{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:30:55Z","timestamp":1793179855586,"version":"4.5.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.nbd.2014.11.023","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T19:43:27Z","timestamp":1417808607000},"page":"281-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain"],"prefix":"10.1016","volume":"74","author":[{"given":"Pritika J.","family":"Narayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Dragunow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.11.023_bb0370","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2007.12.002","article-title":"Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders","volume":"8","author":"Abel","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0375","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.11.023_bb0380","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nn.3618","article-title":"Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency","volume":"17","author":"Bie","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0385","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0390","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer's disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb9000","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S1041610297004973","article-title":"Staging of Alzheimer-related cortical destruction","volume":"9","author":"Braak","year":"1997","journal-title":"Int. Psychogeriatr. \/ IPA."},{"key":"10.1016\/j.nbd.2014.11.023_bb0395","doi-asserted-by":"crossref","DOI":"10.1038\/srep04618","article-title":"Pharmacological targeting of the \u00ce 2-amyloid precursor protein intracellular domain","volume":"4","author":"Branca","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2014.11.023_bb0400","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1212\/WNL.59.4.627","article-title":"CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects","volume":"59","author":"Buerger","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0405","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1083\/jcb.115.3.717","article-title":"Tau protein binds to microtubules through a flexible array of distributed weak sites","volume":"115","author":"Butner","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0410","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.11.023_bb0415","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1091\/mbc.E05-08-0778","article-title":"Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT\/enhancer-binding protein \u03b4 and CREB-binding protein","volume":"16","author":"Chen","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2014.11.023_bb0420","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0896-6273(03)00606-8","article-title":"The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg","volume":"40","author":"Ciechanover","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2014.11.023_bb0425","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neurobiolaging.2013.11.031","article-title":"Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain","volume":"35","author":"Coppieters","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0430","article-title":"Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise","volume":"6","author":"Cos\u00edn-Tom\u00e1s","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0435","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0167-4889(96)00139-5","article-title":"Reduction of histone cytotoxicity by the Alzheimer [beta]-amyloid peptide precursor","volume":"1355","author":"Currie","year":"1997","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0024-3205(80)90013-2","article-title":"Senile dementia and Alzheimer's disease: A current view","volume":"27","author":"De Boni","year":"1980","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0445","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.1186777","article-title":"Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones","volume":"328","author":"Deal","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.11.023_bb0450","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/glia.440070113","article-title":"Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease","volume":"7","author":"Dickson","year":"1993","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2014.11.023_bb0455","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1074\/jbc.M111.310136","article-title":"Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation","volume":"287","author":"Ding","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0460","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1091\/mbc.3.10.1141","article-title":"Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau","volume":"3","author":"Drechsel","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2014.11.023_bb0465","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature05772","article-title":"Recovery of learning and memory is associated with chromatin remodelling","volume":"447","author":"Fischer","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.11.023_bb0470","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.amjopharm.2007.09.001","article-title":"Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication","volume":"5","author":"Forester","year":"2007","journal-title":"Am. J. Geriatr. Pharmacother."},{"key":"10.1016\/j.nbd.2014.11.023_bb0475","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nn.3639","article-title":"Tau promotes neurodegeneration through global chromatin relaxation","volume":"17","author":"Frost","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0480","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0490","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","article-title":"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau","volume":"85","author":"Goedert","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.11.023_bb0485","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1073\/pnas.90.11.5066","article-title":"The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development","volume":"90","author":"Goedert","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.11.023_bb0495","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2011-110080","article-title":"Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression","volume":"26","author":"Govindarajan","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2014.11.023_bb0500","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2008.01.021","article-title":"Epigenetic codes in cognition and behaviour","volume":"192","author":"Graff","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0505","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Graff","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.11.023_bb0510","doi-asserted-by":"crossref","first-page":"19702","DOI":"10.1074\/jbc.270.34.19702","article-title":"Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro","volume":"270","author":"Gregori","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0515","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-4580(99)00063-9","article-title":"Memory and mental status correlates of modified Braak staging","volume":"20","author":"Grober","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0520","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0525","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.11.023_bb0530","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neurobiolaging.2012.10.013","article-title":"Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production","volume":"34","author":"Gu","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0535","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.11.023_bb0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.mp.4001473","article-title":"Value of CSF B-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment","volume":"9","author":"Hampel","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099467","article-title":"Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of alzheimer disease","volume":"9","author":"Hendrickx","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.11.023_bb0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrg2206","article-title":"Nucleosome destabilization in the epigenetic regulation of gene expression","volume":"9","author":"Henikoff","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.nbd.2014.11.023_bb0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/070674379804300108","article-title":"Valproic acid treatment of agitation in dementia","volume":"43","author":"Herrmann","year":"1998","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000097757","article-title":"A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease","volume":"23","author":"Herrmann","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.nbd.2014.11.023_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/10799893.2013.848891","article-title":"Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN\/Akt\/GSK-3beta signaling pathway","volume":"34","author":"Huang","year":"2014","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)00051-9","article-title":"Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis","volume":"102","author":"Ikura","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.11.023_bb0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/brain\/aws013","article-title":"Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies","volume":"135","author":"Irwin","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.11.023_bb0055","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0011-393X(97)80065-3","article-title":"A pilot study on the use of divalproex sodium in the treatment of behavioral agitation in elderly patients with dementia: Assessment with the BEHAVE-AD and CGI rating scales","volume":"58","author":"Kasckow","year":"1997","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"10.1016\/j.nbd.2014.11.023_bb0060","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1101\/gr.143008.112","article-title":"Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules","volume":"22","author":"Kelly","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0065","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Kilgore","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jnr.10845","article-title":"Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein","volume":"75","author":"Kim","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1099-1166(199801)13:1<29::AID-GPS726>3.0.CO;2-Z","article-title":"The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances","volume":"13","author":"Kunik","year":"1998","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2174\/1568007053005091","article-title":"Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents","volume":"4","author":"Langley","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.nbd.2014.11.023_bb0090","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrn1604","article-title":"Epigenetic mechanisms in memory formation","volume":"6","author":"Levenson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0085","doi-asserted-by":"crossref","first-page":"40545","DOI":"10.1074\/jbc.M402229200","article-title":"Regulation of histone acetylation during memory formation in the hippocampus","volume":"279","author":"Levenson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0095","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1471-4159.1981.tb04670.x","article-title":"Changes in chromatin structure associated with Alzheimer's disease","volume":"37","author":"Lewis","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0100","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tox.2012.08.010","article-title":"Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats","volume":"302","author":"Liang","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0105","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.neurobiolaging.2012.12.028","article-title":"Disruption of neocortical histone H3 homeostasis by soluble Abeta: implications for Alzheimer's disease","volume":"34","author":"Lithner","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0110","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1176\/jnp.7.3.314","article-title":"Valproate in the treatment of behavioral agitation in elderly patients with dementia","volume":"7","author":"Lott","year":"1995","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1385\/JMN:19:3:301","article-title":"Neuroprotective properties of valproate: potential benefit for AD and tauopathies","volume":"19","author":"Loy","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0120","article-title":"Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.11.023_bb0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0169-328X(90)90032-9","article-title":"Chromatin structure and gene expression in Alzheimer's disease","volume":"7","author":"Lukiw","year":"1990","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0130","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1471-4892(03)00084-5","article-title":"Histone deacetylases","volume":"3","author":"Marks","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0135","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroscience.2012.06.029","article-title":"Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice","volume":"220","author":"Marques","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2014.11.023_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041423","article-title":"Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease","volume":"7","author":"McFarland","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.11.023_bb0145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0317167100037057","article-title":"Chromatin structure in scrapie and Alzheimer's disease","volume":"13","author":"McLachlan","year":"1986","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0150","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00036.2006","article-title":"Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease","volume":"87","author":"Mehler","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2014.11.023_bb0155","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","article-title":"SIRT1 is essential for normal cognitive function and synaptic plasticity","volume":"30","author":"Michan","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0160","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1182\/blood-2008-08-174797","article-title":"Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: A mechanism for synergy in leukemia cells","volume":"113","author":"Miller","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.nbd.2014.11.023_bb0165","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0170","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1126\/science.3029875","article-title":"Ubiquitin is a component of paired helical filaments in Alzheimer's disease","volume":"235","author":"Mori","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.nbd.2014.11.023_bb0175","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/FBP.0b013e32833c20c0","article-title":"Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain","volume":"21","author":"Morris","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0190","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneumeth.2010.08.032","article-title":"High content analysis of histone acetylation in human cells and tissues","volume":"193","author":"Narayan","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2014.11.023_bb0185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4088\/JCP.v58n0804","article-title":"Treatment of dementia with behavioral disturbance using divalproex or a combination of divalproex and a neuroleptic","volume":"58","author":"Narayan","year":"1997","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00005072-199405000-00001","article-title":"Astrocyte responses to CNS injury","volume":"53","author":"Norenberg","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0200","first-page":"473","article-title":"A new fluorometric assay for cytotoxicity measurements in-vitro","volume":"3","author":"Page","year":"1993","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0205","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/pmic.200900818","article-title":"Proteomic identification of interactions between histones and plasma proteins: Implications for cytoprotection","volume":"10","author":"Pemberton","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.nbd.2014.11.023_bb0210","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2165\/00002512-200623110-00003","article-title":"Divalproex sodium for the treatment of behavioural problems associated with dementia in the elderly","volume":"23","author":"Porsteinsson","year":"2006","journal-title":"Drugs Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0215","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1176\/appi.ajgp.9.1.58","article-title":"Placebo-controlled study of divalproex sodium for agitation in dementia","volume":"9","author":"Porsteinsson","year":"2001","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0220","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1176\/appi.ajgp.11.4.434","article-title":"Valproate therapy for agitation in dementia: open-label extension of a double-blind trial","volume":"11","author":"Porsteinsson","year":"2003","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0225","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/abbi.1993.1374","article-title":"Interaction between the beta-amyloid peptide precursor and histones","volume":"304","author":"Potempska","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.nbd.2014.11.023_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.55","article-title":"Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients","volume":"2","author":"Rao","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0235","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/npp.2008.229","article-title":"Phenylbutyrate ameliorates cognitive deficit and reduces Tau pathology in an Alzheimer's disease mouse model","volume":"34","author":"Ricobaraza","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2014.11.023_bb0240","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0245","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.bcp.2004.05.035","article-title":"Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders","volume":"68","author":"Rouaux","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0250","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.11.023_bb0255","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jneumeth.2008.02.007","article-title":"High throughput quantification of mutant huntingtin aggregates","volume":"171","author":"Scotter","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2014.11.023_bb0260","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1111\/febs.12572","article-title":"Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity","volume":"280","author":"Seo","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2014.11.023_bb0265","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.ajpath.2013.02.031","article-title":"A phenotypic change but not proliferation underlies glial responses in Alzheimer disease","volume":"182","author":"Serrano-Pozo","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000895","article-title":"DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons","volume":"2","author":"Siegmund","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.11.023_bb0275","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/gps.653","article-title":"Sodium valproate in the treatment of aggressive behavior in patients with dementia\u2013a randomized placebo controlled clinical trial","volume":"17","author":"Sival","year":"2002","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2014.11.023_bb0280","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.11.023_bb0285","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1097\/00001756-199412000-00031","article-title":"Immunohistochemical evidence for apoptosis in Alzheimer's disease","volume":"5","author":"Su","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2014.11.023_bb0290","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0197-0186(96)00158-1","article-title":"Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus","volume":"31","author":"Sugaya","year":"1997","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2014.11.023_bb0295","doi-asserted-by":"crossref","first-page":"42364","DOI":"10.1074\/jbc.M504278200","article-title":"Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment","volume":"280","author":"Sumioka","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0300","doi-asserted-by":"crossref","DOI":"10.1101\/gr.163485.113","article-title":"Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer","author":"Taberlay","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2014.11.023_bb0310","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0011-393X(01)80042-4","article-title":"Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo-controlled trial","volume":"62","author":"Tariot","year":"2001","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"10.1016\/j.nbd.2014.11.023_bb0305","first-page":"942","article-title":"Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: A randomized, controlled trial","volume":"13","author":"Tariot","year":"2005","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.nbd.2014.11.023_bb0315","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(02)01080-2","article-title":"Cellular memory and the histone code","volume":"111","author":"Turner","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.11.023_bb0320","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1523\/JNEUROSCI.0296-07.2007","article-title":"Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation","volume":"27","author":"Vecsey","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.11.023_bb0330","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2006.354","article-title":"Immunohistochemical staining of post-mortem adult human brain sections","volume":"1","author":"Waldvogel","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2014.11.023_bb0325","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10561-008-9068-1","article-title":"The collection and processing of human brain tissue for research","volume":"9","author":"Waldvogel","year":"2008","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.nbd.2014.11.023_bb0340","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nsmb.2017","article-title":"An effect of DNA sequence on nucleosome occupancy and removal","volume":"18","author":"Wang","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.nbd.2014.11.023_bb0335","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2337\/db13-1063","article-title":"Epigenetic mechanisms linking diabetes and synaptic impairments","volume":"63","author":"Wang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2014.11.023_bb0345","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/cns.12186","article-title":"Valproic acid reduces neuritic plaque formation and improves learning deficits in APPSwe\/PS1A246E transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin","volume":"20","author":"Wang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.nbd.2014.11.023_bb0350","doi-asserted-by":"crossref","first-page":"33313","DOI":"10.1074\/jbc.M706024200","article-title":"Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain","volume":"282","author":"Wiley","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0355","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1101\/lm.213906","article-title":"A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes","volume":"13","author":"Wood","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.nbd.2014.11.023_bb0360","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.neurobiolaging.2013.06.003","article-title":"Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency","volume":"34","author":"Wu","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.11.023_bb0365","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.conb.2010.04.005","article-title":"Joining the dots: From chromatin remodeling to neuronal plasticity","volume":"20","author":"Zocchi","year":"2010","journal-title":"Curr. Opin. Neurobiol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T19:36:56Z","timestamp":1650742616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114003696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":107,"alternative-id":["S0969996114003696"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.11.023","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}