{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:46:06Z","timestamp":1788385566175,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007393","name":"AFM","doi-asserted-by":"publisher","award":["15288\/2011"],"award-info":[{"award-number":["15288\/2011"]}],"id":[{"id":"10.13039\/100007393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006510","name":"ARSLA","doi-asserted-by":"crossref","award":["FP7-223388"],"award-info":[{"award-number":["FP7-223388"]}],"id":[{"id":"10.13039\/501100006510","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.nbd.2014.09.009","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T05:06:21Z","timestamp":1412053581000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-9150","authenticated-orcid":false,"given":"Nathalie","family":"Bernard-Marissal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Sunyach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marissal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Raoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Pettmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.09.009_bb0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00401-012-1022-4","article-title":"The genetics and neuropathology of amyotrophic lateral sclerosis","volume":"124","author":"Al-Chalabi","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0125","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tcb.2012.02.006","article-title":"Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling","volume":"22","author":"Appenzeller-Herzog","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0035","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1523\/JNEUROSCI.5431-11.2012","article-title":"Reduced calreticulin levels link endoplasmic reticulum stress and Fas-triggered cell death in motoneurons vulnerable to ALS","volume":"32","author":"Bernard-Marissal","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.09.009_bb0120","doi-asserted-by":"crossref","first-page":"e61020","DOI":"10.1371\/journal.pone.0061020","article-title":"mTOR-controlled autophagy requires intracellular Ca(2+) signaling","volume":"8","author":"Decuypere","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.09.009_bb0105","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.1128\/MCB.22.21.7398-7404.2002","article-title":"Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression","volume":"22","author":"Denzel","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.coph.2009.03.007","article-title":"Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models","volume":"9","author":"Dupuis","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0045","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0140","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJM199412223312516","article-title":"Transgenic-mouse model of amyotrophic lateral sclerosis","volume":"331","author":"Gurney","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2014.09.009_bb0110","doi-asserted-by":"crossref","first-page":"11354","DOI":"10.1074\/jbc.M309804200","article-title":"Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response","volume":"279","author":"Hong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.09.009_bb0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2013.12.009","article-title":"Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration","volume":"81","author":"Kaplan","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.09.009_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2014.04.005","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2014.09.009_bb0060","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1471-4159.2010.06806.x","article-title":"AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway","volume":"114","author":"Langou","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.09.009_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/674751","article-title":"ER dysfunction and protein folding stress in ALS","volume":"2013","author":"Matus","year":"2013","journal-title":"Int. J. Cell. Biol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0080","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.144.5.857","article-title":"Calreticulin is essential for cardiac development","volume":"144","author":"Mesaeli","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/BJ20081847","article-title":"Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum","volume":"417","author":"Michalak","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2014.09.009_bb0050","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1073\/pnas.0611134104","article-title":"Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion","volume":"104","author":"Miles","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.09.009_bb0135","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1172\/JCI12412","article-title":"Complete heart block and sudden death in mice overexpressing calreticulin","volume":"107","author":"Nakamura","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2014.09.009_bb0055","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fgene.2012.00200","article-title":"Calcium homeostasis in aging neurons","volume":"3","author":"Nikoletopoulou","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.nbd.2014.09.009_bb0085","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/embr.201337948","article-title":"Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively","volume":"15","author":"Otsmane","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2014.09.009_bb0130","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1093\/hmg\/ddi357","article-title":"No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model","volume":"14","author":"Perrin","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2014.09.009_bb0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF","volume":"9","author":"Pun","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2014.09.009_bb0075","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0896-6273(02)00905-4","article-title":"Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations","volume":"35","author":"Raoul","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.09.009_bb0025","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2297","article-title":"A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice","volume":"12","author":"Saxena","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2014.09.009_bb0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuron.2013.07.027","article-title":"Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival","volume":"80","author":"Saxena","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.09.009_bb0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24012","article-title":"Amyotrophic lateral sclerosis: problems and prospects","volume":"74","author":"Sreedharan","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.09.009_bb0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1242\/dmm.013615","article-title":"TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS","volume":"7","author":"Thompson","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2014.09.009_bb0065","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbadis.2006.05.002","article-title":"The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis","volume":"1762","author":"Van Den Bosch","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2014.09.009_bb0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4161\/auto.7.4.14541","article-title":"Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis","volume":"7","author":"Zhang","year":"2011","journal-title":"Autophagy"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114002812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114002812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T20:26:26Z","timestamp":1538166386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114002812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":28,"alternative-id":["S0969996114002812"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.09.009","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}