{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:49:40Z","timestamp":1778546980776,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Operational Infrastructure Support Grant"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.nbd.2015.06.016","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T23:34:41Z","timestamp":1435188881000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way"],"prefix":"10.1016","volume":"81","author":[{"given":"He","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veer B.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Adlard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.nbd.2015.06.016_bb0110","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1039\/C4CS00138A","article-title":"Biological metals and metal-targeting compounds in major neurodegenerative diseases","volume":"43","author":"Barnham","year":"2014","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10534-009-9277-5","article-title":"Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability","volume":"23","author":"Baum","year":"2010","journal-title":"Biometals"},{"issue":"3","key":"10.1016\/j.nbd.2015.06.016_bb0285","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1194\/jlr.R300017-JLR200","article-title":"Functions of lipoprotein receptors in neurons","volume":"45","author":"Beffert","year":"2004","journal-title":"J. Lipid Res."},{"issue":"11","key":"10.1016\/j.nbd.2015.06.016_bb0115","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.122249699","article-title":"The galvanization of beta-amyloid in Alzheimer's disease","volume":"99","author":"Bush","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/JAD-2008-15208","article-title":"Drug development based on the metals hypothesis of Alzheimer's disease","volume":"15","author":"Bush","year":"2008","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.nbd.2015.06.016_bb0315","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2008-01-136820","article-title":"The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis","volume":"112","author":"Buyue","year":"2008","journal-title":"Blood"},{"issue":"89","key":"10.1016\/j.nbd.2015.06.016_bb0295","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.nbd.2015.06.016_bb0265","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1011179426420","article-title":"Immunolocalization of plasma kallikrein in human brain","volume":"15","author":"Cerf","year":"2000","journal-title":"Metab. Brain Dis."},{"issue":"5123","key":"10.1016\/j.nbd.2015.06.016_bb0010","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat. Genet."},{"issue":"20","key":"10.1016\/j.nbd.2015.06.016_bb0245","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1093\/hmg\/dds296","article-title":"Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease","volume":"21","author":"Cruchaga","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.06.016_bb0280","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.brainres.2009.10.021","article-title":"Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide","volume":"1306","author":"Crutcher","year":"2010","journal-title":"Brain Res."},{"issue":"26","key":"10.1016\/j.nbd.2015.06.016_bb0175","doi-asserted-by":"crossref","first-page":"19439","DOI":"10.1074\/jbc.C000165200","article-title":"Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc","volume":"275","author":"Cuajungco","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0080","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neurobiolaging.2009.02.006","article-title":"Isoform-specific proteolysis of apolipoprotein-E in the brain","volume":"32","author":"Elliott","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"16","key":"10.1016\/j.nbd.2015.06.016_bb0215","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"23","key":"10.1016\/j.nbd.2015.06.016_bb0025","doi-asserted-by":"crossref","first-page":"8913","DOI":"10.1073\/pnas.1207022109","article-title":"Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease","volume":"109","author":"Frieden","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"27","key":"10.1016\/j.nbd.2015.06.016_bb0220","doi-asserted-by":"crossref","first-page":"25754","DOI":"10.1074\/jbc.M502143200","article-title":"The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice","volume":"280","author":"Fryer","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.nbd.2015.06.016_bb0125","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1365-2362.1999.00471.x","article-title":"Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers","volume":"29","author":"Gonzalez","year":"1999","journal-title":"Eur. J. Clin. Investig."},{"issue":"8","key":"10.1016\/j.nbd.2015.06.016_bb0320","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1515\/BC.2006.139","article-title":"Heparin modulation of human plasma kallikrein on different substrates and inhibitors","volume":"387","author":"Gozzo","year":"2006","journal-title":"Biol. Chem."},{"issue":"12","key":"10.1016\/j.nbd.2015.06.016_bb0055","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1212\/WNL.0b013e318211c352","article-title":"Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging","volume":"76","author":"Gupta","year":"2011","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.nbd.2015.06.016_bb0300","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamaneurol.2013.396","article-title":"Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial","volume":"70","author":"Hanson","year":"2013","journal-title":"JAMA Neurol."},{"issue":"19","key":"10.1016\/j.nbd.2015.06.016_bb0090","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.1434398100","article-title":"Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice","volume":"100","author":"Harris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0290","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2010.09.001","article-title":"Apolipoprotein E: from lipid transport to neurobiology","volume":"50","author":"Hauser","year":"2011","journal-title":"Prog. Lipid Res."},{"issue":"39","key":"10.1016\/j.nbd.2015.06.016_bb0230","doi-asserted-by":"crossref","first-page":"41197","DOI":"10.1074\/jbc.M407962200","article-title":"Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain","volume":"279","author":"Hirsch-Reinshagen","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"Pt A","key":"10.1016\/j.nbd.2015.06.016_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases","volume":"72","author":"Huang","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"2 Suppl. 1","key":"10.1016\/j.nbd.2015.06.016_bb0020","first-page":"S79","article-title":"Apolipoprotein E and Alzheimer disease","volume":"66","author":"Huang","year":"2006","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.nbd.2015.06.016_bb0040","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.molmed.2010.04.004","article-title":"Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease","volume":"16","author":"Huang","year":"2010","journal-title":"Trends Mol. Med."},{"issue":"6","key":"10.1016\/j.nbd.2015.06.016_bb0100","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"issue":"5S Suppl.","key":"10.1016\/j.nbd.2015.06.016_bb0150","doi-asserted-by":"crossref","first-page":"1488S","DOI":"10.1093\/jn\/130.5.1488S","article-title":"Alzheimer's disease, beta-amyloid protein and zinc","volume":"130","author":"Huang","year":"2000","journal-title":"J. Nutr."},{"issue":"15","key":"10.1016\/j.nbd.2015.06.016_bb0275","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1073\/pnas.151254698","article-title":"Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons","volume":"98","author":"Huang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"212","key":"10.1016\/j.nbd.2015.06.016_bb0065","doi-asserted-by":"crossref","first-page":"212ra161","DOI":"10.1126\/scitranslmed.3007000","article-title":"Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain","volume":"5","author":"Hudry","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2015.06.016_bb0325","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/jth.12252","article-title":"Thrombin inhibition by the serpins","volume":"11","author":"Huntington","year":"2013","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.nbd.2015.06.016_bb0165","doi-asserted-by":"crossref","first-page":"11995","DOI":"10.1074\/jbc.M403172200","article-title":"Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases","volume":"280","author":"Hwang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0145","doi-asserted-by":"crossref","first-page":"e14586","DOI":"10.1371\/journal.pone.0014586","article-title":"Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-beta in human Alzheimer brain","volume":"6","author":"Jones","year":"2011","journal-title":"PLoS One"},{"issue":"26","key":"10.1016\/j.nbd.2015.06.016_bb0035","doi-asserted-by":"crossref","first-page":"14231","DOI":"10.1073\/pnas.94.26.14231","article-title":"Classification of mononuclear zinc metal sites in protein structures","volume":"94","author":"Karlin","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.nbd.2015.06.016_bb0190","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s10534-010-9354-9","article-title":"Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain","volume":"23","author":"Lee","year":"2010","journal-title":"Biometals"},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0200","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0240","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuron.2007.08.008","article-title":"Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1","volume":"56","author":"Liu","year":"2007","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.nbd.2015.06.016_bb0270","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12975-010-0039-z","article-title":"Proteomic identification of novel plasma kallikrein substrates in the astrocyte secretome","volume":"1","author":"Liu","year":"2010","journal-title":"Transl. Stroke Res."},{"issue":"9","key":"10.1016\/j.nbd.2015.06.016_bb0305","doi-asserted-by":"crossref","first-page":"R903","DOI":"10.1152\/ajpregu.00219.2012","article-title":"Apolipoprotein E does not cross the blood\u2013cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice","volume":"303","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.nbd.2015.06.016_bb0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-0404.2006.00679.x","article-title":"Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology","volume":"185","author":"Mahley","year":"2006","journal-title":"Acta Neurol. Scand. Suppl."},{"issue":"4852","key":"10.1016\/j.nbd.2015.06.016_bb0005","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.nbd.2015.06.016_bb0210","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-014-1266-2","article-title":"Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls","volume":"127","author":"Martinez-Morillo","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/JMN:24:1:073","article-title":"Progress toward identification of protease activity involved in proteolysis of apolipoprotein e in human brain","volume":"24","author":"Marques","year":"2004","journal-title":"J. Mol. Neurosci."},{"issue":"15-17","key":"10.1016\/j.nbd.2015.06.016_bb0260","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1097\/00001756-199611040-00025","article-title":"A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity","volume":"7","author":"Marques","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2015.06.016_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnagi.2014.00077","article-title":"The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease","volume":"6","author":"McCord","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng0996-55","article-title":"Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides","volume":"14","author":"Miyata","year":"1996","journal-title":"Nat. Genet."},{"issue":"38","key":"10.1016\/j.nbd.2015.06.016_bb0045","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1021\/bi000099m","article-title":"Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain","volume":"39","author":"Morrow","year":"2000","journal-title":"Biochemistry"},{"issue":"52","key":"10.1016\/j.nbd.2015.06.016_bb0050","doi-asserted-by":"crossref","first-page":"50380","DOI":"10.1074\/jbc.M204898200","article-title":"Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease","volume":"277","author":"Morrow","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2015.06.016_bb0180","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12263-013-0379-x","article-title":"Zinc and the aging brain","volume":"9","author":"Nuttall","year":"2014","journal-title":"Genes Nutr."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0310","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ana.24326","article-title":"Plasma levels of apolipoprotein E and risk of dementia in the general population","volume":"77","author":"Rasmussen","year":"2015","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.nbd.2015.06.016_bb0205","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1074\/jbc.275.12.8564","article-title":"Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis","volume":"275","author":"Rensen","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.nbd.2015.06.016_bb0070","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1523\/JNEUROSCI.1972-08.2008","article-title":"Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels","volume":"28","author":"Riddell","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.016_bb0095","doi-asserted-by":"crossref","first-page":"e93120","DOI":"10.1371\/journal.pone.0093120","article-title":"Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease","volume":"9","author":"Tamboli","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(01)00476-7","article-title":"New frontiers in Alzheimer's disease genetics","volume":"32","author":"Tanzi","year":"2001","journal-title":"Neuron"},{"issue":"15","key":"10.1016\/j.nbd.2015.06.016_bb0135","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1523\/JNEUROSCI.17-15-05678.1997","article-title":"Neurotoxicity of the 22kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated","volume":"17","author":"Tolar","year":"1997","journal-title":"J. Neurosci."},{"issue":"16","key":"10.1016\/j.nbd.2015.06.016_bb0255","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1523\/JNEUROSCI.19-16-07100.1999","article-title":"Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity","volume":"19","author":"Tolar","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.06.016_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-8-13","article-title":"In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis","volume":"8","author":"Ulrich","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"39","key":"10.1016\/j.nbd.2015.06.016_bb0225","doi-asserted-by":"crossref","first-page":"40987","DOI":"10.1074\/jbc.M407963200","article-title":"ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE","volume":"279","author":"Wahrle","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0235","first-page":"671","article-title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","volume":"118","author":"Wahrle","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.nbd.2015.06.016_bb0060","doi-asserted-by":"crossref","first-page":"e89041","DOI":"10.1371\/journal.pone.0089041","article-title":"Meta-analysis of peripheral blood apolipoprotein E levels in Alzheimer's disease","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.06.016_bb0140","article-title":"Chymotrypsin","volume":"1009\u20131012","author":"Wirnt","year":"1974","journal-title":"Methods Enzym. Anal."},{"key":"10.1016\/j.nbd.2015.06.016_bb0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fnagi.2014.00121","article-title":"Interactions of metals and Apolipoprotein E in Alzheimer's disease","volume":"6","author":"Xu","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2015.06.016_bb0155","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neurobiolaging.2012.07.003","article-title":"Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation","volume":"34","author":"Xiong","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.nbd.2015.06.016_bb0250","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neuroscience.2006.08.019","article-title":"Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease","volume":"143","author":"Zhou","year":"2006","journal-title":"Neuroscience"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999611500234X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999611500234X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:09:21Z","timestamp":1760850561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999611500234X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":65,"alternative-id":["S096999611500234X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.06.016","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}