{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:43:15Z","timestamp":1769838195601,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.nbd.2014.10.020","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T20:00:49Z","timestamp":1415044849000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["18FDG-microPET and MR DTI findings in Tor1a+\/\u2212 heterozygous knock-out mice"],"prefix":"10.1016","volume":"73","author":[{"given":"An","family":"Vo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Sako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Dewey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-0322","authenticated-orcid":false,"given":"Aziz M.","family":"Ulu\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.10.020_bb0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: a consensus update","volume":"28","author":"Albanese","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2014.10.020_bb0010","doi-asserted-by":"crossref","first-page":"9740","DOI":"10.1523\/JNEUROSCI.2300-09.2009","article-title":"Cerebellothalamocortical connectivity regulates penetrance in dystonia","volume":"29","author":"Argyelan","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.10.020_bb0015","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/1531-8249(199911)46:5<761::AID-ANA12>3.0.CO;2-Z","article-title":"Distribution of the mRNA encoding torsinA and torsinB in the normal adult human brain","volume":"46","author":"Augood","year":"1999","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2014.10.020_bb0040","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuroscience.2008.12.041","article-title":"Abnormal structure\u2013function relationships in hereditary dystonia","volume":"164","author":"Carbon","year":"2009","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.nbd.2014.10.020_bb0025","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1212\/01.WNL.0000120541.97467.FE","article-title":"Regional metabolism in primary torsion dystonia: effects of penetrance and genotype","volume":"62","author":"Carbon","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.10.020_bb0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ana.20177","article-title":"Microstructural white matter changes in carriers of the DYT1 gene mutation","volume":"56","author":"Carbon","year":"2004","journal-title":"Annu. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2014.10.020_bb0030","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/mds.21806","article-title":"Microstructural white matter changes in primary torsion dystonia","volume":"23","author":"Carbon","year":"2008","journal-title":"Mov. Disord."},{"issue":"38","key":"10.1016\/j.nbd.2014.10.020_bb0020","doi-asserted-by":"crossref","first-page":"16068","DOI":"10.1073\/pnas.1107904108","article-title":"Cerebellar vermis is a target of projections from the motor areas in the cerebral cortex","volume":"108","author":"Coffman","year":"2011","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.nbd.2014.10.020_bb0045","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.expneurol.2005.08.025","article-title":"Generation and characterization of Dyt1 \u0394GAG knock-in mouse as a model for early-onset dystonia","volume":"196","author":"Dang","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.10.020_bb9000","series-title":"An introduction to the bootstrap","author":"Efron","year":"1998"},{"issue":"Pt 6","key":"10.1016\/j.nbd.2014.10.020_bb0055","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/brain\/118.6.1473","article-title":"The metabolic topography of idiopathic torsion dystonia","volume":"118","author":"Eidelberg","year":"1995","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.nbd.2014.10.020_bb0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.410440304","article-title":"Functional brain networks in DYT1 dystonia","volume":"44","author":"Eidelberg","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.10.020_bb0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainres.2004.02.080","article-title":"TorsinA negatively controls neurite outgrowth of SH-SY5Y human neuronal cell line","volume":"1012","author":"Ferrari-Toninelli","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2014.10.020_bb0060","article-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2007"},{"key":"10.1016\/j.nbd.2014.10.020_bb0070","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1074\/jbc.M704097200","article-title":"The dystonia-associated protein torsinA modulates synaptic vesicle recycling","volume":"283","author":"Granata","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.10.020_bb0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2007.04.015","article-title":"Overexpression of human wildtype torsinA and human \u0394GAG torsinA in a transgenic mouse model causes phenotypic abnormalities","volume":"27","author":"Grundmann","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.10.020_bb0080","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.nbd.2005.10.012","article-title":"Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics","volume":"22","author":"Hewett","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.10.020_bb0085","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.10.020_bb0090","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archneur.58.6.921","article-title":"Cellular distribution of torsin A and torsin B in normal human brain","volume":"58","author":"Konakova","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2014.10.020_bb0095","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.nbd.2010.11.006","article-title":"Animal models of dystonia: lessons from a mutant rat","volume":"42","author":"LeDoux","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.nbd.2014.10.020_bb0100","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.neuroscience.2005.07.014","article-title":"A three-dimensional digital atlas database of the adult C57BL\/6J mouse brain by magnetic resonance microscopy","volume":"135","author":"Ma","year":"2005","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nbd.2014.10.020_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroimage.2007.06.032","article-title":"A novel approach for imaging brain\u2013behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator","volume":"38","author":"Mirrione","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.10.020_bb0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2006.08.012","article-title":"Principles of diffusion tensor imaging and its applications to basic neuroscience research","volume":"51","author":"Mori","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2014.10.020_bb0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/mrm.1155","article-title":"Diffusion tensor imaging of the developing mouse brain","volume":"46","author":"Mori","year":"2001","journal-title":"Magn. Reson. Med."},{"issue":"9","key":"10.1016\/j.nbd.2014.10.020_bb0120","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1109\/TMI.2003.816960","article-title":"A penalized-likelihood image reconstruction method for emission tomography, compared to postsmoothed maximum-likelihood with matched spatial resolution","volume":"22","author":"Nuyts","year":"2003","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.nbd.2014.10.020_bb0125","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng0997-40","article-title":"The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein","volume":"17","author":"Ozelius","year":"1997","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2014.10.020_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/hmg\/ddi012","article-title":"Transgenic mouse model of early-onset DYT1 dystonia","volume":"14","author":"Sashidaran","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2014.10.020_bb0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nbd.2008.09.016","article-title":"Voxel-based morphometry in the R6\/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry","volume":"33","author":"Sawiak","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.10.020_bb0145","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.nbd.2013.01.008","article-title":"Subtle microstructural changes of the striatum in a DYT1 knock-in mouse model of dystonia","volume":"54","author":"Song","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.10.020_bb0140","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.nbd.2013.10.003","article-title":"Subtle microstructural changes of the cerebellum in a knock-in mouse model of DYT1 dystonia","volume":"62","author":"Song","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.10.020_bb0150","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrneurol.2009.160","article-title":"Primary dystonia: molecules and mechanisms","volume":"5","author":"Tanabe","year":"2009","journal-title":"Nat. Rev. Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2014.10.020_bb0155","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/ana.10418","article-title":"Primary dystonia: is abnormal functional brain architecture linked to genotype?","volume":"52","author":"Trost","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.10.020_bb0160","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.1016445108","article-title":"Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice","volume":"108","author":"Ulug","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.10.020_bb0165","article-title":"Thalamocortical connectivity mediates phenotypic variability in primary dystonia","author":"Vo","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2014.10.020_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devbrainres.2004.05.012","article-title":"Developmental expression of rat torsinA transcript and protein","volume":"152","author":"Xiao","year":"2004","journal-title":"Dev. Brain Res."},{"issue":"8","key":"10.1016\/j.nbd.2014.10.020_bb0175","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1523\/JNEUROSCI.4129-04.2005","article-title":"Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis","volume":"25","author":"Zhang","year":"2005","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2014.10.020_bb0180","doi-asserted-by":"crossref","first-page":"e18357","DOI":"10.1371\/journal.pone.0018357","article-title":"Altered dendritic morphology of Purkinje cells in Dyt1 \u0394GAG knock-in and Purkinje cell-specific Dyt1 conditional knock-out mice","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.10.020_bb0185","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2011.01.015","article-title":"The dyt1 carrier state increases energy demand in the olivocerebellar network","volume":"177","author":"Zhao","year":"2011","journal-title":"Neuroscience"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T21:56:25Z","timestamp":1538085385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114003337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":38,"alternative-id":["S0969996114003337"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.10.020","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"18FDG-microPET and MR DTI findings in Tor1a+\/\u2212 heterozygous knock-out mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}