{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:10:56Z","timestamp":1771625456844,"version":"3.50.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Govt. of India","doi-asserted-by":"crossref","award":["2010\/21\/02-BRNS\/2115"],"award-info":[{"award-number":["2010\/21\/02-BRNS\/2115"]}],"id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001403","name":"Institute of Technology Kanpur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.nbd.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T14:55:25Z","timestamp":1483628125000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models"],"prefix":"10.1016","volume":"100","author":[{"given":"Mamta","family":"Upadhyay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saloni","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratibha","family":"Bhadauriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-9177","authenticated-orcid":false,"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2017.01.002_bb0005","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/hmg\/ddq190","article-title":"Laforin, the most common protein mutated in Lafora disease, regulates autophagy","volume":"19","author":"Aguado","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2008.01.010","article-title":"Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations","volume":"211","author":"Amiott","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cub.2012.02.005","article-title":"Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons","volume":"22","author":"Cai","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0025","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ng1238","article-title":"Mutations in NHLRC1 cause progressive myoclonus epilepsy","volume":"35","author":"Chan","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.278","article-title":"Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin","volume":"5","author":"Charan","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2017.01.002_bb0040","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0045","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0050","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/emmm.201000102","article-title":"Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli","volume":"2","author":"Costa","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2017.01.002_bb0055","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/hmg\/ddr590","article-title":"Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy","volume":"21","author":"Criado","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0060","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0065","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1073\/pnas.0803998105","article-title":"The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and\/or inhibit fusion in Drosophila","volume":"105","author":"Deng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0070","doi-asserted-by":"crossref","first-page":"25372","DOI":"10.1074\/jbc.M110.148668","article-title":"Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin","volume":"285","author":"DePaoli-Roach","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0075","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/hmg\/ddu024","article-title":"Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease","volume":"23","author":"Duran","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0080","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1093\/hmg\/ddg340","article-title":"Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5(PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation","volume":"12","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0085","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/hmg\/11.11.1251","article-title":"Targeted disruption of the EPM2A gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice","volume":"11","author":"Ganesh","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10038-005-0321-1","article-title":"Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy","volume":"51","author":"Ganesh","year":"2006","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0095","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/hmg\/ddn398","article-title":"The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system","volume":"18","author":"Garyali","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0100","doi-asserted-by":"crossref","first-page":"8501","DOI":"10.1073\/pnas.0503285102","article-title":"Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin","volume":"102","author":"Gentry","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0105","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.0737556100","article-title":"Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants","volume":"100","author":"Greene","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0110","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2017.01.002_bb0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nature12748","article-title":"High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy","volume":"504","author":"Hasson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.01.002_bb0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0304-3940(84)90132-0","article-title":"Depolarization of the mitochondrial membrane potential increases free cytosolic calcium in synaptosomes","volume":"49","author":"Heinonen","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2017.01.002_bb0125","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.2004.02445.x","article-title":"Parkin attenuates manganese-induced dopaminergic cell death","volume":"89","author":"Higashi","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0130","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.2337\/db14-0758","article-title":"Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model","volume":"64","author":"Huang","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.nbd.2017.01.002_bb0135","doi-asserted-by":"crossref","first-page":"35661","DOI":"10.1074\/jbc.C000447200","article-title":"Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity","volume":"275","author":"Imai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1097-2765(02)00583-X","article-title":"CHIP is associated with parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity","volume":"10","author":"Imai","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2017.01.002_bb0145","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1073\/pnas.1113248109","article-title":"The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax","volume":"109","author":"Johnson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0150","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.cdd.4401260","article-title":"Dynamics of mitochondrial morphology in healthy cells and during apoptosis","volume":"10","author":"Karbowski","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2017.01.002_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.nbd.2017.01.002_bb0160","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4161\/auto.19522","article-title":"Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora disease","volume":"8","author":"Knecht","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2017.01.002_bb0165","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","article-title":"Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1","volume":"18","author":"Kong","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.01.002_bb0170","doi-asserted-by":"crossref","first-page":"13543","DOI":"10.1074\/jbc.M114.553321","article-title":"Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment","volume":"289","author":"Kumar","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0175","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.1073\/pnas.94.18.9705","article-title":"Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases","volume":"94","author":"Luo","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.01.002_bb0180","doi-asserted-by":"crossref","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","article-title":"Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation","volume":"284","author":"Lutz","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0185","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000101","article-title":"Late-onset Lafora disease with prominent parkinsonism due to a rare mutation in EPM2A","volume":"2","author":"Lynch","year":"2016","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0190","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0195","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","article-title":"Measurement of co-localization of objects in dual-colour confocal images","volume":"169","author":"Manders","year":"1993","journal-title":"J. Microsc."},{"key":"10.1016\/j.nbd.2017.01.002_bb0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/excr.1998.4290","article-title":"Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells","volume":"246","author":"Minamikawa","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.nbd.2017.01.002_bb0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/2470","article-title":"Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy","volume":"20","author":"Minassian","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0210","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/hmg\/ddm006","article-title":"Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment","volume":"16","author":"Mittal","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0215","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s12038-015-9570-0","article-title":"Interdependence of laforin and malin proteins for their stability and functions could underlie the molecular basis of locus heterogeneity in Lafora disease","volume":"40","author":"Mittal","year":"2015","journal-title":"J. Biosci."},{"key":"10.1016\/j.nbd.2017.01.002_bb0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/hmg\/ddi007","article-title":"Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress","volume":"14","author":"Moore","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0225","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0230","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/jcs.139394","article-title":"Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway","volume":"127","author":"Pennanen","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2017.01.002_bb0235","first-page":"334","article-title":"Myopathological findings in progressive myoclonus epilepsy","volume":"7","author":"Pierobon-Bormioli","year":"1981","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.nbd.2017.01.002_bb0240","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1091\/mbc.10.12.4403","article-title":"The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells","volume":"10","author":"Pitts","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2017.01.002_bb0245","doi-asserted-by":"crossref","first-page":"22657","DOI":"10.1074\/jbc.M109.009688","article-title":"Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease","volume":"284","author":"Puri","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0250","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/hmg\/ddr452","article-title":"Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease","volume":"21","author":"Puri","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0255","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1091\/mbc.e10-06-0551","article-title":"Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo","volume":"22","author":"Qi","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2017.01.002_bb0260","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.nbd.2014.08.016","article-title":"Phosphorylated tau potentiates Abeta-induced mitochondrial damage in mature neurons","volume":"71","author":"Quintanilla","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.01.002_bb0265","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1074\/jbc.M109.006312","article-title":"Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease","volume":"285","author":"Rao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0270","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s12035-014-8747-0","article-title":"Increased oxidative stress and impaired antioxidant response in Lafora disease","volume":"51","author":"Rom\u00e1-Mateo","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0275","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/iub.71","article-title":"Shaping mitochondria: the complex posttranslational regulation of the mitochondrial fission protein DRP1","volume":"60","author":"Santel","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1016\/j.nbd.2017.01.002_bb0280","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson's disease","volume":"54","author":"Schapira","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0285","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI200317741","article-title":"Neuronal degeneration and mitochondrial dysfunction","volume":"111","author":"Schon","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2017.01.002_bb0290","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1242\/jcs.082800","article-title":"Malin and laforin are essential components of a protein complex that protects cells from thermal stress","volume":"124","author":"Sengupta","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2017.01.002_bb0295","series-title":"Jasper's Basic Mechanisms of the Epilepsies","first-page":"874","article-title":"Progressive myoclonus epilepsy of Lafora","author":"Serratosa","year":"2012"},{"key":"10.1016\/j.nbd.2017.01.002_bb0300","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1074\/jbc.M112.416180","article-title":"Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease","volume":"288","author":"Sharma","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0305","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1128\/MCB.06353-11","article-title":"The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters","volume":"32","author":"Singh","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0310","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.4161\/rna.22708","article-title":"Lafora disease E3 ubiquitin ligase malin is recruited to the processing bodies and regulates the microRNA-mediated gene silencing process via the decapping enzyme Dcp1a","volume":"9","author":"Singh","year":"2012","journal-title":"RNA Biol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0315","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1091\/mbc.12.8.2245","article-title":"Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells","volume":"12","author":"Smirnova","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.nbd.2017.01.002_bb0320","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2017.01.002_bb0325","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1074\/jbc.M212235200","article-title":"Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function","volume":"278","author":"Tsai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002037","article-title":"PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease","volume":"7","author":"Turnbull","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.nbd.2017.01.002_bb0335","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ana.24104","article-title":"PTG protein depletion rescues malin-deficient Lafora disease in mouse","volume":"75","author":"Turnbull","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0340","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbrc.2015.06.018","article-title":"Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway","volume":"464","author":"Upadhyay","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2017.01.002_bb0345","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-012-1036-y","article-title":"Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion","volume":"125","author":"Vielhaber","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2017.01.002_bb0350","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.1074\/jbc.M110.144238","article-title":"Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0355","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2011.10.018","article-title":"PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility","volume":"147","author":"Wang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2017.01.002_bb0360","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0896-6273(95)90259-7","article-title":"An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria","volume":"14","author":"Wong","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2017.01.002_bb0365","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1172\/JCI37617","article-title":"Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation","volume":"119","author":"Xiong","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2017.01.002_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.7","article-title":"Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity","volume":"4","author":"Xu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2017.01.002_bb0375","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1074\/jbc.M407724200","article-title":"Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity","volume":"280","author":"Yamamoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.01.002_bb0380","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3\u03b2-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2017.01.002_bb0385","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/ars.2010.3284","article-title":"High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission","volume":"14","author":"Yu","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2017.01.002_bb0390","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Zuchner","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117300025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117300025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:56:37Z","timestamp":1536123397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996117300025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":78,"alternative-id":["S0969996117300025"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2017.01.002","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}