{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:58:15Z","timestamp":1790420295100,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS052741"],"award-info":[{"award-number":["5R01NS052741"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001214","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["PP2009"],"award-info":[{"award-number":["PP2009"]}],"id":[{"id":"10.13039\/100001214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001214","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["CA1060A11"],"award-info":[{"award-number":["CA1060A11"]}],"id":[{"id":"10.13039\/100001214","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mayo Clinic Center for Regenerative Medicine"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.nbd.2015.08.021","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:01:56Z","timestamp":1440460916000},"page":"75-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury"],"prefix":"10.1016","volume":"83","author":[{"given":"Maja","family":"Radulovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyesook","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-635X","authenticated-orcid":false,"given":"Karim","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Fehlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel A.","family":"Scarisbrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.08.021_bb0005","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0079-6123(01)32106-4","article-title":"Chondroitin sulphate proteoglycans: inhibitory components of the glial scar","volume":"132","author":"Asher","year":"2001","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.021_bb0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2015.08.021_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.expneurol.2014.04.006","article-title":"Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury","volume":"258","author":"Bastien","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0020","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1096\/fj.03-1212fje","article-title":"Targeting kallikrein 6-proteolysis attenuates CNS inflammatory disease","volume":"19","author":"Blaber","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2015.08.021_bb0025","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.08.021_bb0030","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/glia.22534","article-title":"Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy","volume":"61","author":"Burda","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2015.08.021_bb0035","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1523\/JNEUROSCI.2245-02.2004","article-title":"Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice","volume":"24","author":"Cafferty","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0040","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.17.11.6508","article-title":"STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation","volume":"17","author":"Chung","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0045","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbr.2006.11.042","article-title":"Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury","volume":"177","author":"Cummings","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.021_bb0050","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.08.021_bb0055","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1083\/jcb.148.6.1267","article-title":"beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1\/2","volume":"148","author":"DeFea","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0060","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.5007-09.2010","article-title":"SOCS3-mediated blockade of JAK\/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury","volume":"30","author":"Dominguez","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1172\/JCI16913","article-title":"Essential role for proteinase-activated receptor-2 in arthritis","volume":"111","author":"Ferrell","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.021_bb0070","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1476-5381.2011.01293.x","article-title":"Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2","volume":"163","author":"Gan","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0075","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury","volume":"28","author":"Herrmann","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0080","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.jcbfm.9600021","article-title":"Deficiency of PAR-2 gene increases acute focal ischemic brain injury","volume":"25","author":"Jin","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2015.08.021_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/08977150252806956","article-title":"Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery","volume":"19","author":"Joshi","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2015.08.021_bb0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/08977150252806947","article-title":"Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology","volume":"19","author":"Joshi","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2015.08.021_bb0095","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI25141","article-title":"IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis","volume":"115","author":"Kaplin","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.021_bb0100","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.3111-09.2010","article-title":"Synergistic effects of transplanted adult neural stem\/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord","volume":"30","author":"Karimi-Abdolrezaee","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1254\/jjp.88.77","article-title":"Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear","volume":"88","author":"Kawagoe","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0110","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1073\/pnas.0500607102","article-title":"On the utility of pooling biological samples in microarray experiments","volume":"102","author":"Kendziorski","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.021_bb0115","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.1523\/JNEUROSCI.21-17-06617.2001","article-title":"Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury","volume":"21","author":"Kim","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0120","doi-asserted-by":"crossref","first-page":"40594","DOI":"10.1074\/jbc.M203885200","article-title":"JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1098-1136(199703)19:3<227::AID-GLIA5>3.0.CO;2-W","article-title":"Impaired neuroglial activation in interleukin-6 deficient mice","volume":"19","author":"Klein","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2015.08.021_bb0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0006-8993(97)00381-8","article-title":"Effects of pro-inflammatory cytokines in experimental spinal cord injury","volume":"762","author":"Klusman","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.021_bb0135","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.4049\/jimmunol.0900904","article-title":"Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2","volume":"183","author":"Kouzaki","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0140","doi-asserted-by":"crossref","first-page":"14494","DOI":"10.1523\/JNEUROSCI.2807-07.2007","article-title":"Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans","volume":"27","author":"Laabs","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0145","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/embor.2013.117","article-title":"STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury","volume":"14","author":"Lang","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2015.08.021_bb0150","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1471-4159.2001.00595.x","article-title":"Intermediate filaments regulate astrocyte motility","volume":"79","author":"Lepekhin","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","article-title":"Regulation of immune responses by TGF-beta","volume":"16","author":"Letterio","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2013.01.003","article-title":"Protein kinase C gamma (PKCgamma) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE)","volume":"256","author":"Lieu","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0165","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3892\/etm.2013.1371","article-title":"MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury","volume":"7","author":"Lin","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.nbd.2015.08.021_bb0170","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1471-4159.2010.06747.x","article-title":"Inhibition of extracellular signal-regulated kinases 1\/2 provides neuroprotection in spinal cord ischemia\/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms","volume":"114","author":"Lu","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0175","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.brainresrev.2007.08.002","article-title":"Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection","volume":"56","author":"Luo","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.nbd.2015.08.021_bb0180","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/mol.109.062018","article-title":"PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology","volume":"77","author":"McCoy","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0185","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cne.902990204","article-title":"Immunocytochemical localization of protein kinase C subspecies in the rat spinal cord: light and electron microscopic study","volume":"299","author":"Mori","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0190","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.4049\/jimmunol.174.11.7320","article-title":"Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection","volume":"174","author":"Noorbakhsh","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0195","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1084\/jem.20052148","article-title":"Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"203","author":"Noorbakhsh","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2015.08.021_bb0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jnr.20044","article-title":"Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury","volume":"76","author":"Okada","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2015.08.021_bb0205","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm1425","article-title":"Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury","volume":"12","author":"Okada","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2015.08.021_bb0210","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1515\/hsz-2014-0141","article-title":"Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response","volume":"395","author":"Panos","year":"2014","journal-title":"Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0220","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/path.1645","article-title":"Astrocyte intermediate filaments in CNS pathologies and regeneration","volume":"204","author":"Pekny","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0215","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1023\/A:1022572304626","article-title":"The impact of genetic removal of GFAP and\/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes","volume":"24","author":"Pekny","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2015.08.021_bb0225","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","article-title":"Interleukin-10 and related cytokines and receptors","volume":"22","author":"Pestka","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0230","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/NEN.0000000000000007","article-title":"Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration","volume":"72","author":"Radulovic","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrd3615","article-title":"Targeting proteinase-activated receptors: therapeutic potential and challenges","volume":"11","author":"Ramachandran","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2015.08.021_bb0275","series-title":"Handbook of Proteolytic Enzymes","first-page":"2780","article-title":"Kallikrein-related peptidase 6","author":"Scarisbrick","year":"2012"},{"key":"10.1016\/j.nbd.2015.08.021_bb0240","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1523\/JNEUROSCI.17-21-08156.1997","article-title":"Nervous system specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury","volume":"17","author":"Scarisbrick","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0245","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1523\/JNEUROSCI.19-18-07757.1999","article-title":"Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4\/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid","volume":"19","author":"Scarisbrick","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0250","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/brain\/awf142","article-title":"Activity of a newly identified serine protease in CNS demyelination","volume":"125","author":"Scarisbrick","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.021_bb0255","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jneuroim.2006.05.022","article-title":"Potential scope of action of tissue kallikreins in CNS immune-mediated disease","volume":"178","author":"Scarisbrick","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0260","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1460-9568.2006.05021.x","article-title":"Dynamic role of kallikrein 6 in traumatic spinal cord injury","volume":"24","author":"Scarisbrick","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0265","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1515\/BC.2008.085","article-title":"Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration","volume":"389","author":"Scarisbrick","year":"2008","journal-title":"Biol. Chem."},{"issue":"e18376","key":"10.1016\/j.nbd.2015.08.021_bb0270","article-title":"Functional role of kallikrein 6 in regulating immune cell survival","volume":"6","author":"Scarisbrick","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.08.021_bb0280","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1515\/hsz-2011-0241","article-title":"Kallikrein 6 is a novel molecular trigger of reactive astrogliosis","volume":"393","author":"Scarisbrick","year":"2012","journal-title":"Biol. Chem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0285","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1750-3639.2012.00577.x","article-title":"Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis","volume":"22","author":"Scarisbrick","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0290","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1073\/pnas.95.19.11107","article-title":"Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases","volume":"95","author":"Sengupta","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.021_bb0295","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0300","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0305","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/glia.20058","article-title":"Differential expression of neuropsin and protease M\/neurosin in oligodendrocytes after injury to the spinal cord","volume":"48","author":"Terayama","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2015.08.021_bb0310","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1471-4159.2008.05658.x","article-title":"Protease activated receptor dependent and independent signaling by Kallikreins 1 and 6 in CNS neuron and astroglial cell lines","volume":"107","author":"Vandell","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0315","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1172\/JCI21689","article-title":"A role for proteinase-activated receptor-1 in inflammatory bowel diseases","volume":"114","author":"Vergnolle","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.021_bb0320","doi-asserted-by":"crossref","first-page":"C1351","DOI":"10.1152\/ajpcell.00001.2002","article-title":"Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways","volume":"283","author":"Wang","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0325","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1745-7254.2005.00152.x","article-title":"Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury","volume":"26","author":"Wang","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.nbd.2015.08.021_bb0330","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/BJ20060732","article-title":"Proteinase-activated receptor-1 and \u22122 induce the release of chemokine GRO\/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain","volume":"401","author":"Wang","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2015.08.021_bb0335","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1523\/JNEUROSCI.2121-13.2013","article-title":"Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury","volume":"33","author":"Wanner","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0340","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1523\/JNEUROSCI.0820-04.2004","article-title":"Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration","volume":"24","author":"Wilhelmsson","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.021_bb0345","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.expneurol.2012.03.019","article-title":"IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation","volume":"236","author":"Yang","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.021_bb0350","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jnc.12293","article-title":"Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity","volume":"127","author":"Yoon","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.08.021_bb0355","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00401-011-0882-3","article-title":"Fas\/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application","volume":"122","author":"Yu","year":"2011","journal-title":"Acta Neuropathol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T18:30:07Z","timestamp":1718044207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115300413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":71,"alternative-id":["S0969996115300413"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.021","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}