{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:56:55Z","timestamp":1791421015102,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.nbd.2014.12.018","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T21:35:21Z","timestamp":1419975321000},"page":"131-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis"],"prefix":"10.1016","volume":"75","author":[{"given":"Fanny","family":"Ehret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-3279","authenticated-orcid":false,"given":"Sherin","family":"Pojar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bradke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-4061","authenticated-orcid":false,"given":"Gerd","family":"Kempermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2014.12.018_bb0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cne.903010304","article-title":"Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods","volume":"301","author":"Altman","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0010","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/01.STR.0000129787.92085.0a","article-title":"Insidious cognitive decline in CADASIL","volume":"35","author":"Amberla","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2014.12.018_bb0015","doi-asserted-by":"crossref","first-page":"E128","DOI":"10.1073\/pnas.1101964108","article-title":"Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease","volume":"108","author":"Arboleda-Velasquez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.12.018_bb0020","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jemt.20829","article-title":"3D reconstruction of histological sections: application to mammary gland tissue","volume":"73","author":"Arganda-Carreras","year":"2010","journal-title":"Microsc. Res. Tech."},{"issue":"45","key":"10.1016\/j.nbd.2014.12.018_bb0025","first-page":"e2393","article-title":"Isolation and expansion of adult mouse neural stem cells using the neurosphere assay","author":"Azari","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2014.12.018_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fnins.2011.00089","article-title":"A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus","volume":"5","author":"Babu","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2014.12.018_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4773(01)00373-2","article-title":"The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity","volume":"104","author":"Beatus","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.nbd.2014.12.018_bb0040","doi-asserted-by":"crossref","first-page":"20558","DOI":"10.1073\/pnas.0710156104","article-title":"Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus","volume":"104","author":"Breunig","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2014.12.018_bb0050","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1161\/01.STR.31.8.1904","article-title":"Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking","volume":"31","author":"Chabriat","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2014.12.018_bb0045","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","article-title":"Cadasil","volume":"8","author":"Chabriat","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0055","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1161\/STROKEAHA.113.003339","article-title":"Archetypal Arg169Cys mutation in Notch3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism","volume":"45","author":"Cognat","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2014.12.018_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(07)70028-5","article-title":"Genetics of ischaemic stroke","volume":"6","author":"Dichgans","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0065","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.410440506","article-title":"The phenotypic spectrum of CADASIL: clinical findings in 102 cases","volume":"44","author":"Dichgans","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0888-7543(03)00206-4","article-title":"Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL","volume":"83","author":"Donahue","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.nbd.2014.12.018_bb0075","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1093\/brain\/awr169","article-title":"Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL","volume":"134","author":"Duering","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.12.018_bb0080","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-0404.1997.tb00224.x","article-title":"CADASIL: skin biopsy allows diagnosis in early stages","volume":"95","author":"Ebke","year":"1997","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.nbd.2014.12.018_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000082134","article-title":"SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult","volume":"26","author":"Ellis","year":"2004","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.nbd.2014.12.018_bb0090","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/nprot.2012.119","article-title":"Three-dimensional imaging of solvent-cleared organs using 3DISCO","volume":"7","author":"Erturk","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2014.12.018_bb0095","doi-asserted-by":"crossref","first-page":"e5464","DOI":"10.1371\/journal.pone.0005464","article-title":"Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies","volume":"4","author":"Garthe","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2014.12.018_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/gbb.12130","article-title":"Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits","volume":"13","author":"Garthe","year":"2014","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.nbd.2014.12.018_bb0105","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1101\/gr.476202","article-title":"Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication","volume":"12","author":"Gong","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.nbd.2014.12.018_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4161\/cam.1.3.4978","article-title":"VEGF and Notch signaling: the yin and yang of angiogenic sprouting","volume":"1","author":"Hellstrom","year":"2007","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.nbd.2014.12.018_bb0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cne.1059","article-title":"Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch\u2013DSL signaling system during brain development","volume":"436","author":"Irvin","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/bies.201000093","article-title":"Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature","volume":"33","author":"Joutel","year":"2011","journal-title":"Bioessays"},{"key":"10.1016\/j.nbd.2014.12.018_bb0125","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/383707a0","article-title":"Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia","volume":"383","author":"Joutel","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2014.12.018_bb0130","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1172\/JCI39733","article-title":"Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease","volume":"120","author":"Joutel","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2014.12.018_bb0135","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrn3319","article-title":"New neurons for \u2018survival of the fittest\u2019","volume":"13","author":"Kempermann","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2014.12.018_bb0140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1242\/dev.00203","article-title":"Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice","volume":"130","author":"Kempermann","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.nbd.2014.12.018_bb0145","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.STR.0000163080.82766.eb","article-title":"Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy","volume":"36","author":"Lacombe","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2014.12.018_bb0150","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.stem.2010.03.017","article-title":"Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging","volume":"6","author":"Lugert","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2014.12.018_bb0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/gene.20091","article-title":"Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype","volume":"41","author":"Lundkvist","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.nbd.2014.12.018_bb0160","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1750-3639.2004.tb00078.x","article-title":"Fibrosis and stenosis of the long penetrating cerebral arteries: the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"14","author":"Miao","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0165","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/brain\/awp049","article-title":"Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain","volume":"132","author":"Monet-Lepretre","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.12.018_bb0170","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/brain\/awt092","article-title":"Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL","volume":"136","author":"Monet-Lepretre","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2014.12.018_bb0175","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/1098-1136(20010101)33:1<72::AID-GLIA1007>3.0.CO;2-A","article-title":"GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue","volume":"33","author":"Nolte","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2014.12.018_bb0180","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.neurobiolaging.2007.09.002","article-title":"Hippocampal volume is an independent predictor of cognitive performance in CADASIL","volume":"30","author":"O'Sullivan","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2014.12.018_bb0185","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3","article-title":"Vascular niche for adult hippocampal neurogenesis","volume":"425","author":"Palmer","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0195","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00571504","article-title":"Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"89","author":"Ruchoux","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0190","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0002-9440(10)63824-2","article-title":"Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"162","author":"Ruchoux","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0200","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(98)80009-1","article-title":"Three-dimensional multi-scale line filter for segmentation and visualization of curvilinear structures in medical images","volume":"2","author":"Sato","year":"1998","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.nbd.2014.12.018_bb0205","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2014.12.018_bb0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0925-4773(02)00043-6","article-title":"Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain","volume":"114","author":"Stump","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.nbd.2014.12.018_bb0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000015825","article-title":"Cognitive alterations in non-demented CADASIL patients","volume":"8","author":"Taillia","year":"1998","journal-title":"Cerebrovasc. Dis."},{"issue":"84","key":"10.1016\/j.nbd.2014.12.018_bb0220","first-page":"e51225","article-title":"One mouse, two cultures: isolation and culture of adult neural stem cells from the two neurogenic zones of individual mice","author":"Walker","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2014.12.018_bb0225","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1523\/JNEUROSCI.0344-08.2008","article-title":"Latent stem and progenitor cells in the hippocampus are activated by neural excitation","volume":"28","author":"Walker","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2014.12.018_bb0230","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1161\/ATVBAHA.111.237859","article-title":"Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"31","author":"Wallays","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2014.12.018_bb0235","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1460-9568.2011.07613.x","article-title":"Neurodegenerative disease and adult neurogenesis","volume":"33","author":"Winner","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2014.12.018_bb0240","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1097\/00001756-200006260-00037","article-title":"Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice","volume":"11","author":"Yamaguchi","year":"2000","journal-title":"Neuroreport"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996114003891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T23:23:50Z","timestamp":1566170630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996114003891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":48,"alternative-id":["S0969996114003891"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2014.12.018","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2014.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}