{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:27:03Z","timestamp":1773296823944,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"NIDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","award":["A-6703"],"award-info":[{"award-number":["A-6703"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.nbd.2016.08.013","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T11:28:32Z","timestamp":1472470112000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease"],"prefix":"10.1016","volume":"96","author":[{"given":"Xavier","family":"Guitart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-0151","authenticated-orcid":false,"given":"Jordi","family":"Bonaventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Rea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Orr\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrezia","family":"Cellai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Dettori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicita","family":"Pedata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Brugarolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicent","family":"Casad\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Pang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manikandan","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijuang","family":"Chern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2016.08.013_bb0005","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1523\/JNEUROSCI.22-20-09122.2002","article-title":"The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity","volume":"22","author":"Blum","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2009.131","article-title":"Adenosine signaling and function in glial cells","volume":"17","author":"Boison","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2016.08.013_bb0015","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1073\/pnas.98.4.1970","article-title":"The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice","volume":"98","author":"Chen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2016.08.013_bb0020","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M413279200","article-title":"cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues","volume":"280","author":"Chiang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2016.08.013_bb0025","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nn1288","article-title":"The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference","volume":"7","author":"Choi","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0030","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nbd.2009.06.009","article-title":"A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease","volume":"35","author":"Dhaenens","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.08.013_bb0035","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1523\/JNEUROSCI.4454-03.2004","article-title":"Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices","volume":"24","author":"Di\u00f3genes","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00005072-198701000-00002","article-title":"Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease","volume":"46","author":"Ferrante","year":"1987","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nbd.2014.08.013","article-title":"Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease","volume":"71","author":"Ferrante","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.08.013_bb0050","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1523\/JNEUROSCI.13-12-05402.1993","article-title":"The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain","volume":"13","author":"Ferr\u00e9","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jad.2010.03.009","article-title":"Contribution of adenosine related genes to the risk of depression with disturbed sleep","volume":"126","author":"Gass","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2016.08.013_bb0065","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0306-4522(00)00008-7","article-title":"The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease","volume":"97","author":"Glass","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2016.08.013_bb0070","doi-asserted-by":"crossref","first-page":"e50717","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease","volume":"7","author":"Heikkinen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2016.08.013_bb0075","doi-asserted-by":"crossref","first-page":"20130594","DOI":"10.1098\/rstb.2013.0594","article-title":"Astrocytic adenosine: from synapses to psychiatric disorders","volume":"369","author":"Hines","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0080","doi-asserted-by":"crossref","first-page":"e20934","DOI":"10.1371\/journal.pone.0020934","article-title":"A new drug design targeting the adenosinergic system for Huntington's disease","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2016.08.013_bb0085","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nbd.2005.12.014","article-title":"Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats","volume":"22","author":"K\u00e1ntor","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.08.013_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/B978-0-12-801022-8.00010-6","article-title":"Adenosine receptors and Huntington's disease","volume":"119","author":"Lee","year":"2014","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0095","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s11064-013-1146-5","article-title":"Expression of nucleotide transporter in freshly isolated neurons and astrocytes from mouse brain","volume":"38","author":"Li","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2016.08.013_bb0100","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s00259-014-2724-8","article-title":"Cross sectional PET study of cerebral adenosine A1 receptors in premanifest and manifest Huntington's disease","volume":"41","author":"Matusch","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2016.08.013_bb0105","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1161\/01.STR.30.11.2448","article-title":"Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage","volume":"30","author":"Melani","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2016.08.013_bb0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2011.09.036","article-title":"Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum","volume":"233","author":"Melani","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0115","doi-asserted-by":"crossref","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2016.08.013_bb0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0301-0082(99)00019-2","article-title":"The selective vulnerability of striatopallidal neurons","volume":"5","author":"Mitchell","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0125","doi-asserted-by":"crossref","first-page":"743","DOI":"10.15252\/msb.20145304","article-title":"Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases","volume":"10","author":"Narayanan","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0130","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.expneurol.2011.08.005","article-title":"Functional changes in postsynaptic adenosine A(2A) receptors during early stages of a rat model of Huntington's disease","volume":"232","author":"Orr\u00fa","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/glia.20216","article-title":"Nucleoside transporter expression and function in cultured mouse astrocytes","volume":"52","author":"Peng","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2016.08.013_bb0140","doi-asserted-by":"crossref","first-page":"e0148839","DOI":"10.1371\/journal.pone.0148839","article-title":"Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 Knock-In mouse model of Huntington's disease","volume":"11","author":"Peng","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2016.08.013_bb0145","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1038\/sj.npp.1301001","article-title":"Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice","volume":"31","author":"Prediger","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2016.08.013_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/abbs\/gmt133","article-title":"Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein","volume":"46","author":"Qi","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.nbd.2016.08.013_bb0155","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1100\/tsw.2009.143","article-title":"Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway","volume":"9","author":"Quiroz","year":"2009","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.nbd.2016.08.013_bb0160","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuropharm.2015.11.006","article-title":"Purine nucleosides in neuroregeneration and neuroprotection","volume":"104","author":"Ribeiro","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2016.08.013_bb0165","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neuropharm.2013.12.010","article-title":"Adenosine A(2A) receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD)","volume":"79","author":"Rodrigues","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2016.08.013_bb0170","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12031-013-0064-y","article-title":"Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats","volume":"51","author":"Sari","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2016.08.013_bb0175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2013.05.013","article-title":"Association between caffeine intake and age at onset in Huntington's disease","volume":"58","author":"Simonin","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2016.08.013_bb0180","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/978-3-540-89615-9_17","article-title":"Adenosine receptors and neurological disease: neuroprotection and neurodegeneration","volume":"193","author":"Stone","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0185","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10048-010-0248-3","article-title":"Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1","volume":"11","author":"Taherzadeh-Fard","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.nbd.2016.08.013_bb0190","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2016.08.013_bb0195","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12017-013-8219-0","article-title":"Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease","volume":"15","author":"Villar-Men\u00e9ndez","year":"2013","journal-title":"Neruomol. Med."},{"key":"10.1016\/j.nbd.2016.08.013_bb0200","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/hmg\/ddg075","article-title":"Transgenic rat model of Huntington's disease","volume":"12","author":"von H\u00f6rsten","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2016.08.013_bb0205","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0210","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/j.1530-0277.2010.01187.x","article-title":"ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes","volume":"34","author":"Wu","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.nbd.2016.08.013_bb0215","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ana.21313","article-title":"Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms","volume":"63","author":"Yu","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2016.08.013_bb0220","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116302054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996116302054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T21:38:10Z","timestamp":1568324290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996116302054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":43,"alternative-id":["S0969996116302054"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2016.08.013","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2016.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}