{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:56:27Z","timestamp":1790286987840,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation Inc.","doi-asserted-by":"crossref","award":["A-3433"],"award-info":[{"award-number":["A-3433"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["606650"],"award-info":[{"award-number":["606650"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VLSCI's Life Sciences Computation Centre"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.nbd.2014.12.009","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T04:20:47Z","timestamp":1418358047000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"special_numbering":"C","title":["Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study"],"prefix":"10.1016","volume":"74","author":[{"given":"Govinda R.","family":"Poudel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-8590","authenticated-orcid":false,"given":"Julie C.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Dom\u00ednguez D.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Churchyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-6760","authenticated-orcid":false,"given":"Nellie","family":"Georgiou-Karistianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.12.009_bb0005","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biopsych.2011.07.030","article-title":"Striatal volume contributes to the prediction of onset of Huntington disease in incident cases","volume":"71","author":"Aylward","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2014.12.009_bb0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.410270217","article-title":"Degeneration of pyramidal projection neurons in Huntington's disease cortex","volume":"27","author":"Cudkowicz","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0015","doi-asserted-by":"crossref","first-page":"e74131","DOI":"10.1371\/journal.pone.0074131","article-title":"Multi-modal neuroimaging in premanifest and early Huntington's disease: 18month longitudinal data from the IMAGE-HD study","volume":"8","author":"Dominguez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2014.12.009_bb0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/hbm.21205","article-title":"Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease","volume":"33","author":"Dumas","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nbd.2014.12.009_bb0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2012.10.001","article-title":"Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study","volume":"51","author":"Georgiou-Karistianis","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.12.009_bb0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bandc.2013.07.004","article-title":"Functional and connectivity changes during working memory in Huntington's disease: 18month longitudinal data from the IMAGE-HD study","volume":"83","author":"Georgiou-Karistianis","year":"2013","journal-title":"Brain Cogn."},{"key":"10.1016\/j.nbd.2014.12.009_bb0035","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hbm.22296","article-title":"Functional magnetic resonance imaging of working memory in Huntington's disease: IMAGE-HD cross-sectional analysis","volume":"35","author":"Georgiou-Karistianis","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nbd.2014.12.009_bb0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.expneurol.2012.10.020","article-title":"Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study","volume":"239","author":"Gray","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroimage.2013.01.044","article-title":"An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's disease","volume":"72","author":"Keihaninejad","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.12.009_bb0050","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/brain\/awm275","article-title":"White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease","volume":"131","author":"Kloppel","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.12.009_bb0055","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin. Genet."},{"key":"10.1016\/j.nbd.2014.12.009_bb0060","series-title":"Axonopathy in Huntington's Disease","author":"Li","year":"2012"},{"key":"10.1016\/j.nbd.2014.12.009_bb0065","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archneur.1991.00530200036015","article-title":"Factors associated with slow progression in Huntington's disease","volume":"48","author":"Myers","year":"1991","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0070","first-page":"533","article-title":"National adult reading test, 2nd edition","volume":"7","author":"Nelson","year":"1992","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2014.12.009_bb0075","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","article-title":"CAG repeat number governs the development rate of pathology in Huntington's disease","volume":"41","author":"Penney","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0080","series-title":"Functional Changes During Working Memory in Huntington's Disease: 30-month Longitudinal Data From the IMAGE-HD Study","author":"Poudel","year":"2013"},{"key":"10.1016\/j.nbd.2014.12.009_bb0085","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nbd.2014.01.013","article-title":"White matter connectivity reflects clinical and cognitive status in Huntington's disease","volume":"65","author":"Poudel","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2014.12.009_bb0095","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.58.5.695","article-title":"Regional and progressive thinning of the cortical ribbon in Huntington's disease","volume":"58","author":"Rosas","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.12.009_bb0105","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.20979","article-title":"Diffusion tensor imaging in presymptomatic and early Huntington's disease: selective white matter pathology and its relationship to clinical measures","volume":"21","author":"Rosas","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2014.12.009_bb0090","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","article-title":"Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical \u201cdisconnection\u201d","volume":"49","author":"Rosas","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.12.009_bb0100","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/mds.23762","article-title":"A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study","volume":"26","author":"Rosas","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2014.12.009_bb0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.12.009_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuroimage.2005.01.028","article-title":"Demyelination increases radial diffusivity in corpus callosum of mouse brain","volume":"26","author":"Song","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2014.12.009_bb0120","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jnnp.2007.142786","article-title":"A longitudinal diffusion tensor imaging study in symptomatic Huntington's disease","volume":"81","author":"Sritharan","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2014.12.009_bb0125","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/WNL.0b013e3181d8c20a","article-title":"Contrasting gray and white matter changes in preclinical Huntington disease: an MRI study","volume":"74","author":"Stoffers","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2014.12.009_bb0130","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0135","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0140","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.expneurol.2008.12.026","article-title":"Longitudinal diffusion tensor imaging in Huntington's disease","volume":"216","author":"Weaver","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2014.12.009_bb0145","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.neuroimage.2010.09.008","article-title":"Enhanced ICBM diffusion tensor template of the human brain","volume":"54","author":"Zhang","year":"2011","journal-title":"Neuroimage"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T22:20:37Z","timestamp":1538000437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114003805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":29,"alternative-id":["S0969996114003805"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.12.009","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}