{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:07:09Z","timestamp":1791328029401,"version":"4.3.1"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish State Support for Clinical Research"},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003415","name":"Ministry of Science, Education and Sports","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008670","name":"Unity through Knowledge Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008670","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.nbd.2014.05.033","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T03:02:09Z","timestamp":1401850929000},"page":"37-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"PA","title":["Bidirectional links between Alzheimer's disease and Niemann\u2013Pick type C disease"],"prefix":"10.1016","volume":"72","author":[{"given":"Martina","family":"Malnar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Hecimovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.nbd.2014.05.033_bb0005","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.0503689102","article-title":"Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein","volume":"102","author":"Andersen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2217\/17520363.1.1.59","article-title":"Aspects of beta-amyloid as a biomarker for Alzheimer's disease","volume":"1","author":"Andreasson","year":"2007","journal-title":"Biomark. Med"},{"issue":"25","key":"10.1016\/j.nbd.2014.05.033_bb0015","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1523\/JNEUROSCI.1317-11.2011","article-title":"Unesterified cholesterol accumulation in late endosomes\/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment","volume":"31","author":"Aqul","year":"2011","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12017-013-8269-3","article-title":"Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease","volume":"16","author":"Armstrong","year":"2014","journal-title":"NeuroMolecular Med."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0025","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00318566","article-title":"Paired helical filament tau (PHFtau) in Niemann\u2013Pick type C disease is similar to PHFtau in Alzheimer's disease","volume":"90","author":"Auer","year":"1995","journal-title":"Acta Neuropathol."},{"issue":"6085","key":"10.1016\/j.nbd.2014.05.033_bb0030","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1219988","article-title":"The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol","volume":"336","author":"Barrett","year":"2012","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0035","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1001\/archneurol.2012.90","article-title":"Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease","volume":"69","author":"Blennow","year":"2012","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13353-010-0021-1","article-title":"Interactions of Npc1 and amyloid accumulation\/deposition in the APP\/PS1 mouse model of Alzheimer's","volume":"52","author":"Borbon","year":"2011","journal-title":"J. Appl. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer's disease in individuals under thirty","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2014.05.033_bb0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0022-510X(89)90197-4","article-title":"Alzheimer's disease: amyloid plaques in the cerebellum","volume":"93","author":"Braak","year":"1989","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0733-8619(18)30829-6","article-title":"Niemann\u2013Pick disease types C and D","volume":"7","author":"Brady","year":"1989","journal-title":"Neurol. Clin."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/nbdi.2002.0551","article-title":"Niemann\u2013Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles","volume":"11","author":"Bu","year":"2002","journal-title":"Neurobiol. Dis."},{"issue":"15","key":"10.1016\/j.nbd.2014.05.033_bb0065","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1523\/JNEUROSCI.22-15-06515.2002","article-title":"Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann\u2013Pick type C murine model","volume":"22","author":"Bu","year":"2002","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0075","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbalip.2010.03.004","article-title":"Intracellular cholesterol homeostasis and amyloid precursor protein processing","volume":"1801","author":"Burns","year":"2010","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Biol. Lipids"},{"issue":"13","key":"10.1016\/j.nbd.2014.05.033_bb0070","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1523\/JNEUROSCI.23-13-05645.2003","article-title":"Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo","volume":"23","author":"Burns","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2121-6-30","article-title":"Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid \u03b2 protein","volume":"6","author":"Carey","year":"2005","journal-title":"BMC Cell Biol."},{"issue":"5323","key":"10.1016\/j.nbd.2014.05.033_bb0085","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"Niemann\u2013Pick C1 disease gene: homology to mediators of cholesterol homeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","article-title":"Endocytic pathway abnormalities precede amyloid \u03b2 deposition in sporadic Alzheimer's disease and Down syndrome","volume":"157","author":"Cataldo","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0090","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neurobiolaging.2004.02.027","article-title":"A\u03b2 localization in abnormal endosomes: association with earliest A\u03b2 elevations in AD and Down syndrome","volume":"25","author":"Cataldo","year":"2004","journal-title":"Neurobiol. Aging"},{"issue":"35","key":"10.1016\/j.nbd.2014.05.033_bb0100","doi-asserted-by":"crossref","first-page":"32569","DOI":"10.1074\/jbc.M304553200","article-title":"Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann\u2013Pick type C disease","volume":"278","author":"Choi","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2008.02.003","article-title":"Endocytosis is required for synaptic activity-dependent release of amyloid-\u03b2 in vivo","volume":"58","author":"Cirrito","year":"2008","journal-title":"Neuron"},{"issue":"5123","key":"10.1016\/j.nbd.2014.05.033_bb0110","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0115","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal","volume":"45","author":"Dietschy","year":"2004","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0120","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s004010000314","article-title":"Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons","volume":"101","author":"Distl","year":"2001","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1083\/jcb.200207113","article-title":"Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts","volume":"160","author":"Ehehalt","year":"2003","journal-title":"J. Cell Biol."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2014.05.033_bb0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neulet.2008.09.046","article-title":"Variation in NPC1, the gene encoding Niemann\u2013Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and\/or aging in the Polish population","volume":"447","author":"Erickson","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0135","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.081620098","article-title":"Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo","volume":"98","author":"Fassbender","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.nbd.2014.05.033_bb0140","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1212\/WNL.0b013e3181d6476a","article-title":"Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe","volume":"74","author":"Feldman","year":"2010","journal-title":"Neurology"},{"issue":"9503","key":"10.1016\/j.nbd.2014.05.033_bb0145","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: a Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0150","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbalip.2010.05.004","article-title":"Lipids in Alzheimer's disease: a century-old story","volume":"1801","author":"Foley","year":"2010","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Biol. Lipids"},{"issue":"11","key":"10.1016\/j.nbd.2014.05.033_bb0155","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/ajmg.a.35395","article-title":"Apolipoprotein E genotype and neurological disease onset in Niemann\u2013Pick disease, type C1","volume":"158A","author":"Fu","year":"2012","journal-title":"Am. J. Med. Genet. A"},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.1149","article-title":"Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann\u2013Pick C disease","volume":"433","author":"German","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0160","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(01)00517-6","article-title":"Neurodegeneration in the Niemann\u2013Pick C mouse: glial involvement","volume":"109","author":"German","year":"2002","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.nbd.2014.05.033_bb0170","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1212\/01.WNL.0000159740.16984.3C","article-title":"Clinical effects of A\u03b2 immunization (AN1792) in patients with AD in an interrupted trial","volume":"64","author":"Gilman","year":"2005","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0175","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopsych.2010.05.030","article-title":"Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression","volume":"68","author":"Ginsberg","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"33","key":"10.1016\/j.nbd.2014.05.033_bb0180","doi-asserted-by":"crossref","first-page":"31261","DOI":"10.1074\/jbc.M304122200","article-title":"Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production","volume":"278","author":"Grbovic","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0185","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1750-3639.2000.tb00269.x","article-title":"Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry","volume":"10","author":"Hamilton","year":"2000","journal-title":"Brain Pathol."},{"issue":"5054","key":"10.1016\/j.nbd.2014.05.033_bb0195","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"issue":"5580","key":"10.1016\/j.nbd.2014.05.033_bb0190","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0200","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0205","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/alzrt226","article-title":"Amyloid \u03b2-protein oligomers and Alzheimer's disease","volume":"5","author":"Hayden","year":"2013","journal-title":"Alzheimers Res. Ther."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1194\/jlr.M300320-JLR200","article-title":"Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease","volume":"45","author":"Heverin","year":"2004","journal-title":"J. Lipid Res."},{"issue":"5\u20136","key":"10.1016\/j.nbd.2014.05.033_bb0215","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000084550","article-title":"The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease","volume":"19","author":"Hoglund","year":"2005","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0220","doi-asserted-by":"crossref","first-page":"a006312","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect Med."},{"issue":"40","key":"10.1016\/j.nbd.2014.05.033_bb0225","doi-asserted-by":"crossref","first-page":"15287","DOI":"10.1073\/pnas.0807328105","article-title":"NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes","volume":"105","author":"Infante","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0230","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1073\/pnas.0908953107","article-title":"Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition","volume":"107","author":"Jiang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9242","key":"10.1016\/j.nbd.2014.05.033_bb0235","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(00)03155-X","article-title":"Statins and the risk of dementia","volume":"356","author":"Jick","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0240","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-9440(10)63185-9","article-title":"Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann\u2013Pick type C defects is associated with endosomal abnormalities","volume":"164","author":"Jin","year":"2004","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.nbd.2014.05.033_bb0245","doi-asserted-by":"crossref","first-page":"e13950","DOI":"10.1371\/journal.pone.0013950","article-title":"Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease","volume":"5","author":"Jones","year":"2010","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0250","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbalip.2010.05.005","article-title":"Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease","volume":"1801","author":"K\u00e5gedal","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"44","key":"10.1016\/j.nbd.2014.05.033_bb0255","doi-asserted-by":"crossref","first-page":"36815","DOI":"10.1074\/jbc.M504484200","article-title":"Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro","volume":"280","author":"Kalvodova","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","article-title":"Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport","volume":"1","author":"Kobayashi","year":"1999","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.nbd.2014.05.033_bb0265","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/glia.21001","article-title":"Altered levels and distribution of APP and its processing enzymes in Niemann\u2013Pick type C1-deficient mouse brains","volume":"58","author":"Kodam","year":"2010","journal-title":"Glia"},{"issue":"26","key":"10.1016\/j.nbd.2014.05.033_bb0270","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","article-title":"Evidence that production and release of amyloid \u03b2-protein involves the endocytic pathway","volume":"269","author":"Koo","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0275","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbrc.2010.02.007","article-title":"Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts","volume":"393","author":"Kosicek","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.nbd.2014.05.033_bb0280","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-\u03b2 in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0285","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.nbd.2014.05.033_bb0290","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0295","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00401-012-1041-1","article-title":"Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients","volume":"125","author":"Lazar","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0300","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0698-730","article-title":"A detergent-insoluble membrane compartment contains A beta in vivo","volume":"4","author":"Lee","year":"1998","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.nbd.2014.05.033_bb0305","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9440(10)65722-7","article-title":"Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes","volume":"153","author":"Lippa","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0310","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0315","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1600-0854.2010.01032.x","article-title":"Lipids on trial: the search for the offending metabolite in Niemann\u2013Pick type C disease","volume":"11","author":"Lloyd-Evans","year":"2010","journal-title":"Traffic"},{"issue":"5323","key":"10.1016\/j.nbd.2014.05.033_bb0325","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.277.5323.232","article-title":"Murine model of Niemann\u2013Pick C disease: mutation in a cholesterol homeostasis gene","volume":"277","author":"Loftus","year":"1997","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.nbd.2014.05.033_bb0320","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1093\/hmg\/11.24.3107","article-title":"Rescue of neurodegeneration in Niemann\u2013Pick C mice by a prion-promoter-driven Npc1 cDNA transgene","volume":"11","author":"Loftus","year":"2002","journal-title":"Hum. Mol. Genet."},{"issue":"Pt 1","key":"10.1016\/j.nbd.2014.05.033_bb0330","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/brain\/118.1.119","article-title":"Neurofibrillary tangles in Niemann\u2013Pick disease type C","volume":"118","author":"Love","year":"1995","journal-title":"Brain J. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0335","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00334507","article-title":"Feline sphingolipidosis resembling Niemann\u2013Pick disease type C","volume":"81","author":"Lowenthal","year":"1990","journal-title":"Acta Neuropathol."},{"issue":"7\u20138","key":"10.1016\/j.nbd.2014.05.033_bb0345","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbadis.2010.05.006","article-title":"Niemann\u2013Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway","volume":"1802","author":"Malnar","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.nbd.2014.05.033_bb0340","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.bbadis.2012.04.002","article-title":"Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells","volume":"1822","author":"Malnar","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0350","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1096\/fj.10-168633","article-title":"Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis","volume":"25","author":"Marquer","year":"2011","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0360","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/WNL.0b013e318208f4ab","article-title":"Gamma-secretase-dependent amyloid-beta is increased in Niemann\u2013Pick type C: a cross-sectional study","volume":"76","author":"Mattsson","year":"2011","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0355","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11011-012-9332-8","article-title":"Amyloid-\u03b2 metabolism in Niemann\u2013Pick C disease models and patients","volume":"27","author":"Mattsson","year":"2012","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.nbd.2014.05.033_bb0365","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/8904_2011_47","article-title":"Miglustat treatment may reduce cerebrospinal fluid levels of the axonal degeneration marker tau in Niemann\u2013Pick type C","volume":"3","author":"Mattsson","year":"2012","journal-title":"JIMD Rep."},{"issue":"22","key":"10.1016\/j.nbd.2014.05.033_bb0370","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1093\/hmg\/dds322","article-title":"Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a \u03b2-cyclodextrin","volume":"21","author":"Maulik","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"49","key":"10.1016\/j.nbd.2014.05.033_bb0375","doi-asserted-by":"crossref","first-page":"38445","DOI":"10.1074\/jbc.M003180200","article-title":"Niemann\u2013Pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis","volume":"275","author":"Millard","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0380","first-page":"140","article-title":"Lysosome lipid storage disorder in NCTR-BALB\/c mice. I. Description of the disease and genetics","volume":"108","author":"Morris","year":"1982","journal-title":"Am. J. Pathol."},{"issue":"5500","key":"10.1016\/j.nbd.2014.05.033_bb0385","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","article-title":"Identification of HE1 as the second gene of Niemann\u2013Pick C disease","volume":"290","author":"Naureckiene","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0390","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0197-4580(95)02074-8","article-title":"Transgenic mice expressing APP-C100 in the brain","volume":"17","author":"Neve","year":"1996","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0395","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nbd.2011.01.028","article-title":"Loss of amyloid precursor protein in a mouse model of Niemann\u2013Pick type C disease exacerbates its phenotype and disrupts tau homeostasis","volume":"42","author":"Nunes","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0400","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: a forgotten player in Alzheimer's disease","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res. Rev."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0405","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1388-1981(99)00070-0","article-title":"A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol","volume":"1438","author":"Okamura","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.nbd.2014.05.033_bb0410","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/hmg\/ddn423","article-title":"Tau deletion exacerbates the phenotype of Niemann\u2013Pick type C mice and implicates autophagy in pathogenesis","volume":"18","author":"Pacheco","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0415","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1194\/jlr.M001859","article-title":"Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry","volume":"51","author":"Panchal","year":"2010","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0420","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1212\/01.WNL.0000070182.02537.84","article-title":"Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology","volume":"61","author":"Pappolla","year":"2003","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0425","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ymgme.2012.03.012","article-title":"Recommendations for the diagnosis and management of Niemann\u2013Pick disease type C: an update","volume":"106","author":"Patterson","year":"2012","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0440","first-page":"225","article-title":"A lysosomal storage disorder in mice characterized by the accumulation of several sphingolipids","volume":"16","author":"Pentchev","year":"1980","journal-title":"Birth Defects Orig. Artic. Ser."},{"issue":"23","key":"10.1016\/j.nbd.2014.05.033_bb0435","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1073\/pnas.82.23.8247","article-title":"A defect in cholesterol esterification in Niemann\u2013Pick disease (type C) patients","volume":"82","author":"Pentchev","year":"1985","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0430","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1096\/fasebj.1.1.3609608","article-title":"Group C Niemann\u2013Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts","volume":"1","author":"Pentchev","year":"1987","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0445","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/emmm.201202215","article-title":"Amyloid precursor protein controls cholesterol turnover needed for neuronal activity","volume":"5","author":"Pierrot","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"8873","key":"10.1016\/j.nbd.2014.05.033_bb0450","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer's disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0455","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0460","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamaneurol.2013.5390","article-title":"Associations between serum cholesterol levels and cerebral amyloidosis","volume":"71","author":"Reed","year":"2014","journal-title":"JAMA Neurol."},{"issue":"16","key":"10.1016\/j.nbd.2014.05.033_bb0465","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0960-9822(01)00394-3","article-title":"Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts","volume":"11","author":"Riddell","year":"2001","journal-title":"Curr. Biol."},{"issue":"5825","key":"10.1016\/j.nbd.2014.05.033_bb0470","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0475","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-2010-100432","article-title":"Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk","volume":"21","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.nbd.2014.05.033_bb0480","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1523\/JNEUROSCI.22-05-01679.2002","article-title":"Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells","volume":"22","author":"Runz","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0490","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ana.10266","article-title":"Niemann\u2013Pick type C disease: accelerated neurofibrillary tangle formation and amyloid \u03b2 deposition associated with apolipoprotein E \u03b54 homozygosity","volume":"52","author":"Saito","year":"2002","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0485","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/jnen\/63.4.323","article-title":"Aberrant phosphorylation of alpha-synuclein in human Niemann\u2013Pick type C1 disease","volume":"63","author":"Saito","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0495","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e318228bf11","article-title":"A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease","volume":"77","author":"Sano","year":"2011","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0500","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pediatrneurol.2013.02.015","article-title":"Cerebrospinal fluid brain injury biomarkers in children: a multicenter study","volume":"49","author":"Shahim","year":"2013","journal-title":"Pediatr. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0505","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2008.11.007","article-title":"Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis","volume":"60","author":"Small","year":"2008","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.nbd.2014.05.033_bb0510","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/mgme.1998.2778","article-title":"Complementation studies in human and feline Niemann\u2013Pick type C disease","volume":"66","author":"Somers","year":"1999","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0515","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00309338","article-title":"Neurofibrillary tangles in Niemann\u2013Pick disease type C","volume":"89","author":"Suzuki","year":"1995","journal-title":"Acta Neuropathol."},{"issue":"8910","key":"10.1016\/j.nbd.2014.05.033_bb0520","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0140-6736(94)92557-7","article-title":"Protection against Alzheimer's disease with apoE epsilon 2","volume":"343","author":"Talbot","year":"1994","journal-title":"Lancet"},{"issue":"46","key":"10.1016\/j.nbd.2014.05.033_bb0525","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.1523\/JNEUROSCI.2635-08.2008","article-title":"Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis","volume":"28","author":"Tamboli","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0530","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nbd.2009.06.003","article-title":"Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice","volume":"35","author":"Tong","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.05.033_bb0535","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1172-5-16","article-title":"Niemann\u2013Pick disease type C","volume":"5","author":"Vanier","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0540","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann\u2013Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0545","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1086\/522374","article-title":"Pathway-based approaches for analysis of genomewide association studies","volume":"81","author":"Wang","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0550","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/cyto.a.20233","article-title":"Microfluorometry of cell membrane dynamics","volume":"69","author":"Weber","year":"2006","journal-title":"Cytometry A"},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0555","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/bi801204g","article-title":"Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase","volume":"48","author":"Winkler","year":"2009","journal-title":"Biochemistry (Mosc)"},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0560","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10048-007-0087-z","article-title":"Association study of cholesterol-related genes in Alzheimer's disease","volume":"8","author":"Wollmer","year":"2007","journal-title":"Neurogenetics"},{"issue":"10","key":"10.1016\/j.nbd.2014.05.033_bb0565","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/archneur.57.10.1439","article-title":"Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors","volume":"57","author":"Wolozin","year":"2000","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.nbd.2014.05.033_bb0570","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/jnen\/59.12.1106","article-title":"Cholesterol is sequestered in the brains of mice with Niemann\u2013Pick type C disease but turnover is increased","volume":"59","author":"Xie","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0575","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2007.10.005","article-title":"Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production","volume":"29","author":"Xiong","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.nbd.2014.05.033_bb0580","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00004647-200004000-00008","article-title":"Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment","volume":"20","author":"Yamada","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"10.1016\/j.nbd.2014.05.033_bb0585","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1074\/jbc.M009598200","article-title":"Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann\u2013Pick type C cells","volume":"276","author":"Yamazaki","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.nbd.2014.05.033_bb0590","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"Yang","year":"2010","journal-title":"Nat. Genet."},{"issue":"13","key":"10.1016\/j.nbd.2014.05.033_bb0595","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1084\/jem.20121239","article-title":"Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease","volume":"209","author":"Yao","year":"2012","journal-title":"J. Exp. Med."},{"issue":"29","key":"10.1016\/j.nbd.2014.05.033_bb0600","doi-asserted-by":"crossref","first-page":"27296","DOI":"10.1074\/jbc.M503922200","article-title":"Neurodegeneration in heterozygous Niemann\u2013Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy","volume":"280","author":"Yu","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2014.05.033_bb0605","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jnen\/60.1.49","article-title":"Neurons in Niemann\u2013Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations","volume":"60","author":"Zervas","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2014.05.033_bb0610","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0002-9440(10)63347-0","article-title":"Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann\u2013Pick Type C mice","volume":"165","author":"Zhang","year":"2004","journal-title":"Am. J. Pathol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999611400151X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999611400151X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T17:52:02Z","timestamp":1649181122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999611400151X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":122,"alternative-id":["S096999611400151X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.05.033","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bidirectional links between Alzheimer's disease and Niemann\u2013Pick type C disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}