neurotoxicity","volume":"285","author":"Fernandez-Funez","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.03.013_bb0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00439-011-1119-1","article-title":"Modeling human neurodegenerative diseases in transgenic systems","volume":"131","author":"Gama Sosa","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.nbd.2014.03.013_bb0050","doi-asserted-by":"crossref","first-page":"12408","DOI":"10.1523\/JNEUROSCI.3372-06.2006","article-title":"Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann\u2013Straussler\u2013Scheinker syndrome","volume":"26","author":"Gavin","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0272-2712(02)00064-1","article-title":"Hereditary prion protein amyloidoses","volume":"23","author":"Ghetti","year":"2003","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.nbd.2014.03.013_bb0060","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1523\/JNEUROSCI.4109-05.2006","article-title":"Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ","volume":"26","author":"Gu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0065","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1523\/JNEUROSCI.19-20-08866.1999","article-title":"Evidence of presynaptic location and function of the prion protein","volume":"19","author":"Herms","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0070","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1073\/pnas.0400895101","article-title":"Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease","volume":"101","author":"Iijima","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.03.013_bb0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2012.09.011","article-title":"SMN is required for sensory\u2013motor circuit function in Drosophila","volume":"151","author":"Imlach","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.03.013_bb0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1743-422X-8-559","article-title":"An overview of human prion diseases","volume":"8","author":"Imran","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.nbd.2014.03.013_bb0085","doi-asserted-by":"crossref","first-page":"42409","DOI":"10.1074\/jbc.M106928200","article-title":"Mutant prion proteins are partially retained in the endoplasmic reticulum","volume":"276","author":"Ivanova","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.03.013_bb0090","doi-asserted-by":"crossref","first-page":"38699","DOI":"10.1074\/jbc.M005543200","article-title":"The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome","volume":"275","author":"Jin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.03.013_bb0095","doi-asserted-by":"crossref","first-page":"14955","DOI":"10.1073\/pnas.011578098","article-title":"Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation","volume":"98","author":"Ma","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.03.013_bb0100","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.1090187","article-title":"Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis","volume":"302","author":"Mallucci","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.03.013_bb0105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2007.01.005","article-title":"Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice","volume":"53","author":"Mallucci","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.03.013_bb0110","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ng.101","article-title":"Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes","volume":"40","author":"Markstein","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2014.03.013_bb0115","first-page":"16","article-title":"Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila","volume":"220","author":"McGuire","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.nbd.2014.03.013_bb0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrn751","article-title":"Modelling neurodegenerative diseases in Drosophila: a fruitful approach?","volume":"3","author":"Muqit","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2014.03.013_bb0125","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1534\/genetics.106.057976","article-title":"A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene","volume":"173","author":"Neuburger","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2014.03.013_bb0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.278.5336.245","article-title":"Prion diseases and the BSE crisis","volume":"278","author":"Prusiner","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.03.013_bb0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1567-133X(01)00011-4","article-title":"Drosophila cholinergic neurons and processes visualized with Gal4\/UAS-GFP","volume":"1","author":"Salvaterra","year":"2001","journal-title":"Brain Res. Gene Expr. Patterns"},{"key":"10.1016\/j.nbd.2014.03.013_bb0140","doi-asserted-by":"crossref","first-page":"8842","DOI":"10.1073\/pnas.90.19.8842","article-title":"Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit","volume":"90","author":"Saville","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.03.013_bb0145","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neuron.2012.02.027","article-title":"Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC alpha(2)delta-1 subunit","volume":"74","author":"Senatore","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.03.013_bb0150","doi-asserted-by":"crossref","first-page":"28461","DOI":"10.1074\/jbc.272.45.28461","article-title":"Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation","volume":"272","author":"Singh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.03.013_bb0160","doi-asserted-by":"crossref","first-page":"26719","DOI":"10.1074\/jbc.M110.134619","article-title":"Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells","volume":"285","author":"Solomon","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.03.013_bb0155","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4161\/pri.6.1.18627","article-title":"Ion channels induced by the prion protein: mediators of neurotoxicity","volume":"6","author":"Solomon","year":"2012","journal-title":"Prion"},{"key":"10.1016\/j.nbd.2014.03.013_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0092-8674(94)90177-5","article-title":"Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins","volume":"76","author":"Westaway","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.03.013_bb0170","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1073\/pnas.0802759105","article-title":"Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease","volume":"105","author":"White","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.03.013_bb0175","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1038\/nprot.2006.336","article-title":"A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining","volume":"1","author":"Wu","year":"2006","journal-title":"Nat. Protoc."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T06:19:21Z","timestamp":1648707561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":35,"alternative-id":["S0969996114000746"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.03.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}