{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:37:53Z","timestamp":1790267873316,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\/NINDS","award":["2R01NS051419-05"],"award-info":[{"award-number":["2R01NS051419-05"]}]},{"name":"NIH\/NINDS","award":["1R01NS062055-01"],"award-info":[{"award-number":["1R01NS062055-01"]}]},{"name":"NIH\/NINDS","award":["1R01NS084486-01"],"award-info":[{"award-number":["1R01NS084486-01"]}]},{"DOI":"10.13039\/100004952","name":"MDA","doi-asserted-by":"publisher","award":["255345"],"award-info":[{"award-number":["255345"]}],"id":[{"id":"10.13039\/100004952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.nbd.2015.08.004","type":"journal-article","created":{"date-parts":[[2015,8,15]],"date-time":"2015-08-15T17:31:35Z","timestamp":1439659895000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"90","author":[{"given":"Giovanni","family":"Manfredi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Kawamata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.08.004_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2012.04.005","article-title":"Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis","volume":"33","author":"Abramzon","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.08.004_bb0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nbd.2008.08.010","article-title":"Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane","volume":"32","author":"Ahtoniemi","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.08.004_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10048-014-0421-1","article-title":"Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy","volume":"16","author":"Ajroud-Driss","year":"2015","journal-title":"Neurogenetics"},{"key":"10.1016\/j.nbd.2015.08.004_bb0025","first-page":"133","article-title":"Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease","volume":"59","author":"Albers","year":"2000","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.nbd.2015.08.004_bb0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/ana.22534","article-title":"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis","volume":"70","author":"Al-Saif","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0030","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1038\/emboj.2012.202","article-title":"Upregulated function of mitochondria-associated ER membranes in Alzheimer disease","volume":"31","author":"Area-Gomez","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2015.08.004_bb0035","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/nm.3735","article-title":"Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity","volume":"20","author":"Arruda","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2015.08.004_bb0040","doi-asserted-by":"crossref","first-page":"30152","DOI":"10.1074\/jbc.M603393200","article-title":"Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1","volume":"281","author":"Atkin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0045","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.nbd.2008.02.009","article-title":"Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis","volume":"30","author":"Atkin","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.08.004_bb0050","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/brain\/awu138","article-title":"A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement","volume":"137","author":"Bannwarth","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1570-9639(02)00439-9","article-title":"IP3-dependent calcium-induced calcium release mediates bidirectional calcium waves in neurones: functional implications for synaptic plasticity","volume":"1600","author":"Barbara","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.08.004_bb0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature10234","article-title":"Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter","volume":"476","author":"Baughman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.08.004_bb0070","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1523\/JNEUROSCI.5431-11.2012","article-title":"Reduced calreticulin levels link endoplasmic reticulum stress and Fas-triggered cell death in motoneurons vulnerable to ALS","volume":"32","author":"Bernard-Marissal","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0065","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/brain\/awv008","article-title":"Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration","volume":"138","author":"Bernard-Marissal","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0075","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4161\/auto.28981","article-title":"ER-mitochondria contacts as sites of mitophagosome formation","volume":"10","author":"Bockler","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2015.08.004_bb0080","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.devcel.2014.01.012","article-title":"Mitochondrial ER contacts are crucial for mitophagy in yeast","volume":"28","author":"Bockler","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0085","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1046\/j.1471-4159.1998.71031321.x","article-title":"Elevated \u201chydroxyl radical\u201d generation in vivo in an animal model of amyotrophic lateral sclerosis","volume":"71","author":"Bogdanov","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0090","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.91.17.8292","article-title":"Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity","volume":"91","author":"Borchelt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.004_bb0095","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1242\/jcs.080762","article-title":"Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress","volume":"124","author":"Bravo","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0100","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2010.06.007","article-title":"Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria","volume":"142","author":"Cardenas","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0105","first-page":"41","article-title":"Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS","volume":"9","author":"Carri","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0110","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1002\/anie.201200321","article-title":"In vivo tagging and characterization of S-glutathionylated proteins by a chemoenzymatic method","volume":"51","author":"Chiang","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.nbd.2015.08.004_bb0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.08.004_bb0120","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pneurobio.2011.06.003","article-title":"Mitochondrial dysfunction in ALS","volume":"97","author":"Cozzolino","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0125","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200604016","article-title":"Structural and functional features and significance of the physical linkage between ER and mitochondria","volume":"174","author":"Csordas","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0130","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ana.10312","article-title":"Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis","volume":"52","author":"Cutler","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0135","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1471-4159.2006.03619.x","article-title":"Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu\/Zn-superoxide dismutase mutant mice","volume":"96","author":"Damiano","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0140","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"De Stefani","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.08.004_bb0145","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/hmg\/ddr559","article-title":"VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis","volume":"21","author":"De Vos","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0150","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0155","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.1074\/jbc.M109.096040","article-title":"Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling","volume":"285","author":"Eckenrode","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0079-6123(08)63214-8","article-title":"Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture","volume":"118","author":"Estevez","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.004_bb0165","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.neurobiolaging.2012.02.009","article-title":"Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase","volume":"33","author":"Farg","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"551","key":"10.1016\/j.nbd.2015.08.004_bb0170","first-page":"e1","article-title":"No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort","volume":"32","author":"Fernandez-Santiago","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.08.004_bb0175","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1046\/j.1471-4159.1997.69052064.x","article-title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","volume":"69","author":"Ferrante","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nn.3903","article-title":"Marinesco\u2013Sjogren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS","volume":"18","author":"Filezac de L'Etang","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0185","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1093\/hmg\/ddt118","article-title":"Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis","volume":"22","author":"Forrest","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0190","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial form and function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.08.004_bb0195","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbrc.2011.12.022","article-title":"The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria","volume":"417","author":"Fujimoto","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2015.08.004_bb0200","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jphs.2014.12.012","article-title":"The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis","volume":"127","author":"Fukunaga","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0205","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.gene.2015.04.035","article-title":"Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients","volume":"566","author":"Gonzalez-Perez","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.nbd.2015.08.004_bb0210","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ceca.2009.12.002","article-title":"Calcium dysregulation in amyotrophic lateral sclerosis","volume":"47","author":"Grosskreutz","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.nbd.2015.08.004_bb0215","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jnc.12320","article-title":"Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons","volume":"126","author":"Gruszczynska-Biegala","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0220","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","article-title":"Alpha-Synuclein is localized to mitochondria-associated ER membranes","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0225","doi-asserted-by":"crossref","first-page":"797914","DOI":"10.1155\/2013\/797914","article-title":"The role of S-nitrosylation and S-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration","volume":"2013","author":"Halloran","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0230","first-page":"659","article-title":"SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model","volume":"118","author":"Harraz","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.004_bb0235","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/ars.2012.4928","article-title":"S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease","volume":"19","author":"Haun","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2015.08.004_bb0240","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.201004152","article-title":"S-glutathionylation activates STIM1 and alters mitochondrial homeostasis","volume":"190","author":"Hawkins","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0245","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0250","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.molcel.2004.08.025","article-title":"Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death","volume":"15","author":"Haynes","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0255","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1073\/pnas.1300677110","article-title":"Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models","volume":"110","author":"Hedskog","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.004_bb0260","doi-asserted-by":"crossref","first-page":"15826","DOI":"10.1523\/JNEUROSCI.1965-11.2011","article-title":"In vivo pathogenic role of mutant SOD1 localized in the mitochondrial intermembrane space","volume":"31","author":"Igoudjil","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0265","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0270","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2010.07.019","article-title":"Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS","volume":"67","author":"Israelson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0275","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.neuroscience.2006.07.034","article-title":"Temporospatial coupling of networked synaptic activation of AMPA-type glutamate receptor channels and calcium transients in cultured motoneurons","volume":"142","author":"Jahn","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.08.004_bb0280","doi-asserted-by":"crossref","first-page":"9842","DOI":"10.1016\/S0021-9258(17)36960-0","article-title":"Assembly of Bcl-2 into microsomal and outer mitochondrial membranes","volume":"269","author":"Janiak","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0285","doi-asserted-by":"crossref","first-page":"40813","DOI":"10.1074\/jbc.M509255200","article-title":"Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells","volume":"280","author":"Janiszewski","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0290","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fncel.2014.00402","article-title":"ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase","volume":"8","author":"Jaronen","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0295","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12035-013-8562-z","article-title":"Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis","volume":"49","author":"Jeon","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0305","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2010.11.036","article-title":"Exome sequencing reveals VCP mutations as a cause of familial ALS","volume":"68","author":"Johnson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0300","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awu265","article-title":"Mutations in the CHCHD10 gene are a common cause of familial amyotrophic lateral sclerosis","volume":"137","author":"Johnson","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0310","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nn.3688","article-title":"Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis","volume":"17","author":"Johnson","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0315","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/emboj.2011.386","article-title":"Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function","volume":"31","author":"Kakizawa","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2015.08.004_bb0320","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12035-009-8054-3","article-title":"ER stress and unfolded protein response in amyotrophic lateral sclerosis","volume":"39","author":"Kanekura","year":"2009","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0325","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1093\/hmg\/ddn226","article-title":"Different regulation of wild-type and mutant Cu, Zn superoxide dismutase localization in mammalian mitochondria","volume":"17","author":"Kawamata","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0330","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.2689-13.2014","article-title":"Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis","volume":"34","author":"Kawamata","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0335","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1093\/brain\/aws208","article-title":"The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis","volume":"135","author":"Kim","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0340","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuron.2013.02.029","article-title":"VCP is essential for mitochondrial quality control by PINK1\/Parkin and this function is impaired by VCP mutations","volume":"78","author":"Kim","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0345","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.stem.2014.03.004","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","volume":"14","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0350","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1242\/jcs.058636","article-title":"ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology","volume":"123","author":"Kornmann","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0355","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2013.01.001","article-title":"Association studies indicate that protein disulfide isomerase is a risk factor in amyotrophic lateral sclerosis","volume":"58","author":"Kwok","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2015.08.004_bb0360","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/ars.2007.2011","article-title":"Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases","volume":"10","author":"Laurindo","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2015.08.004_bb0365","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.expneurol.2013.03.027","article-title":"Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons","volume":"247","author":"Lautenschlager","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0370","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1093\/hmg\/ddp421","article-title":"Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities","volume":"18","author":"Magrane","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0375","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainres.2014.10.009","article-title":"Genetic causes of amyotrophic lateral sclerosis: new genetic analysis methodologies entailing new opportunities and challenges","volume":"1607","author":"Marangi","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.004_bb0380","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1172\/JCI31265","article-title":"Redox modifier genes in amyotrophic lateral sclerosis in mice","volume":"117","author":"Marden","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.004_bb0385","doi-asserted-by":"crossref","first-page":"29626","DOI":"10.1074\/jbc.M203065200","article-title":"Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice","volume":"277","author":"Mattiazzi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0390","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj1900095","article-title":"Role of calcium ions in the regulation of intramitochondrial metabolism. Properties of the Ca2+-sensitive dehydrogenases within intact uncoupled mitochondria from the white and brown adipose tissue of the rat","volume":"190","author":"McCormack","year":"1980","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2015.08.004_bb0395","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1750-1326-6-34","article-title":"Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation","volume":"6","author":"Meng","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2015.08.004_bb0400","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/hmg\/dds011","article-title":"Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria","volume":"21","author":"Morotz","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0405","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/hmg\/ddt594","article-title":"The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control","volume":"23","author":"Moustaqim-Barrette","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0410","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0415","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1640108","article-title":"ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1","volume":"22","author":"Nishitoh","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2015.08.004_bb0420","doi-asserted-by":"crossref","first-page":"41332","DOI":"10.1074\/jbc.M509700200","article-title":"ATPase activity of p97\/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif","volume":"280","author":"Noguchi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0425","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biochi.2014.01.015","article-title":"Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase pi isoform 2 (GSTpi2) in thymoma cells","volume":"101","author":"Osman","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.nbd.2015.08.004_bb0430","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2014.09.065","article-title":"Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control","volume":"1607","author":"Palomo","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.004_bb0435","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1523\/JNEUROSCI.1119-12.2013","article-title":"Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis","volume":"33","author":"Parone","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0440","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2004.06.021","article-title":"Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria","volume":"43","author":"Pasinelli","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0445","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/hmg\/ddq202","article-title":"ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2","volume":"19","author":"Pedrini","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0450","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1091\/mbc.E08-05-0498","article-title":"Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport","volume":"19","author":"Peretti","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2015.08.004_bb0455","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/hmg\/ddt008","article-title":"Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis","volume":"22","author":"Prause","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0460","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1460-9568.2012.08008.x","article-title":"The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis","volume":"35","author":"Prell","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0465","doi-asserted-by":"crossref","first-page":"293893","DOI":"10.1155\/2013\/293893","article-title":"Mitochondrial fusion proteins and human diseases","volume":"2013","author":"Ranieri","year":"2013","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.nbd.2015.08.004_bb0470","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ceca.2011.04.007","article-title":"Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis","volume":"50","author":"Rasola","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.nbd.2015.08.004_bb0475","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2015.08.004_bb0480","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.8235595","article-title":"Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria","volume":"262","author":"Rizzuto","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.08.004_bb0485","doi-asserted-by":"crossref","first-page":"re1","DOI":"10.1126\/stke.2152004re1","article-title":"Flirting in little space: the ER\/mitochondria Ca2+ liaison","volume":"2004","author":"Rizzuto","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.nbd.2015.08.004_bb0490","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.08.004_bb0495","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.0608354","article-title":"Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages","volume":"86","author":"Santos","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0500","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/NEN.0b013e3181d44992","article-title":"Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis","volume":"69","author":"Sasaki","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.004_bb0505","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2297","article-title":"A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice","volume":"12","author":"Saxena","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0515","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1073\/pnas.0610923104","article-title":"Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology","volume":"104","author":"Son","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.nbd.2015.08.004_bb0510","doi-asserted-by":"crossref","first-page":"12267","DOI":"10.1074\/jbc.M708523200","article-title":"Isolated cytochrome c oxidase deficiency in G93A SOD1 mice over-expressing CCS protein","volume":"283","author":"Son","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0520","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2012.06.050","article-title":"Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G(9)(3)A) mice","volume":"220","author":"Staats","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.08.004_bb0525","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1038\/ncomms4996","article-title":"ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS\/FTD-associated TDP-43","volume":"5","author":"Stoica","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2015.08.004_bb0530","doi-asserted-by":"crossref","first-page":"22961","DOI":"10.1074\/jbc.M113.480228","article-title":"Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor\/Ca2+ release channel (RyR1): sites and nature of oxidative modification","volume":"288","author":"Sun","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.004_bb0535","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1007\/s00018-013-1385-2","article-title":"Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells","volume":"70","author":"Sundaramoorthy","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0540","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fncel.2014.00147","article-title":"The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis","volume":"8","author":"Tadic","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0545","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.bbadis.2014.02.009","article-title":"Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis","volume":"1842","author":"Tan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.08.004_bb0550","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1523\/JNEUROSCI.2661-07.2007","article-title":"Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates","volume":"27","author":"Teuling","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0560","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nn1603","article-title":"Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis","volume":"9","author":"Urushitani","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0555","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1096\/fj.07-092783","article-title":"The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS","volume":"22","author":"Urushitani","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2015.08.004_bb0565","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng.2007.52","article-title":"Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis","volume":"40","author":"van Es","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0570","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.bbamcr.2014.03.009","article-title":"New functions of mitochondria associated membranes in cellular signaling","volume":"1843","author":"van Vliet","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.08.004_bb0575","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbalip.2013.11.014","article-title":"MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond","volume":"1841","author":"Vance","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.08.004_bb0580","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1523\/JNEUROSCI.4385-04.2005","article-title":"Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice","volume":"25","author":"Vijayvergiya","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.004_bb0585","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.243","article-title":"Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances","volume":"5","author":"Vollrath","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2015.08.004_bb0590","doi-asserted-by":"crossref","first-page":"317340","DOI":"10.1155\/2011\/317340","article-title":"Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis","volume":"2011","author":"Walker","year":"2011","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.nbd.2015.08.004_bb0595","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/brain\/awp267","article-title":"Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis","volume":"133","author":"Walker","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.004_bb0600","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081170","article-title":"ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation","volume":"8","author":"Walker","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.08.004_bb0605","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/hmg\/ddq546","article-title":"The unfolded protein response in familial amyotrophic lateral sclerosis","volume":"20","author":"Wang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.08.004_bb0610","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2015.08.004_bb0615","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1073\/pnas.0404161101","article-title":"Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity","volume":"101","author":"Yao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.004_bb0620","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00401-014-1336-5","article-title":"Aggregation-prone c9FTD\/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress","volume":"128","author":"Zhang","year":"2014","journal-title":"Acta Neuropathol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:52:43Z","timestamp":1653054763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115300267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":124,"alternative-id":["S0969996115300267"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.004","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}