{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:03:13Z","timestamp":1790424193374,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 HD064817"],"award-info":[{"award-number":["1R01 HD064817"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2905"],"award-info":[{"award-number":["2905"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","award":["U54 HD079125"],"award-info":[{"award-number":["U54 HD079125"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.nbd.2017.09.006","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T01:15:37Z","timestamp":1505783737000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"PA","title":["Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome"],"prefix":"10.1016","volume":"109","author":[{"given":"Chao-Yin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-5542","authenticated-orcid":false,"given":"Jacopo","family":"Di Lucente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chang","family":"Lien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Rogawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Maezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Way","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2017.09.006_bb0005","doi-asserted-by":"crossref","first-page":"18208","DOI":"10.1073\/pnas.1012104107","article-title":"Correction of respiratory disorders in a mouse model of Rett syndrome","volume":"107","author":"Abdala","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.09.006_bb0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/JP270966","article-title":"Deficiency of GABAergic synaptic inhibition in the Kolliker-Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome","volume":"594","author":"Abdala","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.ph.56.030194.000521","article-title":"Nucleus tractus solitarius\u2014gateway to neural circulatory control","volume":"56","author":"Andresen","year":"1994","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0020","doi-asserted-by":"crossref","first-page":"E7287","DOI":"10.1073\/pnas.1615330113","article-title":"Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome","volume":"113","author":"Banerjee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.09.006_bb0025","doi-asserted-by":"crossref","first-page":"19796","DOI":"10.1038\/srep19796","article-title":"Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice","volume":"6","author":"Bittolo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.nbd.2017.09.006_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0034-5687(95)00045-F","article-title":"Neurotransmitters in the CNS control of breathing","volume":"101","author":"Bonham","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0035","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1152\/japplphysiol.00143.2006","article-title":"Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes","volume":"101","author":"Bonham","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0040","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.resp.2006.02.010","article-title":"Plasticity of brainstem mechanisms of cough","volume":"152","author":"Bonham","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2011.12.012","article-title":"Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease","volume":"73","author":"Brickley","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2017.09.006_bb0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0034-5687(00)00153-5","article-title":"Neurotransmitters in central respiratory control","volume":"122","author":"Burton","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2017.09.006_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number","volume":"56","author":"Chao","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2017.09.006_bb0065","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.09.006_bb0070","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1113\/jphysiol.2004.076885","article-title":"Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats","volume":"562","author":"Chen","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0075","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2017.09.006_bb0080","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1523\/JNEUROSCI.4413-08.2009","article-title":"Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats","volume":"29","author":"Chen","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.09.006_bb0085","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2017.09.006_bb0090","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1440-1754.1999.355403.x","article-title":"Rett syndrome: clinical update and review of recent genetic advances","volume":"35","author":"Ellaway","year":"1999","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.nbd.2017.09.006_bb0095","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2017.09.006_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11920-010-0097-7","article-title":"The role of MeCP2 in brain development and neurodevelopmental disorders","volume":"12","author":"Gonzales","year":"2010","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.nbd.2017.09.006_bb0105","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2017.09.006_bb0110","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1523\/JNEUROSCI.2330-15.2016","article-title":"Progressive changes in a distributed neural circuit underlie breathing abnormalities in mice lacking MeCP2","volume":"36","author":"Huang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.09.006_bb0115","doi-asserted-by":"crossref","first-page":"C844","DOI":"10.1152\/ajpcell.00399.2012","article-title":"GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice","volume":"304","author":"Jin","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1164\/rccm.200308-1139OC","article-title":"Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P","volume":"169","author":"Joad","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.nbd.2017.09.006_bb0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.resp.2009.04.017","article-title":"Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth","volume":"168","author":"Katz","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0130","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1523\/JNEUROSCI.5503-09.2010","article-title":"Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice","volume":"30","author":"Kline","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.09.006_bb0135","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1172\/JCI37934","article-title":"The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders","volume":"119","author":"Levitt","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2017.09.006_bb2017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.nbd.2017.09.006_bb0140","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1152\/jn.00826.2007","article-title":"Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome","volume":"99","author":"Medrihan","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0145","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14199","article-title":"Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders","volume":"5","author":"Meng","year":"2016","journal-title":"elife"},{"key":"10.1016\/j.nbd.2017.09.006_bb0150","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1523\/JNEUROSCI.18-05-01693.1998","article-title":"Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells","volume":"18","author":"Nusser","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.09.006_bb0155","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1093\/hmg\/ddv217","article-title":"Rett syndrome: disruption of epigenetic control of postnatal neurological functions","volume":"24","author":"Pohodich","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.09.006_bb0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00359-011-0706-x","article-title":"Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species","volume":"198","author":"Sekizawa","year":"2012","journal-title":"J. Comp. Physiol. A."},{"key":"10.1016\/j.nbd.2017.09.006_bb0165","first-page":"R1153","article-title":"Protection of signal processing at low temperature in baroreceptive neurons in the nucleus tractus solitarius of Syrian hamsters, a hibernating species","volume":"305","author":"Sekizawa","year":"2013","journal-title":"Am. J. Physiol.-Reg I"},{"key":"10.1016\/j.nbd.2017.09.006_bb0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14198","article-title":"Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome","volume":"5","author":"Ure","year":"2016","journal-title":"elife"},{"key":"10.1016\/j.nbd.2017.09.006_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.resp.2011.02.002","article-title":"The benzodiazepine midazolam mitigates the breathing defects of Mecp2-deficient mice","volume":"177","author":"Voituron","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0180","doi-asserted-by":"crossref","first-page":"R1423","DOI":"10.1152\/ajpregu.00488.2001","article-title":"GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat","volume":"283","author":"Wasserman","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.nbd.2017.09.006_bb0185","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/hipo.20389","article-title":"The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability","volume":"18","author":"Zhang","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2017.09.006_bb0190","doi-asserted-by":"crossref","first-page":"18400","DOI":"10.1074\/jbc.M115.650465","article-title":"Methyl CpG binding protein 2 gene disruption augments tonic currents of gamma-aminobutyric acid receptors in locus coeruleus neurons: impact on neuronal excitability and breathing","volume":"290","author":"Zhong","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2017.09.006_bb0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s11689-016-9169-2","article-title":"Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome","volume":"8","author":"Zhong","year":"2016","journal-title":"J. Neurodev. Disord."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117302164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117302164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:10:25Z","timestamp":1760850625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996117302164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":40,"alternative-id":["S0969996117302164"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2017.09.006","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2017.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}