{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:29:45Z","timestamp":1792045785760,"version":"4.4.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS051715"],"award-info":[{"award-number":["NS051715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG030539"],"award-info":[{"award-number":["AG030539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13SDG16860017"],"award-info":[{"award-number":["13SDG16860017"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["NIRG-12-240372"],"award-info":[{"award-number":["NIRG-12-240372"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ZEN-14-283969"],"award-info":[{"award-number":["ZEN-14-283969"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Blas Frangione Foundation New Investigator Research Grant"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.nbd.2015.11.006","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T16:55:18Z","timestamp":1447347318000},"page":"29-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-222X","authenticated-orcid":false,"given":"Silvia","family":"Fossati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Giannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Solesio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Cocklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ghiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agueda","family":"Rostagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.11.006_bb0005","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.neuropharm.2011.06.010","article-title":"Enhancing effects of acetazolamide on neuronal activity correlate with enhanced visual processing ability in humans","volume":"61","author":"Aamand","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2015.11.006_bb0010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/febs.12653","article-title":"Structural determinants of the hydrogen peroxide permeability of aquaporins","volume":"281","author":"Almasalmeh","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2015.11.006_bb0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.mito.2007.06.001","article-title":"Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease","volume":"7","author":"Atamna","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.nbd.2015.11.006_bb0020","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3233\/JAD-121711","article-title":"Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease","volume":"34","author":"Balietti","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12017-013-8268-4","article-title":"Beta-amyloid-evoked apoptotic cell death is mediated through MKK6\u2013p66shc pathway","volume":"16","author":"Bashir","year":"2014","journal-title":"Neruomol. Med."},{"key":"10.1016\/j.nbd.2015.11.006_bb0030","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neurobiolaging.2004.09.022","article-title":"Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment","volume":"26","author":"Beal","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.11.006_bb0035","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1152\/jappl.1988.65.1.422","article-title":"Effects of acetazolamide on cerebral acid\u2013base balance","volume":"65","author":"Bickler","year":"1988","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.nbd.2015.11.006_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/6514","article-title":"Neuroprotection by a caspase inhibitor in acute bacterial meningitis","volume":"5","author":"Braun","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2015.11.006_bb0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature09788","article-title":"Caspase signalling controls microglia activation and neurotoxicity","volume":"472","author":"Burguillos","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.11.006_bb0055","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.11.006_bb0060","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1111\/febs.12813","article-title":"The coexistence of an equal amount of Alzheimer's amyloid-beta 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway","volume":"281","author":"Chang","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2015.11.006_bb0065","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/j.1471-4159.2005.03503.x","article-title":"Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo","volume":"95","author":"Choi","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.11.006_bb0070","doi-asserted-by":"crossref","first-page":"18258","DOI":"10.1073\/pnas.0509276102","article-title":"Solvent and mutation effects on the nucleation of amyloid beta-protein folding","volume":"102","author":"Cruz","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.11.006_bb0075","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1097\/00001756-199908200-00030","article-title":"Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration","volume":"10","author":"Cutillas","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2015.11.006_bb0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nn.2709","article-title":"Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease","volume":"14","author":"D'Amelio","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0085","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.11.006_bb0090","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2353\/ajpath.2008.070429","article-title":"Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation","volume":"172","author":"Ding","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0095","doi-asserted-by":"crossref","first-page":"18670","DOI":"10.1073\/pnas.1006586107","article-title":"Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model","volume":"107","author":"Du","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.11.006_bb0100","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.expneurol.2011.03.008","article-title":"A selective role for ARMS\/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons","volume":"229","author":"Duffy","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0105","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0006-2952(03)00534-3","article-title":"Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease","volume":"66","author":"Eckert","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0110","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1196\/annals.1299.113","article-title":"Increased apoptotic cell death in sporadic and genetic Alzheimer's disease","volume":"1010","author":"Eckert","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0115","doi-asserted-by":"crossref","first-page":"C246","DOI":"10.1152\/ajpcell.00516.2003","article-title":"Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers","volume":"287","author":"Forman","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1096\/fj.09-139584","article-title":"Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls","volume":"24","author":"Fossati","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2015.11.006_bb0125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000332821","article-title":"Insights into caspase-mediated apoptotic pathways induced by amyloid-beta in cerebral microvascular endothelial cells","volume":"10","author":"Fossati","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0130","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1038\/cddis.2012.55","article-title":"TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Abeta","volume":"3","author":"Fossati","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0135","doi-asserted-by":"crossref","DOI":"10.1042\/BJ20130652","article-title":"Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-beta and the Asparagine 23 Iowa mutation","author":"Fossati","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2015.11.006_bb0140","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJMra022366","article-title":"Apoptosis and caspases in neurodegenerative diseases","volume":"348","author":"Friedlander","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2015.11.006_bb0145","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1093\/hmg\/ddp358","article-title":"Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy","volume":"18","author":"Giacomotto","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2015.11.006_bb0150","doi-asserted-by":"crossref","first-page":"26246","DOI":"10.1074\/jbc.M113.476895","article-title":"Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction","volume":"288","author":"Gill","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.11.006_bb0155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000016027","article-title":"The dose\u2013response relationship of acetazolamide on the cerebral blood flow in normal subjects","volume":"10","author":"Grossmann","year":"2000","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0160","doi-asserted-by":"crossref","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.11.006_bb0165","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1073\/pnas.0507900102","article-title":"Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1","volume":"102","author":"Kim","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.11.006_bb0170","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.bpj.2014.07.074","article-title":"Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release","volume":"107","author":"Kim","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.nbd.2015.11.006_bb0175","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/cr.2011.55","article-title":"Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation","volume":"21","author":"Lee","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.nbd.2015.11.006_bb0180","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3109\/10715762.2012.678340","article-title":"Protective effect of Homer 1a against hydrogen peroxide-induced oxidative stress in PC12 cells","volume":"46","author":"Luo","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.nbd.2015.11.006_bb0185","doi-asserted-by":"crossref","first-page":"28294","DOI":"10.1074\/jbc.M212265200","article-title":"Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway","volume":"278","author":"Marques","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.11.006_bb0190","doi-asserted-by":"crossref","first-page":"e103606","DOI":"10.1371\/journal.pone.0103606","article-title":"A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease","volume":"9","author":"Modi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2015.11.006_bb0195","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","article-title":"Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.11.006_bb0200","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbadis.2009.10.007","article-title":"Mitochondria: a therapeutic target in neurodegeneration","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.11.006_bb0205","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1038\/cddis.2013.503","article-title":"Oligomeric amyloid beta induces IL-1beta processing via production of ROS: implication in Alzheimer's disease","volume":"4","author":"Parajuli","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1750-1326-9-41","article-title":"Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-beta oligomers and no plaque pathology","volume":"9","author":"Price","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2015.11.006_bb0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0969-9961(03)00002-0","article-title":"Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies","volume":"12","author":"Ryu","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0220","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.freeradbiomed.2006.12.004","article-title":"Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action","volume":"42","author":"Saito","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2015.11.006_bb0225","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1089\/ars.2012.5039","article-title":"Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease","volume":"18","author":"Santos","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2015.11.006_bb0230","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/sj.cdd.4400420","article-title":"Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia","volume":"5","author":"Schulz","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2015.11.006_bb0235","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbrc.2013.09.086","article-title":"High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: implications for cerebral microvascular disease in diabetes","volume":"440","author":"Shah","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2015.11.006_bb0240","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1124\/jpet.112.201400","article-title":"Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis","volume":"344","author":"Shah","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2015.11.006_bb0245","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/exnr.1995.1025","article-title":"Evidence for apoptotic cell death in Alzheimer's disease","volume":"133","author":"Smale","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0250","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbadis.2012.07.009","article-title":"The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease","volume":"1832","author":"Solesio","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2015.11.006_bb0255","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1476-5381.2012.01994.x","article-title":"3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway","volume":"168","author":"Solesio","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0260","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yexcr.2008.11.002","article-title":"Dutch and Arctic mutant peptides of beta amyloid(1\u201340) differentially affect the FGF-2 pathway in brain endothelium","volume":"315","author":"Solito","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.nbd.2015.11.006_bb0265","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)65460-0","article-title":"Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death","volume":"155","author":"Stadelmann","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"Suppl. 2","key":"10.1016\/j.nbd.2015.11.006_bb0270","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.3233\/JAD-2010-100339","article-title":"The Alzheimer's disease mitochondrial cascade hypothesis","volume":"20","author":"Swerdlow","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2015.11.006_bb0275","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(98)01618-4","article-title":"Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation-induced apoptosis","volume":"442","author":"Tada-Oikawa","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2015.11.006_bb0280","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s00018-009-8746-x","article-title":"Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells","volume":"66","author":"Viana","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0285","doi-asserted-by":"crossref","first-page":"25945","DOI":"10.1074\/jbc.274.36.25945","article-title":"Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates","volume":"274","author":"Walsh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2015.11.006_bb0290","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.1832501100","article-title":"Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease","volume":"100","author":"Wang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.11.006_bb0295","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1523\/JNEUROSCI.1867-08.2008","article-title":"Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0300","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1161\/STROKEAHA.108.540765","article-title":"Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury","volume":"40","author":"Wang","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2015.11.006_bb0305","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/14656566.9.1.119","article-title":"High hopes at high altitudes: pharmacotherapy for acute mountain sickness and high-altitude cerebral and pulmonary oedema","volume":"9","author":"Wright","year":"2008","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.nbd.2015.11.006_bb0310","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/NEN.0b013e3181d1afe4","article-title":"Loss of neuronal protein expression in mouse hippocampus after irradiation","volume":"69","author":"Wu","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.11.006_bb0315","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1523\/JNEUROSCI.1836-13.2013","article-title":"Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model","volume":"33","author":"Xie","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0320","article-title":"Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1\/eIF4E pathways, leading to neuronal apoptosis","author":"Zhou","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.nbd.2015.11.006_bb0325","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/417074a","article-title":"Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice","volume":"417","author":"Zhu","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.11.006_bb0330","first-page":"437","article-title":"Cytochrome C release and apoptosis in neonatal rat cerebral hypoxia\u2013ischemia","volume":"42","author":"Zhu","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.nbd.2015.11.006_bb0335","doi-asserted-by":"crossref","first-page":"e53117","DOI":"10.1371\/journal.pone.0053117","article-title":"Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-beta peptide injection in rats","volume":"8","author":"Zussy","year":"2013","journal-title":"PLoS One"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115300851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T09:48:47Z","timestamp":1567331327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115300851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":67,"alternative-id":["S0969996115300851"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.11.006","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}