{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:07:09Z","timestamp":1791266829383,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T00:00:00Z","timestamp":1407542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008390","name":"Forskerakademiet","doi-asserted-by":"publisher","award":["831301"],"award-info":[{"award-number":["831301"]}],"id":[{"id":"10.13039\/100008390","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.nbd.2014.08.003","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T12:02:27Z","timestamp":1407672147000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"special_numbering":"C","title":["MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions"],"prefix":"10.1016","volume":"71","author":[{"given":"Hjalte H.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Duroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Gazerani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.08.003_bb0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcb.2012.08.013","article-title":"MicroRNAs and neurodegeneration: role and impact","volume":"23","author":"Abe","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0010","first-page":"680","article-title":"MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm","volume":"137","author":"Ahmad","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0015","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/annrheumdis-2011-200519","article-title":"MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes","volume":"71","author":"Akhtar","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2014.08.003_bb9000","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.neuroscience.2009.08.033","article-title":"Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation","volume":"164","author":"Aldrich","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.08.003_bb0500","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/j.1532-2149.2013.00380.x","article-title":"A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia","volume":"18","author":"Andersen","year":"2014","journal-title":"Eur. J. pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0030","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/pme.12066","article-title":"The miRNA and mRNA changes in Rat hippocampi after chronic constriction injury","volume":"14","author":"Arai","year":"2013","journal-title":"Pain Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0035","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jpain.2009.02.002","article-title":"Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera","volume":"10","author":"Arendt-Nielsen","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-3-15","article-title":"Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain","volume":"3","author":"Bai","year":"2007","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0050","first-page":"1","article-title":"Noncoding RNAs: key molecules in understanding and treating pain","author":"Bali","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1744-8069-10-22","article-title":"Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing","volume":"10","author":"Bali","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0055","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.00075.2013","article-title":"Changes in circulating microRNAs levels with exercise modality","author":"Banzet","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.08.003_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpain.2003.12.004","article-title":"Clinical characteristics and economic costs of patients with painful neuropathic disorders","volume":"5","author":"Berger","year":"2004","journal-title":"J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb7000","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2014-eular.1839","article-title":"Signature of circulating microRNAs in osteoarthritis","author":"Beyer","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2014.08.003_bb0070","doi-asserted-by":"crossref","first-page":"17935","DOI":"10.1523\/JNEUROSCI.3860-12.2012","article-title":"MicroRNA-21 regulates astrocytic response following spinal cord injury","volume":"32","author":"Bhalala","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0075","doi-asserted-by":"crossref","first-page":"e78762","DOI":"10.1371\/journal.pone.0078762","article-title":"Profile of cerebrospinal microRNAs in fibromyalgia","volume":"8","author":"Bjersing","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.08.003_bb0080","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/ATVBAHA.112.300139","article-title":"Intercellular transport of microRNAs","volume":"33","author":"Boon","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0505","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2011.11.023","article-title":"Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain","volume":"506","author":"Brandenburger","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2014.08.003_bb0090","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0095","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1158\/0008-5472.CAN-06-0800","article-title":"MicroRNA-cancer connection: the beginning of a new tale","volume":"66","author":"Calin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1744-8069-8-17","article-title":"Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy","volume":"8","author":"Chattopadhyay","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tcb.2011.12.001","article-title":"Secreted microRNAs: a new form of intercellular communication","volume":"22","author":"Chen","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11064-013-1192-z","article-title":"Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury","author":"Chen","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/NRL.0b013e31825cf181","article-title":"Cluster headache and parietal glioblastoma multiforme","volume":"18","author":"Edvardsson","year":"2012","journal-title":"Neurologist"},{"key":"10.1016\/j.nbd.2014.08.003_bb0120","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1038\/emboj.2011.249","article-title":"Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain","volume":"30","author":"Favereaux","year":"2011","journal-title":"EMBO J."},{"issue":"243\u20135","key":"10.1016\/j.nbd.2014.08.003_bb0125","first-page":"247","article-title":"Challenges of chronic pain management: public health consequences and considered responses","volume":"74","author":"Finch","year":"2013","journal-title":"N. C. Med. J."},{"key":"10.1016\/j.nbd.2014.08.003_bb0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2010.02.005","article-title":"The role of microRNA in rheumatoid arthritis and other autoimmune diseases","volume":"136","author":"Furer","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0140","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1242\/dmm.011502","article-title":"Pain hypersensitivity mechanisms at a glance","volume":"6","author":"Gangadharan","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2014.08.003_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3892\/ijmm.2012.1163","article-title":"MicroRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: a TaqMan\u00ae Low Density Array study","volume":"31","author":"Genda","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0150","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-013-1275-7","article-title":"Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome","author":"Gheinani","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0155","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0160","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1210\/me.2010-0371","article-title":"Functional microRNA involved in endometriosis","volume":"25","author":"Hawkins","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0165","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/brain\/awh712","article-title":"Clinical, pathological and genetic characterization of hereditary sensory and autonomic neuropathy type 1 (HSAN I)","volume":"129","author":"Houlden","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0170","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1038\/cddis.2012.168","article-title":"Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord","volume":"3","author":"Im","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2014.08.003_bb0175","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1523\/JNEUROSCI.0921-11.2011","article-title":"Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain","volume":"31","author":"Imai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0180","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/2049463713506408","article-title":"Human pain and genetics: some basics","volume":"7","author":"James","year":"2013","journal-title":"Br. J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0510","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0190","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1586\/14737159.2014.893828","article-title":"Emerging technologies in extracellular vesicle-based molecular diagnostics","volume":"14","author":"Jia","year":"2014","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.nbd.2014.08.003_bb0195","article-title":"A comprehensive overview of exosomes as drug delivery vehicles \u2014 endogenous nanocarriers for targeted cancer therapy","author":"Johnsen","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2014.08.003_bb0515","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.08.003_bb0520","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1373\/clinchem.2009.141580","article-title":"Robust microRNA stability in degraded RNA preparations from human tissue and cell samples","volume":"56","author":"Jung","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.nbd.2014.08.003_bb0525","series-title":"MicroRNAs as biomarkers in blood and other biofluids \u2014 commercial publication","author":"Kemppainen","year":"2010"},{"key":"10.1016\/j.nbd.2014.08.003_bb0215","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fgene.2013.00214","article-title":"Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication","volume":"4","author":"Kinet","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2014.08.003_bb0530","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1744-8069-7-17","article-title":"Differential expression of microRNAs in mouse pain models","volume":"7","author":"Kusuda","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0225","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1586\/ern.13.34","article-title":"Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets","volume":"13","author":"Kynast","year":"2013","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.nbd.2014.08.003_bb0230","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pain.2012.11.010","article-title":"Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice","volume":"154","author":"Kynast","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0235","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Lagos-Quintana","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.08.003_bb0240","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.08.003_bb0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2011.03.003","article-title":"MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis","volume":"480","author":"Li","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.nbd.2014.08.003_bb0245","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3892\/ijmm.2013.1381","article-title":"Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury","volume":"32","author":"Li","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2002","article-title":"Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints","author":"Li","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb6300","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.expneurol.2009.06.015","article-title":"Altered microRNA expression following traumatic spinal cord injury","volume":"219","author":"Liu","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0260","doi-asserted-by":"crossref","DOI":"10.1097\/ALN.0000000000000265","article-title":"Noncoding RNAs: new players in chronic pain","author":"Lutz","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2014.08.003_bb0265","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11916-010-0157-z","article-title":"Chronic migraine: epidemiology and disease burden","volume":"15","author":"Manack","year":"2011","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.nbd.2014.08.003_bb0270","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1464-410X.1998.00507.x","article-title":"Increased expression of substance P receptor-encoding mRNA in bladder biopsies from patients with interstitial cystitis","volume":"81","author":"Marchand","year":"1998","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0275","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1044-579X(03)00038-5","article-title":"MicroRNAs and cancer","volume":"13","author":"McManus","year":"2003","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0280","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12035-012-8349-7","article-title":"A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasion","volume":"47","author":"M\u00f8ller","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2014.08.003_bb2250","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/sc.2009.89","article-title":"Responses of microRNAs 124a and 223 following spinal cord injury in mice","volume":"48","author":"Nakanishi","year":"2010","journal-title":"Spinal Cord"},{"key":"10.1016\/j.nbd.2014.08.003_bb0285","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/j.1532-2149.2012.00197.x","article-title":"Regulation of \u03bc-opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation","volume":"17","author":"Ni","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0290","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.pain.2011.01.042","article-title":"MicroRNAs as new players in the pain game","volume":"152","author":"Niederberger","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0535","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1479-5876-9-195","article-title":"MicroRNA modulation in complex regional pain syndrome","volume":"9","author":"Orlova","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0495","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2008.05.001","article-title":"MicroRNA-10a binds the 5\u2032 UTR of ribosomal protein mRNAs and enhances their translation","volume":"30","author":"\u00d8rom","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2014.08.003_bb0300","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jcp.20693","article-title":"Neurobiology of pain","volume":"209","author":"Pace","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0305","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/molehr\/gam063","article-title":"The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression","volume":"13","author":"Pan","year":"2007","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.nbd.2014.08.003_bb1590","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1523\/JNEUROSCI.5346-13.2014","article-title":"Epigenetic Modification of Spinal miR-219 Expression Regulates Chronic Inflammation Pain by Targeting CaMKII","volume":"34","author":"Pan","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0315","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.joca.2013.04.012","article-title":"MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1\u03b2-induced catabolic effects in human articular chondrocytes","volume":"21","author":"Park","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.nbd.2014.08.003_bb0310","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuron.2014.02.011","article-title":"Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1","volume":"82","author":"Park","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.08.003_bb0320","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.08.003_bb0325","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/ar2493","article-title":"Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"10","author":"Pauley","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.nbd.2014.08.003_bb0540","first-page":"1","article-title":"High prevalence of confirmed, but also of potential and believed, neuropathic pain in pain clinics","author":"P\u00e9rez","year":"2012","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2165\/00003495-200363992-00007","article-title":"Pain management: health economics and quality of life considerations","volume":"63","author":"Phillips","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.nbd.2014.08.003_bb0340","article-title":"MicroRNA changes in the mouse prefrontal cortex after inflammatory pain","volume":"15","author":"Poh","year":"2011","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0345","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nm.2266","article-title":"MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C\/EBP-\u03b1-PU.1 pathway","volume":"17","author":"Ponomarev","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0350","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.08.003_bb0355","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pain.2006.10.023","article-title":"Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene","volume":"130","author":"Reyes-Gibby","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0360","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2353\/ajpath.2010.090552","article-title":"MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome","volume":"176","author":"Sanchez Freire","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0365","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2014.08.003_bb0370","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0375","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/ACO.0b013e32834a1079","article-title":"Functional and structural imaging of pain-induced neuroplasticity","volume":"24","author":"Seifert","year":"2011","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0380","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pain.2012.09.002","article-title":"MicroRNA-mediated GABA A\u03b1-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats","volume":"154","author":"Sengupta","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0385","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/art.23386","article-title":"Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis","volume":"58","author":"Stanczyk","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2014.08.003_bb0390","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1182\/blood-2011-11-389478","article-title":"Functional transfer of microRNA by exosomes","volume":"119","author":"Stoorvogel","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.nbd.2014.08.003_bb0395","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/ALN.0b013e31826571aa","article-title":"miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression","volume":"117","author":"Sun","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nbd.2014.08.003_bb0400","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/bies.201200045","article-title":"Amedeo Avogadro's cry: what is 1\u03bcg of exosomes?","volume":"34","author":"Sverdlov","year":"2012","journal-title":"Bioessays"},{"key":"10.1016\/j.nbd.2014.08.003_bb6515","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00441-011-1263-x","article-title":"MicroRNA-143 expression in dorsal root ganglion neurons","volume":"346","author":"Tam Tam","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0405","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1093\/nar\/gkr330","article-title":"Experimental strategies for microRNA target identification","volume":"39","author":"Thomson","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0410","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2217\/bmm.12.91","article-title":"Circulating miRNA profiling to identify biomarkers of dysmetabolism","volume":"6","author":"Tomaselli","year":"2012","journal-title":"Biomark. Med"},{"key":"10.1016\/j.nbd.2014.08.003_bb0415","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jpain.2005.11.008","article-title":"The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey","volume":"7","author":"Torrance","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0420","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bse0540017","article-title":"Biogenesis and the regulation of the maturation of miRNAs","volume":"54","author":"Tran","year":"2013","journal-title":"Essays Biochem."},{"key":"10.1016\/j.nbd.2014.08.003_bb0425","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/CS20130203","article-title":"microRNAs in the onset and development of cardiovascular disease","volume":"126","author":"Vickers","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.nbd.2014.08.003_bb0545","doi-asserted-by":"crossref","first-page":"e17670","DOI":"10.1371\/journal.pone.0017670","article-title":"Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain","volume":"6","author":"Von Schack","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.08.003_bb2220","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/jc.2012-2415","article-title":"Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis","volume":"98","author":"Wang","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2014.08.003_bb0435","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1742-2094-9-143","article-title":"MicroRNA-124 as a novel treatment for persistent hyperalgesia","volume":"9","author":"Willemen","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2014.08.003_bb0440","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0445","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.nbd.2014.08.003_bb0455","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1096\/fj.08-108175","article-title":"Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3\u2032 untranslated region: a role for microRNA23b","volume":"22","author":"Wu","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2014.08.003_bb0450","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuroscience.2011.06.017","article-title":"MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern","volume":"190","author":"Wu","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.08.003_bb6540","doi-asserted-by":"crossref","first-page":"e31861","DOI":"10.1371\/journal.pone.0031861","article-title":"MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.08.003_bb0460","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/art.24404","article-title":"Expression of microRNA-146a in osteoarthritis cartilage","volume":"60","author":"Yamasaki","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2014.08.003_bb0465","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1101\/gad.1158803","article-title":"Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs","volume":"17","author":"Yi","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2014.08.003_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/147323001103900101","article-title":"MicroRNA in osteoarthritis","volume":"39","author":"Yu","year":"2011","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.nbd.2014.08.003_bb0550","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1523\/JNEUROSCI.1980-10.2010","article-title":"Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds","volume":"30","author":"Zhao","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.08.003_bb0475","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3892\/ijmm.2013.1543","article-title":"Characterization of microRNA expression profiles in patients with intervertebral disc degeneration","volume":"33","author":"Zhao","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.nbd.2014.08.003_bb0490","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrgastro.2011.83","article-title":"New insights into visceral hypersensitivity\u2014clinical implications in IBS","volume":"8","author":"Zhou","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.nbd.2014.08.003_bb0485","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gut.2009.181834","article-title":"MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome","volume":"59","author":"Zhou","year":"2010","journal-title":"Gut"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114002320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114002320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:08:53Z","timestamp":1760850533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114002320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":107,"alternative-id":["S0969996114002320"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.08.003","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}