{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:47:08Z","timestamp":1781286428453,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Ministry of Health, Associations \u201cGli Amici di Valentina\u201d and \u201cUn vero sorriso\u201d"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.nbd.2015.04.001","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T23:03:10Z","timestamp":1429138990000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Blood metal levels and related antioxidant enzyme activities in patients with ataxia telangiectasia"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-7258","authenticated-orcid":false,"given":"Stefania","family":"Squadrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Brizio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Cavalieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cesarina","family":"Abete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Brusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.04.001_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jtemb.2014.05.003","article-title":"Copper mediated neurological disorder: Visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease","volume":"29","author":"Ahuja","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0010","first-page":"204","article-title":"Antioxidant enzymes in red blood cells and lymphocytes of ataxia-telangiectasia patients","volume":"46","author":"Aksoy","year":"2004","journal-title":"Turk. J. Pediatr."},{"key":"10.1016\/j.nbd.2015.04.001_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.trsl.2008.06.001","article-title":"Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients","volume":"152","author":"Bao","year":"2008","journal-title":"Transl. Res."},{"key":"10.1016\/j.nbd.2015.04.001_bb0020","doi-asserted-by":"crossref","first-page":"17482","DOI":"10.1074\/jbc.M601895200","article-title":"Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells","volume":"281","author":"Biton","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0025","first-page":"8","article-title":"Ataxia-telangiectasia. (Clinical and immunological aspects)","volume":"13\u201314","author":"Boder","year":"1970","journal-title":"Psychiatr. Neurol. Med. Psychol. Beih."},{"key":"10.1016\/j.nbd.2015.04.001_bb0030","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.freeradbiomed.2004.01.003","article-title":"Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice","volume":"36","author":"Browne","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2015.04.001_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(03)00067-5","article-title":"The metallobiology of Alzheimer's disease","volume":"26","author":"Bush","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2015.04.001_bb0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00249-007-0228-1","article-title":"Twenty years of metallo-neurobiology: where to now?","volume":"37","author":"Bush","year":"2008","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.nbd.2015.04.001_bb0050","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/humu.9454","article-title":"ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions","volume":"27","author":"Cavalieri","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.nbd.2015.04.001_bb0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1469-1809.2007.00399.x","article-title":"Large genomic mutations within the ATM gene detected by MLPA, including a duplication of 41kb from exon 4 to 20","volume":"72","author":"Cavalieri","year":"2008","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.nbd.2015.04.001_bb0055","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/ejhg.2012.266","article-title":"Deep-intronic ATM mutation detected by genomic resequencing and corrected in vitro by antisense morpholino oligonucleotide (AMO)","volume":"21","author":"Cavalieri","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2015.04.001_bb0060","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1038\/sj.onc.1206760","article-title":"ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response","volume":"22","author":"Chen","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.nbd.2015.04.001_bb0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0306-4522(88)90312-0","article-title":"Zinc neurotoxicity in cortical cell culture","volume":"24","author":"Choi","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.04.001_bb0070","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neurobiolaging.2008.05.009","article-title":"Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase\/catalase mimetics in aged mice","volume":"31","author":"Clausen","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.04.001_bb0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0306-9877(91)90277-6","article-title":"The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles","volume":"35","author":"Constantinidis","year":"1991","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.nbd.2015.04.001_bb0080","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1113\/jphysiol.2005.089458","article-title":"Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus","volume":"566","author":"Cote","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0085","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3945\/ajcn.2010.29686","article-title":"Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala","volume":"92","author":"DiGirolamo","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.nbd.2015.04.001_bb0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2013.05.027","article-title":"SOD2 in mitochondrial dysfunction and neurodegeneration","volume":"62","author":"Flynn","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2015.04.001_bb0095","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/02841860152619115","article-title":"The inherited basis of human radiosensitivity","volume":"40","author":"Gatti","year":"2001","journal-title":"Acta Oncol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0100","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.4161\/cc.9.24.14323","article-title":"ATM activation in the presence of oxidative stress","volume":"9","author":"Guo","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.nbd.2015.04.001_bb0105","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid peroxidation and antioxidants as biomarkers of tissue damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0110","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0032-1313915","article-title":"Neurodegeneration in ataxia telangiectasia: what is new? What is evident?","volume":"43","author":"Hoche","year":"2012","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.nbd.2015.04.001_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-410502-7.00002-8","article-title":"The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations","volume":"110","author":"Jellinger","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0130","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.nbd.2015.04.001_bb0135","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1523\/JNEUROSCI.21-17-06687.2001","article-title":"Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status","volume":"21","author":"Lee","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.04.001_bb0140","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/labinvest.3700354","article-title":"ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes","volume":"85","author":"Liu","year":"2005","journal-title":"Lab. Investig."},{"key":"10.1016\/j.nbd.2015.04.001_bb0145","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.nutr.24.012003.132402","article-title":"Mammalian zinc transporters","volume":"24","author":"Liuzzi","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.nbd.2015.04.001_bb0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.nbd.2015.04.001_bb0155","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000097348","article-title":"Possible control of cell death pathways in ataxia telangiectasia. A case report","volume":"4","author":"Lynn","year":"1997","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2015.04.001_bb0160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000322544","article-title":"Pregabalin antagonizes copper-induced toxicity in the brain: in vitro and in vivo studies","volume":"18","author":"Marmolino","year":"2010","journal-title":"Neurosignals"},{"key":"10.1016\/j.nbd.2015.04.001_bb0165","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1093\/emboj\/18.16.4361","article-title":"Metal ion transporters and homeostasis","volume":"18","author":"Nelson","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2015.04.001_bb0170","doi-asserted-by":"crossref","first-page":"18530","DOI":"10.1074\/jbc.272.30.18530","article-title":"Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis","volume":"272","author":"Perry","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0175","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.nbd.2015.04.001_bb0180","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ajcn\/85.3.837","article-title":"Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress","volume":"85","author":"Prasad","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.nbd.2015.04.001_bb0190","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2249.1999.01000.x","article-title":"Anti-oxidative capacity in patients with ataxia telangiectasia","volume":"117","author":"Reichenbach","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0185","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/15230860260196254","article-title":"Elevated oxidative stress in patients with ataxia telangiectasia","volume":"4","author":"Reichenbach","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2015.04.001_bb0200","doi-asserted-by":"crossref","first-page":"229S","DOI":"10.1093\/jn\/137.1.229S","article-title":"Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice","volume":"137","author":"Reliene","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.nbd.2015.04.001_bb0195","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.fct.2007.08.028","article-title":"Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice","volume":"46","author":"Reliene","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0205","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/01.wnl.0000223644.08653.b5","article-title":"Elevated cortical zinc in Alzheimer disease","volume":"67","author":"Religa","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2015.04.001_bb0210","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jmb.2007.07.043","article-title":"Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS","volume":"373","author":"Roberts","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0215","doi-asserted-by":"crossref","first-page":"259","DOI":"10.17219\/acem\/37074","article-title":"Trace elements, magnesium, and the efficacy of antioxidant systems in children with type 1 diabetes mellitus and in their siblings","volume":"23","author":"Salmonowicz","year":"2014","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.nbd.2015.04.001_bb0220","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/hmg\/ddh189","article-title":"Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice","volume":"13","author":"Schubert","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.04.001_bb0225","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tibs.2006.05.004","article-title":"The ATM-mediated DNA-damage response: taking shape","volume":"31","author":"Shiloh","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.nbd.2015.04.001_bb0230","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.atherosclerosis.2005.11.035","article-title":"Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?","volume":"187","author":"Shukla","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.nbd.2015.04.001_bb0235","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1074\/jbc.M106798200","article-title":"Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice","volume":"277","author":"Stern","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0240","first-page":"573","article-title":"The incidence and gene frequency of ataxia-telangiectasia in the United States","volume":"39","author":"Swift","year":"1986","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2015.04.001_bb0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnagi.2013.00033","article-title":"Zinc homeostasis and neurodegenerative disorders","volume":"5","author":"Szewczyk","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2015.04.001_bb0250","series-title":"Metal Ions and Neurodegenerative Disorders World Scientific","first-page":"1","article-title":"Metal-Catalyzed Redox Activity in Neurodegenerative Disease","author":"Taddeo","year":"2003"},{"key":"10.1016\/j.nbd.2015.04.001_bb0255","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.biochem.72.121801.161647","article-title":"Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis","volume":"74","author":"Valentine","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0265","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nbd.2015.04.001_bb0260","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.nbd.2015.04.001_bb0270","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1179\/135100003125001206","article-title":"Oxidative stress in ataxia telangiectasia","volume":"8","author":"Watters","year":"2003","journal-title":"Redox Rep."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115001254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115001254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T12:12:49Z","timestamp":1717848769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115001254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":54,"alternative-id":["S0969996115001254"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.04.001","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood metal levels and related antioxidant enzyme activities in patients with ataxia telangiectasia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}