{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:20:30Z","timestamp":1784035230952,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG044486"],"award-info":[{"award-number":["AG044486"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG15379"],"award-info":[{"award-number":["AG15379"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Discovery"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.nbd.2015.06.013","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T22:05:45Z","timestamp":1435010745000},"page":"109-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"special_numbering":"C","title":["Oxidative stress and lipid peroxidation are upstream of amyloid pathology"],"prefix":"10.1016","volume":"84","author":[{"given":"Muriel","family":"Arimon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Svirsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Berezovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.nbd.2015.06.013_bb0005","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1073\/pnas.0600134103","article-title":"Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease","volume":"103","author":"Atamna","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0169-328X(99)00119-9","article-title":"The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons","volume":"69","author":"Berezovska","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"11","key":"10.1016\/j.nbd.2015.06.013_bb0015","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1523\/JNEUROSCI.0364-05.2005","article-title":"Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein","volume":"25","author":"Berezovska","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1474-4422(09)70332-1","article-title":"gamma-secretases: from cell biology to therapeutic strategies","volume":"9","author":"Bergmans","year":"2010","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.nbd.2015.06.013_bb0025","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42\/1-40 ratio in vitro and in vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.nbd.2015.06.013_bb0030","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","article-title":"Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review","volume":"36","author":"Butterfield","year":"2002","journal-title":"Free Radic. Res."},{"issue":"6","key":"10.1016\/j.nbd.2015.06.013_bb0040","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1046\/j.1471-4159.1997.68062451.x","article-title":"Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease","volume":"68","author":"Butterfield","year":"1997","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/JAD-2002-4309","article-title":"Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists","volume":"4","author":"Butterfield","year":"2002","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0045","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2005.12.017","article-title":"Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment","volume":"397","author":"Butterfield","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.nbd.2015.06.013_bb0050","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12017-011-8155-9","article-title":"Oxidative stress and beta-amyloid protein in Alzheimer's disease","volume":"13","author":"Cai","year":"2011","journal-title":"Neruomol. Med."},{"issue":"10","key":"10.1016\/j.nbd.2015.06.013_bb0055","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1038\/emboj.2012.79","article-title":"The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease","volume":"31","author":"Chavez-Gutierrez","year":"2012","journal-title":"EMBO J."},{"issue":"26","key":"10.1016\/j.nbd.2015.06.013_bb0060","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1523\/JNEUROSCI.23-26-08844.2003","article-title":"In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life","volume":"23","author":"Cirrito","year":"2003","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.nbd.2015.06.013_bb0065","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.0305799101","article-title":"Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease","volume":"101","author":"Cutler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.embor.7400897","article-title":"Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease","volume":"8","author":"De Strooper","year":"2007","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.013_bb0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"issue":"6809","key":"10.1016\/j.nbd.2015.06.013_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.nbd.2015.06.013_bb0085","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/01.jnen.0000240468.12543.af","article-title":"Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model","volume":"65","author":"Garcia-Alloza","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"7","key":"10.1016\/j.nbd.2015.06.013_bb0090","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/emmm.201200243","article-title":"Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease","volume":"4","author":"Guix","year":"2012","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.nbd.2015.06.013_bb0095","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1474-9726.2012.00817.x","article-title":"Oxidative lipid modification of nicastrin enhances amyloidogenic gamma-secretase activity in Alzheimer's disease","volume":"11","author":"Gwon","year":"2012","journal-title":"Aging Cell"},{"issue":"5580","key":"10.1016\/j.nbd.2015.06.013_bb0100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-4886(95)90041-1","article-title":"Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons","volume":"131","author":"Harris","year":"1995","journal-title":"Exp. Neurol."},{"issue":"17","key":"10.1016\/j.nbd.2015.06.013_bb0110","doi-asserted-by":"crossref","first-page":"12388","DOI":"10.1074\/jbc.M611549200","article-title":"Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2N-terminal elongation and fenofibrate","volume":"282","author":"Isoo","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"6007","key":"10.1016\/j.nbd.2015.06.013_bb0115","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1198668","article-title":"Genetics. Gamma-secretase and human disease","volume":"330","author":"Kelleher","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nbd.2015.06.013_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2012.236","article-title":"Deciphering the mechanism underlying late-onset Alzheimer disease","volume":"9","author":"Krstic","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"19","key":"10.1016\/j.nbd.2015.06.013_bb0125","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1038\/emboj.2010.211","article-title":"Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta42 to Abeta40 ratio","volume":"29","author":"Kuperstein","year":"2010","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0130","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0197-4580(03)00086-1","article-title":"Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42\/Abeta40 ratio and total tau","volume":"25","author":"Lewczuk","year":"2004","journal-title":"Neurobiol. Aging"},{"issue":"10","key":"10.1016\/j.nbd.2015.06.013_bb0135","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1112","article-title":"Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation","volume":"10","author":"Lleo","year":"2004","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0140","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/archneur.58.3.392","article-title":"Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid","volume":"58","author":"Lovell","year":"2001","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2015.06.013_bb0145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.arr.2009.04.002","article-title":"Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment","volume":"8","author":"Mangialasche","year":"2009","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.013_bb0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","article-title":"A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide","volume":"68","author":"Mark","year":"1997","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0155","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1523\/JNEUROSCI.17-03-01046.1997","article-title":"Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation","volume":"17","author":"Mark","year":"1997","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2015.06.013_bb0160","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.23-06-02212.2003","article-title":"In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy","volume":"23","author":"McLellan","year":"2003","journal-title":"J. Neurosci."},{"issue":"19","key":"10.1016\/j.nbd.2015.06.013_bb0165","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1128\/MCB.20.19.7311-7318.2000","article-title":"Role for mitochondrial oxidants as regulators of cellular metabolism","volume":"20","author":"Nemoto","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"6779","key":"10.1016\/j.nbd.2015.06.013_bb0170","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.nbd.2015.06.013_bb0175","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1523\/JNEUROSCI.21-12-04183.2001","article-title":"Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis","volume":"21","author":"Pratico","year":"2001","journal-title":"J. Neurosci."},{"issue":"8B","key":"10.1016\/j.nbd.2015.06.013_bb0180","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/j.1582-4934.2008.00478.x","article-title":"Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule","volume":"13","author":"Reed","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.nbd.2015.06.013_bb0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2009.04.009","article-title":"Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD","volume":"1274","author":"Reed","year":"2009","journal-title":"Brain Res."},{"issue":"4665","key":"10.1016\/j.nbd.2015.06.013_bb0190","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1126\/science.6206567","article-title":"Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex","volume":"225","author":"Sajdel-Sulkowska","year":"1984","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.nbd.2015.06.013_bb0195","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1046\/j.1471-4159.1997.68052092.x","article-title":"4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease","volume":"68","author":"Sayre","year":"1997","journal-title":"J. Neurochem."},{"issue":"5927","key":"10.1016\/j.nbd.2015.06.013_bb0200","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.1171176","article-title":"gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease","volume":"324","author":"Serneels","year":"2009","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0205","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1073\/pnas.0608332104","article-title":"The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism","volume":"104","author":"Shen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.nbd.2015.06.013_bb0210","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.freeradbiomed.2011.03.023","article-title":"alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome","volume":"50","author":"Shichiri","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0215","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1046\/j.1471-4159.1997.69031161.x","article-title":"The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins","volume":"69","author":"Subramaniam","year":"1997","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.nbd.2015.06.013_bb0220","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/tx1004375","article-title":"Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione","volume":"24","author":"Subramanian","year":"2011","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.013_bb0225","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JAD-2010-1222","article-title":"Role of oxidative stress in the progression of Alzheimer's disease","volume":"19","author":"Sultana","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0230","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4161\/cbt.9.2.10583","article-title":"N-acetylcysteine, reactive oxygen species and beyond","volume":"9","author":"Sun","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.nbd.2015.06.013_bb0235","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuroscience.2011.04.035","article-title":"Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse","volume":"186","author":"Takeda","year":"2011","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0240","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/nbdi.2002.0515","article-title":"Oxidative stress increases expression and activity of BACE in NT2 neurons","volume":"10","author":"Tamagno","year":"2002","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.013_bb0245","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1471-4159.2004.02895.x","article-title":"Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways","volume":"92","author":"Tamagno","year":"2005","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.nbd.2015.06.013_bb0250","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0163-7827(03)00014-6","article-title":"4-Hydroxy-2-nonenal: a product and mediator of oxidative stress","volume":"42","author":"Uchida","year":"2003","journal-title":"Prog. Lipid Res."},{"issue":"11","key":"10.1016\/j.nbd.2015.06.013_bb0260","doi-asserted-by":"crossref","first-page":"e7893","DOI":"10.1371\/journal.pone.0007893","article-title":"Allosteric modulation of PS1\/gamma-secretase conformation correlates with amyloid beta(42\/40) ratio","volume":"4","author":"Uemura","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.06.013_bb0255","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ncomms1129","article-title":"Substrate docking to gamma-secretase allows access of gamma-secretase modulators to an allosteric site","volume":"1","author":"Uemura","year":"2010","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0265","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00401-012-1065-6","article-title":"Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease","volume":"125","author":"Wahlster","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0270","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1073\/pnas.0509822102","article-title":"Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.nbd.2015.06.013_bb0275","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neurobiolaging.2005.06.004","article-title":"Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease","volume":"27","author":"Williams","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.nbd.2015.06.013_bb0280","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2006.04404.x","article-title":"Amyloid beta peptide ratio 42\/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load","volume":"101","author":"Wiltfang","year":"2007","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.013_bb0285","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/sj.embor.7400896","article-title":"When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42\/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease","volume":"8","author":"Wolfe","year":"2007","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.nbd.2015.06.013_bb0290","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.neuron.2015.02.010","article-title":"Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease","volume":"85","author":"Xia","year":"2015","journal-title":"Neuron"},{"issue":"19","key":"10.1016\/j.nbd.2015.06.013_bb0295","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.1073\/pnas.1217938110","article-title":"Rapid cell death is preceded by amyloid plaque-mediated oxidative stress","volume":"110","author":"Xie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115002314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115002314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:21:57Z","timestamp":1566904917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115002314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":59,"alternative-id":["S0969996115002314"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.06.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress and lipid peroxidation are upstream of amyloid pathology","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}