{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:12:11Z","timestamp":1769577131574,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Stanley Medical Research Institute (SMRI), Chevy Chase, MD, USA"},{"name":"Silvio O. Conte","award":["MH-094268"],"award-info":[{"award-number":["MH-094268"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.nbd.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T02:30:36Z","timestamp":1457404236000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii"],"prefix":"10.1016","volume":"91","author":[{"given":"Geetha","family":"Kannan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChunXia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin L.","family":"Gressitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-646X","authenticated-orcid":false,"given":"Chinezimuzo","family":"Ihenatu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina N.","family":"Krasnova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Lud","family":"Cadet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily G.","family":"Severance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail V.","family":"Pletnikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2016.03.005_bb0005","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.biopsych.2010.09.022","article-title":"Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology","volume":"68","author":"Abazyan","year":"2010","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.nbd.2016.03.005_bb0010","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.npp.1300366","article-title":"Behavioral and neurochemical vulnerability during adolescence in mice: studies with nicotine","volume":"29","author":"Adriani","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2016.03.005_bb0015","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.biopsych.2010.05.028","article-title":"Early life programming and neurodevelopmental disorders","volume":"68","author":"Bale","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2016.03.005_bb0020","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01428-15","article-title":"Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous sytem","volume":"6","author":"Brooks","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.nbd.2016.03.005_bb0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.dr.2007.08.003","article-title":"The adolescent brain","volume":"28","author":"Casey","year":"2008","journal-title":"Dev. Rev."},{"key":"10.1016\/j.nbd.2016.03.005_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1196\/annals.1440.010","article-title":"The adolescent brain","volume":"1124","author":"Casey","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119280","article-title":"Chronic toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity","volume":"10","author":"Eells","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nbd.2016.03.005_bb0040","doi-asserted-by":"crossref","first-page":"18569","DOI":"10.1073\/pnas.1006980107","article-title":"Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms","volume":"107","author":"Faust","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0045","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/schbul\/sbl074","article-title":"Effects of toxoplasma on human behavior","volume":"33","author":"Flegr","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0050","first-page":"1095","article-title":"Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice","volume":"339","author":"Giovanoli","year":"2013"},{"key":"10.1016\/j.nbd.2016.03.005_bb0055","doi-asserted-by":"crossref","first-page":"e978","DOI":"10.1016\/j.ijid.2010.05.018","article-title":"Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia","volume":"14","author":"Hamidinejat","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.nbd.2016.03.005_bb0060","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/mp.2013.110","article-title":"Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood brain barrier integrity","volume":"19","author":"Hammer","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2016.03.005_bb0065","first-page":"110","article-title":"Higher perceived dominance in toxoplasma infected men\u2014a new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior","volume":"28","author":"Hodkova","year":"2007","journal-title":"Neuro. Endocrinol. Lett."},{"key":"10.1016\/j.nbd.2016.03.005_bb0075","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.tins.2009.05.007","article-title":"Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1","volume":"32","author":"Jaaro-Peled","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0080","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pbb.2011.01.013","article-title":"Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine","volume":"98","author":"Kameda","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2016.03.005_bb0085","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbs079","article-title":"Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspective","author":"Kannan","year":"2012","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0090","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14411\/fp.2010.019","article-title":"Toxoplasma gondii strain-dependent effects on mouse behaviour","volume":"57","author":"Kannan","year":"2010","journal-title":"Folia Parasitol."},{"key":"10.1016\/j.nbd.2016.03.005_bb0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nbd.2013.05.012","article-title":"Mouse models of gene-environment interactions in schizophrenia","volume":"57","author":"Kannan","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.03.005_bb0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainresbull.2010.04.006","article-title":"N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?","volume":"83","author":"Kantrowitz","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0105","article-title":"Anti-NMDA receptor encephalitics, autoimmunity, and psychosis","author":"Kayser","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.nbd.2016.03.005_bb0110","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1523\/JNEUROSCI.4722-05.2006","article-title":"A specific role for GLUN2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons","volume":"26","author":"Kinney","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpsychires.2012.11.018","article-title":"Prepulse inhibition in psychiatric disorders\u2013apart from schizophrenia","volume":"47","author":"Kohl","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.nbd.2016.03.005_bb0120","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0306-4522(99)00400-5","article-title":"Intracerebroventricular administration of substance P increases dopamine content in the brain of 6-hydroxydopamine-lesioned rats","volume":"95","author":"Krasnova","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2016.03.005_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0306-4522(01)00351-7","article-title":"Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL\/6J mice: complex roles for oxygen-based species and temperature regulation","volume":"107","author":"Krasnova","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2016.03.005_bb0130","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1017\/S0031182008004666","article-title":"Specificity of the Toxoplasma gondii-altered behaviour to definitive versus non-definitive host predation risk","volume":"135","author":"Lamberton","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.nbd.2016.03.005_bb0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1212\/WNL.0b013e318224afde","article-title":"Encephalitis and antibodies to synaptic and neuronal cell surface proteins","volume":"77","author":"Lancaster","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2016.03.005_bb0140","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00702-014-1193-3","volume":"121","author":"Levite","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2016.03.005_bb0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2015.09.003","article-title":"Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus","volume":"308","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2016.03.005_bb0150","first-page":"151","article-title":"Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit","volume":"19","author":"Miyamoto","year":"2004","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2016.03.005_bb0155","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1523\/JNEUROSCI.4825-12.2013","article-title":"Altered synaptic dynamics during normal brain aging","volume":"33","author":"Mostany","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1126\/science.1226931","article-title":"Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids","volume":"339","author":"Niwa","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nbd.2016.03.005_bb0165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dmm.014183","article-title":"Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity","volume":"7","author":"Parlog","year":"2014","journal-title":"Dis. Mod. and Mech."},{"key":"10.1016\/j.nbd.2016.03.005_bb0170","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/ana.23689","article-title":"N-methyl-d-aspartate receptor antibodies in herpes simplex encephalitis","volume":"72","author":"Pruss","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2016.03.005_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2016.03.005_bb0180","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.nbd.2012.07.005","article-title":"Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia","volume":"48","author":"Severance","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.03.005_bb0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/09687680801971367","article-title":"Assembly and forward trafficking of NMDA receptors (review)","volume":"25","author":"Stephenson","year":"2008","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.nbd.2016.03.005_bb0200","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2016.03.005_bb0205","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1523\/JNEUROSCI.4147-12.2013","article-title":"Periadolescent exposure to the NMDA antagonist MK-801 impairs the functional maturation of local GABAergic circuits in the adult prefrontal cortex","volume":"33","author":"Thomases","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.03.005_bb0210","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/schbul\/sbl050","article-title":"Antibodies to Toxoplasma gondii in patients with schiozphrenia: a meta-analysis","volume":"33","author":"Torrey","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0215","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/schbul\/sbs043","article-title":"Toxoplasma gondii and other risk factors for schizophrenia: an update","volume":"38","author":"Torrey","year":"2012","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-244X-12-37","article-title":"Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features","volume":"12","author":"Tsutsui","year":"2012","journal-title":"BMC Psychiatry."},{"key":"10.1016\/j.nbd.2016.03.005_bb0225","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neulet.2004.10.013","article-title":"Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice","volume":"373","author":"van den Buuse","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2016.03.005_bb0230","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0447.2006.00780.x","article-title":"Prevalence of toxoplasma infection in first-episode schizophrenia and comparison between toxoplasma-seropositive and toxoplasma-seronegative schizophrenia","volume":"114","author":"Wang","year":"2006","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.nbd.2016.03.005_bb0235","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/schbul\/sbl073","article-title":"The effect of Toxoplasma gondii on animal behavior: playing cat and mouse","volume":"33","author":"Webster","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2016.03.005_bb0240","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.biopsych.2003.10.018","article-title":"Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings","volume":"55","author":"Wynn","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2016.03.005_bb0245","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.micinf.2009.07.007","article-title":"Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring","volume":"11","author":"Xiao","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.nbd.2016.03.005_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2011.12.051","article-title":"Sex-specific changes in gene expression and behavior induced by chronic toxoplasma infection in mice","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2016.03.005_bb0255","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mp.2008.5","article-title":"Are some cases of psychosis caused by microbial agents? A review of the evidence","volume":"13","author":"Yolken","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2016.03.005_bb0260","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.arr.2013.02.001","article-title":"From development to dysfunction: microglia and the complement cascade in CNS homeostasis","volume":"12","author":"Zabel","year":"2013","journal-title":"Ageing Res. Rev."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116300493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116300493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T09:58:25Z","timestamp":1536919105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996116300493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":50,"alternative-id":["S0969996116300493"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2016.03.005","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}