{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:14:21Z","timestamp":1792149261452,"version":"4.4.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.nbd.2016.08.008","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T20:01:41Z","timestamp":1471723301000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Oxidative stress is increased in C. elegans models of Huntington\u2019s disease but does not contribute to polyglutamine toxicity phenotypes"],"prefix":"10.1016","volume":"96","author":[{"given":"Emily","family":"Machiela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan J.","family":"Dues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Senchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Van Raamsdonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2016.08.008_bb0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2202-13-86","article-title":"Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model","volume":"13","author":"Ajayi","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0010","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1046\/j.1471-4159.2000.0750840.x","article-title":"No evidence for increased oxidative damage to lipids, proteins, or DNA in Huntington's disease","volume":"75","author":"Alam","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.coph.2015.09.008","article-title":"Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis","volume":"26","author":"Andre","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0020","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1097\/00001756-200110290-00044","article-title":"Lipoic acid improves survival in transgenic mouse models of Huntington's disease","volume":"12","author":"Andreassen","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2016.08.008_bb0025","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2016.08.008_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2015.06.008","article-title":"SKN-1\/Nrf, stress responses, and aging in Caenorhabditis elegans","author":"Blackwell","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2016.08.008_bb0035","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease","volume":"79","author":"Bogdanov","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129727","article-title":"The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model","volume":"10","author":"Bonanomi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2016.08.008_bb0045","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1523\/JNEUROSCI.0990-06.2006","article-title":"Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model","volume":"26","author":"Brignull","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0050","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1089\/ars.2006.8.2061","article-title":"Oxidative damage in Huntington's disease pathogenesis","volume":"8","author":"Browne","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2016.08.008_bb0055","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington's disease","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0065","first-page":"1","article-title":"Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models","author":"Cooper","year":"2015","journal-title":"Nat. Partn. J. Park. Dis."},{"key":"10.1016\/j.nbd.2016.08.008_bb0070","first-page":"105","article-title":"Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors","volume":"64","author":"Cotto","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.nbd.2016.08.008_bb0075","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1101\/gad.504808","article-title":"Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans","volume":"22","author":"Doonan","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2016.08.008_bb0080","doi-asserted-by":"crossref","first-page":"777","DOI":"10.18632\/aging.100939","article-title":"Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways","volume":"8","author":"Dues","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nbd.2016.08.008_bb0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.96.1.179","article-title":"Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron","volume":"96","author":"Faber","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0090","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1046\/j.1471-4159.1997.69052064.x","article-title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","volume":"69","author":"Ferrante","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0095","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1523\/JNEUROSCI.20-12-04389.2000","article-title":"Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease","volume":"20","author":"Ferrante","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0100","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1523\/JNEUROSCI.22-05-01592.2002","article-title":"Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease","volume":"22","author":"Ferrante","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/dnares\/5.1.25","article-title":"A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans","volume":"5","author":"Fujii","year":"1998","journal-title":"DNA Res."},{"key":"10.1016\/j.nbd.2016.08.008_bb0110","first-page":"41","article-title":"The copper\/zinc superoxide dismutase gene of Caenorhabditis elegans","volume":"33","author":"Giglio","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.nbd.2016.08.008_bb0115","first-page":"37","article-title":"The manganese superoxide dismutase gene of Caenorhabditis elegans","volume":"33","author":"Giglio","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.nbd.2016.08.008_bb0120","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2008.06310.x","article-title":"Mechanisms of neurodegeneration in Huntington's disease","volume":"27","author":"Gil","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0125","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2174\/1389450115666140115113734","article-title":"The role of oxidative stress in Huntington's disease: are antioxidants good therapeutic candidates?","volume":"15","author":"Gil-Mohapel","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.nbd.2016.08.008_bb0130","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1242\/jcs.075119","article-title":"The mitochondrial UPR - protecting organelle protein homeostasis","volume":"123","author":"Haynes","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0135","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tcb.2011.06.008","article-title":"Taking a \"good\" look at free radicals in the aging process","volume":"21","author":"Hekimi","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0140","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0960-9822(01)00594-2","article-title":"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans","volume":"11","author":"Henderson","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0145","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000194318.74946.b6","article-title":"Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG","volume":"66","author":"Hersch","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2016.08.008_bb0150","doi-asserted-by":"crossref","first-page":"28652","DOI":"10.1074\/jbc.272.45.28652","article-title":"Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans","volume":"272","author":"Hunter","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0155","doi-asserted-by":"crossref","first-page":"41373","DOI":"10.1074\/jbc.M509142200","article-title":"Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS","volume":"280","author":"Jensen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jeb.090738","article-title":"The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease","volume":"217","author":"Jovaisaite","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0165","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0006-291X(03)01241-5","article-title":"Polyglutamine-expanded ataxin-1 recruits Cu\/Zn-superoxide dismutase into the nucleus of HeLa cells","volume":"307","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2016.08.008_bb0170","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00415-007-0611-y","article-title":"Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study","volume":"254","author":"Klepac","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0175","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/318207","article-title":"Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo","volume":"68","author":"Leavitt","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2016.08.008_bb0180","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.cub.2010.10.057","article-title":"Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity","volume":"20","author":"Lee","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2016.08.008_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001717","article-title":"HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration","volume":"11","author":"Mielcarek","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jns.2007.08.025","article-title":"Oxidative stress in neurodegeneration in dentatorubral-pallidoluysian atrophy","volume":"264","author":"Miyata","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0200","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1474-9726.2008.00371.x","article-title":"Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans","volume":"7","author":"Morcos","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.nbd.2016.08.008_bb0205","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/jb\/mvp166","article-title":"Signalling pathways in the unfolded protein response: development from yeast to mammals","volume":"146","author":"Mori","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0210","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0215","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.231476398","article-title":"Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death","volume":"98","author":"Parker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0220","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbagen.2009.06.003","article-title":"Is the oxidative stress theory of aging dead?","volume":"1790","author":"Perez","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2016.08.008_bb0225","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(00)02082-5","article-title":"Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease","volume":"862","author":"Perez-Severiano","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2016.08.008_bb0230","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(99)00578-9","article-title":"Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex","volume":"272","author":"Polidori","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2016.08.008_bb0235","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.tem.2010.02.006","article-title":"Hypoxia signaling and resistance in C. elegans","volume":"21","author":"Powell-Coffman","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.nbd.2016.08.008_bb0240","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1427.010","article-title":"Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows","volume":"1147","author":"Pratico","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0245","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1523\/JNEUROSCI.3599-14.2015","article-title":"Distinct Etiological Roles for Myocytes and Motor Neurons in a Mouse Model of Kennedy's Disease\/Spinobulbar Muscular Atrophy","volume":"35","author":"Ramzan","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0250","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/00001756-200307010-00015","article-title":"Ascorbate treatment attenuates the Huntington behavioral phenotype in mice","volume":"14","author":"Rebec","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2016.08.008_bb0255","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.100107297","article-title":"Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans","volume":"97","author":"Satyal","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004972","article-title":"Mitochondrial and cytoplasmic ROS have opposing effects on lifespan","volume":"11","author":"Schaar","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2016.08.008_bb0265","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2016.08.008_bb0270","doi-asserted-by":"crossref","DOI":"10.2119\/molmed.2015.00221","article-title":"Overexpression of cystathionine gamma-lyase suppresses detrimental effects of spinocerebellar ataxia type 3","author":"Snijder","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.nbd.2016.08.008_bb0275","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2008.05.014","article-title":"Proteomic and oxidative stress analysis in human brain samples of Huntington disease","volume":"45","author":"Sorolla","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2016.08.008_bb0280","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/biof.1013","article-title":"Protein oxidation in Huntington disease","volume":"38","author":"Sorolla","year":"2012","journal-title":"Biofactors"},{"key":"10.1016\/j.nbd.2016.08.008_bb0285","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1196\/annals.1427.008","article-title":"Evidence of oxidant damage in Huntington's disease: translational strategies using antioxidants","volume":"1147","author":"Stack","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0290","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-4159.2005.03070.x","article-title":"Tryptophan metabolism and oxidative stress in patients with Huntington's disease","volume":"93","author":"Stoy","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2016.08.008_bb0295","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/dnares\/3.3.171","article-title":"Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans","volume":"3","author":"Suzuki","year":"1996","journal-title":"DNA Res."},{"key":"10.1016\/j.nbd.2016.08.008_bb0300","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2016.08.008_bb0305","doi-asserted-by":"crossref","first-page":"a004390","DOI":"10.1101\/cshperspect.a004390","article-title":"Protein folding in the cytoplasm and the heat shock response","volume":"2","author":"Vabulas","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0310","article-title":"Levels and location are crucial in determining the effect of ROS on lifespan","volume":"4","author":"Van Raamsdonk","year":"2015","journal-title":"WormBook"},{"key":"10.1016\/j.nbd.2016.08.008_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000361","article-title":"Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans","volume":"5","author":"Van Raamsdonk","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2016.08.008_bb0320","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1089\/ars.2010.3215","article-title":"Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?","volume":"13","author":"Van Raamsdonk","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2016.08.008_bb0325","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1073\/pnas.1116158109","article-title":"Superoxide dismutase is dispensable for normal animal lifespan","volume":"109","author":"Van Raamsdonk","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0330","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/hmg\/ddi147","article-title":"Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease","volume":"14","author":"Van Raamsdonk","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2016.08.008_bb0335","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.expneurol.2005.07.021","article-title":"Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease","volume":"196","author":"Van Raamsdonk","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0340","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2202-7-80","article-title":"Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease","volume":"7","author":"Van Raamsdonk","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0345","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.nbd.2007.01.006","article-title":"Testicular degeneration in Huntington disease","volume":"26","author":"Van Raamsdonk","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.08.008_bb0350","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1534\/genetics.110.115378","article-title":"Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage","volume":"185","author":"Van Raamsdonk","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2016.08.008_bb0355","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.nbd.2016.08.008_bb0360","doi-asserted-by":"crossref","first-page":"E2832","DOI":"10.1073\/pnas.1524727113","article-title":"Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans","volume":"113","author":"Wei","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.008_bb0365","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/gerona\/glp020","article-title":"SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation","volume":"64","author":"Yanase","year":"2009","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000556","article-title":"A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans","volume":"8","author":"Yang","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2016.08.008_bb0375","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1534\/genetics.107.080788","article-title":"A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans","volume":"177","author":"Yang","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.nbd.2016.08.008_bb0380","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/jnr.22011","article-title":"Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease","volume":"87","author":"Yu","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2016.08.008_bb0385","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1038\/sj.emboj.7601445","article-title":"Huntingtin inhibits caspase-3 activation","volume":"25","author":"Zhang","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2016.08.008_bb0390","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1196\/annals.1427.023","article-title":"Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance","volume":"1147","author":"Zhou","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0395","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.neuro.23.1.217","article-title":"Glutamine repeats and neurodegeneration","volume":"23","author":"Zoghbi","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.008_bb0400","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington's disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116302029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116302029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T16:36:21Z","timestamp":1568306181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996116302029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":80,"alternative-id":["S0969996116302029"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2016.08.008","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress is increased in C. elegans models of Huntington\u2019s disease but does not contribute to polyglutamine toxicity phenotypes","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2016.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}