{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:21:11Z","timestamp":1790781671491,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100013107","name":"RIKEN Brain Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.nbd.2017.12.003","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T09:47:16Z","timestamp":1512640036000},"page":"180-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures"],"prefix":"10.1016","volume":"110","author":[{"given":"Matthieu","family":"Raveau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shimohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2017.12.003_bb0005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nbd.2005.12.006","article-title":"DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects","volume":"3","author":"Ahn","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.12.003_bb0010","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/hmg\/10.18.1915","article-title":"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome","volume":"10","author":"Altafaj","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002575","article-title":"Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A)","volume":"3","author":"Arqu\u00e9","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.12.003_bb0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2009.07.027","article-title":"Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice","volume":"36","author":"Arqu\u00e9","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.12.003_bb0025","doi-asserted-by":"crossref","first-page":"25893","DOI":"10.1074\/jbc.273.40.25893","article-title":"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases","volume":"273","author":"Becker","year":"1998","journal-title":"Biol. Chem."},{"key":"10.1016\/j.nbd.2017.12.003_bb0030","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0006-8993(79)90163-X","article-title":"A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures","volume":"163","author":"Ben-Ari","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2017.12.003_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.nbd.2005.02.004","article-title":"Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+\/\u2212 mouse","volume":"20","author":"Benavides-Piccione","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.12.003_bb0040","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1399-0004.2010.01544.x","article-title":"Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly","volume":"79","author":"van Bon","year":"2011","journal-title":"Clin. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/mp.2015.5","article-title":"Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID","volume":"21","author":"van Bon","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2017.12.003_bb0050","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/ejhg.2015.29","article-title":"Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A","volume":"23","author":"Bronicki","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0055","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1038\/ncomms5246","article-title":"Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2017.12.003_bb0060","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nbd.2017.12.003_bb0065","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/jmedgenet-2012-101251","article-title":"The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy","volume":"49","author":"Courcet","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0070","first-page":"1","article-title":"Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development","volume":"00","author":"Dang","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2017.12.003_bb0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-scale discovery of novel genetic causes of developmental disorders","volume":"519","author":"Deciphering Developmental Disorders Study","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.12.003_bb0080","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature21062","article-title":"Prevalence and architecture of de novo mutations in developmental disorders","volume":"542","author":"Deciphering Developmental Disorders Study","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.12.003_bb0085","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnbeh.2016.00104","article-title":"DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome","volume":"10","author":"Duchon","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0090","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1128\/MCB.22.18.6636-6647.2002","article-title":"Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice","volume":"22","author":"Fotaki","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.nbd.2017.12.003_bb0095","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1037\/0735-7044.118.4.815","article-title":"Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity","volume":"118","author":"Fotaki","year":"2004","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fncel.2014.00331","article-title":"DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1\/GluN2A receptors","volume":"8","author":"Grau","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0105","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1460-9568.2008.06092.x","article-title":"The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb\/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development","volume":"27","author":"H\u00e4mmerle","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0110","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1242\/dev.066167","article-title":"Transient expression of Mnb\/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling","volume":"138","author":"H\u00e4mmerle","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.nbd.2017.12.003_bb0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature11356","article-title":"Autistic-like behaviour in Scn1a+\/\u2212 mice and rescue by enhanced GABA-mediated neurotransmission","volume":"489","author":"Han","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.12.003_bb0120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20059.023","article-title":"MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders","author":"Harrington","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2017.12.003_bb0125","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-3565(24)29466-0","article-title":"Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action","volume":"298","author":"Huang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2017.12.003_bb0130","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ejhg.2015.71","article-title":"DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies","volume":"23","author":"Ji","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jnr.23279","article-title":"Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)","volume":"92","author":"Kaczmarski","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2017.12.003_bb0140","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1523\/JNEUROSCI.4243-05.2006","article-title":"Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies","volume":"26","author":"Kang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature21678","article-title":"Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1","volume":"543","author":"Krishnan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2017.12.003_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tins.2013.11.005","article-title":"A de novo convergence of autism genetics and molecular neuroscience","volume":"37","author":"Krumm","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0155","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.devcel.2008.10.014","article-title":"The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development","volume":"15","author":"Laguna","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.nbd.2017.12.003_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2015.03.009","article-title":"Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration","volume":"260","author":"L\u00e9vesque","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2017.12.003_bb0165","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.nbd.2017.12.003_bb0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(02)04069-6","article-title":"Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system","volume":"964","author":"Mart\u00ed","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2017.12.003_bb0175","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/cercor\/bhr362","article-title":"Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons","volume":"22","author":"Martinez de Lagran","year":"2012","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2017.12.003_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbr.2003.09.019","article-title":"Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat","volume":"146","author":"McAlonan","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2017.12.003_bb0185","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1601-183X.2007.00330.x","article-title":"Autism-like behavioral phenotypes in BTBR T+tf\/J mice","volume":"7","author":"McFarlane","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2017.12.003_bb0190","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ajhg.2008.03.001","article-title":"Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly","volume":"82","author":"M\u00f8ller","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0195","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/hmg\/ddi016","article-title":"Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome","volume":"14","author":"Moretti","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2017.12.003_bb0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13229-015-0003-6","article-title":"Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin","volume":"6","author":"Mosienko","year":"2015","journal-title":"Mol. Autism"},{"key":"10.1016\/j.nbd.2017.12.003_bb0205","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.neuron.2016.03.027","article-title":"Phosphorylation of \u03b2-tubulin by the Down syndrome kinase, minibrain\/DYRK1a, regulates microtubule dynamics and dendrite morphogenesis","volume":"90","author":"Ori-McKenney","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2017.12.003_bb0210","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.1227764","article-title":"Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders","volume":"338","author":"O'Roak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.nbd.2017.12.003_bb0215","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1471-4159.2012.07861.x","article-title":"Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11\u03b1","volume":"122","author":"Park","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2017.12.003_bb0220","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.nbd.2017.12.003_bb0225","doi-asserted-by":"crossref","first-page":"271ra8","DOI":"10.1126\/scitranslmed.3010257","article-title":"Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism","volume":"7","author":"Pe\u00f1agarikano","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2017.12.003_bb0230","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/j.1471-4159.2008.05576.x","article-title":"Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus","volume":"106","author":"Qu","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2017.12.003_bb0235","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.nbd.2007.06.003","article-title":"Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats","volume":"27","author":"Qu","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.12.003_bb0240","doi-asserted-by":"crossref","first-page":"e44816","DOI":"10.1371\/journal.pone.0044816","article-title":"Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits","volume":"7","author":"Roy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.12.003_bb0245","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1523\/JNEUROSCI.2517-15.2016","article-title":"Overexpression of Dyrk1A, a down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex","volume":"36","author":"Ruiz-Mejias","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003067","article-title":"Unusual repertoire of vocalizations in the BTBR T+tf\/J mouse model of autism","volume":"3","author":"Scattoni","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.12.003_bb0255","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biopsych.2016.06.008","article-title":"Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene","volume":"81","author":"Schoch","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2017.12.003_bb0260","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.29104","article-title":"The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation","volume":"13","author":"Soppa","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.nbd.2017.12.003_bb0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nbd.2014.04.016","article-title":"Excitation\/inhibition balance and learning are modified by Dyrk1a gene dosage","volume":"69","author":"Souchet","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2017.12.003_bb0270","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1601-183X.2005.00123.x","article-title":"Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome","volume":"4","author":"Spencer","year":"2005","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.nbd.2017.12.003_bb0275","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-0-444-63326-2.00005-3","article-title":"Mechanisms underlying epilepsies associated with sodium channel mutations","volume":"213","author":"Steinlein","year":"2014","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2017.12.003_bb0280","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1523\/JNEUROSCI.2852-13.2014","article-title":"Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a","volume":"34","author":"Thomazeau","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2017.12.003_bb0285","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cell.2013.04.025","article-title":"One-step generation of mice carrying mutations in multiple genes by CRISPR\/Cas-mediated genome engineering","volume":"153","author":"Wang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2017.12.003_bb0290","doi-asserted-by":"crossref","first-page":"e20631","DOI":"10.1371\/journal.pone.0020631","article-title":"Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior","volume":"6","author":"W\u00f6hr","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2017.12.003_bb0295","series-title":"Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability","first-page":"233","article-title":"Mutations of voltage-gated sodium channel genes SCN1A and SCN2A in epilepsy, intellectual disability, and autism","author":"Yamakawa","year":"2016"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117302814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996117302814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:03:29Z","timestamp":1771967009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996117302814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":59,"alternative-id":["S0969996117302814"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2017.12.003","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2017.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}