{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:49:27Z","timestamp":1791326967162,"version":"4.3.1"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.nbd.2014.05.019","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T13:04:44Z","timestamp":1401195884000},"page":"104-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"PA","title":["Nuclear receptors in neurodegenerative diseases"],"prefix":"10.1016","volume":"72","author":[{"given":"Rebecca","family":"Skerrett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Landreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.05.019_bb0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.immuni.2009.06.018","article-title":"Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR","volume":"31","author":"A-Gonzalez","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2014.05.019_bb0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1750-1326-5-36","article-title":"Increased expression of RXR\u03b1 in dementia: an early harbinger for the cholesterol dyshomeostasis?","volume":"5","author":"Akram","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2014.05.019_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.mito.2008.02.001","article-title":"Nuclear receptors, mitochondria and lipid metabolism","volume":"8","author":"Alaynick","year":"2008","journal-title":"Mitochondrion"},{"key":"10.1016\/j.nbd.2014.05.019_bb0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0025","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1073\/pnas.0500634102","article-title":"Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice","volume":"102","author":"Andersson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.jcbfm.9600200","article-title":"Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor beta-deficient mice","volume":"26","author":"Arsenijevic","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2014.05.019_bb0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pnpbp.2014.02.009","article-title":"PPAR-\u03b1 agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease","volume":"53C","author":"Barbiero","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2014.05.019_bb0040","doi-asserted-by":"crossref","first-page":"11351","DOI":"10.1074\/jbc.M111.272427","article-title":"Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival","volume":"287","author":"Barneda-Zahonero","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0045","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.bbadis.2013.03.006","article-title":"Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPAR\u03b2\/\u03b4-null mice","volume":"1832","author":"Barroso","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2014.05.019_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.med.57.121304.131428","article-title":"Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia","volume":"57","author":"Beaven","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.nbd.2014.05.019_bb0055","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1523\/JNEUROSCI.5198-13.2014","article-title":"Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene","volume":"34","author":"Boehm-Cagan","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Braissant","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2014.05.019_bb0065","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00990.x","article-title":"Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease","volume":"82","author":"Breidert","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nlm.2013.06.020","article-title":"The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity","volume":"105","author":"Bridi","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0075","doi-asserted-by":"crossref","first-page":"34674","DOI":"10.1074\/jbc.M402324200","article-title":"Differential expression of cholesterol hydroxylases in Alzheimer's disease","volume":"279","author":"Brown","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12640-012-9342-7","article-title":"Modulating microglia activity with PPAR-\u03b3 agonists: a promising therapy for Parkinson's disease?","volume":"23","author":"Carta","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuroscience.2011.07.046","article-title":"Rosiglitazone decreases peroxisome proliferator receptor-\u03b3 levels in microglia and inhibits TNF-\u03b1 production: new evidences on neuroprotection in a progressive Parkinson's disease model","volume":"194","author":"Carta","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.05.019_bb0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.cellbio.20.012103.134432","article-title":"Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation","volume":"20","author":"Castrillo","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0095","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: opening the X-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0100","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejpb.2013.12.005","article-title":"Bexarotene nanocrystal\u2014oral and parenteral formulation development, characterization and pharmacokinetic evaluation","volume":"87","author":"Chen","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.nbd.2014.05.019_bb0105","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1093\/hmg\/ddq322","article-title":"Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma","volume":"19","author":"Chiang","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2014.05.019_bb0110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.diabet.2013.07.005","article-title":"NR4A orphan nuclear receptors in glucose homeostasis: a minireview","volume":"39","author":"Close","year":"2013","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.nbd.2014.05.019_bb0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11481-009-9164-4","article-title":"Heterogeneity of microglial activation in the innate immune response in the brain","volume":"4","author":"Colton","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0120","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.20-02-00558.2000","article-title":"Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists","volume":"20","author":"Combs","year":"2000","journal-title":"J. Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2014.05.019_bb0125","first-page":"S263","article-title":"Insulin and Alzheimer's disease: untangling the web","volume":"33","author":"Craft","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0130","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models","volume":"335","author":"Cramer","year":"2012","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroscience.2012.02.047","article-title":"Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP\/PS1 transgenic mice","volume":"210","author":"Cui","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.05.019_bb0140","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI58656","article-title":"The immunology of neurodegeneration","volume":"122","author":"Czirr","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2014.05.019_bb0145","doi-asserted-by":"crossref","first-page":"13112","DOI":"10.1073\/pnas.1210833109","article-title":"Liver X receptor \u03b2 protects dopaminergic neurons in a mouse model of Parkinson disease","volume":"109","author":"Dai","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbalip.2011.09.014","article-title":"The retinoid X receptors and their ligands","volume":"1821","author":"Dawson","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2014.05.019_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(95)00263-R","article-title":"HZF-3, an immediate-early orphan receptor homologous to NURR1\/NOT: induction upon membrane depolarization and seizures","volume":"38","author":"de Ortiz","year":"1996","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0160","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1126\/science.290.5499.2140","article-title":"Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain","volume":"290","author":"de Urquiza","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuint.2012.04.002","article-title":"Differences in NGFI-B, Nurr1, and NOR-1 expression and nucleocytoplasmic translocation in glutamate-treated neurons","volume":"61","author":"Debernard","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2014.05.019_bb0170","doi-asserted-by":"crossref","first-page":"163ra156","DOI":"10.1126\/scitranslmed.3004676","article-title":"\u03b1-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons","volume":"4","author":"Decressac","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2014.05.019_bb0175","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneurol.2013.209","article-title":"NURR1 in Parkinson disease-from pathogenesis to therapeutic potential","volume":"9","author":"Decressac","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0180","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1471-4159.2003.02210.x","article-title":"Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation","volume":"88","author":"Dehmer","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0185","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1523\/JNEUROSCI.2153-12.2012","article-title":"Cognitive enhancement with rosiglitazone links the hippocampal PPAR\u03b3 and ERK MAPK signaling pathways","volume":"32","author":"Denner","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0190","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.23-12-05219.2003","article-title":"Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein+presenilin-1 transgenic mice","volume":"23","author":"Dickey","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0195","doi-asserted-by":"crossref","first-page":"34144","DOI":"10.1074\/jbc.M110.108100","article-title":"ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein\/presenilin 1 mice","volume":"285","author":"Donkin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0200","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1093\/hmg\/dds355","article-title":"Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice","volume":"21","author":"Dumont","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2014.05.019_bb0205","doi-asserted-by":"crossref","first-page":"e37885","DOI":"10.1371\/journal.pone.0037885","article-title":"A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis","volume":"7","author":"Dupuis","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.05.019_bb0215","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2008.12.071","article-title":"Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model","volume":"379","author":"Escribano","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2014.05.019_bb0210","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/npp.2010.32","article-title":"Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology","volume":"35","author":"Escribano","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2014.05.019_bb0220","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1523\/JNEUROSCI.2154-10.2010","article-title":"beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1","volume":"30","author":"Espa\u00f1a","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0225","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.jalz.2013.12.010","article-title":"Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease","volume":"10","author":"Ferreira","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2014.05.019_bb0235","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1523\/JNEUROSCI.1051-10.2010","article-title":"Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice","volume":"30","author":"Fitz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0240","doi-asserted-by":"crossref","first-page":"924-c","DOI":"10.1126\/science.1235809","article-title":"Comment on \u201cApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models\u201d","volume":"340","author":"Fitz","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0230","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-132789","article-title":"Improvement of memory deficits and amyloid-\u03b2 clearance in aged APP23 mice treated with a combination of anti-amyloid-\u03b2 antibody and LXR agonist","author":"Fitz","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0245","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1074\/jbc.M112.439190","article-title":"Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress","volume":"288","author":"Garc\u00eda-Yag\u00fce","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0250","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1101\/gad.1773109","article-title":"Cooperative NCoR\/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways","volume":"23","author":"Ghisletti","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2014.05.019_bb0255","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"Glass","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0260","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000318845","article-title":"Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study","volume":"30","author":"Gold","year":"2010","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.nbd.2014.05.019_bb0265","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2014.05.019_bb0270","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1172\/JCI64145","article-title":"NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors","volume":"122","author":"Hawk","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2014.05.019_bb0280","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/brain\/awh452","article-title":"Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice","volume":"128","author":"Heneka","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.05.019_bb0275","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/ncpneuro0586","article-title":"Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders","volume":"3","author":"Heneka","year":"2007","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0285","doi-asserted-by":"crossref","first-page":"30003","DOI":"10.1074\/jbc.M110.184697","article-title":"Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer","volume":"286","author":"Holla","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0290","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/en.2006-0070","volume":"147","author":"Hondares","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2014.05.019_bb0295","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.gde.2008.07.016","article-title":"Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors","volume":"18","author":"Hong","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.nbd.2014.05.019_bb0300","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1021\/jm301913k","article-title":"Synthesis and identification of new flavonoids targeting liver X receptor \u03b2 involved pathway as potential facilitators of A\u03b2 clearance with reduced lipid accumulation","volume":"56","author":"Hu","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0305","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1038\/sj.emboj.7600209","article-title":"In vivo activation of PPAR target genes by RXR homodimers","volume":"23","author":"IJpenberg","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2014.05.019_bb0310","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.plipres.2012.02.003","article-title":"Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs","volume":"51","author":"Im","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0315","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3233\/JAD-2012-120397","article-title":"Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease","volume":"33","author":"Inestrosa","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0320","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.bbrc.2012.01.102","article-title":"NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600","volume":"418","author":"Ishizawa","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2014.05.019_bb0325","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1124\/jpet.106.115758","article-title":"Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo","volume":"320","author":"Iwashita","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2014.05.019_bb0330","doi-asserted-by":"crossref","first-page":"e78075","DOI":"10.1371\/journal.pone.0078075","article-title":"The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair","volume":"8","author":"Jagirdar","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.05.019_bb0335","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2004.08.035","article-title":"Age-dependent dopaminergic dysfunction in Nurr1 knockout mice","volume":"191","author":"Jiang","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00023210-200822010-00001","article-title":"The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications","volume":"22","author":"Jiang","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.nbd.2014.05.019_bb0345","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of A\u03b2","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.05.019_bb0350","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/jnr.23053","article-title":"Activation of peroxisome proliferator-activated receptor-\u03b4 attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells","volume":"90","author":"Jin","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0355","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jnc.12190","article-title":"Neuroprotective effects of PPAR-\u03b3 agonist rosiglitazone in N171-82Q mouse model of Huntington's disease","volume":"125","author":"Jin","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0360","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease","volume":"21","author":"Johri","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2014.05.019_bb0365","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2013.04.016","article-title":"PGC-1\u03b1, mitochondrial dysfunction, and Huntington's disease","volume":"62","author":"Johri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2014.05.019_bb0370","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/156720509789207949","article-title":"A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease","volume":"6","author":"Kalinin","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0375","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/iub.1097","article-title":"Peroxisome proliferator-activated receptor-\u03b3 cofactors in neurodegeneration","volume":"64","author":"Katsouri","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.nbd.2014.05.019_bb0380","doi-asserted-by":"crossref","first-page":"418765","DOI":"10.1155\/2008\/418765","article-title":"Peroxisome proliferator-activated receptor-gamma in amyotrophic lateral sclerosis and Huntington's disease","volume":"2008","author":"Kiaei","year":"2008","journal-title":"PPAR Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0385","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.expneurol.2004.10.007","article-title":"Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis","volume":"191","author":"Kiaei","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0390","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1073\/pnas.0711599105","article-title":"Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis\u2013Parkinson's dementia","volume":"105","author":"Kim","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0395","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.05.019_bb0400","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1073\/pnas.94.9.4318","article-title":"Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma","volume":"94","author":"Kliewer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0405","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1074\/jbc.M411420200","article-title":"The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0415","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbr.2008.10.010","article-title":"Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease","volume":"197","author":"Kumar","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0420","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/JAD-2006-10113","article-title":"Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease","volume":"10","author":"de la Monte","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0425","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1326-8-18","article-title":"Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP\/PS1 mice","volume":"8","author":"LaClair","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2014.05.019_bb0430","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1742-2094-1-11","article-title":"Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised","volume":"1","author":"Lacombe","year":"2004","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2014.05.019_bb0435","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.phrs.2012.02.008","article-title":"Differential susceptibility to the PPAR-\u03b3 agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease","volume":"65","author":"Laloux","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0440","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.nurt.2008.05.003","article-title":"PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease","volume":"5","author":"Landreth","year":"2008","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2014.05.019_bb0445","doi-asserted-by":"crossref","first-page":"924-g","DOI":"10.1126\/science.1234114","article-title":"Response to comments on \u201cApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models\u201d","volume":"340","author":"Landreth","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0455","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.molcel.2009.07.021","article-title":"Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes","volume":"35","author":"Lee","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2014.05.019_bb0450","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.toxlet.2012.07.016","article-title":"Rosiglitazone, a PPAR-\u03b3 agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats","volume":"213","author":"Lee","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.nbd.2014.05.019_bb0460","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-1326-2-20","article-title":"Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment","volume":"2","author":"Lefterov","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2014.05.019_bb0465","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1111\/j.1471-4159.2007.04888.x","article-title":"Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta","volume":"103","author":"Madrigal","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0470","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1101\/gad.16872411","article-title":"Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair","volume":"25","author":"Malewicz","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2014.05.019_bb0480","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1517\/14728222.2011.594043","article-title":"Nuclear receptors as therapeutic targets for Alzheimer's disease","volume":"15","author":"Mandrekar-Colucci","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.nbd.2014.05.019_bb0475","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1523\/JNEUROSCI.5268-11.2012","article-title":"Mechanisms underlying the rapid peroxisome proliferator-activated receptor-\u03b3-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease","volume":"32","author":"Mandrekar-Colucci","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0485","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.expneurol.2012.02.017","article-title":"Pharmacological manipulation of peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) reveals a role for anti-oxidant protection in a model of Parkinson's disease","volume":"235","author":"Martin","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0490","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2013.02.058","article-title":"A peroxisome proliferator-activated receptor-\u03b4 agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"240","author":"Martin","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.05.019_bb0495","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.1038\/cddis.2012.189","article-title":"Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice","volume":"3","author":"Masciopinto","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0500","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.04002","article-title":"The NR4A subgroup: immediate early response genes with pleiotropic physiological roles","volume":"4","author":"Maxwell","year":"2006","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.nbd.2014.05.019_bb0505","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1021\/cn400100f","article-title":"Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease","volume":"4","author":"McFarland","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0510","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1471-4159.2005.03458.x","article-title":"Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity","volume":"95","author":"Michelhaugh","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0515","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1158\/1078-0432.CCR-11-2953","article-title":"Molecular pathways: the role of NR4A orphan nuclear receptors in cancer","volume":"18","author":"Mohan","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0520","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2003.08.064","article-title":"Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS","volume":"123","author":"Moreno","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.05.019_bb0525","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bcp.2005.10.017","article-title":"Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1","volume":"71","author":"Morita","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0530","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nlm.2013.07.002","article-title":"Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research","volume":"105","author":"Morris","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.nbd.2014.05.019_bb0535","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bcp.2014.01.008","article-title":"Microglial dysfunction in brain aging and Alzheimer's disease","volume":"88","author":"Mosher","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0540","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00018-011-0850-z","article-title":"Transgenic expression and activation of PGC-1\u03b1 protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease","volume":"69","author":"Mud\u00f2","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0545","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nm.2048","article-title":"PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance","volume":"15","author":"Mukundan","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2014.05.019_bb0550","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0555","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1523\/JNEUROSCI.3413-13.2014","article-title":"Cognitive enhancing treatment with a PPAR\u03b3 agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice","volume":"34","author":"Nenov","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0565","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2010.00021","article-title":"The nuclear receptor PPARgamma as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease","volume":"2","author":"Nicolakakis","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0560","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1523\/JNEUROSCI.3348-08.2008","article-title":"Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist","volume":"28","author":"Nicolakakis","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0570","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1073\/pnas.0913545107","article-title":"Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression","volume":"107","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0575","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-pathol-011110-130138","article-title":"Alternative macrophage activation and metabolism","volume":"6","author":"Odegaard","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0580","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.immuni.2013.04.001","article-title":"The immune system as a sensor of the metabolic state","volume":"38","author":"Odegaard","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2014.05.019_bb0585","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.05.019_bb0590","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11481-011-9282-7","article-title":"Rosiglitazone improves spatial memory and decreases insoluble A\u03b2(1-42) in APP\/PS1 mice","volume":"7","author":"O'Reilly","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0595","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2174\/1389450111314070005","article-title":"PPARs: a potential target for a disease-modifying strategy in stroke","volume":"14","author":"Ouk","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.nbd.2014.05.019_bb0600","doi-asserted-by":"crossref","first-page":"e68612","DOI":"10.1371\/journal.pone.0068612","article-title":"Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-\u03b2 and cerebrovascular pathology","volume":"8","author":"Papadopoulos","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.05.019_bb0605","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1073\/pnas.1015413108","article-title":"Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta","volume":"108","author":"Park","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0610","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1523\/JNEUROSCI.5288-13.2014","article-title":"Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages","volume":"34","author":"Parra-Damas","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0615","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1124\/jpet.110.165605","article-title":"Evidence for the role of peroxisome proliferator-activated receptor-beta\/delta in the development of spinal cord injury","volume":"333","author":"Paterniti","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2014.05.019_bb0620","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.expneurol.2006.01.018","article-title":"Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice","volume":"199","author":"Pedersen","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0625","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1128\/MCB.20.14.5119-5128.2000","article-title":"Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)","volume":"20","author":"Peters","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0630","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/nbm.1157","article-title":"MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice","volume":"20","author":"Pialat","year":"2007","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nbd.2014.05.019_bb0635","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2005.07.006","article-title":"Protective effects of a peroxisome proliferator-activated receptor-beta\/delta agonist in experimental autoimmune encephalomyelitis","volume":"168","author":"Polak","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0640","doi-asserted-by":"crossref","first-page":"924-d","DOI":"10.1126\/science.1234089","article-title":"Comment on \u201cApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models\u201d","volume":"340","author":"Price","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0645","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/bjp.2008.78","article-title":"The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B","volume":"154","author":"Quinn","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0650","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.mcn.2007.01.011","article-title":"The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease","volume":"34","author":"Riddell","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0655","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbr.2010.08.002","article-title":"Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status","volume":"216","author":"Rodriguez-Rivera","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0660","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tem.2013.04.004","article-title":"Retinoid X receptors in macrophage biology","volume":"24","author":"R\u0151szer","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2014.05.019_bb0665","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1093\/nar\/gkl712","article-title":"Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1","volume":"34","author":"Sacchetti","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0670","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.stem.2009.08.019","article-title":"Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells","volume":"5","author":"Sacchetti","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2014.05.019_bb0675","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jneuroim.2012.03.010","article-title":"Full and partial peroxisome proliferation-activated receptor-\u03b3 agonists, but not \u03b4 agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression","volume":"246","author":"Sadeghian","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0685","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Saijo","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.05.019_bb0680","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/glia.22423","article-title":"Regulation of microglia activation and deactivation by nuclear receptors","volume":"61","author":"Saijo","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2014.05.019_bb0690","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0695","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02736848","article-title":"Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system","volume":"7","author":"Saucedo-Cardenas","year":"1996","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0700","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1460-9568.2009.06657.x","article-title":"PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease","volume":"29","author":"Schintu","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0705","doi-asserted-by":"crossref","first-page":"7805","DOI":"10.1523\/JNEUROSCI.2038-05.2005","article-title":"The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice","volume":"25","author":"Sch\u00fctz","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0710","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3233\/JAD-2012-111661","article-title":"Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease","volume":"30","author":"Searcy","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.05.019_bb0715","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.expneurol.2011.02.002","article-title":"Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors","volume":"229","author":"Semple","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0720","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1440-1789.2008.00890.x","article-title":"Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis","volume":"28","author":"Shibata","year":"2008","journal-title":"Neuropathology"},{"key":"10.1016\/j.nbd.2014.05.019_bb0725","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1\u03b1 contributes to neurodegeneration in Parkinson's disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.05.019_bb0730","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/ncb2125","article-title":"The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells","volume":"12","author":"Sirin","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0735","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jnr.20153","article-title":"Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons","volume":"77","author":"Smith","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0740","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00210-011-0654-6","article-title":"Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease","volume":"384","author":"Sodhi","year":"2011","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0750","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1742-2094-8-91","article-title":"The PPAR-\u03b3 agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys","volume":"8","author":"Swanson","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2014.05.019_bb0745","doi-asserted-by":"crossref","first-page":"582809","DOI":"10.1155\/2013\/582809","article-title":"Neuroprotective properties of a novel non-thiazoledinedione partial PPAR- \u03b3 agonist against MPTP","volume":"2013","author":"Swanson","year":"2013","journal-title":"PPAR Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0755","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1210\/me.2010-0215","article-title":"Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells","volume":"24","author":"Sz\u00e9les","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0760","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1523\/JNEUROSCI.6546-10.2011","article-title":"Critical role of astroglial apolipoprotein E and liver X receptor-\u03b1 expression for microglial A\u03b2 phagocytosis","volume":"31","author":"Terwel","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0765","doi-asserted-by":"crossref","first-page":"924-e","DOI":"10.1126\/science.1233937","article-title":"Comment on \u201cApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models\u201d","volume":"340","author":"Tesseur","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0770","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nchembio.1156","article-title":"Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis","volume":"9","author":"Theofilopoulos","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0775","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/mp.2009.72","article-title":"Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe\/PSEN1\u0394E9 mouse model of Alzheimer's disease","volume":"15","author":"Toledo","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2014.05.019_bb0780","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-8-13","article-title":"In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis","volume":"8","author":"Ulrich","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2014.05.019_bb0785","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.brainresbull.2011.05.001","article-title":"Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease","volume":"85","author":"Ulusoy","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2014.05.019_bb0790","doi-asserted-by":"crossref","first-page":"753587","DOI":"10.1155\/2014\/753587","article-title":"Neuroprotective potential of peroxisome proliferator activated receptor-\u03b1 agonist in cognitive impairment in Parkinson's disease: behavioral, biochemical, and PBPK profile","volume":"2014","author":"Uppalapati","year":"2014","journal-title":"PPAR Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0795","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.neurobiolaging.2009.07.005","article-title":"Liver X receptor activation restores memory in aged AD mice without reducing amyloid","volume":"32","author":"Vanmierlo","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.05.019_bb0800","doi-asserted-by":"crossref","first-page":"924-f","DOI":"10.1126\/science.1235505","article-title":"Comment on \u201cApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models\u201d","volume":"340","author":"Veeraraghavalu","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2014.05.019_bb0805","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbrc.2009.10.116","article-title":"NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5","volume":"390","author":"Volakakis","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2014.05.019_bb0810","doi-asserted-by":"crossref","first-page":"12317","DOI":"10.1073\/pnas.1007088107","article-title":"NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection","volume":"107","author":"Volakakis","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0815","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1073\/pnas.172510899","article-title":"Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0820","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1523\/JNEUROSCI.2085-11.2011","article-title":"Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's \u03b2-amyloidosis mouse model","volume":"31","author":"Wesson","year":"2011","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0825","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/mend.16.6.0835","article-title":"Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system","volume":"16","author":"Whitney","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0830","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/glia.20975","article-title":"Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis","volume":"58","author":"Xiao","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2014.05.019_bb0835","doi-asserted-by":"crossref","first-page":"17321","DOI":"10.1523\/JNEUROSCI.1569-12.2012","article-title":"PPAR\u03b3\/RXR\u03b1-induced and CD36-mediated microglial amyloid-\u03b2 phagocytosis results in cognitive improvement in amyloid precursor protein\/presenilin 1 mice","volume":"32","author":"Yamanaka","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0840","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1523\/JNEUROSCI.23-20-07504.2003","article-title":"Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease","volume":"23","author":"Yan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0845","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1242\/jcs.086421","article-title":"miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression","volume":"125","author":"Yang","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0850","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1523\/JNEUROSCI.0780-10.2010","article-title":"Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury","volume":"30","author":"Yin","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.05.019_bb0855","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/ATVBAHA.110.221267","article-title":"Vascular PPAR\u03b4 protects against stroke-induced brain injury","volume":"31","author":"Yin","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0865","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2014.05.019_bb0860","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors","volume":"104","author":"Zelcer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.05.019_bb0870","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0169-328X(96)00074-5","article-title":"Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system","volume":"41","author":"Zetterstr\u00f6m","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2014.05.019_bb0875","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2006.11.007","article-title":"Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes","volume":"183","author":"Zhang-Gandhi","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2014.05.019_bb0880","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/jamaneurol.2013.2152","article-title":"Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease","volume":"70","author":"Zlokovic","year":"2013","journal-title":"JAMA Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114001375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114001375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T01:30:30Z","timestamp":1716773430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114001375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":175,"alternative-id":["S0969996114001375"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.05.019","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear receptors in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}