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Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.nbd.2017.06.006_bb0345","series-title":"Jasper's Basic Mechanisms of the Epilepsies","first-page":"1199","article-title":"Histopathology of human epilepsy","author":"de Lanerolle","year":"2012"},{"key":"10.1016\/j.nbd.2017.06.006_bb0350","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1037\/0735-7044.119.1.145","article-title":"The role of hippocampal subregions in detecting spatial novelty","volume":"119","author":"Lee","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2017.06.006_bb0355","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1101\/lm.66106","article-title":"Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance","volume":"13","author":"Leung","year":"2006","journal-title":"Learn. 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Sci."},{"key":"10.1016\/j.nbd.2017.06.006_bb0390","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.yebeh.2015.01.008","article-title":"Associative episodic memory and recollective processes in childhood temporal lobe epilepsy","volume":"44","author":"Martins","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2017.06.006_bb0395","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0920-1211(98)00016-3","article-title":"Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man","volume":"31","author":"Matagne","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2017.06.006_bb0400","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0306-4522(96)00516-7","volume":"77","author":"Mathern","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2017.06.006_bb0405","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0920-1211(98)00048-5","article-title":"Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy","volume":"32","author":"Mathern","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2017.06.006_bb0410","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1140263","article-title":"Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network","volume":"317","author":"McHugh","year":"2007","journal-title":"Science"},{"issue":"Suppl. 9","key":"10.1016\/j.nbd.2017.06.006_bb0415","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1528-1167.2007.01396.x","article-title":"The basic science of memory as it applies to epilepsy","volume":"48","author":"Meador","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2017.06.006_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2004.03.009","article-title":"Kindling and status epilepticus models of epilepsy: rewiring the brain","volume":"73","author":"Morimoto","year":"2004","journal-title":"Prog. 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Neurosci. Res."},{"key":"10.1016\/j.nbd.2017.06.006_bb0465","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1523\/JNEUROSCI.1574-14.2015","article-title":"Reactive astrogliosis causes the development of spontaneous seizures","volume":"35","author":"Robel","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.06.006_bb0470","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.eplepsyres.2010.09.002","article-title":"Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: correlation with other seizure and epilepsy models","volume":"92","author":"Rowley","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2017.06.006_bb0475","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2011.08.039","article-title":"Disambiguating the similar: the dentate gyrus and pattern separation","volume":"226","author":"Schmidt","year":"2012","journal-title":"Behav. 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