{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:14:48Z","timestamp":1781104488220,"version":"3.54.1"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1F30AI109984"],"award-info":[{"award-number":["1F30AI109984"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institutes of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS081026"],"award-info":[{"award-number":["NS081026"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","award":["3119"],"award-info":[{"award-number":["3119"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.nbd.2015.05.005","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T13:42:15Z","timestamp":1431610935000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"PA","title":["Unexpected cellular players in Rett syndrome pathology"],"prefix":"10.1016","volume":"92","author":[{"given":"James C.","family":"Cronk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel C.","family":"Derecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Litvak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-517X","authenticated-orcid":false,"given":"Jonathan","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.05.005_bb0010","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/hmg\/ddm185","article-title":"Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis","volume":"16","author":"Alvarez-Saavedra","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0005","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/hmg\/ddq096","article-title":"Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development","volume":"19","author":"Alvarez-Saavedra","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0015","series-title":"Diagnostic and statistical manual of mental disorders: DSM-5","author":"American Psychiatric Association., American Psychiatric Association. DSM-5 Task Force.","year":"2013"},{"key":"10.1016\/j.nbd.2015.05.005_bb0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.05.005_bb0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology","volume":"12","author":"Ballas","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0035","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0040","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/hmg\/ddr602","article-title":"Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome","volume":"21","author":"Braun","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0045","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ng.2714","article-title":"A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome","volume":"45","author":"Buchovecky","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.05.005_bb0050","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.05.005_bb0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number","volume":"56","author":"Chao","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.05.005_bb0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.05.005_bb0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0075","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1210\/en.2012-2076","article-title":"Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression","volume":"154","author":"Chen","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.nbd.2015.05.005_bb0080","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/ard.2009.122903","article-title":"Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren's syndrome","volume":"69","author":"Cobb","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2015.05.005_bb0085","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuron.2011.08.022","article-title":"Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function","volume":"72","author":"Cohen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.05.005_bb0090","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.immuni.2015.03.013","article-title":"Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli","volume":"42","author":"Cronk","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2015.05.005_bb0095","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/jmedgenet-2013-102113","article-title":"Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome","volume":"51","author":"Cuddapah","year":"2014","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0100","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","article-title":"Microglia regulate the number of neural precursor cells in the developing cerebral cortex","volume":"33","author":"Cunningham","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0105","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1093\/nar\/gkp723","article-title":"MeCP2\/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines","volume":"37","author":"Dandrea","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2015.05.005_bb0110","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-resident macrophages","volume":"14","author":"Davies","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0115","doi-asserted-by":"crossref","first-page":"560120","DOI":"10.1155\/2014\/560120","article-title":"Inflammatory lung disease in Rett syndrome","volume":"2014","author":"De Felice","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.nbd.2015.05.005_bb0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome","volume":"484","author":"Derecki","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.05.005_bb0125","doi-asserted-by":"crossref","first-page":"e1687","DOI":"10.1542\/peds.2006-0395","article-title":"Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28","volume":"118","author":"Friez","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.nbd.2015.05.005_bb0130","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1101\/gad.1773109","article-title":"Cooperative NCoR\/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways","volume":"23","author":"Ghisletti","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2015.05.005_bb0135","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.0610593104","article-title":"Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2","volume":"104","author":"Giacometti","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0140","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/08830738050200082301","article-title":"Neurophysiology of Rett syndrome","volume":"20","author":"Glaze","year":"2005","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mito.2014.02.012","article-title":"Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): implications for the disease phenotype","volume":"15","author":"Gold","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.nbd.2015.05.005_bb0150","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/nn.3531","article-title":"A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation","volume":"16","author":"Goldmann","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0165","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0160","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.05.005_bb0155","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev-cellbio-092910-154121","article-title":"The role of MeCP2 in the brain","volume":"27","author":"Guy","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0170","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ana.410140412","article-title":"A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases","volume":"14","author":"Hagberg","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0175","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/srep04323","article-title":"Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone","volume":"4","author":"Haim","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2015.05.005_bb0180","doi-asserted-by":"crossref","first-page":"12776","DOI":"10.1073\/pnas.1202556109","article-title":"Modeling an autism risk factor in mice leads to permanent immune dysregulation","volume":"109","author":"Hsiao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0185","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/nen.0b013e3180302078","article-title":"Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains","volume":"66","author":"Itoh","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0190","doi-asserted-by":"crossref","first-page":"ra25","DOI":"10.1126\/scisignal.2004824","article-title":"MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5","volume":"7","author":"Jiang","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2015.05.005_bb0195","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1523\/JNEUROSCI.2778-14.2015","article-title":"Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity","volume":"35","author":"Jin","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0200","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/annrheumdis-2012-201851","article-title":"Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups","volume":"72","author":"Kaufman","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2015.05.005_bb0210","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mcn.2004.07.006","article-title":"MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions","volume":"27","author":"Kishi","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0215","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jaut.2012.12.012","article-title":"Functional characterization of the MECP2\/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse","volume":"41","author":"Koelsch","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.nbd.2015.05.005_bb0220","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1182\/blood-2010-05-282913","article-title":"Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)","volume":"116","author":"Lepelletier","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.nbd.2015.05.005_bb0225","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1073\/pnas.76.11.5495","article-title":"Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus","volume":"76","author":"Lerner","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0230","doi-asserted-by":"crossref","first-page":"E2807","DOI":"10.1073\/pnas.1401505111","article-title":"MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation","volume":"111","author":"Li","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature10214","article-title":"A role for glia in the progression of Rett's syndrome","volume":"475","author":"Lioy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.05.005_bb0240","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature11428","article-title":"A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses","volume":"490","author":"Litvak","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.05.005_bb0245","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.0401626101","article-title":"Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice","volume":"101","author":"Luikenhuis","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0250","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT co-repressor","volume":"16","author":"Lyst","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0255","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1523\/JNEUROSCI.5966-09.2010","article-title":"Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate","volume":"30","author":"Maezawa","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0260","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1523\/JNEUROSCI.0324-09.2009","article-title":"Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions","volume":"29","author":"Maezawa","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0265","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cell.2010.10.016","article-title":"A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells","volume":"143","author":"Marchetto","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.05.005_bb0270","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1206593","article-title":"Adult neural function requires MeCP2","volume":"333","author":"McGraw","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.05.005_bb0275","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/nar\/20.19.5085","article-title":"Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA","volume":"20","author":"Meehan","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2015.05.005_bb0280","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","article-title":"MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system","volume":"151","author":"Mellen","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.05.005_bb0285","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0295","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/MPG.0b013e31824b6159","article-title":"Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome","volume":"55","author":"Motil","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.nbd.2015.05.005_bb0290","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/MPG.0000000000000440","article-title":"Low bone mineral mass is associated with decreased bone formation and diet in girls with Rett syndrome","volume":"59","author":"Motil","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.nbd.2015.05.005_bb0300","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.05.005_bb0305","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: revised diagnostic criteria and nomenclature","volume":"68","author":"Neul","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0310","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1866-1955-6-20","article-title":"Developmental delay in Rett syndrome: data from the natural history study","volume":"6","author":"Neul","year":"2014","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.nbd.2015.05.005_bb0315","doi-asserted-by":"crossref","first-page":"18764","DOI":"10.1523\/JNEUROSCI.2657-13.2013","article-title":"Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology","volume":"33","author":"Nguyen","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.05.005_bb0320","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jneuroim.2013.09.002","article-title":"MeCP2 deficiency enhances glutamate release through NF-kappaB signaling in myeloid derived cells","volume":"265","author":"O'Driscoll","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2015.05.005_bb0330","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2005.06.029","article-title":"Molecular determinants of crosstalk between nuclear receptors and toll-like receptors","volume":"122","author":"Ogawa","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.05.005_bb0335","doi-asserted-by":"crossref","first-page":"e35354","DOI":"10.1371\/journal.pone.0035354","article-title":"Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome","volume":"7","author":"Okabe","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.05.005_bb0340","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.05.005_bb0345","first-page":"723","article-title":"On a unusual brain atrophy syndrome in hyperammonemia in childhood","volume":"116","author":"Rett","year":"1966","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.nbd.2015.05.005_bb0350","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/hmg\/ddn062","article-title":"A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome","volume":"17","author":"Samaco","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0355","doi-asserted-by":"crossref","first-page":"21966","DOI":"10.1073\/pnas.0912257106","article-title":"Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities","volume":"106","author":"Samaco","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0360","doi-asserted-by":"crossref","first-page":"e1727","DOI":"10.1371\/journal.pone.0001727","article-title":"Common variants within MECP2 confer risk of systemic lupus erythematosus","volume":"3","author":"Sawalha","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.05.005_bb0365","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.05.005_bb0370","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.biochem.76.052705.162114","article-title":"Functions of site-specific histone acetylation and deacetylation","volume":"76","author":"Shahbazian","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.nbd.2015.05.005_bb0375","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1086\/345360","article-title":"Rett syndrome and MeCP2: linking epigenetics and neuronal function","volume":"71","author":"Shahbazian","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2015.05.005_bb0380","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2010.01.030","article-title":"Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state","volume":"37","author":"Skene","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2015.05.005_bb0385","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.05.005_bb0390","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0395","doi-asserted-by":"crossref","first-page":"e3669","DOI":"10.1371\/journal.pone.0003669","article-title":"Mecp2-null mice provide new neuronal targets for Rett syndrome","volume":"3","author":"Urdinguio","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.05.005_bb0400","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1006\/bbrc.1997.7533","article-title":"Dexamethasone and interleukin-1 potently synergize to stimulate the production of granulocyte colony-stimulating factor in differentiated THP-1 cells","volume":"239","author":"Wang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2015.05.005_bb0405","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/art.24360","article-title":"Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus","volume":"60","author":"Webb","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nbd.2015.05.005_bb0410","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1093\/hmg\/ddu008","article-title":"Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons","volume":"23","author":"Williams","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.nbd.2015.05.005_bb0415","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jb\/mvu086","article-title":"Glucocorticoid augments lipopolysaccharide-induced activation of the IkappaBzeta-dependent genes encoding the anti-microbial glycoproteins lipocalin 2 and pentraxin 3","volume":"157","author":"Yamazaki","year":"2015","journal-title":"J. Biochem."},{"key":"10.1016\/j.nbd.2015.05.005_bb0420","doi-asserted-by":"crossref","first-page":"14140","DOI":"10.1073\/pnas.1119842109","article-title":"Nuclear factor-kappaB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome","volume":"109","author":"Yan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0425","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004430","article-title":"Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses","volume":"4","author":"Yang","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2015.05.005_bb0430","doi-asserted-by":"crossref","first-page":"19416","DOI":"10.1073\/pnas.0707442104","article-title":"Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes","volume":"104","author":"Yasui","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.05.005_bb0435","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2040-2392-4-3","article-title":"MeCP2 modulates gene expression pathways in astrocytes","volume":"4","author":"Yasui","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.nbd.2015.05.005_bb0440","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuron.2014.01.043","article-title":"Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase","volume":"82","author":"Zhang","year":"2014","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115001679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115001679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T12:22:09Z","timestamp":1537618929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115001679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":88,"alternative-id":["S0969996115001679"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.05.005","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unexpected cellular players in Rett syndrome pathology","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}