{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:23:48Z","timestamp":1786994628501,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2010-2316671"],"award-info":[{"award-number":["GR-2010-2316671"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2013-02357386"],"award-info":[{"award-number":["RF-2013-02357386"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RBFR13S4LE_002"],"award-info":[{"award-number":["RBFR13S4LE_002"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2014-0660"],"award-info":[{"award-number":["2014-0660"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.nbd.2015.11.022","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T12:45:53Z","timestamp":1448628353000},"page":"140-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms"],"prefix":"10.1016","volume":"86","author":[{"given":"Veronica","family":"Ghiglieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Cacace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pendolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mellone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stanic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Tronci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camino","family":"Fidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Stancampiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolo","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gardoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Usiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-1021","authenticated-orcid":false,"given":"Barbara","family":"Picconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2015.11.022_bb0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/syn.20195","article-title":"Effects of sarizotan on the corticostriatal glutamate pathways","volume":"58","author":"Antonelli","year":"2005","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2015.11.022_bb0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0006-8993(95)01281-8","article-title":"Aromatic L-amino acid decarboxylase is present in serotonergic fibers of the striatum of the rat. A double-labeling immunofluorescence study","volume":"706","author":"Arai","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.20296","article-title":"Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia","volume":"57","author":"Aubert","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0020","doi-asserted-by":"crossref","first-page":"17921","DOI":"10.1523\/JNEUROSCI.2664-12.2012","article-title":"Rebalance of striatal NMDA\/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease","volume":"32","author":"Bagetta","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/mds.25366","article-title":"Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia","volume":"28","author":"Bezard","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2015.11.022_bb0030","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/jnr.21978","article-title":"Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats","volume":"87","author":"Bishop","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3940(92)90628-K","article-title":"Coactivation of D1 and D2 dopamine receptors is required for long-term synaptic depression in the striatum","volume":"142","author":"Calabresi","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2015.11.022_bb0040","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1460-9568.1992.tb00119.x","article-title":"Long-term potentiation in the striatum is unmasked by removing the voltage-dependent magnesium block of NMDA receptor channels","volume":"4","author":"Calabresi","year":"1992","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0045","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S1474-4422(06)70600-7","article-title":"A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance","volume":"5","author":"Calabresi","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0050","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1474-4422(10)70218-0","article-title":"Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap","volume":"9","author":"Calabresi","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0055","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/nn.3743","article-title":"Direct and indirect pathways of basal ganglia: a critical reappraisal","volume":"17","author":"Calabresi","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fnbeh.2013.00175","article-title":"Rodent models of Parkinson's disease: beyond the motor symptomatology","volume":"7","author":"Campos","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuroscience.2011.07.070","article-title":"Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesia","volume":"198","author":"Carta","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.11.022_bb0070","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fneur.2014.00078","article-title":"Serotonin system implication in l-DOPA-induced dyskinesia: from animal models to clinical investigations","volume":"5","author":"Carta","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0075","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/brain\/awm082","article-title":"Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats","volume":"130","author":"Carta","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.11.022_bb0080","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0079-6123(08)00922-9","article-title":"Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias","volume":"172","author":"Carta","year":"2008","journal-title":"Prog. Brain Res."},{"issue":"Suppl 1","key":"10.1016\/j.nbd.2015.11.022_bb0085","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1002\/mds.22792","article-title":"Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease","volume":"25","author":"Carta","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2015.11.022_bb0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1750-1326-8-14","article-title":"Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits","volume":"8","author":"Carvalho","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2015.11.022_bb0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tins.2007.03.005","article-title":"Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia","volume":"30","author":"Cenci","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0079-6123(10)83011-0","article-title":"Maladaptive striatal plasticity in L-DOPA-induced dyskinesia","volume":"183","author":"Cenci","year":"2010","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0105","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1152\/jn.1999.82.6.3575","article-title":"Unilateral dopamine denervation blocks corticostriatal LTP","volume":"82","author":"Centonze","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0110","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biopsych.2014.04.002","article-title":"Derangement of Ras-Guanine Nucleotide-Releasing Factor 1 (Ras-GRF1) and extracellular signal-regulated kinase (ERK) dependent striatal plasticity in L-DOPA-induced dyskinesia","volume":"77","author":"Cerovic","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2015.11.022_bb0115","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.1073\/pnas.94.13.7036","article-title":"In vivo activity-dependent plasticity at cortico-striatal connections: evidence for physiological long-term potentiation","volume":"94","author":"Charpier","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2015.11.022_bb0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/157015906776359540","article-title":"Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology","volume":"4","author":"Ciranna","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0125","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.biopsych.2009.04.025","article-title":"Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation","volume":"66","author":"Darmopil","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2015.11.022_bb0130","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn1632","article-title":"Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models","volume":"9","author":"Day","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JPD-120155","article-title":"mTOR inhibition alleviates L-DOPA-induced dyskinesia in parkinsonian rats","volume":"3","author":"Decressac","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0140","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.neuropharm.2008.08.031","article-title":"Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat","volume":"55","author":"Dupre","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0145","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.expneurol.2011.02.012","article-title":"Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats","volume":"229","author":"Dupre","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0150","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/cn300234z","article-title":"Effects of 5-HT1A receptor stimulation on D1 receptor agonist-induced striatonigral activity and dyskinesia in hemiparkinsonian rats","volume":"4","author":"Dupre","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0155","doi-asserted-by":"crossref","first-page":"11089","DOI":"10.1523\/JNEUROSCI.1616-09.2009","article-title":"Dopamine is necessary for cue-dependent fear conditioning","volume":"29","author":"Fadok","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fnbeh.2011.00071","article-title":"L-DOPA-induced dyskinesia and abnormal signaling in striatal medium spiny neurons: focus on dopamine D1 receptor-mediated transmission","volume":"5","author":"Feyder","year":"2011","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0165","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1038\/ncomms6316","article-title":"Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia","volume":"5","author":"Fieblinger","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2015.11.022_bb0170","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1523\/JNEUROSCI.21-05-01501.2001","article-title":"Hippocampal synaptic plasticity involves competition between Ca2+\/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor","volume":"21","author":"Gardoni","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0175","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1523\/JNEUROSCI.5326-05.2006","article-title":"A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia","volume":"26","author":"Gardoni","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0180","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1523\/JNEUROSCI.3921-08.2009","article-title":"Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression","volume":"29","author":"Gardoni","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0079-6123(10)83009-2","article-title":"Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson's disease","volume":"183","author":"Gardoni","year":"2010","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0190","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.neurobiolaging.2011.06.019","article-title":"Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias","volume":"33","author":"Gardoni","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2015.11.022_bb0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0306-4522(02)00809-6","article-title":"Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU\/ZN superoxide dismutase (GLY(93)\u2013>ALA) mutation","volume":"118","author":"Geracitano","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.11.022_bb0200","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nn832","article-title":"Postsynaptic endocannabinoid release is critical to long-term depression in the striatum","volume":"5","author":"Gerdeman","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0205","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/npp.2010.23","article-title":"TrkB\/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid","volume":"35","author":"Ghiglieri","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0210","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuroscience.2008.05.029","article-title":"Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectives","volume":"158","author":"Groc","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.11.022_bb0215","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.parkreldis.2004.02.010","article-title":"DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia","volume":"10","author":"Hakansson","year":"2004","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2015.11.022_bb0220","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuropharm.2004.11.008","article-title":"Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease","volume":"48","author":"Hallett","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0225","doi-asserted-by":"crossref","first-page":"S249","DOI":"10.1007\/s00415-010-5741-y","article-title":"A brief history of levodopa","volume":"257","author":"Hornykiewicz","year":"2010","journal-title":"J. Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0230","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1113\/jphysiol.2010.191361","article-title":"Reversal of plasticity-like effects in the human motor cortex","volume":"588","author":"Huang","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0235","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00221-013-3621-2","article-title":"The serotonergic system in motor and non-motor manifestations of Parkinson's disease","volume":"230","author":"Huot","year":"2013","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0240","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1124\/pr.111.005678","article-title":"The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease","volume":"65","author":"Huot","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2015.11.022_bb0245","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S1474-4422(10)70212-X","article-title":"Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease","volume":"9","author":"Kehagia","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0250","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJM198804073181402","article-title":"Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and Clinical Implications","volume":"318","author":"Kish","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2015.11.022_bb0255","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2009.04.016","article-title":"NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro","volume":"1274","author":"Li","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0260","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1471-4159.2009.06556.x","article-title":"L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia","volume":"112","author":"Lindgren","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.11.022_bb0265","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00213-008-1452-9","article-title":"Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats","volume":"204","author":"Marin","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0270","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1523\/JNEUROSCI.6250-10.2011","article-title":"Serotonin induces long-term depression at corticostriatal synapses","volume":"31","author":"Mathur","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0275","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.nbd.2006.01.009","article-title":"Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine","volume":"22","author":"Meissner","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0280","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1101\/lm.80604","article-title":"Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe","volume":"11","author":"Middei","year":"2004","journal-title":"Learn. Mem."},{"key":"10.1016\/j.nbd.2015.11.022_bb0285","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00213-002-1121-3","article-title":"Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted rat","volume":"163","author":"Mignon","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0290","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1093\/brain\/awn235","article-title":"Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia","volume":"131","author":"Munoz","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.11.022_bb0295","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.expneurol.2009.05.033","article-title":"Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model","volume":"219","author":"Munoz","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0300","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.nbd.2010.01.012","article-title":"Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease","volume":"38","author":"Navailles","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0305","doi-asserted-by":"crossref","first-page":"14182","DOI":"10.1523\/JNEUROSCI.2149-10.2010","article-title":"Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition","volume":"30","author":"Paille","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0310","doi-asserted-by":"crossref","DOI":"10.1002\/mds.26326","article-title":"Eltoprazine prevents dyskinesias by reducing striatal glutamate and direct pathway neuron activity","author":"Paolone","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2015.11.022_bb0315","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1152\/jn.2000.84.3.1422","article-title":"Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum","volume":"84","author":"Partridge","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0320","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopsych.2005.05.044","article-title":"ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice","volume":"59","author":"Pavon","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2015.11.022_bb0325","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.nbd.2015.11.022_bb0330","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nn1040","article-title":"Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia","volume":"6","author":"Picconi","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0335","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2007.10.001","article-title":"l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation","volume":"29","author":"Picconi","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/brain\/awq342","article-title":"Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia","volume":"134","author":"Picconi","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.11.022_bb0345","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/brain\/awn322","article-title":"Levodopa enhances synaptic plasticity in the substantia nigra pars reticulata of Parkinson's disease patients","volume":"132","author":"Prescott","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.11.022_bb0350","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2014.08.002","article-title":"Lack of depotentiation at basal ganglia output neurons in PD patients with levodopa-induced dyskinesia","volume":"71","author":"Prescott","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0355","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1523\/JNEUROSCI.0852-07.2007","article-title":"Critical involvement of cAMP\/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia","volume":"27","author":"Santini","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0360","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1471-4159.2008.05831.x","article-title":"L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice","volume":"108","author":"Santini","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2015.11.022_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012322","article-title":"Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia","volume":"5","author":"Santini","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2015.11.022_bb0370","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0306-4522(94)90605-X","article-title":"Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat","volume":"59","author":"Sauer","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2015.11.022_bb0375","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1515\/DMDI.1990.8.1-2.85","article-title":"Neurochemical profile of eltoprazine","volume":"8","author":"Schipper","year":"1990","journal-title":"Drug Metabol. Drug Interact."},{"key":"10.1016\/j.nbd.2015.11.022_bb0380","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fnbeh.2014.00331","article-title":"Spontaneous locomotor activity and L-DOPA-induced dyskinesia are not linked in 6-OHDA parkinsonian rats","volume":"8","author":"Sgroi","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0385","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1160575","article-title":"Dichotomous dopaminergic control of striatal synaptic plasticity","volume":"321","author":"Shen","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.nbd.2015.11.022_bb0390","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0014-2999(90)90008-T","article-title":"The anti-aggressive drug eltoprazine preferentially binds to 5-HT1A and 5-HT1B receptor subtypes in rat brain: sensitivity to guanine nucleotides","volume":"187","author":"Sijbesma","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0395","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-2999(90)90549-L","article-title":"Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study","volume":"177","author":"Sijbesma","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2015.11.022_bb0400","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0006-8993(91)90355-Y","article-title":"Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig","volume":"555","author":"Sijbesma","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0405","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00213-006-0630-x","article-title":"Evaluation of reward processes in an animal model of depression","volume":"190","author":"Slattery","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0410","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1111\/j.1460-9568.2006.04758.x","article-title":"L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus","volume":"23","author":"Soghomonian","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0415","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nn.2994","article-title":"Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia","volume":"15","author":"Subramaniam","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2015.11.022_bb0420","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/brain\/awu409","article-title":"Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study","volume":"138","author":"Svenningsson","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2015.11.022_bb0425","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nbd.2013.08.014","article-title":"5-Hydroxy-tryptophan for the treatment of L-DOPA-induced dyskinesia in the rat Parkinson's disease model","volume":"60","author":"Tronci","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2015.11.022_bb0430","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbr.2015.06.034","article-title":"Effect of selective and non-selective serotonin receptor activation on l-DOPA-induced therapeutic efficacy and dyskinesia in parkinsonian rats","volume":"292","author":"Tronci","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2015.11.022_bb0435","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35041572","article-title":"Distinct functions of the two isoforms of dopamine D2 receptors","volume":"408","author":"Usiello","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2015.11.022_bb0440","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1212\/WNL.59.3.408","article-title":"Nonmotor fluctuations in Parkinson's disease: frequent and disabling","volume":"59","author":"Witjas","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2015.11.022_bb0445","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1073\/pnas.0711839105","article-title":"Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115301005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996115301005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T23:06:59Z","timestamp":1668726419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996115301005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":89,"alternative-id":["S0969996115301005"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2015.11.022","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2015.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}