{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:56:07Z","timestamp":1775678167799,"version":"3.50.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2011-02351422"],"award-info":[{"award-number":["GR-2011-02351422"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2011-02347036"],"award-info":[{"award-number":["GR-2011-02347036"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.nbd.2017.07.019","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T09:02:55Z","timestamp":1501146175000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Interferon-\u03b3 causes mood abnormalities by altering cannabinoid CB1 receptor function in the mouse striatum"],"prefix":"10.1016","volume":"108","author":[{"given":"Georgia","family":"Mandolesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bullitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Fresegna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"De Vito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Dolcetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca R.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Strimpakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8545","authenticated-orcid":false,"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Musella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2017.07.019_bb0005","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1523\/JNEUROSCI.2916-06.2007","article-title":"Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum","volume":"27","author":"Ade","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0010","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1523\/JNEUROSCI.1289-05.2005","article-title":"Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32kDa at the protein kinase A site in striatal projection neurons","volume":"25","author":"Andersson","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00492","article-title":"Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"6","author":"Arellano","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0020","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1523\/JNEUROSCI.1554-07.2007","article-title":"The role of the dorsal striatum in reward and decision-making","volume":"27","author":"Balleine","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","article-title":"The mouse light\/dark box test","volume":"463","author":"Bourin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0163-1047(82)90289-8","article-title":"Nest-building behavior in two cerebellar mutant mice: staggerer and weaver","volume":"36","author":"Bulloch","year":"1982","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0035","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/1352458509106510","article-title":"Magnetic resonance evidence of cortical onset of multiple sclerosis","volume":"15","author":"Calabrese","year":"2009","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2017.07.019_bb0040","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ana.410370404","article-title":"The adhesion molecule and cytokine profile of multiple sclerosis lesions","volume":"37","author":"Cannella","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0045","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1093\/brain\/awm160","article-title":"The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis","volume":"130","author":"Centonze","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2017.07.019_bb0050","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1460-9568.2007.05433.x","article-title":"Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors","volume":"25","author":"Centonze","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0055","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1523\/JNEUROSCI.5804-08.2009","article-title":"Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis","volume":"29","author":"Centonze","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0065","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2017.07.019_bb0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0091-3057(81)90007-1","article-title":"Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines","volume":"15","author":"Crawley","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2017.07.019_bb0075","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nbd.2017.07.019_bb0080","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0085","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1523\/JNEUROSCI.1683-10.2010","article-title":"Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum","volume":"30","author":"De Chiara","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2013.06.069","article-title":"Interleukin-1\u03b2 alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum","volume":"250","author":"De Chiara","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2017.07.019_bb0095","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1212\/01.WNL.0000055926.69643.03","article-title":"Evidence of early cortical atrophy in MS: relevance to white matter changes and disability","volume":"60","author":"De Stefano","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2017.07.019_bb0100","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2017.07.019_bb0105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrneurol.2014.139","article-title":"The link between multiple sclerosis and depression","volume":"10","author":"Feinstein","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0115","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.nbd.2017.07.019_bb0120","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1093\/brain\/awt279","article-title":"Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats","volume":"136","author":"Gardner","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2017.07.019_bb0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.nbd.2014.11.022","article-title":"Dopaminergic dysfunction is associated with IL-1\u03b2-dependent mood alterations in experimental autoimmune encephalomyelitis","volume":"74","author":"Gentile","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.07.019_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0682-8","article-title":"Interaction between interleukin-1\u03b2 and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis","volume":"13","author":"Gentile","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2017.07.019_bb0135","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1152\/jn.2001.85.1.468","article-title":"CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum","volume":"85","author":"Gerdeman","year":"2001","journal-title":"J. Neurophysiol."},{"issue":"7","key":"10.1016\/j.nbd.2017.07.019_bb0140","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/jnnp.2010.230029","article-title":"Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression","volume":"82","author":"Gold","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2017.07.019_bb0145","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.expneurol.2012.07.010","article-title":"TNF-\u03b1-mediated anxiety in a mouse model of multiple sclerosis","volume":"237","author":"Haji","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2014.02.039","article-title":"Cytokine production profiles in chronic relapsing-remitting experimental autoimmune encephalomyelitis: IFN-gamma and TNF-alpha are important participants in the first attack but not in the relapse","volume":"340","author":"Hidaka","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0155","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2190\/PM.40.4.e","article-title":"IFN-gamma reduction by tricyclic antidepressants","volume":"40","author":"Himmerich","year":"2010","journal-title":"Int. J. Psychiatry Med."},{"key":"10.1016\/j.nbd.2017.07.019_bb0160","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1469-7793.2001.0731e.x","article-title":"Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons","volume":"532","author":"Huang","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2004.11.007","article-title":"Cytokines in multiple sclerosis: from bench to bedside","author":"Imitola","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2017.07.019_bb0170","first-page":"9","article-title":"Depression and multiple sclerosis: a potential way to understand the biology of major depressive illness","volume":"30","author":"Joffe","year":"2005","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0306-4530(01)00068-3","article-title":"Expression of tumor necrosis factor-alpha and interferon-gamma mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis","volume":"27","author":"Kahl","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nbd.2017.07.019_bb0180","first-page":"87","article-title":"Cholinergic and GABAergic interneurons in the striatum","volume":"17","author":"Kawaguchi","year":"1997","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.1016\/j.nbd.2017.07.019_bb0185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/8138","article-title":"Inhibitory control of neostriatal projection neurons by GABAergic interneurons","volume":"2","author":"Koos","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0190","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneuroim.2006.03.001","article-title":"Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons","volume":"175","author":"Lai","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0195","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.intimp.2006.03.015","article-title":"The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive disorder","volume":"6","author":"Lee","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0200","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/09540261.2013.813442","article-title":"Cytokines as biomarkers in depressive disorder: current standing and prospects","volume":"25","author":"Lichtblau","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.nbd.2017.07.019_bb0205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jad.2004.04.002","article-title":"The phenomenology and treatment of interferon-induced depression","volume":"82","author":"Loftis","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2017.07.019_bb0215","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nn2042","article-title":"Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum","volume":"11","author":"Maccarrone","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0220","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1471-4159.2009.05948.x","article-title":"Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum","volume":"109","author":"Maccarrone","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2017.07.019_bb0225","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrneurol.2015.222","article-title":"Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis","volume":"11","author":"Mandolesi","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0230","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.4049\/jimmunol.1302008","article-title":"Absence of IFN-gamma increases brain pathology in experimental autoimmune encephalomyelitis-susceptible DRB1*0301.DQ8 HLA transgenic mice through secretion of proinflammatory cytokine IL-17 and induction of pathogenic monocytes\/microglia into the central","volume":"193","author":"Mangalam","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0235","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-3999(03)00601-9","article-title":"Social support as a buffer in the relationship between treatment for depression and T-cell production of interferon gamma in patients with multiple sclerosis","volume":"57","author":"Mohr","year":"2004","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.nbd.2017.07.019_bb0240","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archneur.58.7.1081","article-title":"Treatment of depression is associated with suppression of nonspecific and antigen-specific T(H)1 responses in multiple sclerosis","volume":"58","author":"Mohr","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0245","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuroscience.2010.02.058","article-title":"Transient receptor potential vanilloid 1 channels control acetylcholine\/2-arachidonoylglicerol coupling in the striatum","volume":"167","author":"Musella","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2017.07.019_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2014.01.007","article-title":"Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis","volume":"79","author":"Musella","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2017.07.019_bb0255","doi-asserted-by":"crossref","DOI":"10.1177\/1352458515581875","article-title":"Linking synaptopathy and gray matter damage in multiple sclerosis","volume":"22","author":"Musella","year":"2016","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2017.07.019_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054666","article-title":"Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis","volume":"8","author":"Nistic\u00f2","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.07.019_bb0265","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1523\/JNEUROSCI.5032-08.2009","article-title":"Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin","volume":"29","author":"O'Connor","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0270","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1111\/j.1476-5381.2011.01658.x","article-title":"Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling","volume":"165","author":"Oddi","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0275","first-page":"1","article-title":"Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function","volume":"6736","author":"Ontaneda","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2017.07.019_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00539","article-title":"Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation","volume":"6","author":"Ottum","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0285","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1212\/WNL.37.7.1097","article-title":"Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system","volume":"37","author":"Panitch","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2017.07.019_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070274","article-title":"Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease","volume":"8","author":"Paumier","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.07.019_bb0300","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0305","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1068-607X(00)00082-2","article-title":"Interferon therapy in primary care","volume":"8","author":"Piper","year":"2001","journal-title":"Prim. Care Update Ob. Gyns."},{"key":"10.1016\/j.nbd.2017.07.019_bb0310","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.clineuro.2012.02.048","article-title":"Stimulated peripheral production of interferon-gamma is related to fatigue and depression in multiple sclerosis","volume":"114","author":"Pokryszko-Dragan","year":"2012","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.nbd.2017.07.019_bb0320","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.nbd.2017.07.019_bb0325","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/088922201750251981","article-title":"A phase III study of recombinant human interferon gamma to prevent opportunistic infections in advanced HIV disease","volume":"17","author":"Riddell","year":"2001","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.nbd.2017.07.019_bb0330","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/sj.bjp.0707561","article-title":"Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line","volume":"153","author":"Rimmerman","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0335","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1523\/JNEUROSCI.5346-07.2008","article-title":"Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum","volume":"28","author":"Rossi","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0340","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1124\/mol.110.064196","article-title":"Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition","volume":"78","author":"Rossi","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0345","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbi.2010.10.004","article-title":"Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis","volume":"25","author":"Rossi","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2017.07.019_bb0350","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ana.22512","article-title":"Interleukin-1\u03b2 causes synaptic hyperexcitability in multiple sclerosis","volume":"71","author":"Rossi","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0355","doi-asserted-by":"crossref","first-page":"13896","DOI":"10.1523\/JNEUROSCI.1515-12.2012","article-title":"Interleukin-1beta causes anxiety by interacting with the endocannabinoid system","volume":"32","author":"Rossi","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.07.019_bb0360","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1177\/1352458512440207","article-title":"Inflammation inhibits GABA transmission in multiple sclerosis","volume":"18","author":"Rossi","year":"2012","journal-title":"Mult. Scler. J."},{"issue":"Pt A","key":"10.1016\/j.nbd.2017.07.019_bb0365","first-page":"105","article-title":"The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission","volume":"96","author":"Rossi","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2017.07.019_bb0370","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1352458513498128","article-title":"Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration","volume":"20","author":"Rossi","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2017.07.019_bb0375","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/clin.1996.0012","article-title":"Increased CD56+ natural killer cells and related cytokines in major depression","volume":"78","author":"Seidel","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.nbd.2017.07.019_bb0380","series-title":"From Stress to Inflammation and Major Depressive Disorder a Social Signal Transduction Theory of Depression","first-page":"774","volume":"140","author":"Slavich","year":"2014"},{"key":"10.1016\/j.nbd.2017.07.019_bb0385","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nm0395-244","article-title":"The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis","volume":"1","author":"Sommer","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2017.07.019_bb0390","doi-asserted-by":"crossref","first-page":"E5038","DOI":"10.1073\/pnas.1505955112","article-title":"IFN-gamma ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation","volume":"112","author":"Sosa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.07.019_bb0395","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.07.019_bb0400","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0306-4522(97)00597-6","article-title":"Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum","volume":"85","author":"Szabo","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2017.07.019_bb0405","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s11910-016-0706-x","article-title":"Mental health comorbidity in MS: depression, anxiety, and bipolar disorder","volume":"16","author":"Turner","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.nbd.2017.07.019_bb0410","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0166-4328(02)00402-3","article-title":"Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning","volume":"142","author":"White","year":"2003","journal-title":"Behav. Brain Res."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117301717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117301717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T10:44:58Z","timestamp":1565347498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996117301717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":77,"alternative-id":["S0969996117301717"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2017.07.019","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon-\u03b3 causes mood abnormalities by altering cannabinoid CB1 receptor function in the mouse striatum","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2017.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}