{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:33:57Z","timestamp":1790012037238,"version":"4.0.1"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRA_POR\/2012\/56"],"award-info":[{"award-number":["HRA_POR\/2012\/56"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Irish Research Council, and Science Foundation Ireland","award":["12\/RC\/2272"],"award-info":[{"award-number":["12\/RC\/2272"]}]},{"name":"Irish Research Council, and Science Foundation Ireland","award":["14\/ADV\/RC2721"],"award-info":[{"award-number":["14\/ADV\/RC2721"]}]},{"name":"Irish Research Council, and Science Foundation Ireland","award":["13\/SIRG\/2014"],"award-info":[{"award-number":["13\/SIRG\/2014"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.nbd.2015.08.023","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T16:20:21Z","timestamp":1441124421000},"page":"100-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice"],"prefix":"10.1016","volume":"83","author":[{"given":"Natalia","family":"Rodriguez-Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Jimenez-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dunleavy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Henshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.08.023_bb0005","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0166-2236(02)02241-5","article-title":"Stressed-out, or in (utero)?","volume":"25","author":"Avishai-Eliner","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrn3677","article-title":"Hippocampal synaptic plasticity, spatial memory and anxiety","volume":"15","author":"Bannerman","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","article-title":"The mouse light\/dark box test","volume":"463","author":"Bourin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.08.023_bb9000","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.siny.2015.01.001","article-title":"Seizures and hypothermia: importance of electroencephalographic monitoring and considerations for treatment","volume":"20","author":"Boylan","year":"2015","journal-title":"Semin Fetal Neonatal Med."},{"key":"10.1016\/j.nbd.2015.08.023_bb0020","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1460-9568.2012.08140.x","article-title":"Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette","volume":"35","author":"Chapman","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0025","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/0024-3205(85)90478-3","article-title":"Long-term effect of postnatal hypoxia on the seizure susceptibility in rats","volume":"37","author":"Chiba","year":"1985","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(01)00171-3","article-title":"Translating developmental time across mammalian species","volume":"105","author":"Clancy","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.08.023_bb0035","doi-asserted-by":"crossref","first-page":"e57148","DOI":"10.1371\/journal.pone.0057148","article-title":"Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures","volume":"8","author":"Cleary","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2015.08.023_bb0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pediatrneurol.2004.04.010","article-title":"A new model of stroke and ischemic seizures in the immature mouse","volume":"31","author":"Comi","year":"2004","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0045","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D'Amelio","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2015.08.023_bb0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2353\/ajpath.2010.090119","article-title":"Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis","volume":"176","author":"Dunleavy","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0055","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/1531-8249(200010)48:4<632::AID-ANA10>3.0.CO;2-3","article-title":"Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus","volume":"48","author":"Dzhala","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0060","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","article-title":"NKCC1 transporter facilitates seizures in the developing brain","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2015.08.023_bb0065","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/brain\/aws337","article-title":"CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures","volume":"136","author":"Engel","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.08.023_bb0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0006-8993(97)00683-5","article-title":"Quantitative analysis of GAD65 and GAD67 immunoreactivities in somata of GABAergic neurons in the mouse hippocampus proper (CA1 and CA3 regions), with special reference to parvalbumin-containing neurons","volume":"764","author":"Fukuda","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0075","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/BF00294239","article-title":"Golgi-like demonstration of \u201cdark\u201d neurons with an argyrophil III method for experimental neuropathology","volume":"79","author":"Gallyas","year":"1990","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0080","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1542\/pir.33.9.387","article-title":"Neonatal hypoxia and seizures","volume":"33","author":"Gillam-Krakauer","year":"2012","journal-title":"Pediatr. Rev."},{"key":"10.1016\/j.nbd.2015.08.023_bb0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jpeds.2009.03.040","article-title":"Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic\u2013ischemic brain injury","volume":"155","author":"Glass","year":"2009","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2015.08.023_bb0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-3476(98)70458-5","article-title":"High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up","volume":"132","author":"Hall","year":"1998","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nbd.2015.08.023_bb0095","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/85487","article-title":"Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia\u2013ischemia","volume":"7","author":"Han","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2015.08.023_bb0100","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1474-4422(04)00881-6","article-title":"Susceptibility of immature and adult brains to seizure effects","volume":"3","author":"Haut","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-3806(99)00135-2","article-title":"Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study","volume":"118","author":"Huang","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb9005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/FBP.0000000000000118","article-title":"Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement","volume":"26","author":"Ikeda","year":"2015","journal-title":"Behav Pharmacol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0110","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0024-3205(91)90448-K","article-title":"Differential effects of perinatal hypoxia and anoxia on long term seizure susceptibility in the rat","volume":"49","author":"Jensen","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0115","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ana.410290610","article-title":"Epileptogenic effect of hypoxia in the immature rodent brain","volume":"29","author":"Jensen","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0169-328X(93)90001-6","article-title":"Differences in c-fos immunoreactivity due to age and mode of seizure induction","volume":"17","author":"Jensen","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1528-1157.1992.tb01746.x","article-title":"Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats","volume":"33","author":"Jensen","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0130","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/epi.12257","article-title":"Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079","volume":"54","author":"Jimenez-Pacheco","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0135","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/cne.21533","article-title":"Neuropathogical features of a rat model for perinatal hypoxic\u2013ischemic encephalopathy with associated epilepsy","volume":"505","author":"Kadam","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0140","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.0013-9580.2004.69103.x","article-title":"NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury","volume":"45","author":"Koh","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0145","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0883073810380915","article-title":"Clinical seizures in neonatal hypoxic\u2013ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial","volume":"26","author":"Kwon","year":"2011","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0150","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/epi.12347","article-title":"Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation","volume":"54","author":"Leonard","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0155","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2010.03.053","article-title":"Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization","volume":"141","author":"Li","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2015.08.023_bb0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.devbrainres.2005.03.007","article-title":"Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain","volume":"157","author":"Mikati","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0165","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1523\/JNEUROSCI.16-04-01337.1996","article-title":"Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death","volume":"16","author":"Morrison","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0170","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0031-9384(85)90418-4","article-title":"Perinatal hypoxia and subsequent development of seizures","volume":"35","author":"Moshe","year":"1985","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2015.08.023_bb0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2008.03.061","article-title":"Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice","volume":"1213","author":"Mouri","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0180","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/jnr.21573","article-title":"Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia\u2013ischemia","volume":"86","author":"Ness","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0185","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.22419","article-title":"Neuronal cell death in neonatal hypoxia\u2013ischemia","volume":"69","author":"Northington","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0190","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tips.2004.01.002","article-title":"Do pediatric drugs cause developing neurons to commit suicide?","volume":"25","author":"Olney","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0195","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2015.08.023_bb0200","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.nbd.2015.08.023_bb0205","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yebeh.2014.01.004","article-title":"Spike-wave discharges in adult Sprague\u2013Dawley rats and their implications for animal models of temporal lobe epilepsy","volume":"32","author":"Pearce","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2015.08.023_bb0210","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-8993(90)90024-6","article-title":"Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain","volume":"536","author":"Popovici","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0215","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1474-4422(14)70303-5","article-title":"Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1\/2 trial","volume":"14","author":"Pressler","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0220","doi-asserted-by":"crossref","first-page":"17800","DOI":"10.1523\/JNEUROSCI.6121-11.2012","article-title":"Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures","volume":"32","author":"Rakhade","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0225","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0230","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1528-1167.2011.02992.x","article-title":"Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures","volume":"52","author":"Rakhade","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0235","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/ana.21593","article-title":"A KCNQ channel opener for experimental neonatal seizures and status epilepticus","volume":"65","author":"Raol","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0240","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2013ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0245","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(92)91653-V","article-title":"Perinatal hypoxic ischemic encephalopathy affects the proportion of GABA-immunoreactive neurons in the cerebral cortex of the rat","volume":"592","author":"Romijn","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0250","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/epi.12646","article-title":"Characterization of neonatal seizures in an animal model of hypoxic\u2013ischemic encephalopathy","volume":"55","author":"Sampath","year":"2014","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2015.08.023_bb0255","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1528-1167.2012.03481.x","article-title":"Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy","volume":"53","author":"Sanchez","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2015.08.023_bb0260","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nbt.2842","article-title":"CRISPR-Cas systems for editing, regulating and targeting genomes","volume":"32","author":"Sander","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0265","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1177\/0883073807303072","article-title":"Do seizures affect the developing brain? Lessons from the laboratory","volume":"22","author":"Sankar","year":"2007","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0270","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1073\/pnas.94.8.4103","article-title":"Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches","volume":"94","author":"Schauwecker","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.023_bb0275","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1172\/JCI11223","article-title":"Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1","volume":"106","author":"Semenza","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2015.08.023_bb0280","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1073\/pnas.1222738110","article-title":"Conservation and divergence in the transcriptional programs of the human and mouse immune systems","volume":"110","author":"Shay","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.023_bb0285","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ana.21167","article-title":"Neonatal seizures","volume":"62","author":"Silverstein","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0290","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/ana.21517","article-title":"Delayed neural network degeneration after neonatal hypoxia\u2013ischemia","volume":"64","author":"Stone","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.08.023_bb0295","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1073\/pnas.1208010110","article-title":"Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures","volume":"110","author":"Sun","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.08.023_bb0300","doi-asserted-by":"crossref","first-page":"e35885","DOI":"10.1371\/journal.pone.0035885","article-title":"The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway","volume":"7","author":"Talos","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2015.08.023_bb0305","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1523\/JNEUROSCI.18-11-04285.1998","article-title":"Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model","volume":"18","author":"Toth","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0310","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.siny.2013.05.008","article-title":"Epidemiology and aetiology of neonatal seizures","volume":"18","author":"Vasudevan","year":"2013","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.nbd.2015.08.023_bb0315","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1007\/s11064-011-0565-4","article-title":"Downregulation of hippocampal GABA after hypoxia-induced seizures in neonatal rats","volume":"36","author":"Wang","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2015.08.023_bb0320","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.neurobiolaging.2011.07.007","article-title":"Aging impairs hippocampus-dependent long-term memory for object location in mice","volume":"33","author":"Wimmer","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.08.023_bb0325","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000069049","article-title":"Prolonged neonatal seizures exacerbate hypoxic\u2013ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release","volume":"24","author":"Yager","year":"2002","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.nbd.2015.08.023_bb0330","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neulet.2004.08.044","article-title":"Impaired SynGAP expression and long-term spatial learning and memory in hippocampal CA1 area from rats previously exposed to perinatal hypoxia-induced insults: beneficial effects of A68930","volume":"371","author":"Yang","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2015.08.023_bb0335","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2014.03.005","article-title":"Impact of transient acute hypoxia on the developing mouse EEG","volume":"68","author":"Zanelli","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.08.023_bb0340","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ng859","article-title":"c-fos regulates neuronal excitability and survival","volume":"30","author":"Zhang","year":"2002","journal-title":"Nat. Genet."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:09:12Z","timestamp":1760850552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115300437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":70,"alternative-id":["S0969996115300437"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.023","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}